CN102197033B - 吡咯化合物 - Google Patents

吡咯化合物 Download PDF

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Publication number
CN102197033B
CN102197033B CN200980142371.0A CN200980142371A CN102197033B CN 102197033 B CN102197033 B CN 102197033B CN 200980142371 A CN200980142371 A CN 200980142371A CN 102197033 B CN102197033 B CN 102197033B
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CN
China
Prior art keywords
compound
ethyl acetate
fluoro
fluoropyridin
sulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980142371.0A
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English (en)
Chinese (zh)
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CN102197033A (zh
Inventor
西田晴行
有川泰由
藤森郁男
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
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Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN102197033A publication Critical patent/CN102197033A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980142371.0A 2008-08-27 2009-08-26 吡咯化合物 Active CN102197033B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP218851/08 2008-08-27
JP2008218851 2008-08-27
JP2008269099 2008-10-17
JP269099/08 2008-10-17
PCT/JP2009/065279 WO2010024451A1 (en) 2008-08-27 2009-08-26 Pyrrole compounds

Publications (2)

Publication Number Publication Date
CN102197033A CN102197033A (zh) 2011-09-21
CN102197033B true CN102197033B (zh) 2014-07-16

Family

ID=41508823

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980142371.0A Active CN102197033B (zh) 2008-08-27 2009-08-26 吡咯化合物

Country Status (38)

Country Link
US (3) US8969387B2 (cg-RX-API-DMAC7.html)
EP (1) EP2318390B1 (cg-RX-API-DMAC7.html)
JP (1) JP5638515B2 (cg-RX-API-DMAC7.html)
KR (1) KR101629181B1 (cg-RX-API-DMAC7.html)
CN (1) CN102197033B (cg-RX-API-DMAC7.html)
AR (1) AR073136A1 (cg-RX-API-DMAC7.html)
AU (1) AU2009284867B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0917705A2 (cg-RX-API-DMAC7.html)
CA (1) CA2735162C (cg-RX-API-DMAC7.html)
CL (1) CL2011000402A1 (cg-RX-API-DMAC7.html)
CO (1) CO6321166A2 (cg-RX-API-DMAC7.html)
CR (1) CR20110169A (cg-RX-API-DMAC7.html)
CY (1) CY1114452T1 (cg-RX-API-DMAC7.html)
DK (1) DK2318390T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2011000061A (cg-RX-API-DMAC7.html)
EA (1) EA019741B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP11010912A (cg-RX-API-DMAC7.html)
ES (1) ES2423289T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20135786B (cg-RX-API-DMAC7.html)
HR (1) HRP20130653T1 (cg-RX-API-DMAC7.html)
IL (1) IL211335A (cg-RX-API-DMAC7.html)
JO (1) JO2871B1 (cg-RX-API-DMAC7.html)
MA (1) MA32647B1 (cg-RX-API-DMAC7.html)
ME (1) ME01598B (cg-RX-API-DMAC7.html)
MX (1) MX2011001955A (cg-RX-API-DMAC7.html)
MY (1) MY152008A (cg-RX-API-DMAC7.html)
NZ (1) NZ591793A (cg-RX-API-DMAC7.html)
PE (2) PE20141174A1 (cg-RX-API-DMAC7.html)
PL (1) PL2318390T3 (cg-RX-API-DMAC7.html)
PT (1) PT2318390E (cg-RX-API-DMAC7.html)
RS (1) RS52872B (cg-RX-API-DMAC7.html)
SI (1) SI2318390T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201300085B (cg-RX-API-DMAC7.html)
TW (1) TWI473798B (cg-RX-API-DMAC7.html)
UA (1) UA105185C2 (cg-RX-API-DMAC7.html)
UY (1) UY32074A (cg-RX-API-DMAC7.html)
WO (1) WO2010024451A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201101774B (cg-RX-API-DMAC7.html)

