CN1034072C - 四氢咔唑衍生物的制备方法 - Google Patents
四氢咔唑衍生物的制备方法 Download PDFInfo
- Publication number
- CN1034072C CN1034072C CN92108831A CN92108831A CN1034072C CN 1034072 C CN1034072 C CN 1034072C CN 92108831 A CN92108831 A CN 92108831A CN 92108831 A CN92108831 A CN 92108831A CN 1034072 C CN1034072 C CN 1034072C
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- Prior art keywords
- compound
- formula
- amino
- tetrahydro carbazole
- formamyl
- Prior art date
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 7
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
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- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9113802.4 | 1991-06-26 | ||
| GB919113802A GB9113802D0 (en) | 1991-06-26 | 1991-06-26 | Medicaments |
| US08/167,846 US5464864A (en) | 1991-06-26 | 1992-06-17 | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1069726A CN1069726A (zh) | 1993-03-10 |
| CN1034072C true CN1034072C (zh) | 1997-02-19 |
Family
ID=10697363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN92108831A Expired - Lifetime CN1034072C (zh) | 1991-06-26 | 1992-06-25 | 四氢咔唑衍生物的制备方法 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US5464864A (https=) |
| EP (1) | EP0591280B1 (https=) |
| JP (1) | JP3261502B2 (https=) |
| KR (1) | KR100251571B1 (https=) |
| CN (1) | CN1034072C (https=) |
| AP (1) | AP344A (https=) |
| AT (1) | ATE170746T1 (https=) |
| BR (2) | BR9206237A (https=) |
| CA (1) | CA2113726C (https=) |
| CZ (3) | CZ282327B6 (https=) |
| DE (2) | DE69226953T2 (https=) |
| DK (1) | DK0591280T3 (https=) |
| FI (1) | FI103967B1 (https=) |
| GB (1) | GB9113802D0 (https=) |
| HU (1) | HU218907B (https=) |
| IE (1) | IE922062A1 (https=) |
| IL (4) | IL117105A (https=) |
| LU (1) | LU90939I2 (https=) |
| MA (1) | MA22563A1 (https=) |
| MX (1) | MX9203444A (https=) |
| NL (1) | NL300103I2 (https=) |
| NO (2) | NO304774B1 (https=) |
| NZ (1) | NZ243288A (https=) |
| PL (3) | PL169392B1 (https=) |
| PT (1) | PT100620B (https=) |
| RU (1) | RU2137474C1 (https=) |
| SA (1) | SA92130141B1 (https=) |
| SG (1) | SG47877A1 (https=) |
| SI (1) | SI9200125B (https=) |
| SK (3) | SK280906B6 (https=) |
| TW (1) | TW214544B (https=) |
| UA (1) | UA41254C2 (https=) |
| WO (1) | WO1993000086A1 (https=) |
| ZA (1) | ZA924658B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9226530D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US5616603A (en) * | 1995-05-26 | 1997-04-01 | Smithkline Beecham Plc | Enantiomers of carbazole derivatives as 5-HT1 -like agonists |
| GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US5618948A (en) * | 1995-05-26 | 1997-04-08 | Smithkline Beecham P.L.C. | Process for preparing an enantiomer of a carbazole derivative |
| EP0749962B1 (en) * | 1995-06-23 | 2000-11-02 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles |
| US5917054A (en) * | 1995-07-18 | 1999-06-29 | Smithkline Beecham P.L.C. | Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists |
| US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
| US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
| GB9723061D0 (en) * | 1997-10-31 | 1998-01-07 | Vanguard Medica Ltd | Medicaments |
| US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
| GB9817911D0 (en) * | 1998-08-17 | 1998-10-14 | Vanguard Medica Ltd | New use |
| US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
| US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
| US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
| WO2003029214A1 (en) * | 2001-09-28 | 2003-04-10 | F. Hoffmann-La Roche Ag | Pseudopolymorphic forms of carvedilol |
