US3712301A - Gun type hypodermic injector with rapid cartridge displacement within holder - Google Patents

Gun type hypodermic injector with rapid cartridge displacement within holder Download PDF

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US3712301A
US3712301A US3712301DA US3712301A US 3712301 A US3712301 A US 3712301A US 3712301D A US3712301D A US 3712301DA US 3712301 A US3712301 A US 3712301A
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Prior art keywords
ampoule
holder
end
cartridge
plunger
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S Sarnoff
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SURVIVAL Technology
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SURVIVAL Technology
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006Having specific accessories
    • A61M2005/2013Having specific accessories triggering of discharging means by contact of injector with patient body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206With automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock

Abstract

A hypodermic injector is provided comprising a sleeve housing a cocked spring impelled plunger, a cartridge holder with a cannula pierceable stopper at the front end thereof attached to the sleeve and a cartridge with front end attached cannula in the holder wherein the rear end only of the cartridge is frictionally retained in the holder and in air tight sealing engagement therewith, the cartridge being otherwise substantially unrestrained from movement with respect to the holder, the free end of the cannula lying within the holder until the plunger is released, all to maintain cannula sterility and yet allow rapid movement of the cartridge in the holder when the plunger is operative.

Description

United States Sarnoff 1 Jan. 23, 1973 [54] GUN TYPE HYPODERMTC INJECTOR WITH RAPID CARTRIDGE DISPLACEMENT WITHIN HOLDER [75] Inventor: Stanley Sarnoff, Bethesda, Md.

[73] Assignee: Survival Technology Inc., Bethesda,

[63] Continuation-in-part of Ser. No. 751,395, Aug. 9, 1968, abandoned, and a continuation of Ser. No. 839,794, June 26, 1969, abandoned.

[52] U.S. Cl ..128/218 A, 128/218 D, 128/218 F [51] Int. Cl. ..A61m 5/20 [58] Field of Search.....l28/2l8 D, 218 DA, 218 NV,

128/218 M, 218 R, 218 F, 272, 218 A [56] References Cited UNITED STATES PATENTS 2/1955 Krug ..128/218 F 2,607,344 8/1952 Brown ....128/218 M UX 2,832,339 4/1958 Sarnoff et a1... ..128/2l8.2

2,894,509 7/1959 Bednarz ..128/218 NV 3,335,914 8/1967 Strazdins et a1 ..128/218 R X FOREIGN PATENTS OR APPLICATIONS 714,983 9/1954 Great Britain ..128/218 D 1,008,915 11/1965 Great Britain ..128/218 R 282,268 12/1964 Netherlands ..128/218 F Primary Examiner-William E. Kamm Assistant Examiner-]. C. McGowan Att0rney-Fred L. Witherspoon, Jr.

[57] ABSTRACT A hypodermic injector is provided comprising a sleeve housing a cocked spring impelled plunger, a cartridge holder with a cannula pierceable stopper at the front end thereof attached to the sleeve and a cartridge with front end attached cannula in the holder wherein the rear end only of the cartridge is frictionally retained in the holder and in air tight sealing engagement therewith, the cartridge being otherwise substantially unrestrained from movement with respect to the holder, the free end of the cannula lying within the holder until the plunger is released, all to maintain cannula sterility and yet allow rapid movement of the cartridge in the holder when the plunger is operative.

13 Claims, 17 Drawing Figures PATENTEDJAH 23 i975 SHEET 3 OF 5 INVENTOR. Sm/VLEY J SHRNOFF' PATENTEDJAH 23 ms SHEET Q [If 5 IN VEN TOR.

5mm E Y J SARNOFF PATENTEfiJAn 23 um SHEET 5 [IF 5 INVENI'OR STANLEY J SHRNOFF GUN TYPE HYPODERMIC INJECTOR WITH RAPID CARTRIDGE DISPLACEMENT WITHIN HOLDER This application is a continuation-in-part of application Ser. No. 751,395, filed Aug. 9, I968, Stanley J. Sarnoff, titled Gun Type Hypodermic Injector With Rapid Cartridge Displacement Within Holder now abandoned, and a continuation of application Ser. No. 839,794, filed June 26, 1969, of the same inventor and title, now abandoned.

The invention relates to hypodermic injection devices of the gun type, i.e., of the type wherein a plunger is cocked against the force of a source of potential energy which plunger when released will exert a force on a piston to expel medication from an ampoule associated with the gun.

The invention relates more specifically to a type of injection device employing such a gun wherein the gun is combined with a cartridge comprising an ampoule having a cannula attached thereto and a holder for the cartridge, the cartridge and holder constituting a cartridge assembly and providing a sterile atmosphere for the cannula. Upon operation of the gun, the cartridge is shifted relative to the holder, driving the cannula out of the holder after which the medication in the ampoule is rapidly expelled via the cannula.

In such injection devices, in the prior art, attempts have been made to attain sterility of the end of the cannula which ultimately extends out of the holder while it was still within said holder, as by maintaining a close fit between the ampoule and its holder. But in doing so the movement of the cartridge relative to the holder, upon gun operation, was necessarily slowed down because of the friction between the ampoule and holder. Also, as a result of the close fit, a mass of air under compression was built up in advance of the moving ampoule as it advanced in the holder, thereby retarding the rapid exposure of the cannula and causing the possible premature expulsion of the medication from the ampoule.

It is an object of this invention to provide a sterile package for use with a gun, the package comprising a cartridge and a holder therefor, with the ampoule of the cartridge initially frictionally held in the holder but freely movable with respect thereto once the frictional engagement has been released by initial operation of the gun.

Another object of the invention is to provide an injection device comprising a gun, and a package as set forth above separably connected together whereby the same gun may be used with successive packages.

It is yet another object of this invention to provide a component type injection device comprising a sleeve, a cartridge assembly fitted into one end of the sleeve and a gun assembly positioned in the other end of the sleeve FIG. 2. is a cross sectional view of the same injection device with the gun released and the contents of the cartridge expelled therefrom;

FIG. 3 is a cross section of the line 3-3 of FIG. 1;

FIG. 4 is a view similar to FIG. 1 illustrating a modified form of the invention;

FIG. 5 is a view similar to FIG. 2 showing the modified form of invention of FIG. 4;

FIG. 6 is a cross sectional view taken on line 6-6 of FIG. 4;

FIG. 7 is a cross sectional view of the preferred form of the injection device with the gun in cocked position;

FIG. 8 is a sectional view of the device of FIG. 7, illustrating the intermediate position of operation wherein the gun has propelled the plunger and engaged cartridge forward and forced the cannula out through the stoppered end;

FIG. 9 is a sectional view of the device of FIG. 7, illustrating the complete travel of the plunger resulting in full discharge of the medicament from the ampoule;

FIG. 10 is a cross sectional view taken along line 10l0 of FIG. 7 showing the manner in which the plunger engages the end periphery of the ampoule;

FIG. 11 is a cross sectional view taken along line 11-11 of FIG. 10 further illustrating the manner in which the plunger engages the end of the ampoule;

FIG. 12 is a cross sectional view taken along line 12-l2 of FIG. 7 showing the relative disposition of parts of the gun assembly;

FIG. 13 is a cross sectional view taken along line l3l3 of FIG. 7 illustrating the inner profile of the safety cap.

