NO20052546D0 - Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon. - Google Patents

Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon.

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Publication number
NO20052546D0
NO20052546D0 NO20052546A NO20052546A NO20052546D0 NO 20052546 D0 NO20052546 D0 NO 20052546D0 NO 20052546 A NO20052546 A NO 20052546A NO 20052546 A NO20052546 A NO 20052546A NO 20052546 D0 NO20052546 D0 NO 20052546D0
Authority
NO
Norway
Prior art keywords
inhibitors
related compounds
viral reproduction
arylthiourea
substituted
Prior art date
Application number
NO20052546A
Other languages
English (en)
Other versions
NO20052546L (no
Inventor
Milind Deshpande
Dawei Chen
Andrew Thurkauf
Avinash Phadke
Xiangzhu Wang
Yiping Shen
Cuixian Liu
Jesse Quinn
Junko Ohkanda
Shouming Li
Original Assignee
Achillon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillon Pharmaceuticals Inc filed Critical Achillon Pharmaceuticals Inc
Publication of NO20052546D0 publication Critical patent/NO20052546D0/no
Publication of NO20052546L publication Critical patent/NO20052546L/no

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005326813B2 (en) * 2002-11-19 2011-08-04 Achillion Pharmaceuticals, Inc. Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
AP2005003319A0 (en) * 2002-11-19 2005-06-30 Achillion Pharmaceitucals Inc Substituted aryl thioureas and related compounds; inhibitors of viral replication
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
TW200528459A (en) * 2004-01-06 2005-09-01 Achillion Pharmaceuticals Inc Azabenzofuran substituted thioureas; inhibitors of viral replication
US7501510B2 (en) * 2004-03-26 2009-03-10 The University Of Hong Kong Thiourea compositions and uses thereof
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
WO2006113650A1 (en) * 2005-04-18 2006-10-26 Khan Saeed R Design and synthesis of novel tubulin polymerization inhibitors: bonzoylphenyluria (bpu) sulfur analogs
WO2007035895A2 (en) * 2005-09-21 2007-03-29 Cook Incorporated Endoluminal stent graft delivery assembly
TWI329102B (en) * 2006-08-15 2010-08-21 Nat Health Research Institutes Thiourea compounds and method for inhibiting hepatitis c virus infection
AU2007334339A1 (en) * 2006-12-18 2008-06-26 Achillion Pharmaceuticals, Inc. Combination therapy for treating hepatitis C infections
WO2008124300A1 (en) * 2007-04-10 2008-10-16 National Health Research Institutes Hepatitis c virus inhibitors
TW200848016A (en) * 2007-06-08 2008-12-16 Nat Health Research Institutes Thiourea compound and composition of treating hepatitis C virus infection
TWI361808B (en) 2008-01-08 2012-04-11 Nat Health Research Institutes Imidazolidinone and imidazolidinethione derivatives
US8198284B2 (en) * 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds
CA2750577A1 (en) 2008-12-03 2010-06-10 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
EP2435424B1 (en) 2009-05-29 2015-01-21 Merck Sharp & Dohme Corp. Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
WO2010151797A2 (en) * 2009-06-26 2010-12-29 University Of Massachusetts Compounds for modulating rna binding proteins and uses therefor
EP2503881B1 (en) 2009-11-25 2015-05-13 Merck Sharp & Dohme Corp. Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
JP2013515068A (ja) 2009-12-22 2013-05-02 メルク・シャープ・アンド・ドーム・コーポレーション ウイルス性疾患の治療のための縮合三環式化合物およびその使用方法
EA201290882A1 (ru) 2010-03-09 2013-04-30 Мерк Шарп Энд Домэ Корп. Конденсированные трициклические силильные соединения и способы их применения для лечения вирусных заболеваний
US20130157924A1 (en) * 2010-04-23 2013-06-20 The Regents Of The University Of California Reducing transmission of sexually transmitted infections
