AU2012335088B2 - ACC inhibitors and uses thereof - Google Patents

ACC inhibitors and uses thereof Download PDF

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Publication number
AU2012335088B2
AU2012335088B2 AU2012335088A AU2012335088A AU2012335088B2 AU 2012335088 B2 AU2012335088 B2 AU 2012335088B2 AU 2012335088 A AU2012335088 A AU 2012335088A AU 2012335088 A AU2012335088 A AU 2012335088A AU 2012335088 B2 AU2012335088 B2 AU 2012335088B2
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compound
equiv
mmol
synthesis
compounds
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AU2012335088A1 (en
Inventor
Sathesh Bhat
Jeremy Robert Greenwood
Geraldine C. Harriman
James Harwood
Craig E. Masse
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Gilead Apollo LLC
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Gilead Apollo LLC
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Assigned to GILEAD APOLLO, LLC reassignment GILEAD APOLLO, LLC Alteration of Name(s) of Applicant(s) under S113 Assignors: Nimbus Apollo, Inc.
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Priority to AU2017265088A priority Critical patent/AU2017265088B2/en
Priority to AU2019253834A priority patent/AU2019253834B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2012335088A 2011-11-11 2012-11-09 ACC inhibitors and uses thereof Active AU2012335088B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017265088A AU2017265088B2 (en) 2011-11-11 2017-11-23 ACC inhibitors and uses thereof
AU2019253834A AU2019253834B2 (en) 2011-11-11 2019-10-23 ACC inhibitors and uses thereof

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161559023P 2011-11-11 2011-11-11
US61/559,023 2011-11-11
US201261615092P 2012-03-23 2012-03-23
US61/615,092 2012-03-23
US201261651878P 2012-05-25 2012-05-25
US61/651,878 2012-05-25
US201261675513P 2012-07-25 2012-07-25
US61/675,513 2012-07-25
PCT/US2012/064528 WO2013071169A1 (en) 2011-11-11 2012-11-09 Acc inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017265088A Division AU2017265088B2 (en) 2011-11-11 2017-11-23 ACC inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
AU2012335088A1 AU2012335088A1 (en) 2014-05-29
AU2012335088B2 true AU2012335088B2 (en) 2017-08-24

Family

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Application Number Title Priority Date Filing Date
AU2012335088A Active AU2012335088B2 (en) 2011-11-11 2012-11-09 ACC inhibitors and uses thereof
AU2017265088A Active AU2017265088B2 (en) 2011-11-11 2017-11-23 ACC inhibitors and uses thereof
AU2019253834A Active AU2019253834B2 (en) 2011-11-11 2019-10-23 ACC inhibitors and uses thereof

Family Applications After (2)

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AU2017265088A Active AU2017265088B2 (en) 2011-11-11 2017-11-23 ACC inhibitors and uses thereof
AU2019253834A Active AU2019253834B2 (en) 2011-11-11 2019-10-23 ACC inhibitors and uses thereof

Country Status (26)

Country Link
US (5) US8969557B2 (enExample)
EP (3) EP2776038B1 (enExample)
JP (4) JP6114297B2 (enExample)
KR (3) KR102033806B1 (enExample)
CN (3) CN106905346B (enExample)
AU (3) AU2012335088B2 (enExample)
BR (2) BR112014011351B1 (enExample)
CA (1) CA2855372C (enExample)
CL (1) CL2014001241A1 (enExample)
CY (2) CY1120224T1 (enExample)
DK (2) DK2776038T3 (enExample)
EA (2) EA030264B1 (enExample)
ES (3) ES2912574T3 (enExample)
HR (2) HRP20180534T1 (enExample)
HU (2) HUE047049T2 (enExample)
LT (2) LT3329919T (enExample)
MX (3) MX390746B (enExample)
PL (3) PL3628320T3 (enExample)
PT (2) PT3329919T (enExample)
RS (1) RS57157B1 (enExample)
SI (2) SI2776038T1 (enExample)
SM (1) SMT201800191T1 (enExample)
TW (4) TWI655193B (enExample)
UA (2) UA114901C2 (enExample)
WO (1) WO2013071169A1 (enExample)
ZA (3) ZA201403633B (enExample)

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