FIG. 14 is a cross sectional view of yet another form of the injection device with the gun in cocked position;

FIG. 15 is a sectional view of the device of FIG. 14 lllustrating the complete travel of the plunger resulting in full discharge of the medicament from the ampoule;

FIG. 16 is a cross sectional view taken along line 16-46 of FIG. 14, and

FIG. 17 is a cross sectional view taken along line 17-17 of FIG. 14.

Now referring to the drawings with greater particularity, in FIGS. 1 and 2 there is shown an assembly of a gun indicated generally at 10, a cartridge holder 12 and a cartridge 14, the cartridge comprising an ampoule 16 and a cannula 18.

The gun 10 comprises a structure of the general type shown in the U. S. Pat. to Sarnoff et al. No. 2,832,339 and includes an inner tube or inner sleeve 20 having a threaded end portion 24 and being provided with an integral knurled knob 22 for facilitating rotation of the inner sleeve when assembling this sleeve to the threaded portion 52 of cartridge holder 12. The inner sleeve 20 is closed at its unthreaded end 26 except for a central opening 28 for the passage therethrough of the furcated end of plunger 30, the right hand end of which in cooperation with the outer face of the end 26 of the sleeve 20 provides a restraint against the forcing of the plunger 30 out of the inner sleeve by the action of a spring 32 under compression between a shoulder 34 on the plunger 30 and the inner face of the inner sleeve end 26. As explained more fully in the Sarnoff US. Pat. No. 2,832,339, the plunger at its right hand end, as viewed in FIGS. 1 and 2, is furcated and the springy metal of the plunger normally is positioned so that conical portions 36 have flat faces resting against the outer face of end 26. When the furcations are compressed together, the conical portions 36 are of a diameter less than the diameter of the opening 28 and the spring is then free to expand and rapidly move the plunger to the left. An outer sleeve 38 is telescopically movable on the inner sleeve and is provided with a thickened end 40 having an inner central cam face 42 to engage the conical portions 36 and squeeze them together when the outer sleeve is moved to the left. To prevent inadvertent release of the plunger 30, a safety device 44 is provided, comprising a knurled manually engageable cap 46 having an integral pin 48 insertable between the furcations to prevent collapsing movement of the conical portions 36.

The cartridge holder 12 shown in FIGS. 1 and 2 comprises a hollow cylindrical shell 50 of resilient material, such as a plastic material, having a threaded end 52 for engagement with the threaded portion 24 of the gun sleeve 20. The shell tapers from the threaded end 52 toward the other end both internally and externally for ease of removal thereof in molding of the shell and is reinforced by outside longitudinal ribs 54. At the smaller diametered end of the shell there is provided a conical nose 56 with a central opening 58, this opening in the unoperated condition of the injection device being closed off by an air and microorganism impervious stopper, such as a puncturable rubber stopper 60. Closely adjacent the threaded end of the shell 50, there is provided a bead 62 running completely about the inner wall of the shell. The bead is for the purpose of frictionally engaging and retaining an end portion of ampoule 16 and to form a peripheral seal therewith, thus preventing the entrance of microorganisms into the space occupied by the cannula 18.

The cartridge 14 is of the general type disclosed in the Sarnoff US. Pat. No. 3,391,695 issued July 9, 1968, and comprises an ampoule 16 and a cannula 18 attached to the ampoule by a hollow cap 68 firmly embracing a sleeve 66 fixed to the cannula 18 and spun over the flange 70 at the neck portion of the ampoule. Within the ampoule a resilient diaphragm 72 is held to the flange 70 by the cap 68, said diaphragm being adapted to be burst by application of fluid pressure to a thinned wall 74 thereof. Within the ampoule at the right hand end thereof is a piston 76 forming space between it and the diaphragm for the medicament 78. When the medicament is forced to the left by operation of piston 76, the fluid pressure will invert the V-shaped wall 74 and stretch it so that it eventually bursts either by reason of tension in the membrane or by reason of the stretched membrane engaging a sharp projection in the sleeve 66 or the sharp end of the cannula 18 extending into the sleeve 66. The ampoule is slightly tapered in diameter from the piston end to the cannula end with the external diameter of the ampoule at the piston end portion thereof being slightly greater than the internal diameter of the bead 62 so that when the cartridge is forced into the holder, there is a peripheral hermetic seal between the bead 62 and the exterior wall of the ampoule 16. The holder or ampoule or bead must be sufficiently elastic to permit the insertion of the ampoule into the holder without rupturing of parts. Since the front end of the holder is sealed off by the stopper 60, when the cartridge 14 is inserted into the holder 12 while working in a sterile atmosphere, a noncontaminating atmosphere is created and maintained in and about the cannula 18.

The greatest external diameter of the ampoule 16 at the piston end is less than the internal diameter of the holder 12 in front of the head 62 and throughout the entire length of displacement of the ampoule in the holder so that once the ampoule has been freed from the bead 62 there is freedom of motion of the cartridge in the holder. Moreover, there is sufficient clearance between the external diameter of the ampoule l6 and the internal diameter of the holder 12 to permit free movement of gas from in front of the ampoule to the rear thereof on displacement of the cartridge.

In the use of the injector device, first the gun 10 is cocked by forcing the plunger 30 into the inner sleeve 20 until the conical portions 36 pass through the opening 28 and spread out to engage the outer surface of the end 26-of the sleeve 20. For safety reasons, the pin 48 is inserted between the .furcations of the plunger. While in a sterile atmosphere, the cartridge 14 is loaded into the holder 12 with the ampoule 16 in air sealing engagement with the bead 62 and the cannula 18 in nonpierced-through relationship with the stopper 60. The utilizer of the injection device threadedly couples the holder 12 to the gun l0 and the device is now ready for use. To use the device, the safety pin 48 is removed and the stoppered end of the holder 12 is pressed firmly against the desired area of injection. Upon telescopic action of sleeve 38 on sleeve 20, conical portions 36 pass through opening 28 and the plunger 30 is released. Under the action of spring 32, the plunger shifts the cartridge so that the end of the cannula l8 pierces the stopper 60 and enters the flesh of the patient. Movement of the cartridge continues until arrested by the nose of the holder. Continued movement of the plunger and movement of the piston 76 in the ampoule causes an expulsion of the medicament through the cannula into the patient.

In FIGS. 4 to 6 there is disclosed a modified form of the invention. In this species of the invention, the bead 62 in the holder is replaced in part by a plurality of internal ribs and in part by a flanged portion on the ampoule 90. The ribs indicated as 82 are equally spaced around the inner peripheral wall of the holder and run parallel to the longitudinal axis thereof. The number of ribs may be conveniently selected as three. The ribs terminate short of the threaded end 84 of the holder and taper in decreasing height and width as they extend toward the stoppered nose end.

