CN103613587A - 可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物 - Google Patents

可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物 Download PDF

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CN103613587A
CN103613587A CN201310516239.XA CN201310516239A CN103613587A CN 103613587 A CN103613587 A CN 103613587A CN 201310516239 A CN201310516239 A CN 201310516239A CN 103613587 A CN103613587 A CN 103613587A
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group
compound
phenyl
alkyl
fluorophenyl
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Inventor
栗村宗明
平良伸一
友安崇浩
伊藤展明
田井国宪
武村宪昭
松崎敬之
校条康宏
宫村伸
樱井庸二
渡部昭仁
坂田靖代
桝本琢巳
赤泽康平
杉野春日子
天田直树
大桥聪
筱原友一
佐佐木博文
森田知佐子
山下纯子
中岛聪子
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of CN103613587A publication Critical patent/CN103613587A/zh
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CN201310516239.XA 2005-05-13 2006-05-12 可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物 Pending CN103613587A (zh)

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CN201310516239.XA Pending CN103613587A (zh) 2005-05-13 2006-05-12 可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物
CNA2006800164024A Pending CN101175748A (zh) 2005-05-13 2006-05-12 可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物

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Publication number Priority date Publication date Assignee Title
EA010027B1 (ru) 2002-11-27 2008-06-30 Инсайт Корпорейшн Производные 3-аминопирролидина в качестве модуляторов рецепторов хемокинов
TWI439452B (zh) 2005-05-13 2014-06-01 Otsuka Pharma Co Ltd 吡咯烷化合物(二)
JP2009518313A (ja) * 2005-11-30 2009-05-07 スミスクライン・ビーチャム・コーポレイション ピロリジンアニリン
EP1960355A1 (en) * 2005-11-30 2008-08-27 F.Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬
CA2718736A1 (en) * 2008-03-20 2009-09-24 F. Hoffmann-La Roche Ag Pyrrolidinyl derivatives and uses thereof
US8987301B2 (en) 2009-11-07 2015-03-24 Merck Patent Gmbh Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors
EP2560953B1 (en) * 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
CN102766079B (zh) * 2011-05-06 2015-04-08 上海医药工业研究院 一类吡咯烷衍生物、其制备方法及应用
US9353078B2 (en) 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
KR20160148871A (ko) 2015-06-17 2016-12-27 양순구 일방향 클러치 제동장치
WO2017070796A1 (en) * 2015-10-30 2017-05-04 Trillium Therapeutics Inc. Heterocycle derivatives and their use for the treatment of cns disorders
JP2022500499A (ja) 2018-09-07 2022-01-04 ピク セラピューティクス, インコーポレイテッド Eif4e阻害剤およびその使用
RU2698400C1 (ru) * 2018-12-17 2019-08-26 Георгий Сергеевич Немов Способ лечения депрессии у собак и кошек
CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028270A1 (en) * 1996-12-20 1998-07-02 Astra Pharma Inc. Novel compounds with analgesic effect
WO2004110995A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164828A (en) 1965-10-23 1969-09-24 Robins Co Inc A H 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use
BE695817A (pt) 1966-03-22 1967-09-01
US3509171A (en) 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
US3433802A (en) 1968-06-25 1969-03-18 Robins Co Inc A H 3-(n-lower-alkylanilino)pyrrolidines
US3577440A (en) 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
GB1523631A (en) 1975-07-08 1978-09-06 Leo Pharm Prod Ltd Sulphonamide derivatives
US4254135A (en) 1979-10-16 1981-03-03 A. H. Robins Company, Inc. 3-Amino-4-hydroxypyrrolidines
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
EP1138672A1 (en) 1998-01-12 2001-10-04 Basilea Pharmaceutica AG Process for the preparation of 3-amino-pyrrolidine derivatives
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
ES2247132T3 (es) 2000-04-28 2006-03-01 F. Hoffmann-La Roche Ag P-(sulfonil) aril y heteroaril aminas.
BR0209678A (pt) 2001-05-18 2004-09-14 Astrazeneca Ab Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor e de distúrbios gastrintestinais funcionais
GB0314054D0 (en) 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
US7432280B2 (en) 2003-06-20 2008-10-07 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
KR100661118B1 (ko) 2003-11-12 2006-12-26 주식회사 엘지생명과학 멜라노코틴 수용체의 항진제
CA2548304A1 (en) * 2003-12-12 2005-07-07 Eli Lilly And Company Selective norepinephrine reuptake inhibitors for the treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
AR053712A1 (es) 2005-04-18 2007-05-16 Neurogen Corp Heteroarilos sustituidos, antagonistas de cb1 (receptor 1 canabinoide)
TWI439452B (zh) * 2005-05-13 2014-06-01 Otsuka Pharma Co Ltd 吡咯烷化合物(二)
EP2035763A1 (en) * 2006-06-30 2009-03-18 Arcelik Anonim Sirketi A cooling device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028270A1 (en) * 1996-12-20 1998-07-02 Astra Pharma Inc. Novel compounds with analgesic effect
WO2005000811A1 (en) * 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake
WO2004110995A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors

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