WO2003088761A2 - Physiologisch verträgliche, phospholipid-haltige, stabile und harte matrix - Google Patents
Physiologisch verträgliche, phospholipid-haltige, stabile und harte matrix Download PDFInfo
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- WO2003088761A2 WO2003088761A2 PCT/EP2003/004031 EP0304031W WO03088761A2 WO 2003088761 A2 WO2003088761 A2 WO 2003088761A2 EP 0304031 W EP0304031 W EP 0304031W WO 03088761 A2 WO03088761 A2 WO 03088761A2
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- IJTNSXPMYKJZPR-WVRBZULHSA-N alpha-parinaric acid Natural products CCC=C/C=C/C=C/C=CCCCCCCCC(=O)O IJTNSXPMYKJZPR-WVRBZULHSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 239000010480 babassu oil Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- GWHCXVQVJPWHRF-UHFFFAOYSA-N cis-tetracosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-UHFFFAOYSA-N 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- MAMJNXVNGGBHFN-UHFFFAOYSA-N docosa-1,3,5,7,9,11-hexaene Chemical compound CCCCCCCCCCC=CC=CC=CC=CC=CC=C MAMJNXVNGGBHFN-UHFFFAOYSA-N 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- FARYTWBWLZAXNK-WAYWQWQTSA-N ethyl (z)-3-(methylamino)but-2-enoate Chemical compound CCOC(=O)\C=C(\C)NC FARYTWBWLZAXNK-WAYWQWQTSA-N 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 229940116364 hard fat Drugs 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 230000036997 mental performance Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 150000002896 organic halogen compounds Chemical class 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940098695 palmitic acid Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019809 paraffin wax Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000004713 phosphodiesters Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000004170 rice bran wax Substances 0.000 description 1
- 235000019384 rice bran wax Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 239000012176 shellac wax Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical group CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 229940068778 tocotrienols Drugs 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 125000005457 triglyceride group Chemical group 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a physiologically compatible, stable and hard matrix containing phospholipids, in particular a microcapsule consisting of a carrier material and a bioactive component.
- the substance class of the phospholipids are so-called complex lipids with amphiphilic, ie at the same time lipophilic and hydrophilic properties, which among other things enables them to form lipid bilayers in aqueous media.
- phospholipids are phosphodiesters in which the phosphoric acid is esterified on the one hand with a sphingosine or glyceride residue and on the other hand with choline, ethanolamine, serine, inositol or glycerol.
- Phosphatidylcholine is also known as lecithin and is also the eponym for a large group of special phospholipids, the lecithins.
- Phosphatidylserine and phosphatidylethanolamine are also known as cephalins.
- the lyso derivatives which also belong to this group, are formed by hydrolytic cleavage using specific phospholipases.
- Phospholipids are typically not soluble in acetone, which is why they are also called acetone-insoluble phosphatides or acetone-insoluble substances.
- Lecithins are mixtures or fractions of phosphatides that are obtained from animal or vegetable foods using physical methods; Lecithins contain at least 60% of substances insoluble in acetone. Because of this feature, lecithin containing products are checked for their actual phosphatide or phospholipid content using the so-called acetone solubility test.
- Capsules containing phospholipids are well known from the prior art and mostly contain phospholipids as the coating substance. If phospholipids are used in the filling, i.e. in the capsule core, they mostly act in small proportions there as formulation aids with mostly solubilizing properties.
- the phospholipids Due to their amphiphilic properties, the phospholipids also serve as coating substances for the known liposomes and transferosomes. In this context, they are used primarily because of their bioadhesive characteristics in the area of mucosal applications, whereby they are particularly introduced into the nasal and oral cavities.
- phospholipids are also used as surface-active formulation aids (surfactants).
- lysophospholipids are described as solubilizers for hydrophobic bioactive substances.
- PS phosphatidylserine
- the object of the prior art is therefore to provide a physiologically compatible, phospholipid-containing stable and solid matrix consisting of a carrier material and a bioactive component which, on the one hand, has the proportions of the phospholipid based on the starting material contains that go beyond the known amounts in which phospholipids are used as a coating or formulation aid, and thus contain amounts of phospholipid that can be used, for example, as a food supplement.
- the matrix should have a size that allows easy and pleasant intake, but at the same time is sufficient to take up an amount of phospholipid sufficient for a physiological effect.