The cartridge utilized with this form of holder is like the cartridge previously described except that the end of the ampoule, here indicated as 90, is modified by placing a flared portion 92 at the open end thereof, the flared portion being resilient and becoming progressively thinner toward the mouth or right hand end of the ampoule. The external diameter of the ampoule is less than the diameter afforded by the clearance between the ribs 82 to allow free movement by the ampoule with respect to the holder, but the flared portion of the ampoule in the unoperated position of parts resiliently engages the inner wall of the holder to the right of the ribs to form a peripheral hermetic seal therewith.

When the injector device of FIGS. 4 to 6 is put into operation, the plunger 30 moves the cartridge to the left, as previously explained. In this operation the flanged portion 92 engages the ribs 82 and becomes distorted providing avenues for flow of gaseous fluid therearound to the rear of the ampoule, the fluid flowing along the ribs and through passageways opened by flange distortion.

The preferred form of this invention is illustrated in FIGS. 7-13 of the drawings. In this embodiment the device comprises an outer cylindrical sleeve 100 having an inturned shoulder 110 at one end and an annular groove 113 in the inner wall adjacent the other open end. A cartridge assembly 106 is assembled in the shouldered end of the outer sleeve 100. The cartridge assembly 106 includes a cartridge holder sleeve 104 fitted within the sleeve 100 and having a decreased forward end portion 153 forming a shoulder 154 which fits against seat 112 provided by outer sleeve shoulder 1 10. The extreme forward end portion 156 of the holder sleeve 104 is tapered to form a small circular opening which is closed by a cannula pierceable stopper 150 that hermetically seals this end of the cartridge holder 104.

The cartridge assembly 106 includes an ampoule 136 with liquid medicament 146 therewithin and a piston 148 at one end with a cannula 150 at the other end. Within the neck of the ampoule 136 between the inner end of the cannula 150 and the medicament there may be interposed a fluid pressure rupturable diaphragm 152 generally like that described in the embodiment of FIG. 1. More specifically, the ampoule and cannula combination may be essentially like that in US. Pat. No. 3,391,695 to Sarnoff.

Referring particularly to FIG. 7, the cartridge assembly 106 is assembled in the outer sleeve 100 with the cannula 150 spaced from the stoppered end of the holder 104. The piston end of the ampoule 136 is retained in place within the holder sleeve 104 by resilient contact between the exterior surface of the ampoule 136 and an annular bead 160 on the inner wall of the holder sleeve 104 adjacent its open end. This bead 160, as in FIG. 1, hermetically seals the ampoule at its piston end and frictionally retains it in position within the holder sleeve 104. The diameter of the exterior of the ampoule 136 is less than the internal diameter of of the holder sleeve 104 throughout the major length of said holder sleeve so that once the ampoule is moved forward and is free of the annular bead 160 and the cannula 150 has pierced the stopper 158, the ampoule will move freely in the holder sleeve. The gas in front of the ampoule will readily flow past the ampoule in the annular space between the ampoule and the inner wall of the holder sleeve 104 as the ampoule travels forward. By this method of sealing, the cannula 150 may be maintained in a sterile environment until use is made of the device. It should be noted that the forward interior of the holder sleeve 104 is contoured to form a seat 161 for the forward end of the ampoule, when it is advanced thereinto. The overall length of the ampoule 136 and cannula 150 is such that it is all contained within the holder sleeve 104 as illustrated in FIG. 7.

The outer sleeve 100 is of such length that it accommodates the cartridge assembly 106 in one end and receives the gun assembly 200 in the other to complete the device. The gun assembly 200 comprises an inner gun sleeve 101 having an out-turned flange 103 which fits up against the end of the cartridge holder sleeve 104 when the gun assembly is inserted in the outer sleeve 100. The other end of the inner gun sleeve 101 is centrally apertured to form a hole 120. The rear outer face 122 of the inner gun sleeve 101 is planar and perpendicular to the longitudinal axis of the sleeve for a purpose to be brought out later.

A plunger 162 fits within the out turned flange end of the inner gun sleeve 101. This plunger has a cylindrical body portion 163 and a circular head portion 164 of a diameter larger than the body portion 163 and generally slightly less than that of the piston 148 in the ampoule 136. The head 164 has an opening which is sized to align and correspond to the through hole 166 in the plunger body 163. The plunger head 164 is provided with a plurality of eircumferentially spaced, radially extending tabs 168. As best illustrated in FIGS. 10 and 11, these tabs form a diameter greater than that of the plunger head 164 so that the tabs will engage the end of the ampoule 136. It should be noted that each tab tapers inwardly from its outer edge to provide a neck portion 170 of thinner proportions. Longitudinal slots 172 are formed in the plunger head 164 immediately behind the tabs 168. These slots are sized so that they will accommodate the tabs 168 when they are later broken off or bent rearwardly at their neck portion 170 in the operation of the device. These slots extend throughout the length of the head behind the tabs.

Referring to FIGS. 7 and 11, a locking detent 176 is fitted through the hole 166 in the plunger 162 and has a central body portion 178 with outwardly extending lugs 180 on one end fitting on annular shoulder 182 of the plunger head 164. The other end of the locking detent 176 is provided with four equally spaced longitudinally extending springy detent arms 184 terminating in frusto-conical detent heads 186. This locking detent 176 maintains the plunger 162 and inner gun sleeve 101 in assembled position with a coil spring 138 compressed therebetween as follows. A coil spring 138 is positioned over the plunger body 163 and abuts the plunger head 164 at one end and the inner face of the end wall of the inner sleeve 101 at the other. Upon compressing of the coil spring 133 sufficiently the detent heads 186 will be cammed inwardly by engaging the periphery of the end wall opening 120 and pass therethrough whereupon the bases of the detent heads 186 will come to rest on the planar face 122 of the inner gun sleeve 101 to retain the plunger and inner gun sleeve in assembled condition with the coil spring 138 compressed therebetween. When desired the rear planar surface 122 of the inner sleeve 101 may be overlaid with a metal washer 127, in which case it is advantageous to provide a guide and holding flange 128 to surround the opening 120. The flange 128 is provided with a lip portion to retain the washer in place.

As best illustrated in FIG. 12, the inner gun sleeve 101 has a plurality of longitudinally extending raised ribs 129 running from the flange 103 approximately one-half the length of the said sleeve. An outer gun sleeve 192 fits over inner gun sleeve 101 and is sized to frictionally engage ribs 129. The outer sleeve 192 has a closed end 194 with a central aperture 196 from which extends a frusto-conical cam surface 198 sized and shaped to cooperate with frusto-conical detent heads 186 to cam said heads radially inwardly. The outer gun sleeve 192 is provided with a circumferential locking rib 199 which tits in groove 113 in the outer sleeve 100 to retain the gun assembly 200 in position in said outer sleeve. It should be noted that the length of outer gun sleeve 192 is slightly less than that of the inner gun sleeve 101 so as to make certain that there will be space between the inner wall of the outer gun sleeve 192 and the flange 103 of the inner gun sleeve 101 so that the two gun sleeves may move relative to each other to cam frusto-conical detent heads 186 inwardly in operating the device.

