PL2776038T3 - Inhibitory acc i ich zastosowania - Google Patents
Inhibitory acc i ich zastosowaniaInfo
- Publication number
- PL2776038T3 PL2776038T3 PL12848361T PL12848361T PL2776038T3 PL 2776038 T3 PL2776038 T3 PL 2776038T3 PL 12848361 T PL12848361 T PL 12848361T PL 12848361 T PL12848361 T PL 12848361T PL 2776038 T3 PL2776038 T3 PL 2776038T3
- Authority
- PL
- Poland
- Prior art keywords
- acc inhibitors
- acc
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161559023P | 2011-11-11 | 2011-11-11 | |
US201261615092P | 2012-03-23 | 2012-03-23 | |
US201261651878P | 2012-05-25 | 2012-05-25 | |
US201261675513P | 2012-07-25 | 2012-07-25 | |
PCT/US2012/064528 WO2013071169A1 (en) | 2011-11-11 | 2012-11-09 | Acc inhibitors and uses thereof |
EP12848361.7A EP2776038B1 (en) | 2011-11-11 | 2012-11-09 | Acc inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2776038T3 true PL2776038T3 (pl) | 2018-06-29 |
Family
ID=48281206
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL17209455T PL3329919T3 (pl) | 2011-11-11 | 2012-11-09 | Inhibitory ACC i ich zastosowania |
PL19190936.5T PL3628320T3 (pl) | 2011-11-11 | 2012-11-09 | Inhibitory acc i ich zastosowania |
PL12848361T PL2776038T3 (pl) | 2011-11-11 | 2012-11-09 | Inhibitory acc i ich zastosowania |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL17209455T PL3329919T3 (pl) | 2011-11-11 | 2012-11-09 | Inhibitory ACC i ich zastosowania |
PL19190936.5T PL3628320T3 (pl) | 2011-11-11 | 2012-11-09 | Inhibitory acc i ich zastosowania |
Country Status (26)
Country | Link |
---|---|
US (5) | US8969557B2 (pl) |
EP (3) | EP2776038B1 (pl) |
JP (4) | JP6114297B2 (pl) |
KR (3) | KR102172902B1 (pl) |
CN (3) | CN109970760B (pl) |
AU (3) | AU2012335088B2 (pl) |
BR (2) | BR112014011351B1 (pl) |
CA (1) | CA2855372C (pl) |
CL (1) | CL2014001241A1 (pl) |
CY (2) | CY1120224T1 (pl) |
DK (2) | DK2776038T3 (pl) |
EA (2) | EA030264B1 (pl) |
ES (3) | ES2665580T3 (pl) |
HK (1) | HK1201207A1 (pl) |
HR (2) | HRP20180534T1 (pl) |
HU (2) | HUE037444T2 (pl) |
LT (2) | LT3329919T (pl) |
MX (3) | MX370976B (pl) |
PL (3) | PL3329919T3 (pl) |
PT (2) | PT3329919T (pl) |
RS (1) | RS57157B1 (pl) |
SI (2) | SI2776038T1 (pl) |
TW (4) | TWI701253B (pl) |
UA (2) | UA123760C2 (pl) |
WO (1) | WO2013071169A1 (pl) |
ZA (3) | ZA201403633B (pl) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
JP6114297B2 (ja) | 2011-11-11 | 2017-04-12 | ギリアド アポロ, エルエルシー | Acc阻害剤およびその使用 |
CN104395330B (zh) | 2012-05-25 | 2018-03-13 | 爱尔兰詹森科学公司 | 尿嘧啶基螺氧杂环丁烷核苷 |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
AU2013360866A1 (en) | 2012-12-18 | 2015-07-02 | Almirall, S.A. | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activity |
TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
CA2911926A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
CA2911932A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
MX2015015416A (es) * | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
KR20160005364A (ko) | 2013-05-10 | 2016-01-14 | 님버스 아폴로, 인코포레이티드 | Acc 억제제 및 이의 용도 |
WO2015003881A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
WO2015003879A1 (en) * | 2013-07-08 | 2015-01-15 | Syngenta Participations Ag | Microbiocidal heterobicylic derivatives |
WO2015007451A1 (en) | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
WO2015010832A1 (en) * | 2013-07-22 | 2015-01-29 | Syngenta Participations Ag | Microbiocidal heterocyclic derivatives |
TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有maba化合物和皮質類固醇之組合 |
TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽 |
KR20160042089A (ko) | 2013-09-12 | 2016-04-18 | 화이자 인코포레이티드 | 심상성 여드름 치료용 아세틸-CoA 카복실라아제 억제제의 용도 |
SG11201602397XA (en) | 2013-10-07 | 2016-05-30 | Bayer Pharma AG | Cyclic thienouracil-carboxamides and use thereof |
JPWO2015056782A1 (ja) | 2013-10-17 | 2017-03-09 | 塩野義製薬株式会社 | 新規アルキレン誘導体 |
RU2674977C2 (ru) * | 2013-10-30 | 2018-12-14 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Производные пиразолопиримидона или пирролотриазона, способ их получения и их фармацевтические применения |