- This object was achieved with a corresponding matrix which has a total diameter between 0.1 and 5000 ⁇ m and which, as a bioactive component, is> 5% by weight, preferably> 10% by weight and in particular> 20% by weight, based on the Contains starting material of acetone-insoluble phospholipid components.
- this matrix according to the invention that compliance can be significantly increased in accordance with the task, since the small matrix size makes it easier to take and above all does not negatively influence the feeling of swallowing.
- amounts of phospholipid with bioactive activity can be accommodated in the matrix according to the invention, which allow a better dosage of the daily amount.
- the matrix offers the advantage that it can be produced in numerous variants depending on the respective manufacturing process and with regard to the look, feel and taste. These advantages could not have been foreseen.
- the term “matrix” is defined as the entirety of the carrier material and the bioactive component, the bioactive component being distributed homogeneously or heterogeneously in the carrier material or the carrier material being able to at least partially encase the bioactive component; however, the bioactive component can also be applied to the carrier material. Mixed forms of these variants are of course also possible.
- hard defines the physical state of the claimed matrix in the sense of not being soft and includes all states that are in harmony with it and are independent of the external shape, such as pellets, granules, hard capsules, etc. Soft gelatin capsules therefore expressly fall outside this definition , Amorphous, plastic manifestations of hard consistency, but fulfill the conditions of a hard matrix.
- bioactive is to be understood as meaning the effect of the phospholipids in such a way that they have a biological effect in the living organism during or after their release from the capsule in the absorption area, on the transport route or at the destination, which is usually pharmaceutical Preparations in the human and veterinary field apply.
- a matrix which contains between 5 and 90% by weight and in particular between 20 and 80% by weight, based on the starting material, of acetone-insoluble phospholipid constituents, fractions being particularly preferred which are between 40 and 70% by weight.
- Phosphatidylserine, choline, ethanolamine, inositol, glycerol, their lyso compounds and / or their derivatives are preferred acetone-insoluble constituents for the purposes of the present invention.
- these compounds each preferably contain a residue at position sn-1 or sn-2, which is derived from a C 2 -C 30 -carboxylic acid bonded to the hydroxyl groups of glycerol, in particular a C 12 -C 28 carboxylic acid.
- the acid residues can be linear or branched, saturated or mono- or polyunsaturated.
- residues which are caused by the binding of acetic acid, butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, arachic acid, behenic acid, lignoceric acid, linolenic acid, eicosapentaenoic acid, erucic acid, nervonic acid, a- or? -Earic acid or parinaric acid are formed.
- Residues formed by binding palmitic acid, stearic acid, oleic acid, linoleic acid, ⁇ -linolenic acid, arachidonic acid or docosahexaenoic acid are particularly preferred.
- the acid residues bound to the two OH groups of the glycerol still available can be the same or different.
- sphingophospholipids in particular, and preferably sphingomyelin and its derivatives, have been found to be suitable.
- modified carbohydrates and proteins, hydrophobic materials such as waxes, triglycerides, lipids and polymers or mineral components such as silicates and their mixtures have proven to be particularly suitable as “hard” carrier materials.
- the lipids can be hydrogenated or have a special composition; the polymers can be pharmaceutical and / or food-grade polymers.
- cereal products from corn, wheat, oats, rice, etc. which are typical hard carrier materials as flakes or extrudates.
- the invention provides that, as representatives of the carbohydrates, in particular starch (derivatives), mono- and disaccharides and their sugar alcohols, glucose syrup, dextrins and hydrocolloids, such as e.g. Algatin, pectins, chitosan and cellulose (derivatives) can be used.
- starch derivatives
- mono- and disaccharides and their sugar alcohols glucose syrup
- dextrins and hydrocolloids such as e.g. Algatin, pectins, chitosan and cellulose (derivatives)
- Vegetable, animal or microbial proteins such as e.g. Zein, gluten, gelatin, caseins, whey proteins, as well as single-cell proteins, textured proteins such as spun or extruded (soy) protein isolate or mixtures thereof.
- the respective special representatives can of course be extended by other suitable carrier materials, in particular as carbohydrates maltodextrins, sucrose, mono- and disaccharides and their alcohols, modified starches (eg esters and ethers), gum acacia, xanthan gum, gum arabic, carrageenan, Furcelleran, agar, alginates, tragacanth and carboxymethyl cellulose are recommended.
