CN101060874A - 用于卷紧笔的向下拨动机构 - Google Patents

用于卷紧笔的向下拨动机构 Download PDF

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CN101060874A
CN101060874A CNA200580039614XA CN200580039614A CN101060874A CN 101060874 A CN101060874 A CN 101060874A CN A200580039614X A CNA200580039614X A CN A200580039614XA CN 200580039614 A CN200580039614 A CN 200580039614A CN 101060874 A CN101060874 A CN 101060874A
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C·S·默勒
C·P·恩高
B·拉德默
T·H·马库森
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Novo Nordisk AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
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    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
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    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

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  • Pens And Brushes (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
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Abstract

本发明涉及一种用于包括扭力弹簧的注射装置的向下拨动机构，用来辅助从注射装置注射药物剂量，所述向下拨动机构包括向上拨动凸轮和向下拨动凸轮，所述向上拨动凸轮被设置为用来接收并啮合向上拨动键，其中当剂量调整元件在第一方向上旋转时，所述向上拨动凸轮和所述向上拨动键配合用来拉紧注射装置的扭力弹簧，所述向下拨动凸轮被设置为用来接收并啮合向下拨动键，其中当剂量调整元件在第二方向上旋转时，所述向下拨动凸轮和所述向下拨动键配合用来释放注射装置的扭力弹簧，所述第二旋转方向与所述第一旋转方向相反。