In order to make certain that the frusto-conical detent heads 186 are not accidentally cammed inwardly, a safety pin assembly is provided. This safety pin assembly comprises a cap 142 having a cylindrical sleeve 143 sized to fit over the end portion of outer gun sleeve 192. A safety pin 144 extends inwardly from the center of the cap 142 into the opening formed by the inner portions of the detent heads 186 to thereby prevent inward movement of said detent heads. The cap 142 is provided internally with a plurality of spacer abutments 145 to assure proper positioning of the cap on the outer sleeve 192.

In the use of the form of invention disclosed in FIGS. 7 to 13, the parts are furnished to the user thereof as illustrated in FIG. 7.

For use, initially the safety pin 144 is removed and then the forward end of the device is applied to the patient at the locus desired. Subsequently, when the outer gun sleeve 192 is thrust toward the locus, a telescoping action takes place between the outer and inner gun sleeves. An advantage of the arrangement of FIGS. 7 to 13 is that the outer sleeve 100 is long and the injection device may be grasped very conveniently along substantially its entire length to operate it.

Telescoping action of the gun sleeves causes the frusto-conical cam surface 198 to cam the detent heads 186 together, whereby they become smaller in diameter than the opening 120, and the spring 138 becomes effective to advance the plunger 162. In the initial movement, the plunger tabs 168 engage the end of the ampoule 136 and force it forwardly off the bead 160 and upon further travel forces the cannula 150 through stopper 158 into the position illustrated in FIG. 8. At this point, the ampoule 136 and cannula 150 are fully seated whereby further travel of the plunger 162 causes tabs 168 to be sheared off at the neck portion 170 and fall back into slots 172 so that the plunger may continue to move forward by engaging the ampoule piston 148 to force the medicament out of the cannula 150 and ultimately arrive at the position illustrated in FIG. 9 with the piston 148 pressed against the closed end of the ampoule.

The many advantages of the embodiment of FIGS. 7-13 are immediately apparent, for example, the construction lends itself to component assembly operation. The device may be said to comprise three basic components, namely, the outer sleeve 100, the cartridge assembly 106 and the gun assembly 200. The cartridge assembly 106 is slipped into the outer sleeve 100 down against shoulder seat 1 12 after which the gun assembly 200 is inserted in the outer sleeve 100 by having the locking rib 199 engage annular groove 113 in the outer sleeve 100. The device is thus assembled and ready for use.

Yet another embodiment of this invention is shown in FIGS. 14 to 17. In this form of the invention the unit comprises an outer sleeve 400, an inner plunger containing sleeve 402, and a cartridge holder 404 with a cartridge 406 therein.

The outer sleeve is of springy material, as a molded material, the forward end portion of which is slotted as indicated at 408, FIG. 17, there being, for example, two such diametrical slots. The forward end of sleeve 400 is further provided with an outwardly extending flange 410 and is thickened at that end to provide an internal seat 412 for the cartridge holder 404 as will be described. When the cartridge holder 404 is positioned within the outer sleeve 400, a ring such as an aluminum ring 414, is spun around the flange 410 to retain the holder and outer sleeve in assembled relationship. In that condition, the outer sleeve 400 is bowed slightly outwardly away from the cartridge holder 404, as indicated most markedly at 415, so as to permit easy telescopic movements of the parts. The rear right-hand end of the outer sleeve 400 is centrally apertured as indicated at 416 and provided with a bevelled surface interiorly of the sleeve to form a cam surface 418. The.

inner sleeve 402 is also centrally apertured at its rear end as indicated at 420, the rear outer face 422 of the sleeve being perpendicular to the longitudinal axis of the sleeve to provide a seat for the bases of the frustoconical portions 424 of the plunger 426, in the manner shown in greater detail in the US. Pat. to Sarnoff et al. No. 2,832,339. When desired, the rear surface of the inner sleeve may be overlaid with a metal washer 427, in which case it is desirable to provide a guide and holding flange 428 to surround the opening 420, the flange having a turned over portion 430 to hold the washer in place. The interior wall of the inner sleeve 402 is provided with a number of equally circumferentially spaced longitudinal ribs 432 to guide the wide seat por tion 434 of the plunger in its movement and direct it into the ampoule 436 of the cartridge. Under compression, between the seat 434 of the plunger 426 and the inner surface of the rear end of the inner sleeve 402, is a' coil spring 438. The rear end of the plunger 426 is furcated and springy. The furcations of the plunger can be compressed together against its springy force by telescopic movement of the outer sleeve 400 relative to the inner sleeve 402, the cam or bevelled surface 418 then engaging the conical surfaces 424 and squeezing the furcations toward each other sufficiently to enable the frusto-conical portions to move forwardly through the opening 420, thus releasing the plunger 406 to the action of the spring 438. To prevent accidental release of the frusto-conical portions 424 off the seat provided therefor, a safety pin is provided in the form of a cap 442 to be applied to the rear of the outer sleeve 400 and a pin portion 444 to enter between the tines of the furcations, to inhibit their being squeezed together.

The inner sleeve 402 and plunger 426, when the spring is compressed, extend only partially of the length of the outer sleeve, so as to permit of insertion of the cartridge holder 404 into the outer sleeve, with the rear end of the holder 404 abutting the forward end of the inner sleeve 402. In viewof the length of the cartridge 406, the inner sleeve 402 extends a little less than half way of the length of the outer sleeve 400. With a different length cartridge the length of inner sleeve 402 would be different.

The cartridge itself comprises the ampoule 436 having therewithin a liquid or liquid medication 446 with a piston 448 at one end and a cannula 450 at the other end. Within the neck of the ampoule 436, between the rear end of the cannula and the medicament there may be interposed a fluid pressure rupturable diaphragm 452, as is well known in the art. The internal diameter of the ampoule 436 is larger than the diameter of the seat 434 of the plunger 426 to allow free movement of the plunger in the ampoule when the plunger is released to the action of the spring 438. The cartridge may be of the type shown in the Sarnoff US. Pat. No. 3,391 ,695 issued July 9,1968.

The cartridge holder 404 is substantially of the same external diameter at its rear portion as the inner sleeve 402. The forward end of the holder 404 is of reduced diameter to provide a shoulder 454 to cooperate with seat 412 in effecting a coupling of the holder and outer sleeve. The extreme forward end of the holder is tapered as indicated at 456 and a cannula puncturable stopper 458 of rubber or the like hermetically seals the apertured end of the holder. The rear end of the holder is sealed by resilient contact between the exterior surface of the ampoule and an annular bead 460 formed close to the rear end of the holder 404. The resiliency is obtained by making the holder 404, or bead 460, or ampoule 436 of resilient material. The diameter of the exterior of the ampoule is less than the internal diameter of the holder 404 throughout the major length of the holder so that once the cartridge is thrust forward to free it from the bead 460, and the cannula has pierced the stopper, the cartridge is free to move in the holder, the gas in front of the cartridge passing freely past the walls of the ampoule to the rear thereof. By sealing off the interior of the holder 404, the contents thereof may be placed in and maintained in a sterile atmosphere. The interior of the holder at its forward end is contoured to form a seat 462 for the forward end of the ampoule when it is advanced in the holder. The overall length of the cartridge is such that all of it is contained within the holder.

