DK17890A - Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel - Google Patents

Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel Download PDF

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Publication number
DK17890A
DK17890A DK017890A DK17890A DK17890A DK 17890 A DK17890 A DK 17890A DK 017890 A DK017890 A DK 017890A DK 17890 A DK17890 A DK 17890A DK 17890 A DK17890 A DK 17890A
Authority
DK
Denmark
Prior art keywords
piston rod
medicine
movement
injection
mixing
Prior art date
Application number
DK017890A
Other languages
English (en)
Other versions
DK17890D0 (da
Inventor
Frits Bonnichsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK017890A priority Critical patent/DK17890A/da
Publication of DK17890D0 publication Critical patent/DK17890D0/da
Priority to MYPI91000057A priority patent/MY105287A/en
Priority to BR919105948A priority patent/BR9105948A/pt
Priority to AT91903551T priority patent/ATE125160T1/de
Priority to JP3503670A priority patent/JPH05503645A/ja
Priority to AU72130/91A priority patent/AU645525B2/en
Priority to ZA91375A priority patent/ZA91375B/xx
Priority to DE69111427T priority patent/DE69111427T2/de
Priority to EP91903551A priority patent/EP0513128B1/en
Priority to PCT/DK1991/000012 priority patent/WO1991010460A1/en
Priority to NZ236831A priority patent/NZ236831A/xx
Priority to HU9202382A priority patent/HUT67939A/hu
Priority to CA002074256A priority patent/CA2074256A1/en
Priority to IS3669A priority patent/IS3669A7/is
Priority to CS91125A priority patent/CS12591A3/cs
Priority to PT96535A priority patent/PT96535A/pt
Priority to IN39/MAS/91A priority patent/IN171690B/en
Priority to YU9991A priority patent/YU9991A/sh
Priority to IE021191A priority patent/IE910211A1/en
Priority to CN91101123A priority patent/CN1054374A/zh
Priority to IL9699991A priority patent/IL96999A/en
Publication of DK17890A publication Critical patent/DK17890A/da
Priority to FI923318A priority patent/FI923318A/fi
Priority to NO92922893A priority patent/NO922893L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Catching Or Destruction (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nozzles (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
DK017890A 1990-01-22 1990-01-22 Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel DK17890A (da)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DK017890A DK17890A (da) 1990-01-22 1990-01-22 Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel
MYPI91000057A MY105287A (en) 1990-01-22 1991-01-14 A process and apparatus for mixing and injecting a medicine.
CA002074256A CA2074256A1 (en) 1990-01-22 1991-01-18 Process and apparatus for mixing and injecting a medicine
NZ236831A NZ236831A (en) 1990-01-22 1991-01-18 Syringe with adjustable length piston rod and housing for a two-compartment capsule
AT91903551T ATE125160T1 (de) 1990-01-22 1991-01-18 Vorrichtung zum mischen und spritzen eines medikaments.
JP3503670A JPH05503645A (ja) 1990-01-22 1991-01-18 医薬を混合及び注射する方法及び装置
AU72130/91A AU645525B2 (en) 1990-01-22 1991-01-18 A process and apparatus for mixing and injecting a medicine
ZA91375A ZA91375B (en) 1990-01-22 1991-01-18 A process and apparatus for mixing and injecting a medicine
DE69111427T DE69111427T2 (de) 1990-01-22 1991-01-18 Vorrichtung zum mischen und spritzen eines medikaments.
EP91903551A EP0513128B1 (en) 1990-01-22 1991-01-18 Apparatus for mixing and injecting a medicine
PCT/DK1991/000012 WO1991010460A1 (en) 1990-01-22 1991-01-18 A process and apparatus for mixing and injecting a medicine
BR919105948A BR9105948A (pt) 1990-01-22 1991-01-18 Processo e aparelho para misturar um liquido e um medicamento
HU9202382A HUT67939A (en) 1990-01-22 1991-01-18 A process and apparatus for mixing and injecting a medicine
PT96535A PT96535A (pt) 1990-01-22 1991-01-21 Processo e aparelho pra misturar e injectar um medicamento
IS3669A IS3669A7 (is) 1990-01-22 1991-01-21 Aðferð og tæki til blöndunar og innsprautunar lyfs
CS91125A CS12591A3 (en) 1990-01-22 1991-01-21 Syringe for mixing a liquid with a medicament
IN39/MAS/91A IN171690B (da) 1990-01-22 1991-01-22
YU9991A YU9991A (sh) 1990-01-22 1991-01-22 Postupak i uredjaj za mešanje i ubrizgavanje lekova
IE021191A IE910211A1 (en) 1990-01-22 1991-01-22 A process and apparatus for mixing and injecting a medicine
CN91101123A CN1054374A (zh) 1990-01-22 1991-01-22 一种用于混合和注射药物的方法和装置
IL9699991A IL96999A (en) 1990-01-22 1991-01-22 Device for mixing and injecting a drug
FI923318A FI923318A (fi) 1990-01-22 1992-07-21 Foerfarande och anordning foer omblandning och insprutning av ett laekemedel.
NO92922893A NO922893L (no) 1990-01-22 1992-07-21 Fremgangsmaate og apparat for aa blande og injisere en medisin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK017890A DK17890A (da) 1990-01-22 1990-01-22 Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel

Publications (2)

Publication Number Publication Date
DK17890D0 DK17890D0 (da) 1990-01-22
DK17890A true DK17890A (da) 1991-07-23

Family

ID=8090654

Family Applications (1)

Application Number Title Priority Date Filing Date
DK017890A DK17890A (da) 1990-01-22 1990-01-22 Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel

Country Status (23)

Country Link
EP (1) EP0513128B1 (da)
JP (1) JPH05503645A (da)
CN (1) CN1054374A (da)
AT (1) ATE125160T1 (da)
AU (1) AU645525B2 (da)
BR (1) BR9105948A (da)
CA (1) CA2074256A1 (da)
CS (1) CS12591A3 (da)
DE (1) DE69111427T2 (da)
DK (1) DK17890A (da)
FI (1) FI923318A (da)
HU (1) HUT67939A (da)
IE (1) IE910211A1 (da)
IL (1) IL96999A (da)
IN (1) IN171690B (da)
IS (1) IS3669A7 (da)
MY (1) MY105287A (da)
NO (1) NO922893L (da)
NZ (1) NZ236831A (da)
PT (1) PT96535A (da)
WO (1) WO1991010460A1 (da)
YU (1) YU9991A (da)
ZA (1) ZA91375B (da)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
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DE9300177U1 (de) * 1993-01-12 1994-05-19 Bachnick, Martina, 10827 Berlin Behälter, insbesondere Arzneimittel-Behälter
FR2701211B1 (fr) * 1993-02-08 1995-05-24 Aguettant Lab Instrument doseur, notamment d'injection
CA2191472C (en) * 1994-05-30 2005-07-12 Herbert Bechtold Injection device
DE69507088T2 (de) * 1994-07-27 1999-05-27 Meridian Medical Technologies, Inc., Columbia, Md. Automatische Spritze
CA2213682C (en) * 1995-03-07 2009-10-06 Eli Lilly And Company Recyclable medication dispensing device
DE59609513D1 (de) * 1996-04-02 2002-09-05 Disetronic Licensing Ag Injektionsgerät
ATE224216T1 (de) 1996-04-02 2002-10-15 Disetronic Licensing Ag Injektionsgerät
ATE251479T1 (de) 1996-07-05 2003-10-15 Disetronic Licensing Ag Injektionsgerät zum injizieren von flüssigkeit
ATE307628T1 (de) * 1996-07-05 2005-11-15 Tecpharma Licensing Ag Injektionsgerät zum injizieren von flüssigkeit
JP3949752B2 (ja) * 1996-07-29 2007-07-25 日本ケミカルリサーチ株式会社 薬剤溶解機構付注射器
DE29703820U1 (de) * 1997-03-03 1998-07-02 Medico Development Investment Co., Ascona Injektionsgerät
WO1998040115A1 (de) 1997-03-10 1998-09-17 Disetronic Licensing Ag Gerät zur abgabe von flüssigkeiten
DE19717107B4 (de) 1997-04-23 2005-06-23 Disetronic Licensing Ag System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist
EP0978958B1 (en) 1997-04-24 2010-07-21 Ntt Mobile Communications Network Inc. Mobile communication method and mobile communication system
DE19740187C1 (de) * 1997-09-12 1999-04-15 Disetronic Licensing Ag Vorrichtung zur dosierten Ausschüttung eines injizierbaren Produkts
AU4860497A (en) 1997-11-17 1999-06-07 Disetronic Licensing Ag Device for introducing a needle
US6482176B1 (en) 1997-11-27 2002-11-19 Disetronic Licensing Ag Method and device for controlling the introduction depth of an injection needle
US6290679B1 (en) 1999-05-14 2001-09-18 Disetronic Licensing Ag Device for metered administration of an injectable product
DE19821933C1 (de) 1998-05-15 1999-11-11 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
DE19822031C2 (de) 1998-05-15 2000-03-23 Disetronic Licensing Ag Autoinjektionsgerät
EP1091783A4 (en) * 1998-06-29 2002-08-21 Orbon Corp DISTRIBUTOR OF DRUGS