TN2016000253A1 (en) | 2013-12-19 | 2017-10-06 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis. |
JP6573968B2 (ja) * | 2014-08-11 | 2019-09-11 | ハイドラ バイオサイエンシズ インコーポレイテッドHydra Biosciences,Inc. | TRPC5調節因子としての、精神神経障害の処置のためのチエノおよびフロ[2,3−d]ピリミジン−2,4[1H,3H]−ジオン誘導体 |
TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物 |
CN105779463B (zh) * | 2014-12-25 | 2019-08-09 | 深圳华大生命科学研究院 | Vps13b基因突变体及其应用 |
JP2018501276A (ja) * | 2015-01-09 | 2018-01-18 | ギリアド アポロ, エルエルシー | 非アルコール性脂肪肝疾患の処置のためのacc阻害剤併用療法 |
UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
US11078259B2 (en) * | 2015-06-05 | 2021-08-03 | Joslin Diabetes Center, Inc. | Methods and compositions for promoting thermogenic potential |
CN105009933B (zh) * | 2015-06-10 | 2018-08-14 | 邓娟 | 一种以通风曲方式栽培草菇的工艺 |
IL293770B2 (en) | 2015-07-06 | 2023-07-01 | Gilead Sciences Inc | Modulators of cot and methods of using them |
AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
WO2017091627A1 (en) * | 2015-11-25 | 2017-06-01 | Gilead Apollo, Llc | Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine |
JP2018536661A (ja) * | 2015-11-25 | 2018-12-13 | ギリアド アポロ, エルエルシー | トリアゾールacc阻害剤およびその使用 |
CA3004796C (en) * | 2015-11-25 | 2023-11-14 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
EP4219507A3 (en) * | 2015-12-09 | 2023-08-16 | Novartis AG | Thienopyrimidinone nmda receptor modulators and uses thereof |
SI3386591T1 (sl) | 2015-12-09 | 2020-11-30 | Cadent Therapeutics, Inc. | Heteroaromatski NMDA receptorski modulatorji in njihove uporabe |
WO2017147161A1 (en) * | 2016-02-23 | 2017-08-31 | Raju Mohan | Treatment of dermatological disorders or conditions |
BR112018067408A2 (pt) * | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
CN107286174B (zh) * | 2016-04-11 | 2020-08-18 | 上海勋和医药科技有限公司 | 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用 |
CN107629071B (zh) * | 2016-07-19 | 2019-12-27 | 上海勋和医药科技有限公司 | 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用 |
WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
WO2018054846A1 (de) | 2016-09-23 | 2018-03-29 | Bayer Aktiengesellschaft | N3-cyclisch substituierte thienouracile und ihre verwendung |
AU2017382339B2 (en) | 2016-12-22 | 2024-02-15 | Novartis Ag | NMDA receptor modulators and uses thereof |
KR102577824B1 (ko) * | 2017-01-22 | 2023-09-13 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 티에노피리미딘 유도체 및 의약에서 이의 용도 |
EP3589635A1 (en) * | 2017-03-03 | 2020-01-08 | Gilead Apollo, LLC | Processes for the preparation of fungicidal compounds |
KR102424042B1 (ko) * | 2017-03-03 | 2022-07-22 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제 및 그의 고체 형태를 제조하는 방법 |
WO2018171698A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
US11142531B2 (en) | 2017-03-24 | 2021-10-12 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof |
CN110461328A (zh) | 2017-03-28 | 2019-11-15 | 吉利德科学公司 | 治疗肝疾病的治疗组合 |
WO2018183342A1 (en) | 2017-03-28 | 2018-10-04 | Gilead Sciences, Inc. | Methods of treating liver disease |
CA3055076C (en) | 2017-03-31 | 2022-02-22 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
KR20190132515A (ko) | 2017-04-12 | 2019-11-27 | 길리애드 사이언시즈, 인코포레이티드 | 간 질환을 치료하는 방법 |
CN107151251A (zh) * | 2017-05-10 | 2017-09-12 | 江苏开元药业有限公司 | 一种acc抑制剂药物关键中间体的制备方法 |
US10495648B2 (en) | 2017-06-13 | 2019-12-03 | Gilead Sciences, Inc. | Methods of treating liver fibrosis |
CN110709402B (zh) * | 2017-06-15 | 2022-05-10 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
CN111201234A (zh) * | 2017-07-17 | 2020-05-26 | 南京瑞捷医药科技有限公司 | 新型化合物及其作为acc抑制剂的用途 |
US11186587B2 (en) | 2017-07-26 | 2021-11-30 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Compound as ACC inhibitor and use thereof |
JP2020528060A (ja) * | 2017-07-28 | 2020-09-17 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ピリミドンヘテロアリール誘導体の製造方法およびピリミドンヘテロアリール誘導体の中間体 |