Description

用于卷紧笔的向下拨动机构
技术领域
本发明涉及一种用于自动卷紧笔(wind-up pen)的向下拨动机构(dial-down mechanism)。尤其是，本发明涉及一种用于卷紧笔的一体的轴向和径向的向下拨动机构。
背景技术
在已知的基于扭力弹簧的注射装置中，例如卷紧笔，向下拨动机构的使用依赖于注射装置的使用者向注射装置的旋转剂量调整元件施加力。为了将剂量调整元件轴向撤回一定距离，必须施加力以将剂量调整元件从位于注射装置的主体中的齿状机构或棘轮释放。通过从该齿状机构释放剂量调整元件，剂量调整元件可反转并调整到一个新的低剂量。
已知的应用扭力弹簧的卷紧笔的例子例如可以在US 5,104,380中找到。然而，在US 5,104,380中给出的笔没有提供向下拨动机构。在WO 02/053214中给出了一种向下拨动机构。然而在WO 02/053214中提到的解决方法包括线性弹簧。
已知的基于扭力弹簧的向下拨动系统的优势是使用者必须施加力以将剂量调整元件撤回一定的轴向距离，同时，调整剂量调整元件的角位置。尤其对于具有肌肉运动技能退化或手指力量退化的人，例如小孩、老人或残疾人，这是相当复杂的程序。
US 2004/199117公开了一种药物输送笔，包括这样的设置，其中不正确的剂量设置可以由使用者通过能够让使用者重设剂量的回拨部件来改正，不需要排出药物也不需要拨动剂量旋钮到延展的复位位置。US 2004/199117的药物输送笔是所谓的手动笔，其中来自笔的药物的注射仅仅由笔的使用者提供的力来驱动。这样，药物的注射没有通过任何弹性元件(例如弹簧)来辅助，在US 2004/199117中公开的向下拨动装置没有设置为将弹性元件保持在给定的拉紧位置。
本发明的目的是提供一种用于自动卷紧笔的向下拨动机构。自动卷紧笔在这里理解为具有弹性元件(例如弹簧)的笔，以辅助从注射装置注射药物。
发明内容
上述目的通过这样实现，第一方面，提供一种用于包括扭力弹簧的注射装置的向下拨动机构，用来辅助从注射装置注射药物剂量，向下拨动机构包括
-向上拨动凸轮，设置为用来接收和啮合向上拨动键，其中当剂量调整元件在第一方向旋转时，向上拨动凸轮和向上拨动键适于配合以拉紧注射装置的扭力弹簧，和
-向下拨动凸轮，设置为用来接收和啮合向下拨动键，其中当剂量调整元件在第二方向旋转时，向下拨动凸轮和向下拨动键适于配合以释放注射装置的扭力弹簧，第二旋转方向与第一旋转方向相反。
一般而言向下拨动机构可被实现为径向向下拨动机构或轴向向下拨动机构。在径向向下拨动机构中，向下拨动键被设置为在机构的径向方向移动。这也可以是注射装置的径向方向。在轴向向下拨动机构中，向下拨动键被设置为在注射装置的轴向方向移动。
而且还应该注意向上拨动键和向下拨动键可以是不同的键-即被物理分隔的键。然而，它还可以是由同一个键构成的向上拨动和向下拨动的键。这样，根据本发明的机构仅包括用来向上拨动和向下拨动的单个键。
向上拨动和向下拨动凸轮可被设置为盘状凸轮元件外表面部分上的开口或凹陷。可选择地，凸轮元件也可成形为基本为圆柱形的元件。尤其是，向上拨动和向下拨动凸轮可被设置在凸轮元件的基本为平面的部分。这个基本为平面的部分基本垂直于盘状或圆柱形凸轮元件的轴线方向。凸轮元件可以是中空结构，或可选择地，凸轮元件可以是实心结构。
在径向和轴向机构中，向上拨动凸轮可以形成曲线轨道，例如圆、椭圆或抛物线轨道的一部分。向下拨动凸轮可以形成V形轨道的一部分，或可选择地，它可以是矩形的。
向下拨动机构可以包括第一和第二向上拨动凸轮。而且，向下拨动机构可以包括第一和第二向上拨动键，其中第一向上拨动键可以用来与第一向上拨动凸轮啮合并配合，其中第二向上拨动键可以用来与第二向上拨动凸轮啮合并配合。
向下拨动机构还可以包括第一和第二向下拨动凸轮，以及第一和第二向下拨动键。第一向下拨动键可以用来与第一向下拨动凸轮啮合并配合，而第二向下拨动键可以用来与第二向下拨动凸轮啮合并配合。
还可以是向上拨动和向下拨动凸轮形成同一轨道区域的一部分。从而，向上拨动和向下拨动键可由同一个键构成，所述的键用来与同一轨道的向上拨动和向下拨动凸轮啮合并配合。
在轴向机构中，向上拨动和向下拨动凸轮可以设置为具有平行于注射装置轴向方向的轴向元件的凸轮。向上拨动或向下拨动凸轮可被设置在基本为圆柱形的凸轮元件的外部弯曲表面部分上。这种基本为圆柱形的凸轮元件可以是注射装置的计量调整元件，或者是与注射装置的剂量调整元件相配合的独立元件。
在轴向机构中，向上拨动凸轮可以基本平行于注射装置的轴向方向。为了能够将相关的棘轮从齿部释放，向下拨动凸轮可相对向上拨动凸轮形成一个角度，例如大约45度。
第二方面，本发明涉及一种轴向设置的用于注射装置的向下拨动机构，该向下拨动机构包括
-旋转元件，当调整要从注射装置注射的剂量时，所述旋转元件适于被旋转，所述旋转元件包括向上拨动凸轮和向下拨动凸轮，其中向上拨动凸轮用来在剂量调整过程中的向上拨动过程中接收并啮合注射装置的棘轮的键，其中向下拨动凸轮被用来在向下拨动过程中接收并啮合键，
其中向上拨动凸轮基本平行于注射装置的轴向方向。
根据本发明的第二方面，向上拨动和向下拨动凸轮可形成为同一轨道区域的一部分。向上拨动和向下拨动键可由同一个键构成，所述键用来与同一轨道的向上拨动和向下拨动凸轮啮合并配合。