- suitable carrier materials in particular as carbohydrates maltodextrins, sucrose, mono- and disaccharides and their alcohols, modified starches (eg esters and ethers), gum acacia, xanthan gum, gum arabic, carrageenan, Furcelleran, agar, alginates, tragacanth and carboxymethyl cellulose are recommended.
- hydrogenated vegetable oils can also be used on hydrophobic materials; but also natural oils, such as palm oil, cottonseed oil, soybean oil, corn oil, palm kernel oil, babassu oil, sunflower oil and safflower oil can also be used, which can also be used with beeswax, petroleum-based paraffin wax, rice bran wax, castor wax, cardellita wax, carnauba wax, shellac and microcrystalline wax can be mixed.
- Tristearins, stearic acid and fats are recommended as further representatives of the lipids, although the phospholipids themselves can of course also be chosen as the coating or their constituent in accordance with the prior art.
- the range that the carrier material can cover is just as wide as the proportion of the bioactive component. Proportions of ⁇ 95% by weight and in particular those between 30 and 80% by weight, based on the total matrix weight, have proven useful in this regard.
- the proportion of carrier material in the matrix is preferably> 5% by weight, in particular 10% by weight, more preferably> 20% by weight, even more preferably> 40% by weight and most preferably ⁇ 50% by weight.
- the matrix can of course also contain other bioactive substances such as amino acids, vitamins, polyphenols, carbohydrates, lipids, trace elements and minerals and their suitable derivatives contain.
- bioactive substances such as amino acids, vitamins, polyphenols, carbohydrates, lipids, trace elements and minerals and their suitable derivatives contain.
- the essential amino acids come into question, but also, for example, creatine and other special amino acids such as theanine and their derivatives;
- the representatives of the vitamins are primarily the fat-soluble ones, such as the vitamin E family, the tocotrienols, phytosterols and other bioactive fat accompanying substances, as well as representatives of the vitamin D series or vitamin C that deviate from the phospholipids.
- bioactive substances can be added to the carrier material, the bioactive component or both.
- particularly suitable as carrier materials are substances which enable complete encapsulation to be achieved, and substances which provide a matrix with high stability and low shear stress.
- Essential to the invention for the claimed matrix is, among other things, its special diameter, which, in addition to its hard state, distinguishes it, among other things, from the known larger soft gelatin capsules.
- diameters of the total matrix that lie between 10 ⁇ m and 1000 ⁇ m and in particular between 50 and 500 ⁇ m are to be regarded as preferred.
- the claimed matrix is not restricted to a special shape and, consequently, it can be spherical, rounded or irregular in shape.
- spherical or lenticular forms have been shown to be particularly suitable, although of course all other shape variants, such as cylinders, pillows, amorphous states (e.g. flakes) and the like, depending on the application, can of course always consist of the carrier material and the bioactive one Component.
- the invention preferably provides for the matrix content to have a liquid consistency, which of course then necessitates a generally rigid and hard coating.
- Matrix variants in the form of a microcapsule have been shown to be particularly suitable, which the present invention also takes into account.
- the present invention also claims its use in functional foods, special foods and dietary supplements, with particular emphasis on the delayed release of the bioactive component.
- the sustained release effect does not exclude that the complete matrix or its components (carrier material, bioactive component) can be attacked by the gastric juices or that they are subject to chemical and / or enzymatic influences in the GI tract.
- the preferred use for the claimed matrix is to prevent increased serum cholesterol levels and (a) typical diabetes symptoms, as well as to strengthen mental fitness, physical resilience and physical and mental performance.
- the claimed matrix represents a particularly suitable dosage form, since it can be produced in numerous forms and flavors and can therefore be added to solid, semi-solid and liquid foods without problems and with high inherent stability ,
- the most suitable dosage form is direct oral intake.
- the following examples underline the advantages of the physiologically compatible phospholipid-containing, stable and hard matrix according to the invention.
- Example 1 Microcapsule with 8% by weight phosphatidylserine
- phosphatidylserine (LeciPS ' s 20F from Degussa BioActives GmbH), consisting of a mixture of triglycerides, phospholipids and glycolipids, with a natural, vegetable fat in
- the natural, vegetable fat was characterized by the following characteristics: melting point about 55 ° C, peroxide number max. 2 meq O / kg, acid number max. 1 mg KOH / g, iodine number max. 5 gl / 100 g, saponification number 185-215 mg KOH / g, more than 94% of the natural acids (approx. 33% palmitic acid, approx. 60% stearic acid) are saturated.
