BRPI0315959C1 - composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto - Google Patents
composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do compostoInfo
- Publication number
- BRPI0315959C1 BRPI0315959C1 BRPI0315959A BR0315959A BRPI0315959C1 BR PI0315959 C1 BRPI0315959 C1 BR PI0315959C1 BR PI0315959 A BRPI0315959 A BR PI0315959A BR 0315959 A BR0315959 A BR 0315959A BR PI0315959 C1 BRPI0315959 C1 BR PI0315959C1
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- treatment
- pharmaceutical composition
- excess weight
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 3
- 238000000034 method Methods 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto". a presente invenção refere-se a novos compostos de narilasulfonila-3- indolo substituído, seus derivados, seus análogos, suas formas tautoméricas, seus estereoisômeros, suas formas geométricas, seus n-óxidos, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis e às composições farmaceuticamente aceitáveis contendo os mesmos. a presente invenção refere-se particularmente aos novos n-arilasulfonila-3-indolos substituídos tendo a fórmula (i) , seus derivados, seus análogos, suas formas tautoméricas, seus estereoisômeros, suas formas geométricas, seus óxidos de n, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis e às composições farmaceuticamente aceitáveis contendo os mesmos. a presente invenção também refere-se ao processo para a preparação dos compostos da fórmula (i), as composições farmacêuticas que contém tais compostos e ao uso de tais compostos e composições na medicina. esta invenção também está relacionada aos intermediários inovadores envolvidos nos mesmos e ao processo para a sua preparação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN884/MAS/2002 | 2002-11-28 | ||
IN884MA2002 | 2002-11-28 | ||
PCT/IN2003/000209 WO2004048330A1 (en) | 2002-11-28 | 2003-06-05 | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
Publications (4)
Publication Number | Publication Date |
---|---|
BR0315959A BR0315959A (pt) | 2005-09-13 |
BRPI0315959B1 BRPI0315959B1 (pt) | 2017-12-19 |
BRPI0315959B8 BRPI0315959B8 (pt) | 2018-01-16 |
BRPI0315959C1 true BRPI0315959C1 (pt) | 2021-05-25 |
Family
ID=40184827
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0318799A BRPI0318799B8 (pt) | 2002-11-28 | 2003-06-05 | processo para a preparação de um composto |
BRPI0315959A BRPI0315959C1 (pt) | 2002-11-28 | 2003-06-05 | composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0318799A BRPI0318799B8 (pt) | 2002-11-28 | 2003-06-05 | processo para a preparação de um composto |
Country Status (22)
Country | Link |
---|---|
US (1) | US7875605B2 (pt) |
EP (1) | EP1581492B1 (pt) |
JP (1) | JP4559230B2 (pt) |
KR (1) | KR100818508B1 (pt) |
CN (2) | CN1720225B (pt) |
AT (1) | ATE401307T1 (pt) |
AU (1) | AU2003237599B2 (pt) |
BR (2) | BRPI0318799B8 (pt) |
CA (1) | CA2509982C (pt) |
CY (1) | CY1108786T1 (pt) |
DE (1) | DE60322266D1 (pt) |
DK (1) | DK1581492T3 (pt) |
EA (1) | EA011320B1 (pt) |
ES (1) | ES2310243T3 (pt) |
HK (2) | HK1133002A1 (pt) |
MX (1) | MXPA05005701A (pt) |
NO (2) | NO330341B1 (pt) |
NZ (2) | NZ572186A (pt) |
PT (1) | PT1581492E (pt) |
SI (1) | SI1581492T1 (pt) |
WO (1) | WO2004048330A1 (pt) |
ZA (1) | ZA200504043B (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003208711A1 (en) * | 2002-02-12 | 2003-09-04 | Akzo Nobel N.V. | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
KR101049868B1 (ko) | 2004-01-02 | 2011-07-19 | 수벤 라이프 사이언시스 리미티드 | 신규한 인데노[2,1a]인덴 및 이소인돌[2,1-a]인돌 |
AU2006274884B2 (en) | 2005-07-29 | 2012-04-05 | F. Hoffmann-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