In the use of the form of invention disclosed in FIGS. 14 to 17, the parts are furnished to the user thereof cocked as illustrated in FIG. 14.

In use, initially the safety pin 444 is removed and then the forward end of the holder 404 is applied to the patient at the locus desired. Subsequently, when the outer sleeve 400 is thrust toward the patient, a telescoping action takes place between the outer and inner sleeves. An advantage of the arrangement of FIGS. 14 to 17 is that the outer sleeve is long and the injection device may be grasped very conveniently along substantially its entire length to operate it.

Telescoping action of the sleeves 400 and 402 causes the cam surface 418 to cam the furcations together, whereby they become smaller in diameter than the opening 420, and the spring 438 becomes effective to advance the plunger 426. The initial movement of the plunger, and as directed by the ribs 432, causes the plunger to thrust against the piston 448 within the ampoule. However, since the friction between the bead 460 and the ampoule coupled with the resistance to penetration of the stopper by the cannula is less than the force required to move the piston in the ampoule, the initial advance of the plunger results in a translation of the cartridge with respect to the holder whereby the cannula is unsheathed and the ampoule is brought into engagement with the seat 462. Subsequent advance of the plunger, under the force of the spring 438 causes the piston to advance in the ampoule, effecting passage of fluid by the diaphragm 452 and through the cannula 450. The action of parts is so rapid that advance of the cartridge and expulsion of medication appears to take place substantially simultaneously.

I claim:

1. A cylindrical cartridge holder and cartridge for use with a gun having a plunger for cooperation with said cartridge, said cartridge holder including means for positioning the holder in operative relationship with respect to the plunger, said holder being closed off at one end thereof, the cartridge comprising a cylindrical ampoule and fixedly attached cannula and fitting completely and movably within the holder with the cannula facing the closed holder end, said ampoule having an outer diameter less than the inner diameter of the cylindrical holder to form an annular space therebetween, sealing means on the inner surface of the cylindrical holder remote from its closed end and in engagement with the outer surface of the ampoule sealing the aforesaid annular space between the ampoule and holder at the ampoule end opposite the cannula whereby upon movement of the ampoule from the sealed position toward the closed end of the holder the seal is broken and free passage of gaseous fluid from in front of the ampoule to the rear thereof is provided by the aforesaid annular space.

2. The invention as set forth in claim 1 and wherein the ampoule is provided with a piston sea] at its end opposite the cannula and a liquid is contained in the ampoule between the cannula and the piston.

3. The cartridge holder and cartridge of claim 2 in combination with a gun, said gun having an inner sleeve aligned with the holder and an outer sleeve telescopically engaged with the inner sleeve and having means to fire the gun when telescoped.

4. The combination as set forth in claim 3 in which the gun includes a plunger, and in which the inner wall of the inner sleeve is provided with ribs running longitudinally of the sleeve to guide the plunger toward the piston.

5. A cartridge holder as set forth in claim 1 in which the ampoule includes a piston at one end thereof and a fluid in the ampoule between the piston and cannula and in which the ampoule also includes a diaphragm at the end thereof remote from the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the fluid by the piston.

6. A hypodermic injection device comprising in combination,

a gun,

a cartridge holder fixed in operative relationship to the gun and a cartridge including an ampoule with attached cannula within the holder,

said gun having a sleeve open at one end thereof, a plunger within the sleeve, potential energy means acting on said plunger tending to move it out of the open end of the sleeve, restraining means cooperative with said plunger to prevent plunger movement, safety means acting on said restraining means to render it inoperative,

said cartridge holder comprising a cylindrical shell acting as a prolongation of said gun sleeve, said shell at a free end thereof being closed off by a puncturable seal, annular sealing means on the interior portion of the shell remote from the closed end,

said cartridge comprising a cylindrical ampoule with a piston forming a seal in one end thereof, a fluid within said cylinder, the cannula affixed to the end of the cylinder opposite the piston, the cartridge, as a whole, movably fitting within the holder with the free end of the cannula within the holder at the closed-off end and the end, only, of the cartridge remote from the cannula held in sealing engagement with sealing means on the interior portion of the holder shell to allow free passage of gaseous fluid from the advancing end of the cylinder to the rear end thereof as the cartridge is translated relative to the holder.

7. The device of claim 6 wherein the ampoule further includes a diaphragm at the end thereof opposite the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the medicament by the piston.

8. The invention as set forth in claim 6 and wherein the gun plunger is provided with a head portion having a plurality of radially extending tabs adapted to engage the ampoule cylinder at its piston end.

9. The invention as set forth in claim 8 and wherein the plunger head is sized to fit within the ampoule cylinder.

10. The invention as set forth in claim 6 and wherein the gun and the cartridge holder with the cartridge therein are assembled within a single cylindrical housmg.

ll. The device of claim 6 and wherein ampoule engaging means are interposed between the gun plunger and the piston end of the ampoule whereby actuation of the gun plunger forces the ampoule engaging means and the ampoule to be moved toward the closed end of the cartridge holder.

12. The device of claim 11 and wherein abutment means are provided whereby upon prescribed moveand continued movement of the gun plunger causes the tabs to be disengaged from the ampoule whereupon the gun plunger continues its travel pushing the ampoule piston ahead ofit to eject the ampoule fluidv

Claims (13)