- the spherical matrix obtained in this way in the form of microcapsules had an average overall diameter of 100 to 250 // m and the following composition:
- phosphatidylserine 55% by weight of vegetable fat and 37% by weight of a mixture of triglycerides, glycolipids and other phospholipids.
- Table 1 shows for the very hydrolysis-sensitive phosphatidylserine that embedding the phospholipids in the matrix according to the invention effects, among other things, a stabilizing effect against hydrolysis.
- Microcapsule with 14% by weight phosphatidylcholine Using the known "spray technology", a 35% by weight solution of phosphatidylcholine (Epikuron ® 1 35F from Degussa BioActives GmbH) consisting of a mixture of triglycerides, phospholipids and glycolipids with a natural, encapsulated vegetable fat
- phosphatidylcholine Epikuron ® 1 35F from Degussa BioActives GmbH
- the spherical matrix thus obtained in the form of microcapsules had an average overall diameter of 1 00 to 250 ⁇ m and the following composition: 14% by weight phosphatidylcholine, 46% by weight vegetable fat and 40% by weight
- % of a mixture of triglycerides, glycolipids and other phospholipids % of a mixture of triglycerides, glycolipids and other phospholipids.
- Table 1 shows that embedding the phospholipids in the matrix according to the invention has, inter alia, a stabilizing effect against hydrolysis.
- the natural, vegetable fat was characterized by the following characteristics:
- the spherical matrix thus obtained in the form of microcapsules had an average overall diameter of 1 00 to 250 ⁇ m and the following composition:
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03718771A EP1499204A2 (de) | 2002-04-19 | 2003-04-17 | Physiologisch verträgliche, phospholipid-haltige, stabile und harte matrix |
AU2003222823A AU2003222823A1 (en) | 2002-04-19 | 2003-04-17 | Physiologically compatible, phospholipid-containing, stable and hard matrix |
US10/511,884 US20050220857A1 (en) | 2002-04-19 | 2003-04-17 | Physiologically compatible, phospholipid-containing, stable and hard matrix |
JP2003585518A JP2005527207A (ja) | 2002-04-19 | 2003-04-17 | 生理的に認容される、リン脂質を含有する、安定でかつ硬質のマトリックス |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE10217555A DE10217555A1 (de) | 2002-04-19 | 2002-04-19 | Physiologisch verträgliche, Phospholipid-haltige, stabile und harte Matrix |
DE10217555.1 | 2002-04-19 |
Publications (2)
Publication Number | Publication Date |
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WO2003088761A2 true WO2003088761A2 (de) | 2003-10-30 |
WO2003088761A3 WO2003088761A3 (de) | 2004-06-03 |
Family
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PCT/EP2003/004031 WO2003088761A2 (de) | 2002-04-19 | 2003-04-17 | Physiologisch verträgliche, phospholipid-haltige, stabile und harte matrix |
Country Status (6)
Country | Link |
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US (1) | US20050220857A1 (de) |
EP (1) | EP1499204A2 (de) |
JP (1) | JP2005527207A (de) |
AU (1) | AU2003222823A1 (de) |
DE (1) | DE10217555A1 (de) |
WO (1) | WO2003088761A2 (de) |
Cited By (10)
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WO2006128639A2 (en) * | 2005-05-30 | 2006-12-07 | Fidia Farmaceutici S.P.A. | Process for the preparation and isolation of phosphatides |
JP2008546845A (ja) * | 2005-06-28 | 2008-12-25 | ケージーケー シナガイズ インク. | 心臓血管疾患の治療のためのポリメトキシフラボン類およびトコトリエノール類のバイオアベイラビリティーを改善する組成物 |
US7906488B2 (en) | 2004-11-30 | 2011-03-15 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae |
US7968529B2 (en) | 2003-01-20 | 2011-06-28 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Use of sphingolipids for reducing high plasma cholesterol and high triacylglycerol levels |