WO2019031384A1 (ja) * | 2017-08-07 | 2019-02-14 | 日本曹達株式会社 | 1,3,5,6-テトラ置換チエノ[2,3-d]ピリミジン-2,4(1H,3H)ジオン化合物および農園芸用殺菌剤 |
KR20190036705A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
KR20220103807A (ko) | 2017-10-06 | 2022-07-22 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제를 포함하는 조합 요법 |
WO2019072478A1 (en) | 2017-10-10 | 2019-04-18 | Galderma Research & Development | SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE |
US20200340060A1 (en) | 2017-11-13 | 2020-10-29 | Gilead Sciences, Inc. | Compositions and methods for identifying and treating liver diseases and monitoring treatment outcomes |
CN108129251A (zh) * | 2017-12-22 | 2018-06-08 | 上海应用技术大学 | 一种2-乙基苯乙烯的合成工艺 |
EP3805230A4 (en) * | 2018-06-05 | 2022-03-02 | Medshine Discovery Inc. | THIENO[2,3-C]PYRIDAZINE-4(1H)-ONE DERIVATIVE AND USE THEREOF |
DK3830092T3 (en) | 2018-08-03 | 2023-08-07 | Novartis Ag | Heteroaromatic nmda receptor modulators and uses thereof |
CN110950884B (zh) * | 2018-09-27 | 2024-03-26 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
AU2019385438A1 (en) * | 2018-11-20 | 2021-05-27 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
CA3121193C (en) | 2018-12-19 | 2024-03-12 | Corcept Therapeutics Incorporated | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
EP3669652A1 (en) | 2018-12-21 | 2020-06-24 | Bayer AG | Active compound combination |
DK3911647T3 (da) | 2019-01-15 | 2024-02-26 | Gilead Sciences Inc | Isoxazol-forbindelse som FXR-agonist og farmaceutiske sammensætninger, der omfatter en sådan |
AU2020226863B2 (en) | 2019-02-22 | 2023-04-06 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
AU2020234929B2 (en) | 2019-03-11 | 2023-09-14 | Gilead Sciences, Inc. | Formulations of a compound and uses thereof |
CN111747916A (zh) * | 2019-03-27 | 2020-10-09 | 尚科生物医药(上海)有限公司 | (r)-2-(2-甲氧基苯基)-2-(四氢吡喃-4-氧基)乙-1-醇的制备方法 |
CN109810085B (zh) * | 2019-04-19 | 2019-07-19 | 上海皓元生物医药科技有限公司 | Acc抑制剂及其中间体的制备方法 |
CN111850061B (zh) * | 2019-04-30 | 2022-12-09 | 浙江工业大学 | 一种井冈羟胺a酯化物的制备方法 |
CN110343650B (zh) * | 2019-05-28 | 2020-12-29 | 浙江工业大学 | 一种产两性霉素b的重组结节链霉菌及其应用 |
TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
WO2020255946A1 (ja) * | 2019-06-17 | 2020-12-24 | 日本曹達株式会社 | 2,4-ジオキソ-1,4-ジヒドロチエノピリミジン化合物及び農園芸用殺菌剤 |
EP3995498A4 (en) * | 2019-07-02 | 2023-03-01 | Sunshine Lake Pharma Co., Ltd. | THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE |
AR119594A1 (es) * | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
EP4031137A1 (en) | 2019-09-19 | 2022-07-27 | Novartis AG | Treatment comprising fxr agonists |
CN112574253B (zh) * | 2019-09-29 | 2021-08-27 | 上海喀露蓝科技有限公司 | 磷酸或磷酸酯类衍生物、其制备方法及其在医药上的用途 |
CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
CA3157658A1 (en) | 2019-10-28 | 2021-05-06 | Nippon Soda Co., Ltd. | 2,6-dioxo-3,6-dihydropyrimidine compound, agricultural and horticultural bactericide, nematicide, and medical and veterinary antifungal agent |
CN112778325A (zh) * | 2019-11-07 | 2021-05-11 | 南京瑞捷医药科技有限公司 | 一种acc抑制剂及其用途 |
WO2021097039A1 (en) | 2019-11-15 | 2021-05-20 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | 2,4-ジオキソ-1,4-ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
JP7265681B2 (ja) | 2019-12-05 | 2023-04-26 | ▲ザン▼州片仔▲ファン▼薬業股▲フン▼有限公司 | Acc1及びacc2阻害剤としての結晶形及びその製造方法並びに使用 |
CN114787166B (zh) | 2019-12-05 | 2023-09-19 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
EP4072556A4 (en) | 2019-12-11 | 2024-01-03 | Corcept Therapeutics Inc | METHOD FOR TREATING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN WITH MIRICORILANT |
CN115397511A (zh) | 2020-03-30 | 2022-11-25 | 吉利德科学公司 | Cot抑制剂化合物(s)-6-(((1-(双环[1.1.1]戊-1-基)-1h-1,2,3-三唑-4-基)2-甲基-1-氧代-1,2-二氢异喹啉-5-基)甲基)))氨基8-氯-(新戊基氨基)喹啉-3-甲腈的固体形式 |
EP4126862A1 (en) | 2020-04-02 | 2023-02-08 | Gilead Sciences, Inc. | Process for preparing a cot inhibitor compound |
US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
CN111513022B (zh) * | 2020-05-08 | 2021-11-12 | 武汉市农业科学院 | 一种低皮脂率的小体型肉鸭的选育方法 |