WO2007020653A1 (en) * | 2005-08-12 | 2007-02-22 | Suven Life Sciences Limited | Thioether derivatives as functional 5-ht6 ligands |
NZ566495A (en) | 2005-08-12 | 2010-06-25 | Suven Life Sciences Ltd | Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands |
KR101250820B1 (ko) | 2005-08-16 | 2013-04-04 | 수벤 라이프 사이언시스 리미티드 | 개선된 로사르탄 제조 방법 |
AU2007343062B2 (en) * | 2007-01-08 | 2011-02-10 | Suven Life Sciences Limited | 4-(Heterocyclyl)alkyl-N-(arylsulfonyl) indole compounds and their use as 5-HT6 ligands |
WO2008084492A1 (en) | 2007-01-08 | 2008-07-17 | Suven Life Sciences Limited | 5-(heterocyclyl)alkyl-n-(arylsulfonyl)indole compounds and their use as 5-ht6 ligands |
MX2009011461A (es) | 2007-05-03 | 2009-11-10 | Suven Life Sciences Ltd | Compuestos de aminoalcoxiarilsulfonamida y su uso como ligandos de la 5-hidroxitriptamina6. |
WO2008144263A1 (en) * | 2007-05-18 | 2008-11-27 | The Ohio State University Research Foundation | Potent indole-3-carbinol-derived antitumor agents |
CA2703157C (en) | 2007-10-26 | 2013-02-05 | Suven Life Sciences Limited | Amino arylsulfonamide compounds and their use as 5-ht6 ligands |
WO2010032257A1 (en) | 2008-09-17 | 2010-03-25 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands |
EA019496B1 (ru) | 2008-09-17 | 2014-04-30 | Сувен Лайф Сайенсиз Лимитед | Арилсульфонамидные аминосоединения и их применение в качестве лигандов 5-ht |
EP2464227A4 (en) * | 2009-08-10 | 2013-02-20 | Galenea Corp | COMPOUNDS AND METHODS OF USE |
US8153680B2 (en) * | 2009-08-25 | 2012-04-10 | The Ohio State University Research Foundation | Alkyl indole-3-carbinol-derived antitumor agents |
KR101463190B1 (ko) | 2010-01-05 | 2014-11-18 | 수벤 라이프 사이언시스 리미티드 | 5ht6 수용체 리간드인 술폰 화합물 |
CN102093149A (zh) * | 2010-12-08 | 2011-06-15 | 天津理工大学 | 一种促进氰基快速水解制备羧酸类化合物的方法 |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
KR101534136B1 (ko) * | 2013-06-11 | 2015-07-07 | 이화여자대학교 산학협력단 | 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 5-ht6 수용체 관련 질환의 예방 또는 치료용 약학적 조성물 |
AU2014358682B2 (en) | 2013-12-02 | 2016-10-20 | Suven Life Sciences Limited | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate |
WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
AU2015286049B2 (en) | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
PL3180001T3 (pl) * | 2014-08-16 | 2019-07-31 | Suven Life Sciences Limited | Aktywny metabolit monohydrat dimesylanu 1-[(2-bromofenylo)sulfonylo]-5-metoksy-3-[(4-metylo-1-piperazynylo)metylo]-1h-indolu oraz sól dihydrat dimesylanu aktywnego metabolitu |
EA038087B1 (ru) | 2016-05-18 | 2021-07-05 | Сувен Лайф Сайенсиз Лимитед | Трехкомпонентная фармацевтическая комбинация чистых антагонистов 5-ht6 рецепторов, ингибиторов ацетилхолинэстеразы и антагониста nmda рецептора, применение указанной комбинации и содержащей ее фармацевтической композиции в лечении когнитивных расстройств и способ такого лечения |
US11458135B2 (en) | 2016-05-18 | 2022-10-04 | Suven Life Sciences Limited | Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors |
CN109069449A (zh) * | 2016-05-18 | 2018-12-21 | 苏文生命科学有限公司 | 纯5-ht6受体拮抗剂与nmda受体拮抗剂的组合 |
ES2879675T3 (es) * | 2016-10-03 | 2021-11-22 | Suven Life Sciences Ltd | Composición farmacéutica de antagonista de 5-HT6 |
CN107174586B (zh) * | 2017-02-21 | 2020-08-11 | 中国科学院昆明植物研究所 | 以芦竹碱衍生物为活性成分的药物组合物及其应用 |
JP6959371B2 (ja) | 2017-07-03 | 2021-11-02 | スヴェン・ライフ・サイエンシーズ・リミテッドSuven Life Sciences Limited | 純粋な5−ht6受容体アンタゴニストの新たな使用 |
KR20220110518A (ko) | 2019-12-02 | 2022-08-08 | 수벤 라이프 사이언시스 리미티드 | 치매 환자의 행동 및 심리적 증상 치료 |
KR20220108123A (ko) | 2019-12-02 | 2022-08-02 | 수벤 라이프 사이언시스 리미티드 | 치매 환자의 행동 및 심리적 증상 치료 |
CN111233737B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
CN111362858B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
