US2607344A - Syringe assembly - Google Patents

Syringe assembly Download PDF

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Publication number
US2607344A
US2607344A US239782A US23978251A US2607344A US 2607344 A US2607344 A US 2607344A US 239782 A US239782 A US 239782A US 23978251 A US23978251 A US 23978251A US 2607344 A US2607344 A US 2607344A
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Prior art keywords
barrel
wall
bore
ampule
needle
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Expired - Lifetime
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US239782A
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Frank E Brown
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3148Means for causing or aiding aspiration or plunger retraction

Definitions

  • 'It is an object of the invention to provide a structure of this nature in which, without difliculty, air may beV vented from a syringe barrel as an ampule is fully projected into that barrel.
  • a further object is that of providing a structure by means of which this result may be accomplished and which structure may readily be furnished in an economical manner under quantity production procedure.
  • FIGl 1 is a sectional side'view of an assembly in its initial position
  • Fig. 2 is a similar view of that assembly showing the parts in their nal position
  • Fig. 3 is a transverse sectional view in enlarged scale taken along the lines 3--3 and in the direction of the arrows as indicated in Fig. 2.
  • the numeral 5 indicates the barrel of a syringe which may be formed of any desired materials such as a suitable plastic.
  • This barrel has one end closed by a wall 6 from which a nose piece 1 may extend.
  • a needle 8 which is double pointed is mounted by Wall 5 and nose piece l. Its inner end 9 extends within the 'bore of barrel 5.
  • 'I'he opposite end of the barrel is open and may mount outwardly extending flanges I suitable for engagement with the fingers of the operator.
  • An ampule for use with this barrel maybe formed of a piece of glass tubing II. One end of this tube is closed by a piston type stopper I2. The opposite end may be closed by a pierceable stopper I3. Intermediate its ends ampule I I mounts a stopper I4. Thus its body is divided Into compartments, the rear one of which mayv receive a diluent of iiuid I and the front one of which may receive medicament as indicated at I6. A by-pass in the nature of a groove Il may be provided at a point beyond the initial position of stopper I4. 'Ihe length of this bypass is greater than the width of that stopper. All three stoppers of the assembly are conveniently formed of rubber or similar material.
  • a cap I8 may be initially mounted on nose Vpiece 'l and'enclose needle 8 to maintain the sterility of the latter.
  • an ampule II is introduced into the bore of the barrel as shown in Fig. 1.
  • stopper suitable vactuator which may comprise cap I8.
  • stopper I4 will be similarly shifted to the zone of the by-pass I1.
  • a by-pass structure is provided in proximity to Wall 6 and the adjacent bore face of the barrel.
  • This by-pass structure may take one of several different forms. However it is preferred that it embrace an inwardly extending rib 20. That end of the rib which extends ltoward the open end of the barrel presents an inclined edge portion. Thus asgthe ampule is projected to a point at which the inner end 9 of the needle penetrates stopper I3, the flange I9 or head of the stopper will ride onto this rib in the manner indicated in Fig. 3. This will furnish a space between the edge of the stopper head and the adjacent barrel surfaces. Through these spaces air may vent during the nal stage,
  • IMS-plmjected Such vprojection occurs by the use of a Y of projection of the ampule. Therefore a simple l tion a barrel formed with an open end, a; wall closing the opposite end of said barrel, a needle ⁇ extending through said wall intothe bore' of.
  • an ampule insertable through the open end of said barrel means providing a piston carried by said ampule adjacent-its end4 open end of said barrel, a headed pierceable stopperl having its peripheral edge extending outwardly from said ampule adjacent the end of the latter and having wiping engagement with the face of the barrel bore and means forming a part of said barrel in proximity to said Wall and the adjacent bore portion to provide a passage for fluid flow past said piston as the latter is projected into the zone of said end wall.
  • a syringe assembly including in combination a barrel formed with an open end, a wall closing the opposite end of said barrel, a needle l extending through said wall into the bore of carried Vby rsaid 'ampule adjacent its end and Vsaid barrel, an ampule insertable through the open-end of said barrel, means providing a piston Y having wiping engagement with the face of the and having wiping engagement Vwith the Yface* of thepbarrel bore and means forming a part ofV said barrel in proximity to said Wallandv the. adjacent bore portion to provide a passage for' fluid ⁇ Vflow past'saidpiston as thelatter is pro.