WO2012021172A1 (en) * | 2010-08-12 | 2012-02-16 | Nutritional Therapeutics, Inc. | Lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US8703172B2 (en) | 2003-01-20 | 2014-04-22 | Nederlandse Organizatie voor Toegepastnatuurwetenschappelijk Onderzoek TNO | Sphingolipids for improvement of the composition of the intestinal flora |
US9095507B2 (en) | 2011-08-11 | 2015-08-04 | Allergy Research Group, Llc | Chewable wafers containing lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US9468668B2 (en) | 2011-08-11 | 2016-10-18 | Allergy Research Group, Llc | Flavored chewable lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US10117885B2 (en) | 2011-08-11 | 2018-11-06 | Allergy Research Group, Llc | Chewable lipid supplements for treating pain and fibromyalgia |
US11253531B2 (en) | 2011-08-11 | 2022-02-22 | Nutritional Therapeutics, Inc. | Lipid supplements for reducing nerve action potentials |
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DE102004038442A1 (de) * | 2004-08-07 | 2006-03-16 | Bioghurt Biogarde Gmbh & Co. Kg | Verfahren zur Herstellung nicht klebender Phospholipid-Granulate |
EP2172117B1 (de) | 2008-09-25 | 2011-11-16 | Nestec S.A. | Reduktion der Astringenz in Zusammensetzungen mit Phenolverbindungen |
PL2387391T3 (pl) * | 2009-07-24 | 2017-09-29 | Mika Pharma Gesellschaft Für Die Entwicklung Und Vermarktung Pharmazeutischer Produkte Mbh | Sposób otrzymywania ciekłej kompozycji stosowalnej w postaci piany na skórę oraz kompozycja do aplikowania miejscowego |
AU2011252887B2 (en) * | 2010-05-14 | 2016-05-12 | Archer Daniels Midland Company | Food compositions comprising organogels |
EP3171706B1 (de) | 2014-07-25 | 2021-09-01 | Enzymotec Ltd. | Nährstoffzusammensetzung mit phosphatidylserinpulver |
CN109568292A (zh) * | 2018-12-29 | 2019-04-05 | 中山百灵生物技术有限公司 | 一种含gpc的微凝胶及其制备方法 |
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EP0185442A2 (de) * | 1984-10-05 | 1986-06-25 | Warner-Lambert Company | System zum Freimachen von Süssstoff und dieses enthaltende Kaugummizusammensetzung |
WO2001062226A2 (en) * | 2000-02-23 | 2001-08-30 | J.P.M.E.D. Ltd. | Homogenous solid matrix containing vegetable proteins |
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GB8331808D0 (en) * | 1983-11-29 | 1984-01-04 | Unilever Plc | Food product |
GB8616041D0 (en) * | 1986-07-01 | 1986-08-06 | Unilever Plc | Phosphatide-containing compositions |
US5171737A (en) * | 1989-03-03 | 1992-12-15 | The Liposome Company, Inc. | Emulsions |
US6312719B1 (en) * | 1994-03-04 | 2001-11-06 | The University Of British Columbia | Liposome compositions and methods for the treatment of atherosclerosis |
FR2762993B1 (fr) * | 1997-05-06 | 1999-08-13 | Inst Rech Biolog Sa | Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique |
CN1321089A (zh) * | 1998-09-08 | 2001-11-07 | 比奥莫勒克拉制品公司 | 增加肠吸收脂肪的方法和组合物 |
JP2000300186A (ja) * | 1999-04-19 | 2000-10-31 | Kao Corp | 代謝改善剤 |
JP3195594B2 (ja) * | 1999-11-02 | 2001-08-06 | 明治乳業株式会社 | 乳由来のリン脂質を配合した食品組成物。 |
US7226916B1 (en) * | 2000-05-08 | 2007-06-05 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
JP2002226394A (ja) * | 2001-02-01 | 2002-08-14 | Meiji Milk Prod Co Ltd | 脂質代謝改善組成物 |
JP2004520845A (ja) * | 2001-03-26 | 2004-07-15 | ギヴエンテイス・ゲゼルシヤフト・ミット・ベシュレンクテル・ハフツング | 認知能力を高めるための食品 |
JP2003012520A (ja) * | 2001-06-25 | 2003-01-15 | Yaizu Suisankagaku Industry Co Ltd | 抗酸化剤及びそれを含有する飲食品 |
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2002
- 2002-04-19 DE DE10217555A patent/DE10217555A1/de not_active Withdrawn
-
2003
