CN101247807A - 噻唑化合物及使用方法 - Google Patents
噻唑化合物及使用方法 Download PDFInfo
- Publication number
- CN101247807A CN101247807A CNA200680025066XA CN200680025066A CN101247807A CN 101247807 A CN101247807 A CN 101247807A CN A200680025066X A CNA200680025066X A CN A200680025066XA CN 200680025066 A CN200680025066 A CN 200680025066A CN 101247807 A CN101247807 A CN 101247807A
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- yuan
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67913305P | 2005-05-09 | 2005-05-09 | |
US60/679,133 | 2005-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101247807A true CN101247807A (zh) | 2008-08-20 |
Family
ID=36968742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA200680025066XA Pending CN101247807A (zh) | 2005-05-09 | 2006-05-09 | 噻唑化合物及使用方法 |
Country Status (18)
Country | Link |
---|---|
US (2) | US8088806B2 (ja) |
EP (1) | EP1879575A2 (ja) |
JP (1) | JP2008540537A (ja) |
KR (1) | KR20080019213A (ja) |
CN (1) | CN101247807A (ja) |
AP (1) | AP2358A (ja) |
AU (1) | AU2006244203B2 (ja) |
BR (1) | BRPI0608910A2 (ja) |
CA (1) | CA2607617A1 (ja) |
EA (1) | EA200702445A1 (ja) |
IL (1) | IL186970A0 (ja) |
MX (1) | MX2007013955A (ja) |
NO (1) | NO20075723L (ja) |
NZ (1) | NZ563866A (ja) |
SG (1) | SG159561A1 (ja) |
UA (1) | UA92746C2 (ja) |
WO (1) | WO2006122011A2 (ja) |
ZA (1) | ZA200709751B (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010148963A1 (zh) * | 2009-06-25 | 2010-12-29 | 上海唐润医药科技有限公司 | 具有抗肝炎病毒活性的化合物及其用途 |
WO2012136111A1 (zh) * | 2011-04-02 | 2012-10-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯丙酸化合物、其制备方法及其医药用途 |
CN105524056A (zh) * | 2016-01-05 | 2016-04-27 | 中山大学肿瘤防治中心 | 一种氨基噻唑化合物及其制备方法和应用 |
CN107531687A (zh) * | 2015-02-27 | 2018-01-02 | 加利福尼亚大学董事会 | 能够实现软骨复壮的小分子 |
CN114249702A (zh) * | 2022-01-12 | 2022-03-29 | 沈阳药科大学 | N-芳基- [2,4′-双噻唑]-2′-胺类化合物及其制备与用途 |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2617532A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Imidazo [2,1-b] thiazole derivatives as sirtuin modulating compounds |
CA2645072A1 (en) * | 2006-03-08 | 2007-09-13 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole derivatives with anti-hcv activity |
JP5182088B2 (ja) | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
WO2008016968A2 (en) | 2006-08-03 | 2008-02-07 | Trustees Of Tufts College | Non-flushing niacin analogues, and methods of use thereof |
MX2009002019A (es) | 2006-08-24 | 2009-03-09 | Novartis Ag | Derivados de 2-(pirazin-2-il)-tiazol y 2-(1h-pirazol-3-il)-tiazol asi como compuestos relacionados como inhibidores de la estearoil-coa-desaturasa (scd) para el tratamiento de trastornos metabolicos, cardiovasculares, y otros. |
EP2066664A1 (en) | 2006-09-22 | 2009-06-10 | Novartis AG | Heterocyclic organic compounds |
EP2097405A2 (en) * | 2006-11-21 | 2009-09-09 | Smithkline Beecham Corporation | Anti-viral compounds |
BRPI0720452A2 (pt) | 2006-12-20 | 2014-01-14 | Novartis Ag | Compostos orgânicos |
WO2008124300A1 (en) | 2007-04-10 | 2008-10-16 | National Health Research Institutes | Hepatitis c virus inhibitors |
EP2148878A4 (en) * | 2007-04-20 | 2011-08-10 | Merck Canada Inc | NEW HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
CN101801964A (zh) * | 2007-05-22 | 2010-08-11 | 艾其林医药公司 | 杂芳基取代的噻唑及其作为抗病毒剂的用途 |
US20100152208A1 (en) * | 2007-05-23 | 2010-06-17 | Merck Frosst Canada Ltd. | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
WO2008154091A1 (en) | 2007-06-08 | 2008-12-18 | National Health Research Institutes | Thiourea derivatives |
CL2008001821A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras. |
CN101874029A (zh) * | 2007-07-13 | 2010-10-27 | 艾德克斯药品股份有限公司 | 作为代谢型谷氨酸受体调节剂的吡唑衍生物 |
GB2455111A (en) * | 2007-11-28 | 2009-06-03 | Addex Pharmaceuticals Sa | Metabotropic glutamate receptor (mGluR4) modulators having 5- or 6-membered N-heteroaryl ring substituted by both N-cyclylamino & 5-membered N-heteroaryl ring |
CN101801942B (zh) * | 2007-07-17 | 2013-03-27 | 美国艾森生物科学公司 | 杂环化合物和作为抗癌剂的用途 |
JP2010533658A (ja) * | 2007-07-20 | 2010-10-28 | メルク フロスト カナダ リミテツド | ステアロイル補酵素aデルタ−9デサチュラーゼ阻害剤としての二環性へテロ芳香族化合物 |
JP2010534722A (ja) * | 2007-07-27 | 2010-11-11 | ブリストル−マイヤーズ スクイブ カンパニー | 新規グルコキナーゼ活性化薬およびその使用方法 |
BRPI0815057B8 (pt) | 2007-08-03 | 2021-05-25 | Romark Laboratories Lc | composto, composição farmacêutica, e, uso de um composto |
EP2195312B1 (en) * | 2007-10-09 | 2012-11-21 | Merck Patent GmbH | Pyridine derivatives useful as glucokinase activators |
