NO20075723L - Tiazolforbindelser og fremgangsmater for anvendelse - Google Patents
Tiazolforbindelser og fremgangsmater for anvendelseInfo
- Publication number
- NO20075723L NO20075723L NO20075723A NO20075723A NO20075723L NO 20075723 L NO20075723 L NO 20075723L NO 20075723 A NO20075723 A NO 20075723A NO 20075723 A NO20075723 A NO 20075723A NO 20075723 L NO20075723 L NO 20075723L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compounds
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- compound
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- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Foreliggende oppfinnelse tilveiebringer forbindelser, salter og hydrater med formel I, (I) hvor variablene Ar1, R2, R3, R4, r, q og t er definert her. Visse forbindelser med formel I beskrevet her har kraftig antiviral aktivitet. Oppfinnelsen tilveiebringer også forbindelser med formel I som er kraftige og/ eller selektive inhibitorer av Hepatitt C virus-replikasjon. Visse forbindelser beskrevet her hemmer sammensetning av HCV-replikasjonskompleks. Oppfinnelsen tilveiebringer også farmasøytiske preparater inneholdende én eller flere forbindelser med formel I eller et salt, solvat eller acylert prodrug av slike forbindelser og én eller flere farmasøytisk akseptable bærere, tilsetningsmidler eller fortynningsmidler. Oppfinnelsen omfatter videre metoder for behandling av pasienter som lider av visse infeksiøse sykdommer ved administrering til slike pasienter av en mengde av en forbindelse med formel I effektiv til å redusere tegn eller symptomer på sykdommen. Disse infeksiøse sykdommer omfatter virale infeksjoner, spesielt HCV-infeksjoner. Oppfinnelsen omfatter spesielt metoder for behandling av humane pasienter som lider av en infeksiøs sykdom, men omfatter også metoder for behandling av andre dyr, omfattende husdyr og selskapsdyr, som lider av en infeksiøs sykdom. Metoder for behandling omfatter administrering av en forbindelse med formel I som et enkelt aktivt middel eller administrering av en forbindelse med formel I i kombinasjon med ett eller flere andre terapeutiske midler.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67913305P | 2005-05-09 | 2005-05-09 | |
PCT/US2006/017692 WO2006122011A2 (en) | 2005-05-09 | 2006-05-09 | Thiazole compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20075723L true NO20075723L (no) | 2008-02-05 |
Family
ID=36968742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075723A NO20075723L (no) | 2005-05-09 | 2007-11-09 | Tiazolforbindelser og fremgangsmater for anvendelse |
Country Status (18)
Country | Link |
---|---|
US (2) | US8088806B2 (no) |
EP (1) | EP1879575A2 (no) |
JP (1) | JP2008540537A (no) |
KR (1) | KR20080019213A (no) |
CN (1) | CN101247807A (no) |
AP (1) | AP2358A (no) |
AU (1) | AU2006244203B2 (no) |
BR (1) | BRPI0608910A2 (no) |
CA (1) | CA2607617A1 (no) |
EA (1) | EA200702445A1 (no) |
IL (1) | IL186970A0 (no) |
MX (1) | MX2007013955A (no) |
NO (1) | NO20075723L (no) |
NZ (1) | NZ563866A (no) |
SG (1) | SG159561A1 (no) |
UA (1) | UA92746C2 (no) |
WO (1) | WO2006122011A2 (no) |
ZA (1) | ZA200709751B (no) |
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CN101247807A (zh) | 2008-08-20 |
ZA200709751B (en) | 2008-11-26 |
EP1879575A2 (en) | 2008-01-23 |
AU2006244203B2 (en) | 2012-05-03 |
US20070004711A1 (en) | 2007-01-04 |
US20120108576A1 (en) | 2012-05-03 |
AP2358A (en) | 2012-01-30 |
NZ563866A (en) | 2011-03-31 |
AP2007004268A0 (en) | 2007-12-31 |
MX2007013955A (es) | 2008-02-05 |
SG159561A1 (en) | 2010-03-30 |
IL186970A0 (en) | 2008-02-09 |
WO2006122011A3 (en) | 2007-05-03 |
WO2006122011A2 (en) | 2006-11-16 |
JP2008540537A (ja) | 2008-11-20 |
EA200702445A1 (ru) | 2008-04-28 |
CA2607617A1 (en) | 2006-11-16 |
AU2006244203A1 (en) | 2006-11-16 |
US8088806B2 (en) | 2012-01-03 |
BRPI0608910A2 (pt) | 2010-02-17 |
KR20080019213A (ko) | 2008-03-03 |
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