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CN102452979B (zh) * 2010-11-03 2015-04-01 天津药明康德新药开发有限公司 5-氟-3-吡啶磺酰氯的合成方法
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
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WO2014003199A1 (en) 2012-06-27 2014-01-03 Takeda Pharmaceutical Company Limited Liquid preparations of amines and organic acids stabilized by salts
JP6343600B2 (ja) * 2013-02-28 2018-06-13 武田薬品工業株式会社 スルホニルクロライド化合物の製造法
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
UY36547A (es) 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
WO2016138099A1 (en) 2015-02-24 2016-09-01 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
UA124663C2 (uk) 2015-07-30 2021-10-27 Такеда Фармасьютікал Компані Лімітед Таблетка
AU2016307233B2 (en) 2015-08-07 2020-12-24 Bayer Cropscience Aktiengesellschaft 2-(het)aryl-substituted condensed heterocyclic derivatives as pest control agents
CN106430006B (zh) * 2016-08-18 2018-06-12 国网湖南省电力公司带电作业中心 配电线路移动式绝缘登高作业装置及方法
CN108203430A (zh) * 2016-12-16 2018-06-26 天地人和生物科技有限公司 一种新型可逆性质子泵抑制剂及其制备方法和用途
JP7228535B2 (ja) 2017-07-10 2023-02-24 武田薬品工業株式会社 ボノプラザン含有製剤
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CN113527536B (zh) * 2020-04-21 2024-03-22 杭州德柯医疗科技有限公司 一种含氟多糖高分子化合物及其制备方法
US11767311B2 (en) * 2020-06-17 2023-09-26 Ildong Pharmaceutical Co., Ltd. Acid secretion inhibitor and use thereof
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
US20250042872A1 (en) * 2021-12-15 2025-02-06 Ildong Pharmaceutical Co., Ltd. Novel salt of 1-sulfonyl pyrrole derivative, method for preparing same, and pharmaceutical composition including same
KR102802551B1 (ko) * 2021-12-15 2025-05-07 유노비아 주식회사 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물

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Also Published As

Publication number Publication date
KR20110071067A (ko) 2011-06-28
AR073136A1 (es) 2010-10-13
JP2012501296A (ja) 2012-01-19
CN102197033A (zh) 2011-09-21
UA105185C2 (uk) 2014-04-25
JP5638515B2 (ja) 2014-12-10
NZ591793A (en) 2012-11-30
CA2735162A1 (en) 2010-03-04
PE20110300A1 (es) 2011-06-16
SI2318390T1 (sl) 2013-08-30
US20100056577A1 (en) 2010-03-04
HK1157756A1 (en) 2012-07-06
BRPI0917705A2 (pt) 2016-02-16
TWI473798B (zh) 2015-02-21
US8993598B2 (en) 2015-03-31
GEP20135786B (en) 2013-03-11
CR20110169A (es) 2011-05-16
MX2011001955A (es) 2011-03-29
DK2318390T3 (da) 2013-07-08
AU2009284867B2 (en) 2014-08-28
SMT201300085B (it) 2013-09-06
PT2318390E (pt) 2013-07-10
AU2009284867A2 (en) 2011-04-21
CY1114452T1 (el) 2016-10-05
EA019741B1 (ru) 2014-05-30
EP2318390A1 (en) 2011-05-11
US20140031393A1 (en) 2014-01-30
WO2010024451A1 (en) 2010-03-04
US8969387B2 (en) 2015-03-03
RS52872B (sr) 2013-12-31
PE20141174A1 (es) 2014-09-19
MY152008A (en) 2014-08-15
TW201010993A (en) 2010-03-16
ECSP11010912A (es) 2011-04-29
AU2009284867A1 (en) 2010-03-04
US20110172275A1 (en) 2011-07-14
MA32647B1 (fr) 2011-09-01
EP2318390B1 (en) 2013-05-01
IL211335A0 (en) 2011-04-28
IL211335A (en) 2013-12-31
ES2423289T3 (es) 2013-09-19
ME01598B (me) 2014-09-20
JO2871B1 (en) 2015-03-15
DOP2011000061A (es) 2011-04-15
CL2011000402A1 (es) 2011-07-29
UY32074A (es) 2010-03-26
EA201170384A1 (ru) 2011-10-31
PL2318390T3 (pl) 2013-09-30
CA2735162C (en) 2015-06-23
KR101629181B1 (ko) 2016-06-13
CO6321166A2 (es) 2011-09-20
US8592597B2 (en) 2013-11-26
ZA201101774B (en) 2012-06-27
HRP20130653T1 (en) 2013-08-31

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