NO20052546L - Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon. - Google Patents

Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon.

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Publication number
NO20052546L
NO20052546L NO20052546A NO20052546A NO20052546L NO 20052546 L NO20052546 L NO 20052546L NO 20052546 A NO20052546 A NO 20052546A NO 20052546 A NO20052546 A NO 20052546A NO 20052546 L NO20052546 L NO 20052546L
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Norway
Prior art keywords
formula
compounds
compound
administering
treating
Prior art date
Application number
NO20052546A
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English (en)
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NO20052546D0 (no
Inventor
Milind Deshpande
Dawei Chen
Andrew Thurkauf
Avinash Phadke
Xiangzhu Wang
Yiping Shen
Cuixian Liu
Jesse Quinn
Junko Ohkanda
Shouming Li
Original Assignee
Achillon Pharmaceuticals Inc
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Application filed by Achillon Pharmaceuticals Inc filed Critical Achillon Pharmaceuticals Inc
Publication of NO20052546D0 publication Critical patent/NO20052546D0/no
Publication of NO20052546L publication Critical patent/NO20052546L/no

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Oppfinnelsen tilveiebringer forbindelser og farmasøytisk akseptable salter med Formel I hvor variablene A1, A2, R1, R2, V, W, X, Y og Z er definert her. Visse forbindelser med Formel I beskrevet her, har potent antiviral aktivitet. Oppfinnelsen tilveiebringer spesielt forbindelser med Formel I som er potente og/eller selektive inhibitorer av hepatitt C-virusreplikasjon. Oppfinnelsen tilveiebringer også farmasøytiske preparater som inneholder én eller flere forbindelse med Formel I eller et salt, solvat eller acylert prodrug av slike forbindelser, og én eller flere farmasøytisk akseptable bærere, hjelpestoffer eller fortynningsmidler. Oppfinnelsen omfatter videre metoder for behandling av pasienter som lider av visse infeksjonssykdommer, gjennom å administrere til slike pasienter en mengde av en forbindelse med Formel I som effektivt reduserer tegn eller symptomer p'a sykdommen eller lidelsen. Disse infeksjonssykdommene omfatter virusinfeksjoner, spesielt HCV-infeksjoner. Oppfinnelsen omfatter spesielt metoder for behandling av mennesker som lider av en infeksjonssykdom, men omfatter o s'a metoder for behandling av andre dyr, inkludert husdyr og kjæledyr, sorn lider av en infeksjonssykdom. Metoder for behandling omfatter å administrere en forbindelse med Formel I som et enkelt aktivt middel eller å administrere en forbindelse med Formel I i kombinasjon med ett eller flere andre terapeutiske rnidler.
NO20052546A 2002-11-19 2005-05-26 Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon. NO20052546L (no)

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US7476686B2 (en) 2009-01-13
JP4206382B2 (ja) 2009-01-07
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MXPA05005379A (es) 2006-02-17
EA200500846A1 (ru) 2005-12-29
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CA2506415A1 (en) 2004-06-03
OA12961A (en) 2006-10-13
CN1738797A (zh) 2006-02-22
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EP1562895A1 (en) 2005-08-17
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