WO2006116997A1 - Handheld injection device with integrated force sensor - Google Patents

Handheld injection device with integrated force sensor Download PDF

Info

Publication number
WO2006116997A1
WO2006116997A1 PCT/DK2006/000218 DK2006000218W WO2006116997A1 WO 2006116997 A1 WO2006116997 A1 WO 2006116997A1 DK 2006000218 W DK2006000218 W DK 2006000218W WO 2006116997 A1 WO2006116997 A1 WO 2006116997A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection device
force
cartridge
force sensors
handheld
Prior art date
Application number
PCT/DK2006/000218
Other languages
French (fr)
Inventor
John Thrane Hansen
Michael Svendsmark Hansen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP05009462 priority Critical
Priority to EP05009462.2 priority
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2006116997A1 publication Critical patent/WO2006116997A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A61M5/16859Evaluation of pressure response, e.g. to an applied pulse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow

Abstract

The present invention relates to a handheld motor operated injection device comprising a motor for driving a pistol rod operatively connected to a washer in order to inject the set dose of medicament from a cartridge containing the medicament. The injection device further comprises means for determining a reaction force generated in response to the motor driving the piston rod, the washer and a plunger in a forward axial direction in the cartridge.

Description

HANDHELD INJECTION DEVICE WITH INTEGRATED FORCE SENSOR

The present invention relates to a handheld injection device with an integrated force sensor for measuring the force provided to a plunger of a cartridge containing the medicament to be injected from the injection device.

BACKGROUND OF THE INVENTION

US 6,368,314 relates to a process for monitoring the pressure of a liquid medicament to be administered in dosed amounts during an infusion or injection. The liquid medicament is dispensable from a reservoir. Injection or infusion is provided by advancement of a piston received in the reservoir. The reaction force exerted by the piston onto the housing, which serves as a measure for the fluid pressure, is hereby measured and fed to a control unit. The control unit compares the measured reaction force with a predetermined reference force and controls the drive of a motor under consideration of the result of the comparison. The reference force is a nominal value for the reaction force and a direct nominal/actual comparison is carried out between the measured reaction force and its nominal value. US 6,368,314 further relates to a pump arrangement which is especially suited for carrying out the process.

US 6,659,980 relates to an infusion pump for delivering fluid to a user. The infusion pump includes a housing, a motor, a reservoir, one or more drive train components, a force sensor, and an electronics system. The motor is contained within the housing. The reservoir contains the fluid to be delivered. The one or more drive train components react to stimulus from the motor to force the fluid from the reservoir into the user. The sensor is positioned to measure a parameter associated with the motor or a drive train component, and the sensor produces three or more output levels across a range of measurements. The electronics system processes the sensor output levels to declare when an occlusion exists.

Both US 6,368,314 and US 6,659,980 relate to a pump where the medicament to be delivered is provided to a needle via catheter. Thus, both US 6,368,314 and US 6,659,980 are directed to pumps capable of dispensing medicament from a reservoir in the pump and to a infusion needle via a catheter while the relevant forces are monitored by force sensors.

US 5,808,203 discloses a pressure measuring device comprising a pressure sensor arranged to detect the force acting on at least a portion of a contact surface of a syringe plunger during pressurization of a fluid medium within the syringe. GB 2 356 349 relates to a syringe actuator assembly comprising drive means and sensor means, the drive means being capable of controlled a translational movement so as to drive a syringe plunger into a syringe body. The sensor means is positioned in the force path between the drive means and the syringe plunger so as to provide an indication of the force applied by the drive means to the syringe plunger. Since the sensor means is located in the force path between the drive means and the syringe plunger, an accurate indication of the force applied by a carriage to the plunger is provided. Should the pressure sensed by sensor means exceed a predetermined value suitable control means is arranged to halt the drive means and activate an alarm.

Neither of US 5,808,203 and GB 2 356 349 disclose a handheld device. In addition, US

5,808,203 and GB 2 356 349 both relate to determination of action forces in syringes, i.e. not to injection devices with replaceable cartridges.

It is an object of the present invention to provide a handheld, motor operated injection device wherein the force provided by the motor can be accurately determined by measuring a generated reaction force.