DE29818721U1 (de) * 1998-10-21 2000-03-02 Medico Development Investment Co., Ascona Injektionsgerät
DE19900827C1 (de) 1999-01-12 2000-08-17 Disetronic Licensing Ag Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
DE19900792C1 (de) 1999-01-12 2000-06-15 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
DE19925904C1 (de) 1999-06-07 2001-02-01 Disetronic Licensing Ag Vorrichtung zur subkutanen Verabreichung eines injizierbaren Produkts
JP4399752B2 (ja) * 1999-07-06 2010-01-20 日本ケミカルリサーチ株式会社 薬剤溶解機構内蔵注射器
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DE29915878U1 (de) 1999-09-09 2000-10-26 Disetronic Licensing Ag, Burgdorf Vorrichtung zur Umfüllung von Arzneimitteln und Kanülenanordnung
DE19945397C2 (de) 1999-09-22 2001-07-19 Disetronic Licensing Ag Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
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US6673049B2 (en) 2001-02-15 2004-01-06 Disetronic Licensing Ag Injection device for injecting fluid
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ATE331542T1 (de) * 2002-08-29 2006-07-15 Novo Nordisk As Injektionsvorrichtung mit frontladung
US9205197B2 (en) 2003-03-03 2015-12-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device dose setting mechanism
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US7686786B2 (en) 2004-10-21 2010-03-30 Novo Nordiks A/S Dial-down mechanism for wind-up pen
CN101163514B (zh) 2005-04-24 2012-01-25 诺和诺德公司 注射装置
GB0524604D0 (en) 2005-12-02 2006-01-11 Owen Mumford Ltd Injection method and apparatus
WO2007104636A1 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
WO2007104697A2 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device having a gearing arrangement
GB2437924B (en) * 2006-05-11 2010-12-22 Owen Mumford Ltd Injection device
US8226618B2 (en) 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
RU2433840C2 (ru) 2006-05-18 2011-11-20 Ново Нордиск А/С Инъецирующее устройство со средством блокирования функции
US8708972B2 (en) 2006-07-15 2014-04-29 Novo Nordisk A/S Medical delivery system with a rotatable coding element
DE102006038121A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit Echtzeitanzeige
EP2121086B2 (en) 2006-11-21 2015-12-23 Novo Nordisk A/S Medical delivery system comprising locking ring with l-shaped grooves
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IS3669A7 (is) 1991-07-23
YU9991A (sh) 1994-06-24
WO1991010460A9 (en) 2007-10-04
NO922893D0 (no) 1992-07-21
IN171690B (da) 1992-12-05
IL96999A (en) 1995-06-29
DE69111427D1 (de) 1995-08-24
MY105287A (en) 1994-09-30
FI923318A0 (fi) 1992-07-21
WO1991010460A1 (en) 1991-07-25
AU645525B2 (en) 1994-01-20
BR9105948A (pt) 1992-10-27
DK17890D0 (da) 1990-01-22
DE69111427T2 (de) 1996-01-18
NZ236831A (en) 1993-05-26
EP0513128B1 (en) 1995-07-19
PT96535A (pt) 1991-10-15
IE910211A1 (en) 1991-08-14
ZA91375B (en) 1991-09-25
AU7213091A (en) 1991-08-05
CS12591A3 (en) 1992-08-12
NO922893L (no) 1992-09-10
ATE125160T1 (de) 1995-08-15
HUT67939A (en) 1995-05-29
FI923318A (fi) 1992-07-21
EP0513128A1 (en) 1992-11-19
HU9202382D0 (en) 1992-10-28
JPH05503645A (ja) 1993-06-17
IL96999A0 (en) 1992-03-29
CA2074256A1 (en) 1991-07-23
CN1054374A (zh) 1991-09-11

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