US20140377223A1 (en) 2010-07-26 2014-12-25 Joseph A. Kozlowski Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
US9254292B2 (en) 2010-09-29 2016-02-09 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
CA2832459A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2012142075A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2012162025A1 (en) * 2011-05-20 2012-11-29 President And Fellows Of Harvard College Methods of selecting cancer patients for treatment with n,n'-diarylurea compounds and n,n'-diarylthiourea compounds
UA115126C2 (uk) 2011-07-12 2017-09-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Пестицидні композиції і способи, які їх стосуються
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013039876A1 (en) 2011-09-14 2013-03-21 Merck Sharp & Dohme Corp. Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
KR20150036374A (ko) * 2012-07-09 2015-04-07 다우 아그로사이언시즈 엘엘씨 살충 조성물 및 그와 관련된 방법
US10188538B2 (en) 2015-12-30 2019-01-29 Cook Medical Technologies Llc Hybrid trigger wire for endografts
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
BR112019005145B1 (pt) * 2016-12-21 2023-10-24 Dow Agrosciences Llc Moléculas com utilidade pesticida e seus intermediários
US20190167670A1 (en) * 2017-10-31 2019-06-06 Nutech Ventures Methods of treating or preventing zika virus infection

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3699110A (en) 1970-11-05 1972-10-17 Monsanto Co Certain 1-aryl or aralkyl-3-(pyridyl) formimidoyl-ureas or thioureas
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2303761A1 (de) 1973-01-26 1974-08-01 Henkel & Cie Gmbh Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen
GB1433934A (en) 1973-05-31 1976-04-28 Wyeth John & Brother Ltd Thioureas
JPS5143742A (ja) * 1974-09-30 1976-04-14 Haruo Ogura Tansonukureoshidojudotai no seizoho
JPS51125323A (en) * 1975-04-11 1976-11-01 Haruo Ogura Prosecc for preparing new c-nucleoside derivatives
BR7701058A (pt) 1976-02-23 1977-11-01 Gulf Research Development Co Processo e composto para combater insetos
US4160037A (en) 1977-09-30 1979-07-03 The Upjohn Company Compounds, compositions and methods of combatting pest employing thioureas
ZA793186B (en) * 1978-07-06 1981-02-25 Duphar Int Res New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds
JPS55167282A (en) * 1979-06-12 1980-12-26 Fujisawa Pharmaceut Co Ltd Piperazine derivative or its salt and its preparation
JPS5625148A (en) 1979-08-08 1981-03-10 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenoxyphenylurea-based compound, and insecticide comprising it
US4338257A (en) 1980-03-04 1982-07-06 Gulf Oil Corporation Benzoyl arylthioureas and use as plant growth regulators
CH656125A5 (en) 1981-08-24 1986-06-13 Rorer Int Overseas Heterocyclic amidino-substituted ureas
DE3217620A1 (de) 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,5-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US4880838A (en) 1982-06-30 1989-11-14 Rhone-Poulenc Pesticidal 1-(4-Phenoxyphenyl)-5-Benzoyl urea compounds and process for preparation
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5001266A (en) 1982-07-26 1991-03-19 The Dow Chemical Company Substituted aniline compounds
US4868215A (en) 1982-07-26 1989-09-19 The Dow Chemical Company Substituted N-aroyl N'-phenyl urea compounds
US4602109A (en) 1982-12-30 1986-07-22 Union Carbide Corporation Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation
DK147084A (da) 1983-03-19 1984-09-20 Bayer Ag 1-phenyl-3-benzoyl-(thio)-urinstoffer, deres fremstilling og anvendelse som skadedyrsbekaempelsesmidler
US4665097A (en) 1983-03-31 1987-05-12 Union Carbide Corporation Novel bicyclooxyaryl thioureas and process for preparation
US4873264A (en) 1983-05-20 1989-10-10 Rhone-Poulenc Nederlands B.V. Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation
US4659736A (en) 1984-01-21 1987-04-21 Bayer Aktiengesellschaft Benzoyl urea compounds as agents for repelling snails and slugs
JPS61106551A (ja) 1984-10-30 1986-05-24 Sumitomo Chem Co Ltd ジフエニルエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4638088A (en) * 1984-11-15 1987-01-20 Union Carbide Corporation Pesticidal biphenylyloxy and biphenylylalkoxy aryl acyl urea compounds
US5135953A (en) 1984-12-28 1992-08-04 Ciba-Geigy Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
US5166180A (en) 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
US5268389A (en) 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
CA2032559C (en) 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
JPH04366852A (ja) 1991-06-13 1992-12-18 Canon Inc 電子写真感光体、該電子写真感光体を備えた電子写真装置並びにファクシミリ
EP0539709A1 (en) 1991-09-18 1993-05-05 FUJIREBIO Inc. 3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
AU665073B2 (en) 1992-06-03 1995-12-14 Ciba-Geigy Ag Novel thiosemicarbazone derivatives
JPH063787A (ja) 1992-06-18 1994-01-14 Konica Corp ハロゲン化銀写真感光材料用固形発色現像処理剤及び該固形発色現像処理剤を用いた処理方法
US5723409A (en) 1992-10-31 1998-03-03 Hoechst Schering Agrevo Gmbh Intermediates for the preparation of phenylsulfonylurea herbicides and plant growth regulators
DE4236902A1 (de) 1992-10-31 1994-05-05 Hoechst Ag Neue Phenylsulfonylharnstoffe, Darstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
JPH06287171A (ja) 1993-02-05 1994-10-11 Takeda Chem Ind Ltd セミカルバジド誘導体、その製造法およびその殺虫組成物
US5656642A (en) 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
JP3203108B2 (ja) 1993-08-26 2001-08-27 協和メデックス株式会社 グルコース−６−リン酸デヒドロゲナーゼの安定化方法
JPH07206811A (ja) * 1994-01-18 1995-08-08 Wakunaga Pharmaceut Co Ltd チオウレア誘導体、その製造法及びその利用
DE4442236A1 (de) 1994-11-28 1996-05-30 Hoechst Schering Agrevo Gmbh N-substituierte Hydrazinophenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
DE19506742A1 (de) 1995-02-27 1996-08-29 Bayer Ag Verwendung von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen
GB9504460D0 (en) 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
IL117940A (en) 1995-04-19 2003-06-24 Kumiai Chemical Industry Co Benzylsulfide derivatives, process for their production and insecticide compositions containing them
WO1997003976A1 (en) 1995-07-21 1997-02-06 Nissan Chemical Industries, Ltd. Semicarbazone derivatives and pesticides
CN1055083C (zh) 1995-09-08 2000-08-02 化学工业部沈阳化工研究院 用于杀虫杀螨的吡唑类化合物及其制剂
AU7000996A (en) 1995-09-19 1997-04-09 Ube Industries, Ltd. Benzylidenehydrazine compounds, process for producing the same, and agricultural and horticultural pesticides
AU7095296A (en) 1995-09-26 1997-04-17 Takeda Chemical Industries Ltd. Phosphorylamides, their preparation and use
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
WO1997017970A1 (fr) 1995-11-15 1997-05-22 Yamanouchi Pharmaceutical Co., Ltd. Inhibiteurs de la neurotoxicite de l'acide kainique et derives de la pyridothiazine
GB9525262D0 (en) 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
AU1730497A (en) 1996-02-17 1997-09-02 Agrevo Uk Limited Fungicidal 1,2,4-oxadiazoles and analogues
AU3057697A (en) 1996-05-06 1997-11-26 Eli Lilly And Company Anti-viral compounds
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
US6794392B1 (en) 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
AU6422798A (en) 1997-03-25 1998-10-20 Takeda Chemical Industries Ltd. Stabilized urease inhibitor
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
CN1187036C (zh) 1997-10-14 2005-02-02 普罗克特和甘保尔公司 含有中链支化表面活性剂的个人清洁组合物
NZ502963A (en) 1997-12-23 2002-06-28 Warner Lambert Co Thiourea and benzamide compounds and methods of treating or preventing inflammatory diseases and atherosclerosis