第三方面，本发明涉及一种药物输送装置，例如手持式药物输送装置，包括根据本发明第一方面的向下拨动机构。
附图说明
本发明将参考附图进行更详细的描述，其中
图1示出了径向向上拨动和向下拨动机构的工作原理，其中弹性臂上的键用于向上拨动和向下拨动，
图2示出了一种径向向上/向下拨动机构，具有用来向上拨动和向下拨动的分别的键，
图3示出了一种径向向上/向下拨动机构，具有用来向上拨动和向下拨动的分别的键，其中，向下拨动键的运动由螺母中的轨道决定，
图4示出了一种具有一体的径向向下拨动机构的注射装置，和
图5示出了一种具有一体的轴向向下拨动机构的注射装置。
由于本发明可以有各种变型和替换形式，在附图中通过举例的方式给出特定实施例并在此进行详细描述。然而应该理解，本发明不限于公开的特定形式。相反，本发明覆盖所有落入由附加的权利要求所限定的本发明的实质和范围内的变型、等效和替换形式。
具体实施方式
根据本发明的向下拨动机构可被实现为轴向或径向机构。这些机构都可结合到注射装置中，例如注射笔。
图1给出了径向方式。图1a示出了偏压固定外部部件1的可旋转的内部部件2。由扭力弹簧(未示出)在逆时针方向提供偏压力。可绕中心轴线6旋转的内部部件2具有一个或多个用来与固定外部部件1的边缘5相啮合的弹性臂3。图1b示出了带有设置在内部部件2和外部部件1上方的旋转盘7(阴影部分)的图1a的设置。盘7具有开口8。限定开口8的边缘构成了向上拨动和向下拨动的凸轮。当盘7相对外部部件1旋转时，连接于或结合于弹性臂3的拾取键4作为凸轮从动件工作。
图1所示的系统按照下列方式工作：
当要调整剂量时(向上拨动)，内部部件2沿顺时针方向旋转，由此弹性臂3将从一个边缘5移动到相邻的边缘-取决于旋转的角度。内部部件2由盘7驱动，因此，当盘7旋转时，内部部件2同它一起旋转。在顺时针方向旋转过程中，拾取键4在径向方向移入移出。
当盘7沿逆时针方向(向下拨动方向)旋转时，拾取键4以及由此弹性臂3被抬起脱离其与外部部件1的边缘5啮合的位置。当臂3从边缘5完全脱离时，内部部件2可相对外部部件1沿逆时针方向旋转。图1所示的系统的特征在于拾取键4用于向上拨动(增加剂量)和向下拨动(复位或减少剂量)。
应该注意，旋转的方向是可逆的，以使可通过在逆时针方向旋转内部部件2得到向上拨动。在这种构造中，可通过顺时针方向旋转盘7得到向下拨动。
图2示出了根据本发明的向下拨动机构的径向实施例的分解图。与图1所示的实施例相比，主要的不同在于图2的实施例采用了不同的用于向上拨动(拾取键11)和向下拨动(拾取键12)的拾取键。向上拨动键11与盘14的轨道15相啮合，而向下拨动键12与盘14的轨道16相啮合。轨道15，16在盘14的平面上形成通孔或凹陷。向上拨动轨道15采用曲线轨道的形式而向下拨动轨道16为V形的。V形的明显替换方式是矩形。应该注意通常的理念是向上拨动轨道15应当能够将动量传递到扭力弹簧18。当盘14相对螺母10仅仅旋转几度时，通过相同的方式，向下拨动轨道16应当能够释放向下拨动键(并由此释放能量)。
向下拨动键12与弹性臂19相结合。这些臂由弹性材料制成，例如塑料。与向下拨动键12结合的弹性臂19形成为棘轮13的一体部分。因此，包括臂和向下拨动键的棘轮13优选由同样的材料制成，例如塑料。为了将向下拨动键12偏压在螺母10的齿20上，扭力弹簧18与棘轮13同轴设置。在螺母10的中间部分设有开口21。该开口的侧壁设有螺纹22，其用来与活塞杆(未示出)的螺纹外表面啮合。
图3示出了根据本发明的另一个径向实施例。在该实施例中，臂26的运动由螺母27中的轨道23控制。轨道23被轨道/凸轮从动件24啮合，其在向下拨动过程中精确地引导向下拨动键28从一个齿运动到相邻的齿。与图2相比，在螺母27中心的开口25设有轨道从动件29。该轨道从动件用来与位于活塞杆(未示出)外表面的轨道相啮合。
图4示出了具有根据本发明的径向向下拨动机构的注射装置。连同其他元件，图4所示的注射装置示出了剂量调整元件30、具有螺纹外表面和沿活塞杆轴向设置的驱动轨道的活塞杆31、螺母32、扭力弹簧35、驱动元件33、壳体的螺纹部分34、释放机构(lease mechanism)36、齿状机构37、和棘轮38。
通过旋转剂量调整元件30和螺母32来调整剂量由此扭力弹簧35被拉紧。由于位于螺母32和驱动元件33之间的齿状机构37，防止剂量调整元件30回复其初始位置。当使用者想要减少预设剂量时，剂量调整元件30仅在相反方向旋转。在向下拨动过程中棘轮38和螺母32之间的相互作用结合图2进行描述。
图5示出了具有根据本发明的轴向向下拨动机构的注射装置。连同其他元件，图5所示的注射装置包括剂量调整元件40、限定了向上拨动和向下拨动凸轮表面的开口41、凸轮从动件42、扭力弹簧43、棘轮44和活塞杆45。支持轴向向下拨动机构的通常理念是利用扭力弹簧43驱动并旋转活塞杆45，且确保齿状机构48的上部和下部保持在一起。
当要调整剂量时，凸轮从动件42与凸轮表面46啮合。结果由于齿状机构48防止棘轮44反转，扭力弹簧43被拉紧。在向上拨动过程中，当齿状机构48的上部和下部相对彼此旋转时，棘轮44沿着凸轮表面46向上或向下运动。当向下拨动时，凸轮表面47将会抬起从而将齿状机构的上部从齿状机构的下部释放，从而允许棘轮44旋转对应于一个齿的角度。