US20230210822A1 (en) | 2020-05-21 | 2023-07-06 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating fatty liver disease |
EP4161936A1 (en) | 2020-06-03 | 2023-04-12 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
TW202344504A (zh) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
CN111888349B (zh) * | 2020-07-29 | 2021-10-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 印楝素在制备促进缺血超长随意皮瓣存活药物的作用 |
TW202233632A (zh) * | 2021-02-07 | 2022-09-01 | 大陸商正大天晴藥業集團股份有限公司 | 噻吩并嘧啶衍生物 |
WO2022192428A1 (en) | 2021-03-11 | 2022-09-15 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
EP4313967A1 (en) | 2021-03-29 | 2024-02-07 | Gilead Sciences, Inc. | Khk inhibitors |
JPWO2022230804A1 (pl) | 2021-04-28 | 2022-11-03 | ||
JP2024517016A (ja) | 2021-05-11 | 2024-04-18 | ギリアード サイエンシーズ, インコーポレイテッド | Lpa受容体アンタゴニスト及びそれらの使用 |
AU2022273702A1 (en) | 2021-05-13 | 2023-11-02 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
TW202345826A (zh) | 2021-06-04 | 2023-12-01 | 美商基利科學股份有限公司 | 治療nash之方法 |
TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療fxr誘發之搔癢之il-31調節劑 |
WO2023107938A1 (en) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
WO2023106175A1 (ja) * | 2021-12-08 | 2023-06-15 | 日本曹達株式会社 | ウラシル化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
Family Cites Families (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3060084A (en) | 1961-06-09 | 1962-10-23 | Du Pont | Improved homogeneous, readily dispersed, pesticidal concentrate |
US3299566A (en) | 1964-06-01 | 1967-01-24 | Olin Mathieson | Water soluble film containing agricultural chemicals |
US3325503A (en) | 1965-02-18 | 1967-06-13 | Diamond Alkali Co | Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation |
US3296272A (en) | 1965-04-01 | 1967-01-03 | Dow Chemical Co | Sulfinyl- and sulfonylpyridines |
US4144050A (en) | 1969-02-05 | 1979-03-13 | Hoechst Aktiengesellschaft | Micro granules for pesticides and process for their manufacture |
US3920442A (en) | 1972-09-18 | 1975-11-18 | Du Pont | Water-dispersible pesticide aggregates |
US4172714A (en) | 1976-12-20 | 1979-10-30 | E. I. Du Pont De Nemours And Company | Dry compactible, swellable herbicidal compositions and pellets produced therefrom |
GB2095558B (en) | 1981-03-30 | 1984-10-24 | Avon Packers Ltd | Formulation of agricultural chemicals |
DE3338292A1 (de) | 1983-10-21 | 1985-05-02 | Basf Ag, 6700 Ludwigshafen | 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide |
CA1249832A (en) | 1984-02-03 | 1989-02-07 | Shionogi & Co., Ltd. | Azolyl cycloalkanol derivatives and agricultural fungicides |
US5304732A (en) | 1984-03-06 | 1994-04-19 | Mgi Pharma, Inc. | Herbicide resistance in plants |
BR8600161A (pt) | 1985-01-18 | 1986-09-23 | Plant Genetic Systems Nv | Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio |
DE3545319A1 (de) | 1985-12-20 | 1987-06-25 | Basf Ag | Acrylsaeureester und fungizide, die diese verbindungen enthalten |
DE3765449D1 (de) | 1986-03-11 | 1990-11-15 | Plant Genetic Systems Nv | Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen. |
US4670560A (en) | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
MY100846A (en) | 1986-05-02 | 1991-03-15 | Stauffer Chemical Co | Fungicidal pyridyl imidates |
ATE82966T1 (de) | 1986-08-12 | 1992-12-15 | Mitsubishi Chem Ind | Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel. |
FR2629098B1 (fr) | 1988-03-23 | 1990-08-10 | Rhone Poulenc Agrochimie | Gene chimerique de resistance herbicide |
US5180587A (en) | 1988-06-28 | 1993-01-19 | E. I. Du Pont De Nemours And Company | Tablet formulations of pesticides |
CA2005658A1 (en) | 1988-12-19 | 1990-06-19 | Eliahu Zlotkin | Insecticidal toxins, genes encoding these toxins, antibodies binding to them and transgenic plant cells and plants expressing these toxins |
JPH02225485A (ja) * | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―3―酢酸誘導体 |
ATE241699T1 (de) | 1989-03-24 | 2003-06-15 | Syngenta Participations Ag | Krankheitsresistente transgene pflanze |