KR102347372B1 (ko) | 2020-12-14 | 2022-01-07 | (주)케이메디켐 | 신규한 인돌 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물 |
CN115504925B (zh) * | 2021-06-22 | 2024-03-12 | 广东药科大学 | 一类ppar激动剂、其制备方法及其作为药物的用途 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1305458A (pt) * | 1969-02-26 | 1973-01-31 | ||
ZA795239B (en) | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
BE889931A (fr) * | 1980-08-12 | 1982-02-11 | Glaxo Group Ltd | Derives indoliques, leur preparation et leurs applications en tant que medicaments |
GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
GB8719167D0 (en) | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
GB8724912D0 (en) | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
GB8819024D0 (en) | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
JPH04208263A (ja) * | 1990-01-02 | 1992-07-29 | Fujisawa Pharmaceut Co Ltd | インドール誘導体およびそれらの製造法 |
IL96891A0 (en) | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
CA2042295A1 (fr) | 1990-05-15 | 1991-11-16 | Jacques Chauveau | Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant |
MC2210A1 (fr) | 1990-06-07 | 1992-11-26 | Wellcome Found | Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer |
CZ283018B6 (cs) | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
TW263508B (pt) * | 1991-02-12 | 1995-11-21 | Pfizer | |
GB9113802D0 (en) | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
JP3223193B2 (ja) * | 1991-08-09 | 2001-10-29 | 株式会社日清製粉グループ本社 | インドール誘導体およびそれらを有効成分とする抗癌剤耐性克服物質 |
GB9210400D0 (en) | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
KR940007001A (ko) | 1992-09-16 | 1994-04-26 | 최승주 | 새로운 n-신나모일-2-메틸-5-메톡시-3-인돌 아세트산 에스테르, 그 제조방법 및 이를 함유하는 약학적 제제 |
MX9700693A (es) * | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
CA2370147C (en) * | 1999-04-21 | 2009-07-28 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-ht6 affinity |
JP2000344744A (ja) * | 1999-06-04 | 2000-12-12 | Ss Pharmaceut Co Ltd | アセトフェノン誘導体およびその製法 |
PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
CN1317276C (zh) * | 2000-09-29 | 2007-05-23 | 中国科学院上海药物研究所 | 一类吲哚基哌啶类化合物及其制备方法和用途 |
EA006132B1 (ru) * | 2000-10-20 | 2005-10-27 | Биовитрум Аб | 2-, 3-, 4- или 5-замещенные n-(1-(арил-, гетероарил- или арилалкил)сульфонил)индолы и их применение в терапии |
ATE337780T1 (de) * | 2000-11-24 | 2006-09-15 | Smithkline Beecham Plc | Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns |
US20040039017A1 (en) * | 2000-12-11 | 2004-02-26 | Dashyant Dhanak | Urotensin-II receptor antagonists |
IL156518A0 (en) * | 2000-12-22 | 2004-01-04 | Wyeth Corp | Heteocyclylalkylindole or-azaindole compounds as 5-hydroxytryptamine-6 ligands |
EP1359915A4 (en) | 2001-01-26 | 2004-07-21 | Smithkline Beecham | UROTENSIN-II RECEPTOR ANTAGONISTS |
AU2003208711A1 (en) * | 2002-02-12 | 2003-09-04 | Akzo Nobel N.V. | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
-
2003
- 2003-06-05 AU AU2003237599A patent/AU2003237599B2/en not_active Expired
- 2003-06-05 CN CN038254883A patent/CN1720225B/zh not_active Expired - Lifetime
- 2003-06-05 KR KR1020057009512A patent/KR100818508B1/ko active IP Right Grant
- 2003-06-05 EA EA200500881A patent/EA011320B1/ru unknown
- 2003-06-05 BR BRPI0318799A patent/BRPI0318799B8/pt active IP Right Grant
- 2003-06-05 ES ES03735970T patent/ES2310243T3/es not_active Expired - Lifetime
- 2003-06-05 CA CA2509982A patent/CA2509982C/en not_active Expired - Lifetime
- 2003-06-05 US US10/536,618 patent/US7875605B2/en active Active
- 2003-06-05 CN CN200910134498XA patent/CN101544592B/zh not_active Expired - Lifetime
- 2003-06-05 NZ NZ572186A patent/NZ572186A/en not_active IP Right Cessation