  • a syringe assembly including in combina-Y tion a barrel formed with an open end, 'a wall ⁇ closingrthe opposite end of said barrel, a 'needle extending through'said wall into the bore ofy said barrel, anY ampule ⁇ insertablel 4through the openr'end ofVv said barrel, means providing a piston carried by saidy ampule adjacent its end and ⁇ having wiping engagement withthe face of the barrel bore and means forming apart of said barrel i-n proximity to said wall and the adjacent bore portion to provide apassagefor fluid flow past' said piston as vthe 'latter is projected intorthe zone of said end wall; the. length of the needle portion extendingV into said bore being less than the length of. saidI passage.
  • a syringe 'assembly including inv combination a barrel formed with an open" end, a wall closing the opposite end of said barrel, a needle extending through said wall into the bore of said barrel, an ampule insertable through the barrel bore anda' rib extending inwardly of said barrel bore in proximity to said wall, said rib engaging said piston means to provide a passage foruid past vthesameas the latter is projected Ainto the zone of ,said end wall.
  • a barrel formed with an open end, a wall closing the opposite end of said barrel, a needle extending through said wall ,into the bore of saidbarrel, and means.
  • a Y l f 6 In a syringe assembly a barrel formedwith an openY end, a Wall closing the opposite end of saidflbarrel, aneedleextending through said wall into the bore of said barrel, and a rib form# ing an integral part of said barrel and extend.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

Aug. 19, 1952 F. E. BROWN SYRINGE ASSEMBLY mqdAug. 1. 1951 iff BY Emili/amd Km Patented ug. 19, 1952` OFFICE SYRINGE ASSEMBLY Frank E. Brown, Burbank, Calif., assigner to Frederick M. Turnbull, Los Angeles, Calif.
Application August 1, 1951, Serial No. 239,782 6 Claims. VA(Cl. 12S- 218) This invention relates to a structurally and' functionally improved hypodermic syringe assembly. Y
'It is an object of the invention to provide a structure of this nature in which, without difliculty, air may beV vented from a syringe barrel as an ampule is fully projected into that barrel.
A further object is that of providing a structure by means of which this result may be accomplished and which structure may readily be furnished in an economical manner under quantity production procedure.
With these and other objects in mind reference ishad to the attached sheet of drawings illustrating-one practical embodiment of the invention and in which:
'Figl 1 is a sectional side'view of an assembly in its initial position;
Fig. 2 is a similar view of that assembly showing the parts in their nal position; and
Fig. 3 is a transverse sectional view in enlarged scale taken along the lines 3--3 and in the direction of the arrows as indicated in Fig. 2.
In these views the numeral 5 indicates the barrel of a syringe which may be formed of any desired materials such as a suitable plastic. This barrel has one end closed by a wall 6 from which a nose piece 1 may extend. A needle 8 which is double pointed is mounted by Wall 5 and nose piece l. Its inner end 9 extends within the 'bore of barrel 5. 'I'he opposite end of the barrel is open and may mount outwardly extending flanges I suitable for engagement with the fingers of the operator.
An ampule for use with this barrel maybe formed of a piece of glass tubing II. One end of this tube is closed by a piston type stopper I2. The opposite end may be closed by a pierceable stopper I3. Intermediate its ends ampule I I mounts a stopper I4. Thus its body is divided Into compartments, the rear one of which mayv receive a diluent of iiuid I and the front one of which may receive medicament as indicated at I6. A by-pass in the nature of a groove Il may be provided at a point beyond the initial position of stopper I4. 'Ihe length of this bypass is greater than the width of that stopper. All three stoppers of the assembly are conveniently formed of rubber or similar material.
As will be understood with an assembly of this nature a cap I8 may be initially mounted on nose Vpiece 'l and'enclose needle 8 to maintain the sterility of the latter. When the assembly is to be used an ampule II is introduced into the bore of the barrel as shown in Fig. 1. When needle end 9 has pierced cap I3 then stopper suitable vactuator which may comprise cap I8. In any event with lstopper I2 moved to the right as'viewed in Fig. 1, then stopper I4 will be similarly shifted to the zone of the by-pass I1.