DE69032848T2 (de) | 1989-08-30 | 1999-06-24 | Aeci Ltd | Dosierungsmittel und dessen Verwendung |
DK0427529T3 (da) | 1989-11-07 | 1995-06-26 | Pioneer Hi Bred Int | Larvedræbende lactiner og planteinsektresistens baseret derpå |
AU628229B2 (en) | 1989-11-10 | 1992-09-10 | Agro-Kanesho Co. Ltd. | Hexahydrotriazine compounds and insecticides |
JPH05504964A (ja) | 1990-03-12 | 1993-07-29 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 熱―活性化結合剤からの水分散性又は水溶性有害生物防除剤顆粒 |
CA2083948C (en) | 1990-06-25 | 2001-05-15 | Ganesh M. Kishore | Glyphosate tolerant plants |
EP0480679B1 (en) | 1990-10-11 | 1996-09-18 | Sumitomo Chemical Company Limited | Pesticidal composition |
JP2828186B2 (ja) | 1991-09-13 | 1998-11-25 | 宇部興産株式会社 | アクリレート系化合物、その製法及び殺菌剤 |
UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
DE4322211A1 (de) | 1993-07-03 | 1995-01-12 | Basf Ag | Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung |
TW276256B (pl) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
JP3811196B2 (ja) * | 1993-08-26 | 2006-08-16 | 武田薬品工業株式会社 | エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法 |
US5530195A (en) | 1994-06-10 | 1996-06-25 | Ciba-Geigy Corporation | Bacillus thuringiensis gene encoding a toxin active against insects |
DE69624829T2 (de) | 1995-08-17 | 2003-07-31 | Takeda Chemical Industries Ltd | Thienopyrimidinderivate als endothelin antagonisten |
JPH09110873A (ja) * | 1995-08-17 | 1997-04-28 | Takeda Chem Ind Ltd | チエノピリミジン誘導体、その製造法および用途 |
US5773704A (en) | 1996-04-29 | 1998-06-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Herbicide resistant rice |
AU2407997A (en) | 1996-04-30 | 1997-11-19 | Takeda Chemical Industries Ltd. | Combined use of gnrh agonist and antagonist |
JP2007302703A (ja) * | 1996-04-30 | 2007-11-22 | Takeda Chem Ind Ltd | 医薬組成物 |
ATE342960T1 (de) | 1996-07-17 | 2006-11-15 | Univ Michigan State | Imidazolin herbizid resistente zuckerrüben |
US5773702A (en) | 1996-07-17 | 1998-06-30 | Board Of Trustees Operating Michigan State University | Imidazolinone herbicide resistant sugar beet plants |
DE19650197A1 (de) | 1996-12-04 | 1998-06-10 | Bayer Ag | 3-Thiocarbamoylpyrazol-Derivate |
TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
SE9702001D0 (sv) | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
US6984644B2 (en) * | 1997-05-28 | 2006-01-10 | Astrazeneca Ab | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones |
DK1017670T3 (da) | 1997-09-18 | 2002-12-16 | Basf Ag | Benzamidoximderivater, mellemprodukter og fremgangsmåder til deres fremstilling og deres anvendelse som fungicider |
DE19750012A1 (de) | 1997-11-12 | 1999-05-20 | Bayer Ag | Isothiazolcarbonsäureamide |
BR9813376A (pt) | 1997-12-04 | 2001-06-19 | Dow Agrosciences Llc | Composição fungicidas e métodos e compostos para a preparação das mesmas |
DE19754082A1 (de) | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
US6348643B1 (en) | 1998-10-29 | 2002-02-19 | American Cyanamid Company | DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use |
IL143157A0 (en) | 1998-11-17 | 2002-04-21 | Kumiai Chemical Industry Co | Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides |
IT1303800B1 (it) | 1998-11-30 | 2001-02-23 | Isagro Ricerca Srl | Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico. |
JP3417862B2 (ja) | 1999-02-02 | 2003-06-16 | 新東工業株式会社 | 酸化チタン光触媒高担持シリカゲルおよびその製造方法 |
AU770077B2 (en) | 1999-03-11 | 2004-02-12 | Dow Agrosciences Llc | Heterocyclic substituted isoxazolidines and their use as fungicides |
EP1171442B1 (en) | 1999-04-09 | 2005-12-07 | Cell Therapeutics, Inc. | Xanthine derivatives and analogs as cell signalling inhibitors |
US6586617B1 (en) | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
UA73307C2 (uk) | 1999-08-05 | 2005-07-15 | Куміаі Кемікал Індастрі Ко., Лтд. | Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення |
DE10021412A1 (de) | 1999-12-13 | 2001-06-21 | Bayer Ag | Fungizide Wirkstoffkombinationen |
SK10822002A3 (sk) | 2000-01-25 | 2003-05-02 | Syngenta Participations Ag | Herbicídna kompozícia a jej použitie na kontrolu buriny |
US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
IL141034A0 (en) | 2000-02-04 | 2002-02-10 | Sumitomo Chemical Co | Uracil compounds and use thereof |
AU2001259206B2 (en) | 2000-04-28 | 2006-05-25 | Basf Aktiengesellschaft | Use of the maize x112 mutant ahas 2 gene and imidazolinone herbicides for selection of transgenic monocots, maize, rice and wheat plants resistant to the imidazolinone herbicides |
ES2243543T3 (es) | 2000-08-25 | 2005-12-01 | Syngenta Participations Ag | Hibridos de proteinas cristalinas de bacillus thurigiensis. |
BR0114122A (pt) | 2000-09-18 | 2003-07-01 | Du Pont | Composto, composições fungicidas e método de controle de doenças vegetais causadas por patógenos vegetais fúngicos |
AU2002228640B2 (en) | 2000-11-17 | 2005-11-10 | Dow Agrosciences Llc | Compounds having fungicidal activity and processes to make and use same |
BR0207216A (pt) * | 2001-02-14 | 2004-03-09 | Warner Lambert Co | Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz |
JP5034142B2 (ja) | 2001-04-20 | 2012-09-26 | 住友化学株式会社 | 植物病害防除剤組成物 |
DE10136065A1 (de) | 2001-07-25 | 2003-02-13 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
AR037228A1 (es) | 2001-07-30 | 2004-11-03 | Dow Agrosciences Llc | Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada |
FR2828196A1 (fr) | 2001-08-03 | 2003-02-07 | Aventis Cropscience Sa | Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture |
DK1420629T3 (da) | 2001-08-09 | 2013-06-24 | Northwest Plant Breeding Company | Hvedeplanter med forøget resistens over for imidazolinonherbicider |
RU2337532C2 (ru) | 2001-08-09 | 2008-11-10 | Юниверсити Оф Саскачеван | Растения пшеницы с повышенной устойчивостью к имидазолиноновым гербицидам |
US7897845B2 (en) | 2001-08-09 | 2011-03-01 | University Of Saskatchewan | Wheat plants having increased resistance to imidazolinone herbicides |
US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
US7608563B2 (en) | 2001-08-17 | 2009-10-27 | Mitsui Agro Chemicals, Inc. | 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same |
US7230167B2 (en) | 2001-08-31 | 2007-06-12 | Syngenta Participations Ag | Modified Cry3A toxins and nucleic acid sequences coding therefor |
WO2003052073A2 (en) | 2001-12-17 | 2003-06-26 | Syngenta Participations Ag | Novel corn event |
AU2002354251A1 (en) | 2001-12-21 | 2003-07-09 | Nissan Chemical Industries, Ltd. | Bactericidal composition |
TWI327462B (en) | 2002-01-18 | 2010-07-21 | Sumitomo Chemical Co | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same |
DE10204390A1 (de) | 2002-02-04 | 2003-08-14 | Bayer Cropscience Ag | Disubstituierte Thiazolylcarboxanilide |
IL163659A0 (en) * | 2002-02-27 | 2005-12-18 | Pfizer Prod Inc | Acc inhibitors |
MXPA04008314A (es) | 2002-03-05 | 2004-11-26 | Syngenta Participations Ag | O-ciclopropil-carboxaniluros y su uso como funguicidas. |
WO2004016073A2 (en) | 2002-07-10 | 2004-02-26 | The Department Of Agriculture, Western Australia | Wheat plants having increased resistance to imidazolinone herbicides |
WO2004014916A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
GB0227966D0 (en) | 2002-11-29 | 2003-01-08 | Syngenta Participations Ag | Organic Compounds |
WO2004060058A2 (en) * | 2003-01-06 | 2004-07-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Herbicides inhibiting the action of plant acetyl-coa carboxylase for use as pesticides. |
WO2004067535A1 (ja) * | 2003-01-29 | 2004-08-12 | Takeda Pharmaceutical Company Limited | チエノピリミジン化合物およびその用途 |
WO2004083193A1 (ja) | 2003-03-17 | 2004-09-30 | Sumitomo Chemical Company, Limited | アミド化合物およびこれを含有する殺菌剤組成物 |
RU2425152C2 (ru) | 2003-05-28 | 2011-07-27 | Басф Акциенгезельшафт | Растения пшеницы с повышенной толерантностью к имидазолиноновым гербицидам |