Claims (12)

1.一种用于包括扭力弹簧(18)的注射装置的向下拨动机构，用来辅助从注射装置注射药物剂量，所述向下拨动机构包括：
-向上拨动凸轮(15)，设置为用来接收和啮合向上拨动键(11)，其中当剂量调整元件在第一方向旋转时，向上拨动凸轮(15)和向上拨动键(11)适于配合以拉紧注射装置的扭力弹簧(18)，和
-向下拨动凸轮(16)，设置为用来接收和啮合向下拨动键(12)，其中当剂量调整元件在第二方向旋转时，向下拨动凸轮(16)和向下拨动键(12)适于配合以释放注射装置的扭力弹簧(18)，所述第二旋转方向与所述第一旋转方向相反。
2.如权利要求1所述的向下拨动机构，其特征在于所述向上拨动凸轮(15)形成曲线轨道的一部分。
3.如权利要求2所述的向下拨动机构，其特征在于所述曲线向上拨动凸轮(15)形成圆、椭圆或抛物线轨道的一部分。
4.如权利要求1-3中的任何一个所述的向下拨动机构，包括第一和第二向上拨动凸轮。
5.如权利要求4所述的向下拨动机构，包括第一和第二向上拨动键，其中第一向上拨动键适于与第一向上拨动凸轮啮合并配合，第二向上拨动键适于与第二向上拨动凸轮啮合并配合。
6.如上述权利要求的任何一个所述的向下拨动机构，其特征在于所述向下拨动凸轮(16)形成V形轨道的一部分。
7.如上述权利要求的任何一个所述的向下拨动机构，包括第一和第二向下拨动凸轮。
8.如权利要求7所述的向下拨动机构，包括第一和第二向下拨动键，其中所述第一向下拨动键适于与所述第一向下拨动凸轮啮合并配合，所述第二向下拨动键适于与所述第二向下拨动凸轮啮合并配合。
9.如上述权利要求的任何一个所述的向下拨动机构，其特征在于所述向上拨动和所述向下拨动凸轮形成同一轨道区域的一部分。
10.如权利要求9所述的向下拨动机构，其特征在于所述向上拨动和向下拨动键由同一个键构成，所述键适于与同一轨道的向上拨动和向下拨动凸轮啮合并配合。
11.一种药物输送装置，包括根据权利要求1-10中任一所述的向下拨动机构。
12.根据权利要求11所述的药物输送装置，其特征在于所述药物输送装置是手持式药物注射笔。
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EP2438940A1 (en) 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
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CN102196835A (zh) * 2008-10-24 2011-09-21 诺沃—诺迪斯克有限公司 用于卷紧笔的向下拨动机构
CN102196835B (zh) * 2008-10-24 2014-08-27 诺沃—诺迪斯克有限公司 用于卷紧笔的向下拨动机构
CN104159628A (zh) * 2012-02-08 2014-11-19 科佩尼库斯有限责任公司 具有剂量重置机构的注射装置
CN107019829A (zh) * 2012-02-08 2017-08-08 科佩尼库斯有限责任公司 具有剂量重置机构的注射装置
CN104411354B (zh) * 2012-05-09 2017-05-24 欧文蒙福德有限公司 使用弹性可压缩扭力弹簧作为驱动力的注射装置
CN104411354A (zh) * 2012-05-09 2015-03-11 欧文蒙福德有限公司 使用弹性可压缩扭力弹簧作为驱动力的注射装置
CN104363939B (zh) * 2012-05-31 2017-09-12 诺和诺德股份有限公司 用于装有发条的笔的拨动降低机构
CN104363939A (zh) * 2012-05-31 2015-02-18 诺和诺德A/S（股份有限公司） 用于装有发条的笔的拨动降低机构
CN104955505A (zh) * 2013-02-01 2015-09-30 诺和诺德股份有限公司 非轴向工作内含物排空机构和包括该非轴向工作内含物排空机构的注射装置
CN104955505B (zh) * 2013-02-01 2018-01-30 诺和诺德股份有限公司 非轴向工作内含物排空机构和包括该非轴向工作内含物排空机构的注射装置
US10328210B2 (en) 2013-02-01 2019-06-25 Novo Nordisk A/S Non-axial working end-of content mechanism and an injection device comprising the same
CN105307710A (zh) * 2013-06-14 2016-02-03 诺和诺德股份有限公司 具有双层弹簧的药物输送装置
CN105764545A (zh) * 2013-11-22 2016-07-13 赛诺菲-安万特德国有限公司 弹簧辅助式药物输送装置
US10500345B2 (en) 2013-11-22 2019-12-10 Sanofi-Aventis Deutschland Gmbh Spring assisted drug delivery device
CN106999671A (zh) * 2014-12-08 2017-08-01 赛诺菲 剂量设定机构和具有该剂量设定机构的药物输送装置
CN108025138A (zh) * 2015-10-01 2018-05-11 诺和诺德股份有限公司 在自动药物递送装置中的扭力弹簧固定
CN110997041A (zh) * 2017-07-13 2020-04-10 海斯迈股份公司 具有灵活剂量选择的注射装置
US11969584B2 (en) 2017-07-13 2024-04-30 Medmix Switzerland Ag Injection device with flexible dose selection
US11969583B2 (en) 2018-07-17 2024-04-30 Medmix Switzerland Ag Injection device with dose interruption fail safe

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