Therefore uid Vmay ilow through that by-passY In a unit suclifas this it is desirable that anv aspirating action mayv occur. `Such action will be useful, for example, in determiningwhether the needle is lodged in a vein or not. To secure an aspirating function there is provided adjacent the inner end of the ampule II a packing or pistonwhich. slidably'contacts the inner face of the bore of vbarrel `5. Conveniently this piston mayv comprise an outwardly extending flange portion' I9 of stopper I3. It is apparent that by simply withdrawing the ampule II to a slight extent from within barrel 5 a condition of sub-atmospheric pressure will be created Within the space intervening stopper I3 and needle 9. Under these circumstances if the needle is lodged in a vein this will be evidenced by a drop or two of blood discharging from the inner end 9 of the needle. With such a construction it is. of course, apparent that as the ampule is projected within the barrel air will be vented through the bore of the needle. However, when the inner end 9 of the latter once embeds within stopper I3 then continued inward movement of the ampule will cause ra condition of pressure between the stopper and wall 6.
In order to relieve this a by-pass structure is provided in proximity to Wall 6 and the adjacent bore face of the barrel. This by-pass structure may take one of several different forms. However it is preferred that it embrace an inwardly extending rib 20. That end of the rib which extends ltoward the open end of the barrel presents an inclined edge portion. Thus asgthe ampule is projected to a point at which the inner end 9 of the needle penetrates stopper I3, the flange I9 or head of the stopper will ride onto this rib in the manner indicated in Fig. 3. This will furnish a space between the edge of the stopper head and the adjacent barrel surfaces. Through these spaces air may vent during the nal stage,
. IMS-plmjected. Such vprojection occurs by the use of a Y of projection of the ampule. Therefore a simple l tion a barrel formed with an open end, a; wall closing the opposite end of said barrel, a needle` extending through said wall intothe bore' of. said barrel, an ampule insertable through the open end of said barrel, means providing a piston carried by said ampule adjacent-its end4 open end of said barrel, a headed pierceable stopperl having its peripheral edge extending outwardly from said ampule adjacent the end of the latter and having wiping engagement with the face of the barrel bore and means forming a part of said barrel in proximity to said Wall and the adjacent bore portion to provide a passage for fluid flow past said piston as the latter is projected into the zone of said end wall.
4. A syringe assembly including in combination a barrel formed with an open end, a wall closing the opposite end of said barrel, a needle l extending through said wall into the bore of carried Vby rsaid 'ampule adjacent its end and Vsaid barrel, an ampule insertable through the open-end of said barrel, means providing a piston Y having wiping engagement with the face of the and having wiping engagement Vwith the Yface* of thepbarrel bore and means forming a part ofV said barrel in proximity to said Wallandv the. adjacent bore portion to provide a passage for' fluid `Vflow past'saidpiston as thelatter is pro.
jected into the zone of said end wall.
2. A syringe assembly including in combina-Y tion a barrel formed with an open end, 'a wall` closingrthe opposite end of said barrel, a 'needle extending through'said wall into the bore ofy said barrel, anY ampule `insertablel 4through the openr'end ofVv said barrel, means providing a piston carried by saidy ampule adjacent its end and `having wiping engagement withthe face of the barrel bore and means forming apart of said barrel i-n proximity to said wall and the adjacent bore portion to provide apassagefor fluid flow past' said piston as vthe 'latter is projected intorthe zone of said end wall; the. length of the needle portion extendingV into said bore being less than the length of. saidI passage.
3'. A syringe 'assembly including inv combination a barrel formed with an open" end, a wall closing the opposite end of said barrel, a needle extending through said wall into the bore of said barrel, an ampule insertable through the barrel bore anda' rib extending inwardly of said barrel bore in proximity to said wall, said rib engaging said piston means to provide a passage foruid past vthesameas the latter is projected Ainto the zone of ,said end wall.
5. In a syringe assembly a barrel formed with an open end, a wall closing the opposite end of said barrel, a needle extending through said wall ,into the bore of saidbarrel, and means.
forminganintegral part of said barrel and dis-V posedin. proximity to said Wall and the adja-v cent bore portion to provide a passage for fluid past aV pistongprojectible into the barrellgbore. towards said Wall. A Y l f 6. In a syringe assembly a barrel formedwith an openY end, a Wall closing the opposite end of saidflbarrel, aneedleextending through said wall into the bore of said barrel, and a rib form# ing an integral part of said barrel and extend.
ing into the bore ofthe same at a point adja-v cent said wall, said rib providing anl edgeportion to engage with Vpiston material as a piston is projected through vsaid barrel bore towards said wall.r
FRANK E. BROWN.