It is a further object of the present invention to provide a handheld, motor operated injection device wherein the action force provided to a cartridge containing a medicament to be injected from the injection device can be determined more accurately by measuring a generated reaction force so that damages due to malfunctioning of the injection device can be avoided. Such malfunctioning can for example be caused by a blocked needle.

SUMMARY OF THE INVENTION

The above-mentioned object is complied with by providing, in a first aspect, a handheld motor operated injection device for injecting a set dose of medicament, the injection device comprising a motor for driving a pistol rod in order to inject the set dose of medicament from a cartridge containing the medicament, the injection device further comprising means for determining a reaction force generated in response to the motor driving the piston rod, the washer and a plunger in a forward axial direction.

The injection device may be a handheld injection device of the kind also including an infusion needle to be inserted directly into the patient. Such motor operated injection device typically comprises an electrical motor operatively connected to some sort of gear arrangement. The gear arrangement drives the piston rod which has a threaded outer surface. At least one end the piston rod may be operatively connected to a washer which is adapted to push the plunger of the cartridge in the direction, i.e. the forward axial direction, of the infusion needle.

The force determining means may comprise one or more force sensors positioned between a cartridge holder and a housing the injection device. In an alternative embodiment, the determining means may comprise one or more force sensors forming an integral part or integral parts of a cartridge holder. Thus, the one or more force sensors may form an integral part of for example a wall of the cartridge holder. Finally, the determining means may comprise one or more force sensors being positioned between the cartridge and a cartridge holder.

The one or more force sensors may in principle be any kind of force sensors comprising a force sensitive element or member. Such force sensitive elements or members may be constituted by one or more strain gauges or by one or more piezoelectric- or piezoresistive elements.

The force determining means may comprise electronic control means for processing signals generated by the one or more force sensors. The electronic control means may further comprise means for generating an alarm signal if a signal from a force sensor exceeds a predetermined value. Such alarm signal may be a visible or an audible alarm signal informing the user of the injection device that something is not working properly.

In a second aspect, the present invention relates to a method for determining a force applied to inject a set dose of medicament in a handheld motor operated injection device, the method comprising the steps of

- operating an electrical motor of the handheld injection device so as to drive a piston rod in an axial and forward direction in a cartridge containing the medicament to be injected, and

- measuring a reaction force acting on a part or parts of the injection device.

The method may further comprise the step of generating an alarm signal when the measured reaction force exceeds a predetermined value so that the risk of damages to the injection device can be significantly reduced.

To measure the reaction force applied to a part or parts of the injection device one or more force sensors positioned between a cartridge holder and a housing of the injection device, or between the cartridge and a cartridge holder, may be used. Finally, the reaction force may be measured using one or more force sensors forming an integral part or parts of a cartridge holder, such as for example a sidewall portion of the cartridge holder.

Again, the one or more force sensors may in principle be any kind of force sensors comprising a force sensitive element or member. Such force sensitive elements or members may be constituted by one or more strain gauges or by one or more piezoelectric- or piezoresistive elements.

BRIEF DESCRIPTION OF THE DRAWING

The present invention will now be explained in further details with reference to the accompanying Fig. 1 which shows various possible positions of a force sensor for measuring the action force provided to the plunger.

While the invention is susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

DETAILED DESCRIPTION OF THE INVENTION

Fig. 1 illustrates various possible positions of a force sensor being capable of measuring the force provided by the motor in a motor operated injection device. Fig. 1 shows the relevant components of such a motor operated injection device.

