MX2012007548A - Activadores de tienen [2,3-b] piridindiona de proteina quinasa activada con amp y usos terapeuticos de los mismos. - Google Patents
Activadores de tienen [2,3-b] piridindiona de proteina quinasa activada con amp y usos terapeuticos de los mismos.Info
- Publication number
- MX2012007548A MX2012007548A MX2012007548A MX2012007548A MX2012007548A MX 2012007548 A MX2012007548 A MX 2012007548A MX 2012007548 A MX2012007548 A MX 2012007548A MX 2012007548 A MX2012007548 A MX 2012007548A MX 2012007548 A MX2012007548 A MX 2012007548A
- Authority
- MX
- Mexico
- Prior art keywords
- ampk
- activators
- pyridinedione
- thieno
- therapeutic uses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a compuestos que son activadores directos de AMPK (Proteína quinasa activada con AMP) y su uso en el tratamiento de trastornos regulados por la activación de AMPK. Por ejemplo, compuestos de acuerdo con la invención son útiles para el tratamiento de diabetes, síndrome metabólico, obesidad, inflamación, cáncer y enfermedades cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09306344 | 2009-12-29 | ||
PCT/EP2010/070811 WO2011080277A1 (en) | 2009-12-29 | 2010-12-28 | Thieno [2,3-b] pyridinedione activators of ampk and therapeutic uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012007548A true MX2012007548A (es) | 2012-07-23 |
Family
ID=41691577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012007548A MX2012007548A (es) | 2009-12-29 | 2010-12-28 | Activadores de tienen [2,3-b] piridindiona de proteina quinasa activada con amp y usos terapeuticos de los mismos. |
Country Status (24)
Country | Link |
---|---|
US (1) | US9365584B2 (es) |
EP (1) | EP2519527B1 (es) |
JP (1) | JP5559894B2 (es) |
KR (1) | KR101469002B1 (es) |
CN (1) | CN102803269B (es) |
AU (1) | AU2010338280B2 (es) |
BR (1) | BR112012016330B8 (es) |
CA (1) | CA2784553C (es) |
CY (1) | CY1114952T1 (es) |
DK (1) | DK2519527T3 (es) |
EA (1) | EA020588B1 (es) |
ES (1) | ES2445537T3 (es) |
HR (1) | HRP20140035T1 (es) |
IL (1) | IL220432A (es) |
ME (1) | ME01558B (es) |
MX (1) | MX2012007548A (es) |
PL (1) | PL2519527T3 (es) |
PT (1) | PT2519527E (es) |
RS (1) | RS53282B (es) |
SI (1) | SI2519527T1 (es) |
SM (1) | SMT201400013B (es) |
TW (1) | TWI574968B (es) |
WO (1) | WO2011080277A1 (es) |
ZA (1) | ZA201205604B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3628320T3 (pl) | 2011-11-11 | 2022-07-25 | Gilead Apollo, Llc | Inhibitory acc i ich zastosowania |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
EP3089748A4 (en) | 2014-01-02 | 2017-09-27 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
WO2017011917A1 (en) * | 2015-07-23 | 2017-01-26 | Thrasos Therapeutics Inc. | Methods for treating and preventing polycystic kidney diseases (pkd) using amp-activated protein kinase (ampk) modulators and activators |
AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
CN108347939B (zh) | 2015-11-25 | 2021-09-28 | 吉利德阿波罗公司 | 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物 |
EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
PT3380479T (pt) | 2015-11-25 | 2023-03-13 | Gilead Apollo Llc | Inhibidores de triazol acc e seus usos |
EA201890913A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | Пиразоловые соединения в качестве ингибиторов акк и их применение |
BR112018067408A2 (pt) | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
WO2018045969A1 (zh) * | 2016-09-07 | 2018-03-15 | 法玛科技顾问股份有限公司 | 活化腺苷单磷酸活化蛋白激酶之化合物 |
CA3055581C (en) | 2017-03-28 | 2023-03-14 | Gilead Sciences, Inc. | Methods of treating liver disease |
WO2019185413A1 (en) | 2018-03-27 | 2019-10-03 | Basf Se | Pesticidal substituted cyclopropyl derivatives |
MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ,インク. | Ampkアクチベーター |
WO2022072397A1 (en) | 2020-09-30 | 2022-04-07 | Bioverativ Therapeutics Inc. | Ampk activators and methods of use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7119205B2 (en) | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
MX2010011047A (es) * | 2008-04-11 | 2010-10-26 | Merck Patent Gmbh | Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk). |
-
2010
- 2010-12-28 CA CA2784553A patent/CA2784553C/en not_active Expired - Fee Related
- 2010-12-28 ES ES10800766.7T patent/ES2445537T3/es active Active
- 2010-12-28 WO PCT/EP2010/070811 patent/WO2011080277A1/en active Application Filing
- 2010-12-28 JP JP2012546437A patent/JP5559894B2/ja not_active Expired - Fee Related
- 2010-12-28 AU AU2010338280A patent/AU2010338280B2/en not_active Ceased
- 2010-12-28 PT PT108007667T patent/PT2519527E/pt unknown
- 2010-12-28 KR KR1020127018478A patent/KR101469002B1/ko active IP Right Grant
- 2010-12-28 DK DK10800766.7T patent/DK2519527T3/da active
- 2010-12-28 TW TW099146432A patent/TWI574968B/zh not_active IP Right Cessation
- 2010-12-28 RS RS20140028A patent/RS53282B/en unknown
- 2010-12-28 PL PL10800766T patent/PL2519527T3/pl unknown
- 2010-12-28 US US13/519,407 patent/US9365584B2/en active Active
- 2010-12-28 EA EA201200975A patent/EA020588B1/ru not_active IP Right Cessation
- 2010-12-28 BR BR112012016330A patent/BR112012016330B8/pt not_active IP Right Cessation
- 2010-12-28 SI SI201030501T patent/SI2519527T1/sl unknown
- 2010-12-28 ME MEP-2014-10A patent/ME01558B/me unknown
- 2010-12-28 EP EP10800766.7A patent/EP2519527B1/en active Active
- 2010-12-28 CN CN201080064452.6A patent/CN102803269B/zh not_active Expired - Fee Related
- 2010-12-28 MX MX2012007548A patent/MX2012007548A/es active IP Right Grant
-
2012
- 2012-06-14 IL IL220432A patent/IL220432A/en active IP Right Grant
- 2012-07-25 ZA ZA2012/05604A patent/ZA201205604B/en unknown
-
2014
- 2014-01-13 HR HRP20140035AT patent/HRP20140035T1/hr unknown
- 2014-01-24 CY CY20141100066T patent/CY1114952T1/el unknown
- 2014-01-29 SM SM201400013T patent/SMT201400013B/xx unknown
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration |