CN101184494B - 制备和分离磷脂的方法 - Google Patents

制备和分离磷脂的方法 Download PDF

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Publication number
CN101184494B
CN101184494B CN2006800186998A CN200680018699A CN101184494B CN 101184494 B CN101184494 B CN 101184494B CN 2006800186998 A CN2006800186998 A CN 2006800186998A CN 200680018699 A CN200680018699 A CN 200680018699A CN 101184494 B CN101184494 B CN 101184494B
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concentration
reaction
enzyme
add
phosphatidylcholine
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CN2006800186998A
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Chinese (zh)
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CN101184494A (zh
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A·M·赞纳拉托
M·皮塔雷洛
A·甘比拉拉
S·瓦卡罗
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Fidia Farmaceutici SpA
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Fidia Farmaceutici SpA
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00Phosphatide compositions for foodstuffs, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14Liposomes; Vesicles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
CN2006800186998A 2005-05-30 2006-05-26 制备和分离磷脂的方法 Expired - Fee Related CN101184494B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT000164A ITPD20050164A1 (it) 2005-05-30 2005-05-30 Processo per la preparazione e l'isolamento di fosfatidi
ITPD2005A000164 2005-05-30
US70387005P 2005-08-01 2005-08-01
US60/703,870 2005-08-01
PCT/EP2006/005030 WO2006128639A2 (en) 2005-05-30 2006-05-26 Process for the preparation and isolation of phosphatides

Publications (2)

Publication Number Publication Date
CN101184494A CN101184494A (zh) 2008-05-21
CN101184494B true CN101184494B (zh) 2012-03-21

Family

ID=39449427

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800186998A Expired - Fee Related CN101184494B (zh) 2005-05-30 2006-05-26 制备和分离磷脂的方法

Country Status (18)

Country Link
US (1) US7759095B2 (ja)
EP (2) EP2431020B1 (ja)
JP (1) JP5113042B2 (ja)
KR (1) KR101298560B1 (ja)
CN (1) CN101184494B (ja)
AT (1) ATE546145T1 (ja)
AU (1) AU2006254376B2 (ja)
BR (1) BRPI0611316B8 (ja)
CA (1) CA2610575C (ja)
ES (2) ES2382748T3 (ja)
HK (1) HK1119584A1 (ja)
IL (1) IL187749A (ja)
IT (1) ITPD20050164A1 (ja)
MX (1) MX2007015064A (ja)
NO (1) NO337009B1 (ja)
PL (2) PL2431020T3 (ja)
PT (2) PT2431020E (ja)
WO (1) WO2006128639A2 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD20050164A1 (it) 2005-05-30 2006-11-30 Fidia Farmaceutici Processo per la preparazione e l'isolamento di fosfatidi
HUE043241T2 (hu) 2007-06-05 2019-08-28 Bank Of Canada Tinta- vagy festékkészítmények, eljárások alkalmazásukra és azokból származó termékek
CN102439125B (zh) * 2010-12-03 2014-04-30 上海赢贝生物技术有限公司 一种制备富含多不饱和双键脂肪酰基的磷脂酰丝氨酸的高品质南极磷虾油的方法
CN102485899A (zh) * 2010-12-03 2012-06-06 张永志 一种制备富含多不饱和双键脂肪酰基的磷脂酰丝氨酸的高品质南极磷虾油的方法
ITPD20120021A1 (it) 2012-01-26 2013-07-27 Fidia Farmaceutici "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina".
CN104327114A (zh) * 2014-11-06 2015-02-04 江南大学 一种磷脂酰丝氨酸的制备方法
CN112352051A (zh) * 2019-12-31 2021-02-09 邦泰生物工程(深圳)有限公司 一种提高磷脂酶d转脂活性的方法以及用其生产磷脂酰丝氨酸的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711559A2 (en) * 1994-11-08 1996-05-15 Kabushiki Kaisha Yakult Honsha Use of phosphatidylserines for the manufacture of a medicament for improving cerebration
US20030124160A1 (en) * 2001-10-12 2003-07-03 Petrescu Stefana M. Targeted drug delivery
WO2003088761A2 (de) * 2002-04-19 2003-10-30 Bioghurt Biogarde Gmbh & Co. Kg Physiologisch verträgliche, phospholipid-haltige, stabile und harte matrix
US20040235795A1 (en) * 2001-10-05 2004-11-25 Ralf Jager Utilization of phosphatidylserine in the treatment of attention deficit syndrome (adhs)
US20040235119A1 (en) * 2001-08-28 2004-11-25 Hans-Ulrich Hoppe Method for the production of phospholipids
WO2005023271A1 (de) * 2003-09-04 2005-03-17 Bioghurt Biogarde Gmbh & Co. Kg Physiologisch aktive zusammensetzung auf phosphatidylserin-basis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869482A (en) * 1972-07-31 1975-03-04 Etapharm Chem Pharm Lab G M B Method of producing highly purified phosphatides
AT315359B (de) * 1972-07-31 1974-05-27 Etapharm Chem Pharm Lab Ges M Verfahren zur Herstellung von hochgereinigten Phosphatiden aus tierischen Organen
JPS63245684A (ja) * 1987-03-31 1988-10-12 Japanese Res & Dev Assoc Bio Reactor Syst Food Ind ホスフアチジン酸誘導体の製造法
US5183750A (en) * 1989-05-26 1993-02-02 Kao Corporation Processes for the production of phosphatidic acid
IT1260149B (it) * 1992-04-17 1996-03-28 Fidia Spa Metodo per la preparazione e purificazione di miscele di fosfolipidi prive di contaminanti da virus non convenzionali
US5700668A (en) 1995-12-08 1997-12-23 Italfarmaco Sud S.P.A. Process for the industrial preparation of phosphatidylserine
DE19917249C2 (de) 1999-02-26 2001-09-27 Meyer Lucas Gmbh & Co Verfahren zur Herstellung von Phosphatidylserin-Produkten
IT1311929B1 (it) 1999-04-28 2002-03-20 Chemi Spa Procedimento per la preparazione di fosfatidilserine.
DE19926770A1 (de) 1999-06-11 2000-12-14 Basf Ag Nukleinsäurefragment und Vektor, enthaltend eine Halogenase, sowie ein Verfahren zur Halogenierung chemischer Verbindungen
EP1190041B1 (en) * 1999-06-15 2005-01-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Enzymatic preparation of phospholipids in aqueous media
AU2001261647A1 (en) 2000-05-15 2001-11-26 Identix Incorporated Fingerprint imaging device
JP4298902B2 (ja) 2000-08-09 2009-07-22 株式会社ヤクルト本社 リン脂質の製造法
IT1319679B1 (it) 2000-12-05 2003-10-23 Chemi Spa Processo di purificazione di fosfatidilserina.
ITPD20010031A1 (it) 2001-02-09 2002-08-09 Fidia Farmaceutici Procedimento per la preparazione di fosfatidi puri e loro impiego in campo cosmetico, farmaceutico ed alimentare.
DE102004002053A1 (de) * 2004-01-15 2005-08-04 Bioghurt Biogarde Gmbh & Co. Kg Verfahren zur Herstellung von Phosphatidylserin und dessen Reinigung durch Extraktion
ITPD20050164A1 (it) 2005-05-30 2006-11-30 Fidia Farmaceutici Processo per la preparazione e l'isolamento di fosfatidi

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0711559A2 (en) * 1994-11-08 1996-05-15 Kabushiki Kaisha Yakult Honsha Use of phosphatidylserines for the manufacture of a medicament for improving cerebration
US20040235119A1 (en) * 2001-08-28 2004-11-25 Hans-Ulrich Hoppe Method for the production of phospholipids
US20040235795A1 (en) * 2001-10-05 2004-11-25 Ralf Jager Utilization of phosphatidylserine in the treatment of attention deficit syndrome (adhs)
US20030124160A1 (en) * 2001-10-12 2003-07-03 Petrescu Stefana M. Targeted drug delivery
WO2003088761A2 (de) * 2002-04-19 2003-10-30 Bioghurt Biogarde Gmbh & Co. Kg Physiologisch verträgliche, phospholipid-haltige, stabile und harte matrix
WO2005023271A1 (de) * 2003-09-04 2005-03-17 Bioghurt Biogarde Gmbh & Co. Kg Physiologisch aktive zusammensetzung auf phosphatidylserin-basis

Also Published As

Publication number Publication date
IL187749A0 (en) 2008-04-13
AU2006254376B2 (en) 2011-04-21
BRPI0611316B8 (pt) 2021-05-25
JP5113042B2 (ja) 2013-01-09
HK1119584A1 (en) 2009-03-13
EP2431020A1 (en) 2012-03-21
US20080275006A1 (en) 2008-11-06
MX2007015064A (es) 2008-02-19
WO2006128639A3 (en) 2007-08-09
PL1890706T3 (pl) 2012-07-31
PL2431020T3 (pl) 2015-01-30
NO20076158L (no) 2007-11-29
BRPI0611316A2 (pt) 2010-08-31
CA2610575A1 (en) 2006-12-07
PT2431020E (pt) 2014-09-16
NO337009B1 (no) 2015-12-21
ITPD20050164A1 (it) 2006-11-30
IL187749A (en) 2014-04-30
EP1890706B1 (en) 2012-02-22
WO2006128639A2 (en) 2006-12-07
JP2008545420A (ja) 2008-12-18
CN101184494A (zh) 2008-05-21
CA2610575C (en) 2014-09-30
US7759095B2 (en) 2010-07-20
PT1890706E (pt) 2012-05-25
ATE546145T1 (de) 2012-03-15
ES2501015T3 (es) 2014-10-01
EP2431020B1 (en) 2014-07-16
ES2382748T3 (es) 2012-06-13
KR20080011678A (ko) 2008-02-05
KR101298560B1 (ko) 2013-08-22
EP1890706A2 (en) 2008-02-27
AU2006254376A1 (en) 2006-12-07
BRPI0611316B1 (pt) 2020-04-07

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