CN102316735A - 坏死性凋亡的小分子抑制剂 - Google Patents
坏死性凋亡的小分子抑制剂 Download PDFInfo
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- CN102316735A CN102316735A CN2009801569144A CN200980156914A CN102316735A CN 102316735 A CN102316735 A CN 102316735A CN 2009801569144 A CN2009801569144 A CN 2009801569144A CN 200980156914 A CN200980156914 A CN 200980156914A CN 102316735 A CN102316735 A CN 102316735A
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- officinal salt
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- 0 *C(c1ccccc1CC1)(c2c1c(*)c(*)c(*)c2*)O* Chemical compound *C(c1ccccc1CC1)(c2c1c(*)c(*)c(*)c2*)O* 0.000 description 6
- SNLAAGHHNZECPE-UHFFFAOYSA-N COC(C1Oc2ccccc2OC1)=O Chemical compound COC(C1Oc2ccccc2OC1)=O SNLAAGHHNZECPE-UHFFFAOYSA-N 0.000 description 1
- XKVUYEYANWFIJX-UHFFFAOYSA-N Cc1n[nH]cc1 Chemical compound Cc1n[nH]cc1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 description 1
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- 2009-12-23 WO PCT/US2009/069483 patent/WO2010075561A1/en not_active Ceased
- 2009-12-23 CN CN201510081043.1A patent/CN104803986A/zh active Pending
- 2009-12-23 CA CA2772760A patent/CA2772760A1/en not_active Abandoned
- 2009-12-23 US US13/141,545 patent/US20120122889A1/en not_active Abandoned
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- 2009-12-23 CN CN2009801569144A patent/CN102316735A/zh active Pending
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| WO2002002568A1 (de) * | 2000-07-03 | 2002-01-10 | Knoll Gmbh | Pyrimidinderivate und ihre verwendung zur prophylaxe and therapie der zerebralen ischämie |
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| CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
| CN103396376A (zh) * | 2013-07-31 | 2013-11-20 | 葛瑞武 | 一种抗菌抗癌活性化合物 |
| CN107108492A (zh) * | 2014-12-24 | 2017-08-29 | 北京生命科学研究所 | 细胞坏死抑制剂 |
| CN107108467A (zh) * | 2014-12-24 | 2017-08-29 | 北京生命科学研究所 | 细胞坏死抑制剂 |
| CN115197098B (zh) * | 2014-12-24 | 2023-08-08 | 北京生命科学研究所 | 细胞坏死抑制剂 |
| CN115197098A (zh) * | 2014-12-24 | 2022-10-18 | 北京生命科学研究所 | 细胞坏死抑制剂 |
| CN112370452A (zh) * | 2015-05-19 | 2021-02-19 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为激酶抑制剂的杂环酰胺 |
| CN109078187A (zh) * | 2018-08-02 | 2018-12-25 | 中国人民解放军第四军医大学 | 胰腺GnIH受体功能调节剂制备治疗2型糖尿病药物的应用 |
| CN109078187B (zh) * | 2018-08-02 | 2021-04-20 | 中国人民解放军第四军医大学 | 胰腺GnIH受体功能调节剂制备治疗2型糖尿病药物的应用 |
| CN113302183A (zh) * | 2018-11-20 | 2021-08-24 | 圣瑞诺有限公司 | 环脲 |
| WO2020233618A1 (zh) * | 2019-05-21 | 2020-11-26 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| CN111978311A (zh) * | 2019-05-21 | 2020-11-24 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| WO2021233397A1 (en) * | 2020-05-20 | 2021-11-25 | Sironax Ltd. | Piperazine cyclic ureas |
| WO2021233394A1 (en) * | 2020-05-20 | 2021-11-25 | Sironax Ltd. | Receptor-interacting protein 1 inhibitors including piperazine heterocyclic amide ureas |
| CN115697991A (zh) * | 2020-05-20 | 2023-02-03 | 维泰瑞隆有限公司 | 哌嗪环状脲 |
| US12454529B2 (en) | 2020-05-20 | 2025-10-28 | Sironax Ltd. | Piperazine cyclic ureas |
| CN115956070A (zh) * | 2020-06-19 | 2023-04-11 | 阿纳克西斯制药股份有限公司 | 磺酰胺化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2381775A1 (en) | 2011-11-02 |
| JP2015061853A (ja) | 2015-04-02 |
| HK1223272A1 (en) | 2017-07-28 |
| CN104803986A (zh) | 2015-07-29 |
| CA2772760A1 (en) | 2010-07-01 |
| US20190135718A1 (en) | 2019-05-09 |
| AU2016202262A1 (en) | 2016-05-12 |
| WO2010075561A1 (en) | 2010-07-01 |
| AU2009329879A1 (en) | 2011-08-11 |
| US9586880B2 (en) | 2017-03-07 |
| EP3000468A1 (en) | 2016-03-30 |
| US20140024657A1 (en) | 2014-01-23 |
| HK1212973A1 (zh) | 2016-06-24 |
| JP6178777B2 (ja) | 2017-08-09 |
| US20120122889A1 (en) | 2012-05-17 |
| JP2012513481A (ja) | 2012-06-14 |
| BRPI0923126A2 (pt) | 2021-09-08 |
| US20170305824A1 (en) | 2017-10-26 |
| EP2381775A4 (en) | 2012-08-15 |
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