CN103613587A - 可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物 - Google Patents
可用作单胺再摄取抑制剂的n,n-取代的3-氨基吡咯烷化合物 Download PDFInfo
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- CN103613587A CN103613587A CN201310516239.XA CN201310516239A CN103613587A CN 103613587 A CN103613587 A CN 103613587A CN 201310516239 A CN201310516239 A CN 201310516239A CN 103613587 A CN103613587 A CN 103613587A
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- phenyl
- alkyl
- fluorophenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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EA010027B1 (ru) | 2002-11-27 | 2008-06-30 | Инсайт Корпорейшн | Производные 3-аминопирролидина в качестве модуляторов рецепторов хемокинов |
TWI439452B (zh) | 2005-05-13 | 2014-06-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物(二) |
JP2009518313A (ja) * | 2005-11-30 | 2009-05-07 | スミスクライン・ビーチャム・コーポレイション | ピロリジンアニリン |
EP1960355A1 (en) * | 2005-11-30 | 2008-08-27 | F.Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles and aza-substituted indoles |
JP5219465B2 (ja) * | 2006-11-10 | 2013-06-26 | 大塚製薬株式会社 | 医薬 |
CA2718736A1 (en) * | 2008-03-20 | 2009-09-24 | F. Hoffmann-La Roche Ag | Pyrrolidinyl derivatives and uses thereof |
US8987301B2 (en) | 2009-11-07 | 2015-03-24 | Merck Patent Gmbh | Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors |
EP2560953B1 (en) * | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
CN102766079B (zh) * | 2011-05-06 | 2015-04-08 | 上海医药工业研究院 | 一类吡咯烷衍生物、其制备方法及应用 |
US9353078B2 (en) | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
KR20160148871A (ko) | 2015-06-17 | 2016-12-27 | 양순구 | 일방향 클러치 제동장치 |
WO2017070796A1 (en) * | 2015-10-30 | 2017-05-04 | Trillium Therapeutics Inc. | Heterocycle derivatives and their use for the treatment of cns disorders |
JP2022500499A (ja) | 2018-09-07 | 2022-01-04 | ピク セラピューティクス, インコーポレイテッド | Eif4e阻害剤およびその使用 |
RU2698400C1 (ru) * | 2018-12-17 | 2019-08-26 | Георгий Сергеевич Немов | Способ лечения депрессии у собак и кошек |
CN113024517A (zh) * | 2019-12-09 | 2021-06-25 | 武汉九州钰民医药科技有限公司 | 一种制备厄达替尼的方法 |
CN113024518A (zh) * | 2019-12-09 | 2021-06-25 | 武汉九州钰民医药科技有限公司 | 一种厄达替尼的制备方法 |
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