No references cited.
US239782A 1951-08-01 1951-08-01 Syringe assembly Expired - Lifetime US2607344A (en)

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Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2788002A (en) * 1955-08-22 1957-04-09 Owens Illinois Glass Co Medicinal package
US3028052A (en) * 1959-06-01 1962-04-03 John E Archer Mold-filling device
US3091240A (en) * 1958-12-29 1963-05-28 Robert K Mcconnaughey Hypodermic syringe and ventable closure means
US3115137A (en) * 1962-03-12 1963-12-24 Stanley J Sarnoff Aspiration seal
US3115136A (en) * 1962-03-12 1963-12-24 Stanley J Sarnoff Cartridge
US3115875A (en) * 1960-11-14 1963-12-31 Edgar H Wilburn Cartridge syringes
US3187749A (en) * 1962-01-04 1965-06-08 Stanley J Sarnoff Hypodermic cartridge
US3291128A (en) * 1964-01-24 1966-12-13 John G O'neil Hypodermic syringe construction with sealable vent means
US3366103A (en) * 1965-06-24 1968-01-30 Becton Dickinson Co Blood collecting assembly
DE1491850B1 (en) * 1965-08-09 1971-06-24 Upjohn Co Injection ampoule
US3678931A (en) * 1970-06-09 1972-07-25 Milton J Cohen Syringe
US3712301A (en) * 1971-01-11 1973-01-23 Survival Technology Gun type hypodermic injector with rapid cartridge displacement within holder
US3878846A (en) * 1971-12-13 1975-04-22 Spad Lab Hypodermic syringe with parts disposable after use
US3896805A (en) * 1972-05-19 1975-07-29 Kendall & Co Multi-chamber syringe
FR2315954A1 (en) * 1975-07-04 1977-01-28 Chibret Laboratoires Syringe for storing and mixing two medicaments - administrating the reconstituted mixt.
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
US4192919A (en) * 1977-05-17 1980-03-11 Mpl, Inc. Blood sampling and culturing kit
EP0172990A1 (en) * 1984-08-13 1986-03-05 Becton Dickinson and Company Two-component syringe assembly
US4685910A (en) * 1986-01-21 1987-08-11 Abbott Laboratories Apparatus and method for delivering secondary fluids to a patient using an intravenous administration set feeding a primary fluid
EP0295337A1 (en) 1987-06-16 1988-12-21 Akzo Nobel N.V. Two compartment syringe and method of manufacturing
EP0298067A1 (en) * 1987-07-02 1989-01-04 Kabi Pharmacia Ab Method and device for injection
WO1991010460A1 (en) * 1990-01-22 1991-07-25 Novo Nordisk A/S A process and apparatus for mixing and injecting a medicine
US5222948A (en) * 1991-09-09 1993-06-29 Path Injection port for single-use syringe
EP1066847A1 (en) * 1999-07-06 2001-01-10 Nihon Chemical Research Co., Ltd. Injection Syringe
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US20150065991A1 (en) * 2012-04-09 2015-03-05 Becton, Dickinson And Company Vial dosing systems and methods
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US20170151393A1 (en) * 2012-05-22 2017-06-01 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10183116B2 (en) 2011-01-26 2019-01-22 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US10695495B2 (en) 2015-03-24 2020-06-30 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Cited By (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2788002A (en) * 1955-08-22 1957-04-09 Owens Illinois Glass Co Medicinal package
US3091240A (en) * 1958-12-29 1963-05-28 Robert K Mcconnaughey Hypodermic syringe and ventable closure means
US3028052A (en) * 1959-06-01 1962-04-03 John E Archer Mold-filling device
US3115875A (en) * 1960-11-14 1963-12-31 Edgar H Wilburn Cartridge syringes
US3187749A (en) * 1962-01-04 1965-06-08 Stanley J Sarnoff Hypodermic cartridge
US3115137A (en) * 1962-03-12 1963-12-24 Stanley J Sarnoff Aspiration seal
US3115136A (en) * 1962-03-12 1963-12-24 Stanley J Sarnoff Cartridge
US3291128A (en) * 1964-01-24 1966-12-13 John G O'neil Hypodermic syringe construction with sealable vent means
US3366103A (en) * 1965-06-24 1968-01-30 Becton Dickinson Co Blood collecting assembly
DE1491850B1 (en) * 1965-08-09 1971-06-24 Upjohn Co Injection ampoule
US3678931A (en) * 1970-06-09 1972-07-25 Milton J Cohen Syringe
US3712301A (en) * 1971-01-11 1973-01-23 Survival Technology Gun type hypodermic injector with rapid cartridge displacement within holder
US3878846A (en) * 1971-12-13 1975-04-22 Spad Lab Hypodermic syringe with parts disposable after use
US3896805A (en) * 1972-05-19 1975-07-29 Kendall & Co Multi-chamber syringe
FR2315954A1 (en) * 1975-07-04 1977-01-28 Chibret Laboratoires Syringe for storing and mixing two medicaments - administrating the reconstituted mixt.
