CN104105485B - Acc抑制剂和其用途 - Google Patents

Acc抑制剂和其用途 Download PDF

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Publication number
CN104105485B
CN104105485B CN201280066192.5A CN201280066192A CN104105485B CN 104105485 B CN104105485 B CN 104105485B CN 201280066192 A CN201280066192 A CN 201280066192A CN 104105485 B CN104105485 B CN 104105485B
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compound
compounds
synthesis
inhibitors
mmol
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Chinese (zh)
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CN104105485A (zh
Inventor
杰拉尔丁·C·哈里曼
克雷格·E·马斯
詹姆斯·哈伍德
萨瑟斯·巴特
杰里米·罗伯特·格林伍德
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Gilead Apollo LLC
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Nimbus Apollo LLC
Gilead Apollo LLC
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Priority to CN201910342735.5A priority Critical patent/CN109970760B/zh
Priority to CN201710148365.2A priority patent/CN106905346B/zh
Publication of CN104105485A publication Critical patent/CN104105485A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280066192.5A 2011-11-11 2012-11-09 Acc抑制剂和其用途 Active CN104105485B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201910342735.5A CN109970760B (zh) 2011-11-11 2012-11-09 Acc抑制剂和其用途
CN201710148365.2A CN106905346B (zh) 2011-11-11 2012-11-09 Acc抑制剂和其用途

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161559023P 2011-11-11 2011-11-11
US61/559,023 2011-11-11
US201261615092P 2012-03-23 2012-03-23
US61/615,092 2012-03-23
US201261651878P 2012-05-25 2012-05-25
US61/651,878 2012-05-25
US201261675513P 2012-07-25 2012-07-25
US61/675,513 2012-07-25
PCT/US2012/064528 WO2013071169A1 (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201710148365.2A Division CN106905346B (zh) 2011-11-11 2012-11-09 Acc抑制剂和其用途
CN201910342735.5A Division CN109970760B (zh) 2011-11-11 2012-11-09 Acc抑制剂和其用途

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CN104105485A CN104105485A (zh) 2014-10-15
CN104105485B true CN104105485B (zh) 2017-04-12

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CN201710148365.2A Active CN106905346B (zh) 2011-11-11 2012-11-09 Acc抑制剂和其用途
CN201910342735.5A Active CN109970760B (zh) 2011-11-11 2012-11-09 Acc抑制剂和其用途

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EP (3) EP3628320B1 (enExample)
JP (4) JP6114297B2 (enExample)
KR (3) KR102172902B1 (enExample)
CN (3) CN104105485B (enExample)
AU (3) AU2012335088B2 (enExample)
BR (2) BR112014011351B1 (enExample)
CA (1) CA2855372C (enExample)
CL (1) CL2014001241A1 (enExample)
CY (2) CY1120224T1 (enExample)
DK (2) DK2776038T3 (enExample)
EA (2) EA030264B1 (enExample)
ES (3) ES2767956T3 (enExample)
HR (2) HRP20180534T1 (enExample)
HU (2) HUE037444T2 (enExample)
LT (2) LT3329919T (enExample)
MX (3) MX344490B (enExample)
PL (3) PL3628320T3 (enExample)
PT (2) PT2776038T (enExample)
RS (1) RS57157B1 (enExample)
SI (2) SI3329919T1 (enExample)
SM (1) SMT201800191T1 (enExample)
TW (4) TWI655193B (enExample)
UA (2) UA123760C2 (enExample)
WO (1) WO2013071169A1 (enExample)
ZA (3) ZA201403633B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021088980A1 (zh) * 2019-11-07 2021-05-14 南京瑞捷医药科技有限公司 一种acc抑制剂及其用途

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