1. A cylindrical cartridge holder and cartridge for use with a gun having a plunger for cooperation with said cartridge, said cartridge holder including means for positioning the holder in operative relationship with respect to the plunger, said holder being closed off at one end thereof, the cartridge comprising a cylindrical ampoule and fixedly attached cannula and fitting completely and movably within the holder with the cannula facing the closed holder end, said ampoule having an outer diameter less than the inner diameter of the cylindrical holder to form an annular space therebetween, sealing means on the inner surface of the cylindrical holder remote from its closed end and in engagement with the outer surface of the ampoule sealing the aforesaid annular space between the ampoule and holder at the ampoule end opposite the cannula whereby upon movement of the ampoule from the sealed position toward the closed end of the holder the seal is broken and free passage of gaseous fluid from in front of the ampoule to the rear thereof is provided by the aforesaid annular space.
2. The invention as set forth in claim 1 and wherein the ampoule is provided with a piston seal at its end opposite the cannula and a liquid is contained in the ampoule between the cannula and the piston.
3. The cartridge holder and cartridge of claim 2 in combination with a gun, said gun having an inner sleeve aligned with the holder and an outer sleeve telescopically engaged with the inner sleeve and having means to fire the gun when telescoped.
4. The combination as set forth in claim 3 in which the gun includes a plunger, and in which the inner wall of the inner sleeve is provided with ribs running longitudinally of the sleeve to guide the plunger toward the piston.
5. A cartridge holder as set forth in claim 1 in which the ampoule includes a piston at one end thereof and a fluid in the ampoule between the piston and cannula and in which the ampoule also includes a diaphragm at the end thereof remote from the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the fluid by the piston.
6. A hypodermic injection device comprising in combination, a gun, a cartridge holder fixed in operative relationship to the gun and a cartridge including an ampoule with attached cannula within the holder, said gun having a sleeve open at one end thereof, a plunger within the sleeve, potential energy means acting on said plunger tending to move it out of the open end of the sleeve, restraining means cooperative with said plunger to prevent plunger movement, safety means acting on said restraining means to render it inoperative, said cartridge holder comprising a cylindrical shell acting as a prolongation of said gun sleeve, said shell at a free end thereof being closed off by a puncturable seal, annular sealing means on the interior portion of the shell remote from the closed end, said cartridge comprising a cylindrical ampoule with a piston forming a seal in one end thereof, a fluid within said cylinder, the cannula affixed to the end of the cylinder opposite the piston, the cartridge, as a whole, movably fitting within the holder with the free end of the cannula within the holder at the closed-off end and the end, only, of the cartridge remote from the cannula held in sealing engagement with sealing means on the interior portion of the holder shell to allow free passage of gaseous fluid from the advancing end of the cylinder to the rear end thereof as the cartridge is translated relative to the holder.
7. The device of claim 6 wherein the ampoule further includes a diaphragm at the end thereof opposite the piston, said diaphragm being made of a material to allow passage of fluid therebeyond upon sufficient pressure being applied to the medicament by the piston.
8. The invention as set forth in claim 6 and wherein the gun plunger is provided with a head portion having a plurality of radially extending tabs adapted to engage the ampoule cylinder at its piston end.
9. The invention as set forth in claim 8 and wherein the plunger head is sized to fit within the ampoule cylinder.
10. The invention as set forth in claim 6 and wherein the gun and the cartridge holder with the cartridge therein are assembled within a single cylindrical housing.
11. The device of claim 6 and wherein ampoule engaging means are interposed between the gun plunger and the piston end of the ampoule whereby actuation of the gun plunger forces the ampoule engaging means and the ampoule to be moved toward the closed end of the cartridge holder.
12. The device of claim 11 and wherein abutment means are provided whereby upon prescribed movement of the ampoule the ampoule engaging means are disengaged from the ampoule and the gun plunger then continues to move forward pushing the piston ahead of it to eject the ampoule fluid.
13. The device of claim 8 and wherein the tabs are integral with the head portion and have weakened portions to provide for deflection, and further wherein abutment means are provided on the cartridge holder whereby upon prescribed movement of the ampoule the abutment means stop the travel of said ampoule and continued movement of the gun plunger causes the tabs to be disengaged from the ampoule whereupon the gun plunger continues its travel pushing the ampoule piston ahead of it to eject the ampoule fluid.
US3712301A 1971-01-11 1971-01-11 Gun type hypodermic injector with rapid cartridge displacement within holder Expired - Lifetime US3712301A (en)

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Cited By (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795061A (en) * 1973-03-21 1974-03-05 Survival Technology Training injector
US3797490A (en) * 1971-02-11 1974-03-19 Ampoules Inc Hypodermic ampoule with skin tensioning clip
JPS5038983A (en) * 1973-08-01 1975-04-10
US3884229A (en) * 1973-11-29 1975-05-20 Burron Medical Prod Inc Hypodermic syringe and needle assembly
US3941130A (en) * 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US3943926A (en) * 1974-04-10 1976-03-16 Oscar Arvizu Barragan Wholly disposable dental type syringe
US4014331A (en) * 1975-12-30 1977-03-29 Head James E Syringe barrel with protective plastic cover
US4394863A (en) * 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
US4484910A (en) * 1983-12-21 1984-11-27 Survival Technology, Inc. Dual mode automatic injector
US4624660A (en) * 1984-11-02 1986-11-25 Duphar International Research B.V. Automatic injection device
WO1986006966A1 (en) * 1985-05-20 1986-12-04 Survival Technology, Inc. Plural dosage injector with by-pass fitment
US4678461A (en) * 1984-11-01 1987-07-07 Survival Technology, Inc. Automatic injector with improved glass container protector
US4822340A (en) * 1985-10-11 1989-04-18 Duphar International Research B.V. Automatic injector
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
US4902279A (en) * 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
DE4037418A1 (en) * 1989-11-28 1991-05-29 Glaxo Group Ltd Feeder for liquid drug
US5026349A (en) * 1988-10-05 1991-06-25 Autoject Systems Inc. Liquid medicament injector system
WO1991016094A1 (en) * 1990-04-12 1991-10-31 Survival Technology, Inc. Dispersion multi-chamber auto-injector
US5071353A (en) * 1989-10-16 1991-12-10 Duphar International Research B.V. Training device for an automatic injector
US5167632A (en) * 1992-01-24 1992-12-01 New Potency Products, Inc. Syringe
US5167641A (en) * 1991-05-29 1992-12-01 Arnis, Inc. Auto-retracting needle injector system
US5358489A (en) * 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5405362A (en) * 1991-04-29 1995-04-11 The Board Of Regents For The University Of Texas System Interactive external defibrillation and drug injection system
WO1995031235A1 (en) * 1994-05-16 1995-11-23 Washington Biotech Corporation Modular automatic or manual emergency medicine injection system
US5478316A (en) * 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
EP0700307A1 (en) * 1993-05-27 1996-03-13 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5599309A (en) * 1993-03-24 1997-02-04 Owen Mumford Limited Injection devices
US5957897A (en) * 1994-06-17 1999-09-28 Safe-T-Limited Hollow needle applicator for cartridged drugs
US6241772B1 (en) * 1998-06-04 2001-06-05 Benoist Girard Sas Plugging and centralized device for locating the stem of a prosthesis
US6575939B1 (en) 1998-02-04 2003-06-10 Sanofi-Synthelabo Device for automatic injection of a dose of medicinal product
US20050038392A1 (en) * 2003-08-11 2005-02-17 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
US20050171477A1 (en) * 2002-05-23 2005-08-04 Seedlings Life Science Ventures Apparatus and method for rapid auto-injection of medication
US20050277895A1 (en) * 2000-08-02 2005-12-15 Becton, Dickinson And Company Pen needle and safety system
US20050283115A1 (en) * 2000-08-02 2005-12-22 Lucio Giambattista Pen needle and safety shield system
US20080077083A1 (en) * 2006-08-31 2008-03-27 Griffiths Steven M Vortex feature for drug delivery system
US20090299278A1 (en) * 2006-05-03 2009-12-03 Lesch Jr Paul R Injector with adjustable dosing
US20100152658A1 (en) * 2008-12-16 2010-06-17 Medtronic Minimed, Inc. Needle insertion systems and methods
US20100160894A1 (en) * 2006-06-30 2010-06-24 Julian Joseph F Automatic injection device
US20110054414A1 (en) * 2009-04-29 2011-03-03 Abbott Biotechnology Ltd. Automatic Injection Device
EP2311510A1 (en) 2004-08-06 2011-04-20 Meridian Medical Technologies, Inc. Automatic injector
US20110178500A1 (en) * 2009-12-15 2011-07-21 Shang Sherwin S Firing button for automatic injection device
US20110213315A1 (en) * 2008-09-18 2011-09-01 Becton, Dickinson And Company Medical injector with slidable sleeve activation
US8074573B1 (en) * 2008-08-27 2011-12-13 Global Pathogen Solutions, Inc. Impact release stun gun dart
US8162887B2 (en) 2004-06-23 2012-04-24 Abbott Biotechnology Ltd. Automatic injection devices
US20130281933A1 (en) * 2010-10-14 2013-10-24 Owen Mumford Limited Injection devices
EP2698180A1 (en) * 2012-08-15 2014-02-19 Sanofi-Aventis Deutschland GmbH Autoinjector
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US20150034681A1 (en) * 2013-07-31 2015-02-05 Asher Peres Dispensing Gun
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9393367B2 (en) 2013-03-12 2016-07-19 Antares Pharma, Inc. Prefilled syringes and kits thereof
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9486583B2 (en) 2012-03-06 2016-11-08 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US9561333B2 (en) 2008-08-05 2017-02-07 Antares Pharma, Inc. Multiple dosage injector
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9867949B2 (en) 2008-03-10 2018-01-16 Antares Pharma, Inc. Injector safety device
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL282268A (en) *
US2532598A (en) * 1947-12-08 1950-12-05 Surgident Ltd Guard device for syringes for use with heat-fluent materials
US2607344A (en) * 1951-08-01 1952-08-19 Frederick M Turnbull Syringe assembly
GB714983A (en) * 1952-09-04 1954-09-08 Ralph Lee Huber Hypodermic syringe
US2701566A (en) * 1950-02-07 1955-02-08 Becton Dickinson Co Injection apparatus
US2832339A (en) * 1953-09-02 1958-04-29 Potter Pharmaceutical Corp Hypodermic injector
US2866458A (en) * 1956-05-09 1958-12-30 Becton Dickinson Co Hypodermic assembly
US2874694A (en) * 1957-06-24 1959-02-24 Omega Prec Medical Instr Co In Hypodermic syringes
US2894509A (en) * 1952-01-18 1959-07-14 Becton Dickinson Co Hypodermic syringe
US2960087A (en) * 1954-02-16 1960-11-15 Auguste Rooseboom Hypodermic injection apparatus
US3066670A (en) * 1957-05-31 1962-12-04 Stato A G Hypodermic injection apparatus
US3094989A (en) * 1960-06-10 1963-06-25 Int Treuhand A G Ampulla incorporating an injection syringe
GB1008915A (en) * 1961-10-07 1965-11-03 Gerhard Dauelsberg An ampoule member for a hypodermic syringe
US3335914A (en) * 1965-03-10 1967-08-15 Strazdins Atis Fountain syringe
US3391695A (en) * 1966-06-17 1968-07-09 Stanley J. Sarnoff Cartridge with reflexed burstable diaphragm

