IL139616A0 - Recombinant (alpha)-l-iduronidase, methods for producing and purifying the same and methods for treating, diseases caused by deficiencies thereof - Google Patents

Recombinant (alpha)-l-iduronidase, methods for producing and purifying the same and methods for treating, diseases caused by deficiencies thereof

Info

Publication number
IL139616A0
IL139616A0 IL13961699A IL13961699A IL139616A0 IL 139616 A0 IL139616 A0 IL 139616A0 IL 13961699 A IL13961699 A IL 13961699A IL 13961699 A IL13961699 A IL 13961699A IL 139616 A0 IL139616 A0 IL 139616A0
Authority
IL
Israel
Prior art keywords
methods
iduronidase
recombinant
purifying
deficiencies
Prior art date
Application number
IL13961699A
Original Assignee
Harbor Ucla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Ucla filed Critical Harbor Ucla
Publication of IL139616A0 publication Critical patent/IL139616A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01076—L-Iduronidase (3.2.1.76)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
IL13961699A 1998-05-13 1999-05-07 Recombinant (alpha)-l-iduronidase, methods for producing and purifying the same and methods for treating, diseases caused by deficiencies thereof IL139616A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7820998A 1998-05-13 1998-05-13
US17097798A 1998-10-13 1998-10-13
PCT/US1999/010102 WO1999058691A2 (en) 1998-05-13 1999-05-07 Recombinant (alpha)-l-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof

Publications (1)

Publication Number Publication Date
IL139616A0 true IL139616A0 (en) 2002-02-10

Family

ID=26760239

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13961699A IL139616A0 (en) 1998-05-13 1999-05-07 Recombinant (alpha)-l-iduronidase, methods for producing and purifying the same and methods for treating, diseases caused by deficiencies thereof

Country Status (8)

Country Link
EP (1) EP1078075A2 (en)
JP (1) JP2002514429A (en)
CN (1) CN1300323A (en)
AU (1) AU4072499A (en)
BR (1) BR9910323A (en)
CA (1) CA2328518A1 (en)
IL (1) IL139616A0 (en)
WO (1) WO1999058691A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569661B1 (en) 1999-11-12 2003-05-27 Biomarin Pharmaceutical Inc. Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6426208B1 (en) 1999-11-12 2002-07-30 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6585971B1 (en) * 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
AU2001271941B2 (en) 2000-07-18 2007-03-01 Duke University Treatment of glycogen storage disease type II
US7442372B2 (en) * 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
CA2815212A1 (en) * 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
CN103487414A (en) * 2012-06-14 2014-01-01 北京和信非凡生物技术有限公司 Method, substrate and reagents for alpha-L-iduronidase activity detection
MX2015012739A (en) * 2013-03-15 2016-02-19 Univ Pennsylvania Compositions and methods for treating mpsi.
JP7360241B2 (en) 2016-02-03 2023-10-12 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Gene therapy to treat mucopolysaccharidosis type I
CA3049915A1 (en) * 2017-01-31 2018-08-09 Stephen YOO Treatment of mucopolysaccharidosis i with fully-human glycosylated human alpha-l-iduronidase (idua)
KR20240063170A (en) 2017-07-06 2024-05-09 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Aav9-mediated gene therapy for treating mucopolysaccharidosis type i
CN107699590A (en) * 2017-10-13 2018-02-16 成都中医药大学 A kind of method of Prepare restructuring people α L iduronases
CN115109790A (en) * 2021-03-23 2022-09-27 北京据德医药科技有限公司 Recombinant a-L-iduronate prase and preparation method thereof
CN114181318B (en) * 2021-11-08 2023-08-01 四川大学 Recombinant adeno-associated virus for tissue-specific expression of IDUA fusion protein penetrating blood brain barrier and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06504449A (en) * 1991-11-14 1994-05-26 ウイミンズ・アンド・チルドレンズ・ホスピタル Synthetic alpha-L-iduronidase and the gene sequence encoding it
ES2326705T3 (en) * 1995-09-14 2009-10-16 Virginia Tech Intellectual Properties, Inc. PRODUCTION OF LISOSOMIC ENZYMES IN EXPRESSION SYSTEMS BASED ON PLANTS.

Also Published As

Publication number Publication date
EP1078075A2 (en) 2001-02-28
JP2002514429A (en) 2002-05-21
CA2328518A1 (en) 1999-11-18
WO1999058691A2 (en) 1999-11-18
BR9910323A (en) 2001-01-30
CN1300323A (en) 2001-06-20
WO1999058691A3 (en) 2000-02-17
AU4072499A (en) 1999-11-29

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