As seen in Fig. 1, the injection device comprises, among other components, a motor 1, such as an electrical motor, positioned in a housing 2. A drive mechanism 8 is operatively connected to the motor 1 via some sort of gear arrangement 9. The drive mechanism 8 drives the piston rod 10 in a forward direction towards the cartridge 5 containing the medicament, such as insulin, to be injected from the injection device. The cartridge 5, which is positioned in a cartridge holder 6, comprises a plunger 4 which keeps the medicament in the cartridge 6. The plunger 4 is movable along a longitudinal axis of the cartridge 5 whereby the medicament contained in the cartridge 5 can be injected from the cartridge 5 by moving the plunger towards the needle-end of the cartridge 5. At this needle-end an infusion needle 7 is mounted. The medicament contained in the cartridge 5 is injected from the injection device by rotating the motor 1 a predetermined angular distance. This angular distance corresponds to a set dose of medicament to be injected from the injection device. Upon rotation of the motor 1 the drive mechanism 8 causes the piston rod 10 to perform an axial movement in a direction towards the cartridge 5. The piston rod 10 has a treaded outer surface typically arranged in the entire length of the piston rod 10. The threaded outer surface may also be arranged in just part of the entire length of the piston rod 10. This threaded outer surface engages with a corresponding threaded inner surface of the drive mechanism 8. This engagement between the piston rod 10 and the drive mechanism 8 causes the piston rod 10 to perform an axial movement towards the cartridge 5 when the motor 1 is rotating.

A washer 3 is attached to the piston rod 10. The washer 3 abuts the plunger 4 so that a forward movement of the piston rod 10 causes the washer 3 to move the plunger 4 towards the needle-end of the cartridge 5.

As illustrated in Fig. 1 a force sensor for measuring the force applied by the motor can be positioned in various positions. In Fig. 1 these positions are denoted A, B, and C. In positions A force sensors are positioned between the housing of the injection device and the cartridge holder. When a force is applied to the plunger via the piston rod and washer the cartridge pushes the cartridge holder in the direction of the needle. If the cartridge holder is suspended in force sensitive elements relative to the housing of the injection device, the applied force can be measured by positioning one or more force sensors between the cartridge holder and the housing of the injection device.

A force sensor suitable for being integrated with or built into an injection device can be implemented in various manners. For example such a sensor may rely on one or more strain gauges or it may rely on one or more piezo elements, such as piezoelectric or piezoresistive elements. In case of a strain gauge- or piezoresistive-based sensor the resistance of the active component(s) changes when the active component is exposed to stress. In case of a piezoelectric element a voltage change is generated across the piezoelectric element when the piezoelectric element is exposed to stress.

In an alternative embodiment, illustrated as embodiment B in Fig. 1, one or more force sensors can be integrated into the cartridge holder, such as integrated into the side walls of the cartridge holder. Such integration could be implemented by incorporating a set of strain gauges into the side walls of the cartridge holder. When a force is applied to the plunger via the piston rod and the washer the cartridge holder is stretched. This stretching of the cartridge holder can be measured by one or more strain gauges or by one or more piezo elements integrated into the cartridge holder. In another embodiment, illustrated as embodiment C in Fig. 1, one or more force sensors can be positioned between the cartridge and the cartridge holder. When a force is provided to the plunger via the piston rod and the washer the cartridge containing the medicament to be injected from the injection device is pushed against the bottom part of the cartridge holder. By having the force sensor positioned between the cartridge and the cartridge holder the action force provided to the plunger is can be measured.

When the force sensor (or force sensors) is positioned as illustrated in connection with embodiments A and C the force sensor is exposed to a force that compresses the sensor. When the force sensor (or force sensors) is integrated into the side walls of the cartridge holder the force sensor is stretched in that the upper and lower parts of the cartridge holder are pulled apart.

By having a force sensor incorporated in the injection device it becomes possible to detect when the entire dosage has been injected. This can be applied to assist the user of the injection device to remove the needle from the skin only when the injection has been completed. With a force sensor the injection device can register when the full dosage has been delivered since the force measured by the force sensor returns to approximately zero when the injection has been completed.

Furthermore, if the user of the injection device forgets to prime - i.e. move the piston rod forward so that the washer abuts the plunger prior to initiating an injection - there is a significant risk of injecting a dosage that is lower than the intended dosage. The reason for this being that contact between the washer and the plunger may not have been established prior to initiating the injection. If the injection device comprises a force sensor this situation can be avoided because the force sensor is capable of measuring whether or not contact between the washer and plunger has been established before an injection is initiated. This feature is of especially importance when a cartridge has been replaced and physical contact between the washer and the plunger is to be established before the first injection.