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
US4192919A (en) * 1977-05-17 1980-03-11 Mpl, Inc. Blood sampling and culturing kit
US4599082A (en) * 1984-08-13 1986-07-08 Becton, Dickinson And Company Two-component syringe assembly
EP0172990A1 (en) * 1984-08-13 1986-03-05 Becton Dickinson and Company Two-component syringe assembly
US4685910A (en) * 1986-01-21 1987-08-11 Abbott Laboratories Apparatus and method for delivering secondary fluids to a patient using an intravenous administration set feeding a primary fluid
EP0295337A1 (en) 1987-06-16 1988-12-21 Akzo Nobel N.V. Two compartment syringe and method of manufacturing
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
JPH0661361B2 (en) * 1987-07-02 1994-08-17 カビ・フアーマシア・アクチエボラーグ Injection method and injection device
EP0298067A1 (en) * 1987-07-02 1989-01-04 Kabi Pharmacia Ab Method and device for injection
JPS6480371A (en) * 1987-07-02 1989-03-27 Kabivitrum Ab Injecting method and apparatus
US4968299A (en) * 1987-07-02 1990-11-06 Kabivitrum Ab Method and device for injection
WO1991010460A1 (en) * 1990-01-22 1991-07-25 Novo Nordisk A/S A process and apparatus for mixing and injecting a medicine
US5222948A (en) * 1991-09-09 1993-06-29 Path Injection port for single-use syringe
EP1066847A1 (en) * 1999-07-06 2001-01-10 Nihon Chemical Research Co., Ltd. Injection Syringe
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US20040134563A1 (en) * 1999-10-22 2004-07-15 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US7341575B2 (en) 1999-10-22 2008-03-11 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9629959B2 (en) 2005-01-24 2017-04-25 Antares Pharma, Inc. Prefilled syringe jet injector
US11446441B2 (en) 2005-01-24 2022-09-20 Antares Pharma, Inc. Prefilled syringe injector
US10478560B2 (en) 2005-01-24 2019-11-19 Antares Pharma, Inc. Prefilled syringe injector
US11547808B2 (en) 2006-05-03 2023-01-10 Antares Pharma, Inc. Two-stage reconstituting injector
US10688250B2 (en) 2006-05-03 2020-06-23 Antares Pharma, Inc. Two-stage reconstituting injector
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US11497753B2 (en) 2009-03-20 2022-11-15 Antares Pharma, Inc. Hazardous agent injection system
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US10555954B2 (en) 2009-03-20 2020-02-11 Antares Pharma, Inc. Hazardous agent injection system
US9750881B2 (en) 2009-03-20 2017-09-05 Antares Pharma, Inc. Hazardous agent injection system
US10183116B2 (en) 2011-01-26 2019-01-22 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US11185642B2 (en) 2011-07-15 2021-11-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US10568809B2 (en) 2011-07-15 2020-02-25 Ferring B.V. Liquid-transfer adapter beveled spike
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US10279131B2 (en) 2011-07-15 2019-05-07 Antares Pharma, Inc. Injection device with cammed RAM assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US10821072B2 (en) 2012-04-06 2020-11-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US11771646B2 (en) 2012-04-06 2023-10-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10569018B2 (en) * 2012-04-09 2020-02-25 Becton, Dickinson And Company Vial dosing systems and methods
US20150065991A1 (en) * 2012-04-09 2015-03-05 Becton, Dickinson And Company Vial dosing systems and methods
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