- 2003-04-17 WO PCT/EP2003/004031 patent/WO2003088761A2/de active Application Filing
- 2003-04-17 EP EP03718771A patent/EP1499204A2/de not_active Withdrawn
- 2003-04-17 US US10/511,884 patent/US20050220857A1/en not_active Abandoned
- 2003-04-17 JP JP2003585518A patent/JP2005527207A/ja active Pending
- 2003-04-17 AU AU2003222823A patent/AU2003222823A1/en not_active Abandoned
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EP0185442A2 (de) * | 1984-10-05 | 1986-06-25 | Warner-Lambert Company | System zum Freimachen von Süssstoff und dieses enthaltende Kaugummizusammensetzung |
WO2001062226A2 (en) * | 2000-02-23 | 2001-08-30 | J.P.M.E.D. Ltd. | Homogenous solid matrix containing vegetable proteins |
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Cited By (17)
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US7968529B2 (en) | 2003-01-20 | 2011-06-28 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Use of sphingolipids for reducing high plasma cholesterol and high triacylglycerol levels |
US8703172B2 (en) | 2003-01-20 | 2014-04-22 | Nederlandse Organizatie voor Toegepastnatuurwetenschappelijk Onderzoek TNO | Sphingolipids for improvement of the composition of the intestinal flora |
US7906488B2 (en) | 2004-11-30 | 2011-03-15 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae |
WO2006128639A3 (en) * | 2005-05-30 | 2007-08-09 | Fidia Farmaceutici | Process for the preparation and isolation of phosphatides |
WO2006128639A2 (en) * | 2005-05-30 | 2006-12-07 | Fidia Farmaceutici S.P.A. | Process for the preparation and isolation of phosphatides |
US7759095B2 (en) | 2005-05-30 | 2010-07-20 | Fidia Farmaceutici S.P.A. | Process for the preparation and isolation of phosphatides |
CN101184494B (zh) * | 2005-05-30 | 2012-03-21 | 菲迪雅制药股份公司 | 制备和分离磷脂的方法 |
JP2008546845A (ja) * | 2005-06-28 | 2008-12-25 | ケージーケー シナガイズ インク. | 心臓血管疾患の治療のためのポリメトキシフラボン類およびトコトリエノール類のバイオアベイラビリティーを改善する組成物 |
US8877239B2 (en) | 2010-08-12 | 2014-11-04 | Nutritional Therapeutics, Inc. | Lipid supplements for maintaining health and treatment of acute and chronic disorders |
WO2012021172A1 (en) * | 2010-08-12 | 2012-02-16 | Nutritional Therapeutics, Inc. | Lipid supplements for maintaining health and the treatment of acute and chronic disorders |
AU2011289846B2 (en) * | 2010-08-12 | 2015-07-16 | Nutritional Therapeutics, Inc. | Lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US9095507B2 (en) | 2011-08-11 | 2015-08-04 | Allergy Research Group, Llc | Chewable wafers containing lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US9468668B2 (en) | 2011-08-11 | 2016-10-18 | Allergy Research Group, Llc | Flavored chewable lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US9717734B2 (en) | 2011-08-11 | 2017-08-01 | Allergy Research Group, Llc | Chewable lipid supplements containing caffeine for increasing alertness, focus and energy |
US10117885B2 (en) | 2011-08-11 | 2018-11-06 | Allergy Research Group, Llc | Chewable lipid supplements for treating pain and fibromyalgia |
US10874681B2 (en) | 2011-08-11 | 2020-12-29 | Nutritional Therapeutics, Inc. | Oral lipid supplements for treating pain and fibromyalgia |
US11253531B2 (en) | 2011-08-11 | 2022-02-22 | Nutritional Therapeutics, Inc. | Lipid supplements for reducing nerve action potentials |
Also Published As
Publication number | Publication date |
---|---|
US20050220857A1 (en) | 2005-10-06 |
AU2003222823A1 (en) | 2003-11-03 |
JP2005527207A (ja) | 2005-09-15 |
WO2003088761A3 (de) | 2004-06-03 |
DE10217555A1 (de) | 2004-02-19 |
EP1499204A2 (de) | 2005-01-26 |
AU2003222823A8 (en) | 2003-11-03 |
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