EP2294913B1 (en) | 2003-08-29 | 2015-05-27 | Instituto Nacional de Tecnologia Agropecuaria | Rice plants having increased tolerance to imidazolinone herbicides |
TWI355894B (en) | 2003-12-19 | 2012-01-11 | Du Pont | Herbicidal pyrimidines |
SI1725561T1 (sl) | 2004-03-10 | 2010-09-30 | Basf Se | Dialkil amino triazolopirimidini postopek za njihovo proizvodnjo njihova uporaba za nadzor patogenih gljiv in agensi vsebujoči omenjeno spojino |
JP2007527886A (ja) | 2004-03-10 | 2007-10-04 | ビーエーエスエフ アクチェンゲゼルシャフト | 5,6−ジアルキル−7−アミノトリアゾロピリミジン、その調製、および有害真菌を防除するためのその使用、ならびにそれらの化合物を含む組成物 |
MXPA06014019A (es) | 2004-06-03 | 2007-02-08 | Du Pont | Mezclas fungicidas de compuestos de amidinilfenilo. |
CN1968935A (zh) | 2004-06-18 | 2007-05-23 | 巴斯福股份公司 | N-(邻苯基)-1-甲基-3-三氟甲基吡唑-4-甲酰苯胺及其作为杀真菌剂的用途 |
JP2008502636A (ja) | 2004-06-18 | 2008-01-31 | ビーエーエスエフ アクチェンゲゼルシャフト | N−(オルト−フェニル)−1−メチル−3−ジフルオロメチルピラゾール−4−カルボキシアニリドおよびそれらの殺菌剤としての使用 |
WO2006014647A2 (en) * | 2004-07-21 | 2006-02-09 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
GB0418048D0 (en) | 2004-08-12 | 2004-09-15 | Syngenta Participations Ag | Method for protecting useful plants or plant propagation material |
DE102005007160A1 (de) | 2005-02-16 | 2006-08-24 | Basf Ag | Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen |
EP1853608B1 (de) | 2005-02-16 | 2008-07-09 | Basf Se | 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
DE102005009458A1 (de) | 2005-03-02 | 2006-09-07 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
PL1973881T3 (pl) | 2006-01-13 | 2010-04-30 | Dow Agrosciences Llc | 6-(wielo-podstawione arylo)-4-aminopikoliniany i ich zastosowanie jako herbicydy |
WO2007090624A2 (en) | 2006-02-09 | 2007-08-16 | Syngenta Participations Ag | A method of protecting a plant propagation material, a plant, and/or plant organs |
CA2644996A1 (en) * | 2006-03-02 | 2007-09-13 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
JPWO2008143262A1 (ja) * | 2007-05-21 | 2010-08-12 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
US8501804B2 (en) | 2008-10-27 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
US9365584B2 (en) | 2009-12-29 | 2016-06-14 | Poxel | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof |
JP6114297B2 (ja) * | 2011-11-11 | 2017-04-12 | ギリアド アポロ, エルエルシー | Acc阻害剤およびその使用 |
CA2911926A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
JP2018536661A (ja) | 2015-11-25 | 2018-12-13 | ギリアド アポロ, エルエルシー | トリアゾールacc阻害剤およびその使用 |
WO2017091627A1 (en) | 2015-11-25 | 2017-06-01 | Gilead Apollo, Llc | Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine |
EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
CA3004796C (en) | 2015-11-25 | 2023-11-14 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
BR112018067408A2 (pt) | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
-
2012
- 2012-11-09 JP JP2014541351A patent/JP6114297B2/ja active Active
- 2012-11-09 MX MX2016016733A patent/MX370976B/es unknown
- 2012-11-09 EA EA201490826A patent/EA030264B1/ru unknown
- 2012-11-09 UA UAA201703473A patent/UA123760C2/uk unknown
- 2012-11-09 KR KR1020197037686A patent/KR102172902B1/ko active IP Right Grant
- 2012-11-09 MX MX2020000331A patent/MX2020000331A/es unknown
- 2012-11-09 CN CN201910342735.5A patent/CN109970760B/zh active Active
- 2012-11-09 ES ES12848361.7T patent/ES2665580T3/es active Active
- 2012-11-09 PT PT172094559T patent/PT3329919T/pt unknown
- 2012-11-09 DK DK12848361.7T patent/DK2776038T3/en active
- 2012-11-09 EP EP12848361.7A patent/EP2776038B1/en active Active
- 2012-11-09 PL PL17209455T patent/PL3329919T3/pl unknown
- 2012-11-09 CN CN201710148365.2A patent/CN106905346B/zh active Active
- 2012-11-09 BR BR112014011351-3A patent/BR112014011351B1/pt active IP Right Grant
- 2012-11-09 LT LTEP17209455.9T patent/LT3329919T/lt unknown
- 2012-11-09 MX MX2014005693A patent/MX344490B/es active IP Right Grant
- 2012-11-09 TW TW107147492A patent/TWI701253B/zh active
- 2012-11-09 HU HUE12848361A patent/HUE037444T2/hu unknown