US8389736B2 (en) * | 2007-10-16 | 2013-03-05 | The Regents Of The University Of California | Compounds having activity in correcting mutant-CFTR processing and uses thereof |
CA2703106C (en) | 2007-10-24 | 2015-12-01 | Astellas Pharma Inc. | Azolecarboxamide derivatives as trka inhibitors |
EP2070925A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
EP2070924A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel |
EP2070916A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | 2-Aryl-thiazol-4-carbonsäureamid-Derivate, deren Herstellung und Verwendung als Arzneimittel |
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US8198284B2 (en) | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
US8106209B2 (en) * | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
US8362050B2 (en) | 2008-06-24 | 2013-01-29 | Irm Llc | Compounds and methods for modulating G protein-coupled receptors |
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US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
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MX2015001793A (es) * | 2012-08-09 | 2015-05-07 | Neuropore Therapies Inc | Derivados de benceno sustituidos con arilo y heteroarilo como moduladores de las trayectorias de señalizacion de cinasa pi3. |
WO2014063167A1 (en) * | 2012-10-19 | 2014-04-24 | The Broad Institute, Inc. | Thiazole-based inhibitors of scavenger receptor bi |
WO2014063168A1 (en) | 2012-10-19 | 2014-04-24 | The Broad Institute, Inc. | Heterocycle-bisamide inhibitors of scavenger receptor bl |
US9382218B2 (en) * | 2013-03-05 | 2016-07-05 | Hoffmann-La Roche Inc. | N-heteroaryl substituted aniline derivatives as HCV-antivirals |
TW201534586A (zh) | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎cyp17抑制劑/抗雄激素劑 |
WO2015002926A1 (en) | 2013-07-02 | 2015-01-08 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
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- 2006-05-09 CN CNA200680025066XA patent/CN101247807A/zh active Pending
- 2006-05-09 BR BRPI0608910-0A patent/BRPI0608910A2/pt not_active IP Right Cessation
- 2006-05-09 NZ NZ563866A patent/NZ563866A/en not_active IP Right Cessation
- 2006-05-09 AP AP2007004268A patent/AP2358A/xx active
- 2006-05-09 MX MX2007013955A patent/MX2007013955A/es not_active Application Discontinuation
- 2006-05-09 KR KR1020077028496A patent/KR20080019213A/ko not_active Application Discontinuation
- 2006-05-09 UA UAA200713741A patent/UA92746C2/ru unknown
- 2006-05-09 EA EA200702445A patent/EA200702445A1/ru unknown
- 2006-05-09 JP JP2008511226A patent/JP2008540537A/ja active Pending
- 2006-05-09 WO PCT/US2006/017692 patent/WO2006122011A2/en active Application Filing
- 2006-05-09 US US11/431,155 patent/US8088806B2/en not_active Expired - Fee Related
- 2006-05-09 SG SG201001098-1A patent/SG159561A1/en unknown
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WO2010148963A1 (zh) * | 2009-06-25 | 2010-12-29 | 上海唐润医药科技有限公司 | 具有抗肝炎病毒活性的化合物及其用途 |
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WO2012136111A1 (zh) * | 2011-04-02 | 2012-10-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯丙酸化合物、其制备方法及其医药用途 |
CN103097367A (zh) * | 2011-04-02 | 2013-05-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯丙酸化合物、其制备方法及其医药用途 |
CN103097367B (zh) * | 2011-04-02 | 2014-12-03 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯丙酸化合物、其制备方法及其医药用途 |
CN107531687A (zh) * | 2015-02-27 | 2018-01-02 | 加利福尼亚大学董事会 | 能够实现软骨复壮的小分子 |
CN105524056A (zh) * | 2016-01-05 | 2016-04-27 | 中山大学肿瘤防治中心 | 一种氨基噻唑化合物及其制备方法和应用 |
CN114249702A (zh) * | 2022-01-12 | 2022-03-29 | 沈阳药科大学 | N-芳基- [2,4′-双噻唑]-2′-胺类化合物及其制备与用途 |
CN114249702B (zh) * | 2022-01-12 | 2023-09-05 | 沈阳药科大学 | N-芳基-[2,4′-双噻唑]-2′-胺类化合物及其制备与用途 |
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ZA200709751B (en) | 2008-11-26 |
AP2358A (en) | 2012-01-30 |
WO2006122011A2 (en) | 2006-11-16 |
US8088806B2 (en) | 2012-01-03 |
MX2007013955A (es) | 2008-02-05 |
IL186970A0 (en) | 2008-02-09 |
UA92746C2 (en) | 2010-12-10 |
JP2008540537A (ja) | 2008-11-20 |
AU2006244203A1 (en) | 2006-11-16 |
BRPI0608910A2 (pt) | 2010-02-17 |
US20120108576A1 (en) | 2012-05-03 |
AP2007004268A0 (en) | 2007-12-31 |
CA2607617A1 (en) | 2006-11-16 |
EA200702445A1 (ru) | 2008-04-28 |
SG159561A1 (en) | 2010-03-30 |
US20070004711A1 (en) | 2007-01-04 |
AU2006244203B2 (en) | 2012-05-03 |
KR20080019213A (ko) | 2008-03-03 |
WO2006122011A3 (en) | 2007-05-03 |
NO20075723L (no) | 2008-02-05 |
NZ563866A (en) | 2011-03-31 |
EP1879575A2 (en) | 2008-01-23 |
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