US6138826A (en) 1998-02-02 2000-10-31 Fuji Photo Film Co., Ltd. Waterproof case for camera
US5874615A (en) 1998-03-17 1999-02-23 American Cyanamid Co Method for the preparation of insecticidal benzoylurea compounds
AU4005299A (en) 1998-05-19 1999-12-06 Regents Of The University Of California, The Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
JPH11335375A (ja) 1998-05-20 1999-12-07 Mitsui Chem Inc ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体
CA2343522A1 (en) 1998-09-04 2000-03-16 Viropharma Incorporated Methods for treating or preventing viral infections and associated diseases
AU751457B2 (en) 1998-09-25 2002-08-15 Viropharma Incorporated Methods for treating or preventing viral infections and associated diseases
US6207715B1 (en) 1998-12-09 2001-03-27 American Home Products Corporation Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6255349B1 (en) 1998-12-09 2001-07-03 American Home Products Corporation Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en) 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
IL143484A0 (en) 1998-12-16 2002-04-21 Bayer Ag New biphenyl and biphenyl-analogous compounds as integrin antagonists
CN1145613C (zh) 1999-05-28 2004-04-14 第一制糖株式会社 邻苯二酚腙衍生物及其制备方法以及含该衍生物的药物组合物
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6207688B1 (en) 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
US6143780A (en) 1999-09-17 2000-11-07 Uniroyal Chemical Company, Inc. N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
HUP0203075A3 (en) 1999-09-24 2003-02-28 Nihon Nohyaku Co Ltd Aromatic diamide derivatives or salts thereof, agricultural/horticultural chemicals and method of using the same
GB9929988D0 (en) 1999-12-17 2000-02-09 Celltech Therapeutics Ltd Chemical compounds
CN1249020C (zh) 1999-12-22 2006-04-05 日本农药株式会社 芳族二酰胺衍生物、农业与园艺化学药品及其用途
US7135466B2 (en) 1999-12-24 2006-11-14 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives and drugs containing the same
US7005430B2 (en) 1999-12-24 2006-02-28 Kyowa Hakko Kogyo Co., Ltd. Fused purine derivatives
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
US6727267B2 (en) 2000-04-05 2004-04-27 Tularik Inc. NS5B HVC polymerase inhibitors
US6713502B2 (en) 2000-05-05 2004-03-30 Smithkline Beecham Corporation Anti-infectives
EP1292310A1 (en) 2000-05-10 2003-03-19 SmithKline Beecham Corporation Novel anti-infectives
IL153278A0 (en) 2000-06-21 2003-07-06 Hoffmann La Roche Benzothiazole derivatives
US6736336B2 (en) 2000-10-13 2004-05-18 International Concepts, Inc. Shower head
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
BR0213791A (pt) 2001-11-01 2004-12-07 Janssen Pharmaceutica Nv Derivados de amida como inibidores de glicogênio sintase quinase 3-beta
DE60307268T2 (de) 2002-05-16 2007-07-26 Bayer Cropscience Gmbh Pestizide pyridincarbonsäureamidderivate
PL374162A1 (en) 2002-05-16 2005-10-03 Bayer Cropscience Gmbh Pyridine carboxamide derivatives and their use as pesticides
US7517894B2 (en) 2002-07-31 2009-04-14 Bayer Schering Pharma Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
US7148357B2 (en) 2002-07-31 2006-12-12 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
AP2005003319A0 (en) * 2002-11-19 2005-06-30 Achillion Pharmaceitucals Inc Substituted aryl thioureas and related compounds; inhibitors of viral replication

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BR0316397A (pt) 2005-09-27
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US7094807B2 (en) 2006-08-22
OA12961A (en) 2006-10-13
CA2506415A1 (en) 2004-06-03
EP1562895A1 (en) 2005-08-17
US7476686B2 (en) 2009-01-13

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