- 2012-11-09 ES ES17209455T patent/ES2767956T3/es active Active
- 2012-11-09 US US13/673,610 patent/US8969557B2/en active Active
- 2012-11-09 LT LTEP12848361.7T patent/LT2776038T/lt unknown
- 2012-11-09 HU HUE17209455A patent/HUE047049T2/hu unknown
- 2012-11-09 SI SI201231264T patent/SI2776038T1/en unknown
- 2012-11-09 CA CA2855372A patent/CA2855372C/en active Active
- 2012-11-09 SI SI201231695T patent/SI3329919T1/sl unknown
- 2012-11-09 WO PCT/US2012/064528 patent/WO2013071169A1/en active Application Filing
- 2012-11-09 PL PL19190936.5T patent/PL3628320T3/pl unknown
- 2012-11-09 ES ES19190936T patent/ES2912574T3/es active Active
- 2012-11-09 EA EA201692104A patent/EA033598B1/ru unknown
- 2012-11-09 KR KR1020147015759A patent/KR102033806B1/ko active IP Right Grant
- 2012-11-09 BR BR122019026836-3A patent/BR122019026836B1/pt active IP Right Grant
- 2012-11-09 TW TW102116925A patent/TWI582095B/zh active
- 2012-11-09 EP EP19190936.5A patent/EP3628320B1/en active Active
- 2012-11-09 DK DK17209455T patent/DK3329919T3/da active
- 2012-11-09 KR KR1020197010275A patent/KR102060290B1/ko active IP Right Grant
- 2012-11-09 TW TW105139289A patent/TWI612050B/zh active
- 2012-11-09 UA UAA201406462A patent/UA114901C2/uk unknown
- 2012-11-09 PT PT128483617T patent/PT2776038T/pt unknown
- 2012-11-09 PL PL12848361T patent/PL2776038T3/pl unknown
- 2012-11-09 AU AU2012335088A patent/AU2012335088B2/en active Active
- 2012-11-09 CN CN201280066192.5A patent/CN104105485B/zh active Active
- 2012-11-09 EP EP17209455.9A patent/EP3329919B1/en active Active
- 2012-11-09 RS RS20180415A patent/RS57157B1/sr unknown
- 2012-11-09 TW TW106143212A patent/TWI655193B/zh active
-
2014
- 2014-05-12 CL CL2014001241A patent/CL2014001241A1/es unknown
- 2014-05-19 ZA ZA2014/03633A patent/ZA201403633B/en unknown
-
2015
- 2015-01-23 US US14/604,497 patent/US9453026B2/en active Active
- 2015-02-24 HK HK15101877.9A patent/HK1201207A1/xx unknown
-
2016
- 2016-03-11 US US15/067,634 patent/US9944655B2/en active Active
-
2017
- 2017-03-16 JP JP2017051746A patent/JP6276442B2/ja active Active
- 2017-06-19 ZA ZA2017/04173A patent/ZA201704173B/en unknown
- 2017-06-19 ZA ZA2017/04192A patent/ZA201704192B/en unknown
- 2017-11-23 AU AU2017265088A patent/AU2017265088B2/en active Active
-
2018
- 2018-01-11 JP JP2018002648A patent/JP6543358B2/ja active Active
- 2018-03-09 US US15/917,190 patent/US10472374B2/en active Active
- 2018-04-03 HR HRP20180534TT patent/HRP20180534T1/hr unknown
- 2018-04-05 CY CY20181100386T patent/CY1120224T1/el unknown
-
2019
- 2019-06-14 JP JP2019111246A patent/JP6756014B2/ja active Active
- 2019-09-20 US US16/577,455 patent/US20200102323A1/en not_active Abandoned
- 2019-10-23 AU AU2019253834A patent/AU2019253834B2/en active Active
- 2019-12-06 HR HRP20192202TT patent/HRP20192202T1/hr unknown
-
2020
- 2020-02-03 CY CY20201100086T patent/CY1122657T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201704192B (en) | Acc inhibitors and uses thereof | |
HRP20182037T1 (hr) | Inhibitori prmt5 i njihova uporaba | |
HK1210696A1 (en) | Irak inhibitors and uses thereof irak | |
HK1198827A1 (en) | Dyrk1 inhibitors and uses thereof dyrk1 | |
EP2678018A4 (en) | COMBINATION OF CHINESE HEMMER AND USES THEREOF | |
EP2663312A4 (en) | IRAQ INHIBITORS AND THEIR USE | |
EP2721031A4 (en) | BROMODOMA INHIBITORS AND ITS USE | |
EP2705039A4 (en) | BROMODOMAIN INHIBITORS AND USES THEREOF | |
EP2696682A4 (en) | MIF-HEMMER AND USES THEREOF | |
RS58892B1 (sr) | Jedinjenja 3-aminocikloalkila kao inhibitori ror-gama-t i njihove upotrebe | |
EP2802330A4 (en) | IRAQ INHIBITORS AND USES THEREOF | |
EP2683693A4 (en) | ROR-GAMMA-T INHIBITORS | |
EP2872518A4 (en) | IRAQ INHIBITOR AND USES THEREOF | |
IL229844B (en) | Anti-psgl-1 antibodies and their use | |
EP2688901A4 (en) | INHIBITORS OF 17SS-HSD1, 17SS-HSD3 AND 17SS-HSD10 | |
EP2693879A4 (en) | MIGRASTATINES AND THEIR USES | |
GB201120474D0 (en) | Inhibitors |