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL282268A (en) *
US2532598A (en) * 1947-12-08 1950-12-05 Surgident Ltd Guard device for syringes for use with heat-fluent materials
US2701566A (en) * 1950-02-07 1955-02-08 Becton Dickinson Co Injection apparatus
US2607344A (en) * 1951-08-01 1952-08-19 Frederick M Turnbull Syringe assembly
US2894509A (en) * 1952-01-18 1959-07-14 Becton Dickinson Co Hypodermic syringe
GB714983A (en) * 1952-09-04 1954-09-08 Ralph Lee Huber Hypodermic syringe
US2832339A (en) * 1953-09-02 1958-04-29 Potter Pharmaceutical Corp Hypodermic injector
US2960087A (en) * 1954-02-16 1960-11-15 Auguste Rooseboom Hypodermic injection apparatus
US2866458A (en) * 1956-05-09 1958-12-30 Becton Dickinson Co Hypodermic assembly
US3066670A (en) * 1957-05-31 1962-12-04 Stato A G Hypodermic injection apparatus
US2874694A (en) * 1957-06-24 1959-02-24 Omega Prec Medical Instr Co In Hypodermic syringes
US3094989A (en) * 1960-06-10 1963-06-25 Int Treuhand A G Ampulla incorporating an injection syringe
GB1008915A (en) * 1961-10-07 1965-11-03 Gerhard Dauelsberg An ampoule member for a hypodermic syringe
US3335914A (en) * 1965-03-10 1967-08-15 Strazdins Atis Fountain syringe
US3391695A (en) * 1966-06-17 1968-07-09 Stanley J. Sarnoff Cartridge with reflexed burstable diaphragm