| BR0312176A (pt) | 2002-06-21 | 2005-04-05 | Suven Life Sciences Ltd | Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario |
| AU2003249584B9 (en) | 2002-06-21 | 2008-05-15 | Suven Life Sciences Limited | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
| BRPI0315959C1 (pt) | 2002-11-28 | 2021-05-25 | Suven Life Sciences Ltd | composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto |
| PT1567492E (pt) | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| DK1581538T3 (da) | 2002-12-18 | 2007-06-25 | Suven Life Sciences Ltd | Tetracykliske 3-substituerede indoler med serotoninreceptoraffinitet |
| RU2430088C2 (ru) * | 2004-07-14 | 2011-09-27 | Центарис Гмбх | Производные тетрагидрокарбазола и фармацевтическая композиция на их основе |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| BRPI0715179A2 (pt) * | 2006-08-07 | 2013-06-11 | Actelion Pharmaceuticals Ltd | composto, composiÇço farmacÊutica e uso de um composto |
| EP2124556B1 (en) | 2006-10-09 | 2014-09-03 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
| DK2425820T3 (en) | 2007-02-11 | 2015-07-13 | Map Pharmaceuticals Inc | A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile |
| US20090069399A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched frovatriptan |
| ES2620672T3 (es) | 2008-01-09 | 2017-06-29 | Charleston Laboratories, Inc. | Comprimidos de doble capa que comprenden oxicodona y prometazina |
| WO2010073253A1 (en) * | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
| WO2011006012A1 (en) | 2009-07-08 | 2011-01-13 | Charleston Laboratories Inc. | Pharmaceutical compositions |
| WO2011050140A1 (en) | 2009-10-22 | 2011-04-28 | Blue Fury Consulting, L.L.C. | Posterior cervical fusion system and techniques |
| US10098674B2 (en) | 2009-10-22 | 2018-10-16 | Nuvasive, Inc. | System and method for posterior cervical fusion |
| EP3628325A1 (en) | 2011-07-22 | 2020-04-01 | The University of Chicago | Treatments for migraine and related disorders |
| AU2013361337A1 (en) | 2012-12-21 | 2015-07-09 | Map Pharmaceuticals, Inc. | 8'-Hydroxy-Dihydroergotamine compounds and compositions |
| EP2816030A1 (en) | 2013-06-20 | 2014-12-24 | Duke Chem, S. A. | Process for the preparation of frovatriptan and its enantiomer |
| GB201312768D0 (en) * | 2013-07-17 | 2013-08-28 | Ge Healthcare Ltd | Work-up procedure |
| JP2019507181A (ja) | 2016-03-04 | 2019-03-14 | チャールストン ラボラトリーズ，インコーポレイテッド | 医薬組成物 |
| EP3766483A1 (en) | 2019-07-19 | 2021-01-20 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising a triptan |
| AU2024326262A1 (en) * | 2023-08-13 | 2026-03-26 | GATC Health Corp | Compounds and methods for treating addiction |
| CN119499195A (zh) * | 2024-11-26 | 2025-02-25 | 青岛国信制药有限公司 | 一种快速吸收琥珀酸呋罗曲坦片及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642816A (en) * | 1967-08-10 | 1972-02-15 | Sterling Drug Inc | 3-acetamido-1 2 3 4-tetrahydrocarbazole |
| US3959309A (en) | 1968-01-24 | 1976-05-25 | Sterling Drug Inc. | 3-Amido-1,2,3,4-tetrahydrocarbazoles |
| US4062864A (en) * | 1968-01-24 | 1977-12-13 | Sterling Drug Inc. | 3-Hydroxy carbazole derivatives |
| US3592824A (en) * | 1970-03-12 | 1971-07-13 | Miles Lab | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
| BE787537A (fr) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | Tetrahydrocarbazoles |
| US4172834A (en) * | 1971-08-16 | 1979-10-30 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4257952A (en) * | 1977-06-06 | 1981-03-24 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
| US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
| EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
-
1991
- 1991-06-26 GB GB919113802A patent/GB9113802D0/en active Pending
-
1992
- 1992-06-17 EP EP92912379A patent/EP0591280B1/en not_active Expired - Lifetime
- 1992-06-17 CZ CZ961506A patent/CZ282327B6/cs not_active IP Right Cessation
- 1992-06-17 KR KR1019930704055A patent/KR100251571B1/ko not_active Expired - Lifetime
- 1992-06-17 UA UA93002251A patent/UA41254C2/uk unknown
- 1992-06-17 SK SK1054-98A patent/SK280906B6/sk not_active IP Right Cessation
- 1992-06-17 US US08/167,846 patent/US5464864A/en not_active Expired - Lifetime
- 1992-06-17 DE DE69226953T patent/DE69226953T2/de not_active Expired - Lifetime
- 1992-06-17 JP JP51108692A patent/JP3261502B2/ja not_active Expired - Lifetime
- 1992-06-17 CZ CS932861A patent/CZ282083B6/cs not_active IP Right Cessation
- 1992-06-17 PL PL92301883A patent/PL169392B1/pl unknown
- 1992-06-17 SK SK1685-98A patent/SK280907B6/sk not_active IP Right Cessation
- 1992-06-17 DE DE2002199042 patent/DE10299042I2/de active Active
- 1992-06-17 DK DK92912379T patent/DK0591280T3/da active
- 1992-06-17 PL PL92311304A patent/PL171034B1/pl unknown
- 1992-06-17 HU HU9303731A patent/HU218907B/hu active IP Right Revival
- 1992-06-17 SG SG1996004938A patent/SG47877A1/en unknown
- 1992-06-17 BR BR9206237A patent/BR9206237A/pt not_active Application Discontinuation
- 1992-06-17 PL PL92307118A patent/PL169410B1/pl unknown
- 1992-06-17 RU RU93058534A patent/RU2137474C1/ru active Protection Beyond IP Right Term
- 1992-06-17 CA CA002113726A patent/CA2113726C/en not_active Expired - Lifetime
- 1992-06-17 AT AT92912379T patent/ATE170746T1/de active
- 1992-06-17 WO PCT/GB1992/001082 patent/WO1993000086A1/en not_active Ceased
- 1992-06-17 CZ CZ961505A patent/CZ150596A3/cs not_active IP Right Cessation
- 1992-06-17 SK SK1319-93A patent/SK280905B6/sk not_active IP Right Cessation
- 1992-06-24 PT PT100620A patent/PT100620B/pt not_active IP Right Cessation
- 1992-06-24 MA MA22853A patent/MA22563A1/fr unknown
- 1992-06-24 ZA ZA924658A patent/ZA924658B/xx unknown
- 1992-06-24 NZ NZ243288A patent/NZ243288A/en not_active IP Right Cessation
- 1992-06-25 IL IL117105A patent/IL117105A/en not_active IP Right Cessation
- 1992-06-25 CN CN92108831A patent/CN1034072C/zh not_active Expired - Lifetime
- 1992-06-25 AP APAP/P/1992/000403A patent/AP344A/en active
- 1992-06-25 IL IL11710596A patent/IL117105A0/xx unknown
- 1992-06-25 IL IL117104A patent/IL117104A/xx not_active IP Right Cessation
- 1992-06-25 IL IL102322A patent/IL102322A/xx not_active IP Right Cessation
- 1992-06-25 TW TW081104991A patent/TW214544B/zh not_active IP Right Cessation
- 1992-06-26 MX MX9203444A patent/MX9203444A/es unknown
- 1992-06-26 SI SI9200125A patent/SI9200125B/sl unknown
- 1992-07-01 IE IE206292A patent/IE922062A1/en not_active IP Right Cessation
- 1992-10-04 SA SA92130141A patent/SA92130141B1/ar unknown
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1993
- 1993-12-23 NO NO934759A patent/NO304774B1/no not_active IP Right Cessation
- 1993-12-23 FI FI935842A patent/FI103967B1/fi not_active IP Right Cessation
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1995
- 1995-05-15 US US08/442,719 patent/US5637611A/en not_active Expired - Lifetime
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1997
- 1997-05-06 BR BR1100460-6A patent/BR1100460A/pt active IP Right Grant
-
2002
- 2002-07-24 LU LU90939C patent/LU90939I2/fr unknown
- 2002-10-14 NL NL300103C patent/NL300103I2/nl unknown
-
2005
- 2005-05-03 NO NO2005011C patent/NO2005011I2/no unknown
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