- 2003-06-05 JP JP2004554900A patent/JP4559230B2/ja not_active Expired - Lifetime
- 2003-06-05 NZ NZ540840A patent/NZ540840A/en not_active IP Right Cessation
- 2003-06-05 DE DE60322266T patent/DE60322266D1/de not_active Expired - Lifetime
- 2003-06-05 PT PT03735970T patent/PT1581492E/pt unknown
- 2003-06-05 AT AT03735970T patent/ATE401307T1/de active
- 2003-06-05 SI SI200331342T patent/SI1581492T1/sl unknown
- 2003-06-05 DK DK03735970T patent/DK1581492T3/da active
- 2003-06-05 BR BRPI0315959A patent/BRPI0315959C1/pt not_active IP Right Cessation
- 2003-06-05 MX MXPA05005701A patent/MXPA05005701A/es active IP Right Grant
- 2003-06-05 EP EP03735970A patent/EP1581492B1/en not_active Expired - Lifetime
- 2003-06-05 WO PCT/IN2003/000209 patent/WO2004048330A1/en active IP Right Grant
-
2005
- 2005-05-19 ZA ZA200504043A patent/ZA200504043B/en unknown
- 2005-06-08 NO NO20052737A patent/NO330341B1/no not_active IP Right Cessation
-
2006
- 2006-03-10 HK HK09111134.5A patent/HK1133002A1/xx not_active IP Right Cessation
- 2006-03-10 HK HK06103107.8A patent/HK1083217A1/xx not_active IP Right Cessation
-
2008
- 2008-09-17 CY CY20081100999T patent/CY1108786T1/el unknown
- 2008-12-05 NO NO20085054A patent/NO335015B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0315959C1 (pt) | composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto | |
CY1111876T1 (el) | Νεες πυρρολες με υπολiπiδaiμiκες και υποχοληστερολαιμικες δραστικοτητες, μεθοδος για την παρασκευη αυτων και φαρμακευτικες συνθεσεις που τις περιεχουν και η χρηση αυτων στην ιατρικη | |
EA200600925A1 (ru) | Производные триазола в качестве антагонистов вазопрессина | |
ATE324371T1 (de) | N-substituierte heterocyclische nichtaryl- nmda/nr2b-antagonisten | |
AR053301A1 (es) | Derivados de pirazina y su uso farmaceutico | |
BR0306208A (pt) | Compostos de dibenzilamina e seu uso farmacêutico | |
CY1114417T1 (el) | Ετεροκυκλικες ενωσεις, δραστικες ως αναστολεις των βητα-λακταμασων | |
BR0313942A (pt) | Derivados de benzimidazol úteis como agentes antiproliferativos | |
DE60140456D1 (de) | Aza heterocyclische derivate und ihre therapeutische verwendung | |
MX2007006387A (es) | Derivados de piridina 3-substituidos como antagonistas h3. | |
HK1074843A1 (en) | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity | |
BRPI0316895B8 (pt) | composto, processo para a preparação do composto, composição farmacêutica e uso do composto | |
NO20090332L (no) | 4-amino-3-arylamino-6-arylpyrazol[3,4-D]pyrimidinderivater, fremgangsmater for deres fremstilling og dere anvendelse som antivirale midler | |
BR0312175A (pt) | Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso | |
CO5011066A1 (es) | Compuestos de triazina | |
UY27910A1 (es) | Uso de un derivado de amina cíclica específico o de sus sales farmacéuticamente aceptables para tratar o prevenir la insuficiencia cardiaca | |
AR027644A1 (es) | Compuestos de piridacinil fenil hidrazona, composicion farmaceutica que lo comprende y metodo para el tratamiento de una falla del corazon congestiva quelo emplea | |
BR0312174A (pt) | Composto, composição farmacêutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediário e processo para a preparação de um novo intermediário | |
UY26568A1 (es) | Nuevos derivados de amidas heterocíclicas | |
ES2038532B1 (es) | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. | |
UY26328A1 (es) | Derivados de amino-triazolopiridina | |
ECSP982773A (es) | Derivados heterociclicos de benzocicloalqueno y procedimiento para su fabricacion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/06/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |
|
B21H | Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2777 DE 26/03/2024 POR TER SIDO INDEVIDA. |