Cited By (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797490A (en) * 1971-02-11 1974-03-19 Ampoules Inc Hypodermic ampoule with skin tensioning clip
US3795061A (en) * 1973-03-21 1974-03-05 Survival Technology Training injector
JPS5038983A (en) * 1973-08-01 1975-04-10
US3882863A (en) * 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
US3884229A (en) * 1973-11-29 1975-05-20 Burron Medical Prod Inc Hypodermic syringe and needle assembly
US3943926A (en) * 1974-04-10 1976-03-16 Oscar Arvizu Barragan Wholly disposable dental type syringe
US3941130A (en) * 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US4014331A (en) * 1975-12-30 1977-03-29 Head James E Syringe barrel with protective plastic cover
US4394863A (en) * 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
US4484910A (en) * 1983-12-21 1984-11-27 Survival Technology, Inc. Dual mode automatic injector
EP0146937A2 (en) * 1983-12-21 1985-07-03 Survival Technology, Inc. Dual mode automatic injector
WO1985002776A1 (en) * 1983-12-21 1985-07-04 Survival Technology, Inc. Dual mode automatic injector
EP0146937A3 (en) * 1983-12-21 1985-08-07 Survival Technology, Inc. Dual mode automatic injector
US4678461A (en) * 1984-11-01 1987-07-07 Survival Technology, Inc. Automatic injector with improved glass container protector
US4624660A (en) * 1984-11-02 1986-11-25 Duphar International Research B.V. Automatic injection device
WO1986006966A1 (en) * 1985-05-20 1986-12-04 Survival Technology, Inc. Plural dosage injector with by-pass fitment
US4723937A (en) * 1985-05-20 1988-02-09 Survival Technology, Inc. Plural dosage automatic injector with a by-pass fitment
US4822340A (en) * 1985-10-11 1989-04-18 Duphar International Research B.V. Automatic injector
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
US4902279A (en) * 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
US5026349A (en) * 1988-10-05 1991-06-25 Autoject Systems Inc. Liquid medicament injector system
US5071353A (en) * 1989-10-16 1991-12-10 Duphar International Research B.V. Training device for an automatic injector
DE4037418A1 (en) * 1989-11-28 1991-05-29 Glaxo Group Ltd Feeder for liquid drug
DE4037418C2 (en) * 1989-11-28 1998-01-29 Glaxo Group Ltd Feeder for liquid medicines
US5137516A (en) * 1989-11-28 1992-08-11 Glaxo Group Limited Triggered application device for medicament to be more descriptive of the invention
US5092843A (en) * 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
WO1991016094A1 (en) * 1990-04-12 1991-10-31 Survival Technology, Inc. Dispersion multi-chamber auto-injector
US5405362A (en) * 1991-04-29 1995-04-11 The Board Of Regents For The University Of Texas System Interactive external defibrillation and drug injection system
US5167641A (en) * 1991-05-29 1992-12-01 Arnis, Inc. Auto-retracting needle injector system
US5167632A (en) * 1992-01-24 1992-12-01 New Potency Products, Inc. Syringe
US5599309A (en) * 1993-03-24 1997-02-04 Owen Mumford Limited Injection devices
US5695472A (en) * 1993-05-27 1997-12-09 Washington Biotech Corporation Modular automatic or manual emergency medicine injection system
US5358489A (en) * 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
EP0700307A4 (en) * 1993-05-27 1996-05-01 Washington Biotech Corp Reloadable automatic or manual emergency injection system
US5540664A (en) * 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5665071A (en) * 1993-05-27 1997-09-09 Washington Biotech Corp. Reloadable automatic or manual emergency injection system
EP0700307A1 (en) * 1993-05-27 1996-03-13 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5478316A (en) * 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
WO1995031235A1 (en) * 1994-05-16 1995-11-23 Washington Biotech Corporation Modular automatic or manual emergency medicine injection system
US5957897A (en) * 1994-06-17 1999-09-28 Safe-T-Limited Hollow needle applicator for cartridged drugs
US6575939B1 (en) 1998-02-04 2003-06-10 Sanofi-Synthelabo Device for automatic injection of a dose of medicinal product
US6241772B1 (en) * 1998-06-04 2001-06-05 Benoist Girard Sas Plugging and centralized device for locating the stem of a prosthesis
US20050283115A1 (en) * 2000-08-02 2005-12-22 Lucio Giambattista Pen needle and safety shield system
US7314464B2 (en) 2000-08-02 2008-01-01 Becton, Dickinson And Company Pen needle and safety system
US20050277895A1 (en) * 2000-08-02 2005-12-15 Becton, Dickinson And Company Pen needle and safety system
US7666164B2 (en) 2000-08-02 2010-02-23 Becton, Dickinson And Company Pen needle and safety shield system
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
US7658724B2 (en) 2002-05-23 2010-02-09 Seedings Life Science Ventures LLC Apparatus and method for rapid auto-injection of medication
US20050171477A1 (en) * 2002-05-23 2005-08-04 Seedlings Life Science Ventures Apparatus and method for rapid auto-injection of medication
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
US20050038392A1 (en) * 2003-08-11 2005-02-17 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
US8932264B2 (en) 2003-08-11 2015-01-13 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
US9764090B2 (en) 2004-06-23 2017-09-19 Abbvie Biotechnology Ltd Relating to automatic injection devices
US8668670B2 (en) 2004-06-23 2014-03-11 Abbvie Biotechnology Ltd Automatic injection devices
US9017287B2 (en) 2004-06-23 2015-04-28 Abbvie Biotechnology Ltd Automatic injection devices
US8162887B2 (en) 2004-06-23 2012-04-24 Abbott Biotechnology Ltd. Automatic injection devices
EP2311510A1 (en) 2004-08-06 2011-04-20 Meridian Medical Technologies, Inc. Automatic injector
US9629959B2 (en) 2005-01-24 2017-04-25 Antares Pharma, Inc. Prefilled syringe jet injector
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US20090299278A1 (en) * 2006-05-03 2009-12-03 Lesch Jr Paul R Injector with adjustable dosing
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US20100160894A1 (en) * 2006-06-30 2010-06-24 Julian Joseph F Automatic injection device
US9486584B2 (en) 2006-06-30 2016-11-08 Abbvie Biotechnology Ltd. Automatic injection device
US8679061B2 (en) 2006-06-30 2014-03-25 Abbvie Biotechnology Ltd Automatic injection device
US7678073B2 (en) * 2006-08-31 2010-03-16 Meridian Medical Technologies, Inc. Vortex feature for drug delivery system
US20080077083A1 (en) * 2006-08-31 2008-03-27 Griffiths Steven M Vortex feature for drug delivery system
US9867949B2 (en) 2008-03-10 2018-01-16 Antares Pharma, Inc. Injector safety device
US9561333B2 (en) 2008-08-05 2017-02-07 Antares Pharma, Inc. Multiple dosage injector
US8074573B1 (en) * 2008-08-27 2011-12-13 Global Pathogen Solutions, Inc. Impact release stun gun dart
US20110213315A1 (en) * 2008-09-18 2011-09-01 Becton, Dickinson And Company Medical injector with slidable sleeve activation
US9901681B2 (en) * 2008-09-18 2018-02-27 Becton, Dickinson And Company Medical injector with slidable sleeve activation
US20100152658A1 (en) * 2008-12-16 2010-06-17 Medtronic Minimed, Inc. Needle insertion systems and methods
US8992474B2 (en) 2008-12-16 2015-03-31 Medtronic Minimed, Inc. Needle insertion systems and methods
US9364612B2 (en) 2008-12-16 2016-06-14 Medtronic Minimed, Inc. Needle insertion systems and methods
US9370621B2 (en) * 2008-12-16 2016-06-21 Medtronic Minimed, Inc. Needle insertion systems and methods
US9750881B2 (en) 2009-03-20 2017-09-05 Antares Pharma, Inc. Hazardous agent injection system
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
US20110054414A1 (en) * 2009-04-29 2011-03-03 Abbott Biotechnology Ltd. Automatic Injection Device
US9561328B2 (en) 2009-04-29 2017-02-07 Abbvie Biotechnology Ltd Automatic injection device
US20110178500A1 (en) * 2009-12-15 2011-07-21 Shang Sherwin S Firing button for automatic injection device
US8758301B2 (en) 2009-12-15 2014-06-24 Abbvie Biotechnology Ltd Firing button for automatic injection device
US9821117B2 (en) 2010-04-21 2017-11-21 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9579464B2 (en) * 2010-10-14 2017-02-28 Owen Mumford Limited Injection devices
US20130281933A1 (en) * 2010-10-14 2013-10-24 Owen Mumford Limited Injection devices
EP2632518B1 (en) 2010-10-14 2016-06-22 Owen Mumford Limited Injection devices
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
US9878102B2 (en) 2011-01-24 2018-01-30 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9339610B2 (en) 2011-01-24 2016-05-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US10022503B2 (en) 2011-01-24 2018-07-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9486583B2 (en) 2012-03-06 2016-11-08 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
CN104703641B (en) * 2012-08-15 2017-10-10 赛诺菲-安万特德国有限公司 Automatic injector
CN104703641A (en) * 2012-08-15 2015-06-10 赛诺菲-安万特德国有限公司 Autoinjector
EP2698180A1 (en) * 2012-08-15 2014-02-19 Sanofi-Aventis Deutschland GmbH Autoinjector
WO2014026937A1 (en) * 2012-08-15 2014-02-20 Sanofi-Aventis Deutschland Gmbh Autoinjector
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9393367B2 (en) 2013-03-12 2016-07-19 Antares Pharma, Inc. Prefilled syringes and kits thereof
US20150034681A1 (en) * 2013-07-31 2015-02-05 Asher Peres Dispensing Gun

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