Finally, malfunctioning due to for example a blocked needle can also be detected by incorporating a pressure sensor in the injection device.

The injection device will further comprise an electronic control module for processing signals generated by the one or more force sensors. The electronic control module is adapted to generate a visible or audible alarm signal if a signal from a force sensor so demands. An alarm can for example be generated if a signal from a force sensor exceeds a predetermined value.

Claims

1. A handheld motor operated injection device for injecting a set dose of medicament, the injection device comprising a motor (1) for driving a pistol rod (10) operatively connected to a washer (3) in order to inject the set dose of medicament from a cartridge (5) containing the medicament, the injection device further comprising means for determining a reaction force generated in response to the motor (1) driving the piston rod (10), the washer (3) and a plunger (4) in a forward axial direction.
2. A handheld injection device according to claim 1, wherein the determining means comprises one or more force sensors arranged between a cartridge holder (6) and a housing (2) of the injection device.
3. A handheld injection device according to claim 1, wherein the determining means comprises one or more force sensors arranged between the cartridge (5) and a cartridge holder (6).
4. A handheld injection device according to claim 1, wherein the determining means comprises one or more force sensors forming an integral part or parts of a cartridge holder (6).
5. A handheld injection device according to any of claims 2-4, wherein the one or more force sensors comprise one or more strain gauges.
6. A handheld injection device according to any of claims 2-4, wherein the one or more force sensors comprise one or more piezoelectric elements.
7. A handheld injection device according to any of claims 2-6, wherein the force determining means comprises electronic control means for processing signals generated by the one or more force sensors, the electronic control means further comprising means for generating an alarm signal if a signal from a force sensor exceeds a predetermined value.
8. A method for determining a force applied to inject a set dose of medicament in a handheld injection device, the method comprising the steps of
- operating an electrical motor of the handheld injection device so as to drive a piston rod in an axial and forward direction in a cartridge containing the medicament to be injected, and - measuring a reaction force acting a part or parts of the injection device.
9. A method according to claim 8, further comprising the step of generating an alarm signal when the measured reaction force exceeds a predetermined value.
10. A method according to claim 8 or 9, wherein the reaction force is measured using one ore more force sensors arranged between a cartridge holder and a housing of the injection device.
11. A method according to claim 8 or 9, wherein the reaction force is measured using one or more force sensors arranged between the cartridge and a cartridge holder.
12. A method according to claim 8 or 9, wherein the reaction force is measured using one or more force sensors forming an integral part or parts of a cartridge holder.
13. A method according to any of claims 10-12, wherein the one or more force sensors comprise one or more strain gauges.
14. A method according to any of claims 10-12, wherein the one or more force sensors comprise one or more piezoelectric elements.
PCT/DK2006/000218 2005-04-29 2006-04-25 Handheld injection device with integrated force sensor WO2006116997A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05009462 2005-04-29
EP05009462.2 2005-04-29

Publications (1)

Publication Number Publication Date
WO2006116997A1 true WO2006116997A1 (en) 2006-11-09

Family

ID=34935966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000218 WO2006116997A1 (en) 2005-04-29 2006-04-25 Handheld injection device with integrated force sensor

Country Status (1)

Country Link
WO (1) WO2006116997A1 (en)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008083692A1 (en) * 2006-12-22 2008-07-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device and method for checking and monitoring the pressure in pressure pipes and/or conduits
US7682338B2 (en) 2006-08-23 2010-03-23 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7686787B2 (en) 2005-05-06 2010-03-30 Medtronic Minimed, Inc. Infusion device and method with disposable portion
US7736344B2 (en) 2006-08-23 2010-06-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7794434B2 (en) 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7828764B2 (en) 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8025658B2 (en) 2007-04-30 2011-09-27 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8052655B2 (en) 2006-09-29 2011-11-08 Novo Nordisk A/S Injection device with electronic detecting means
US8137314B2 (en) 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US8187228B2 (en) 2006-08-23 2012-05-29 Medtronic Minimed, Inc. Infusion pumps and methods and delivery devices and methods with same
US8197450B2 (en) 2005-04-24 2012-06-12 Novo Nordisk A/S Injection device
US8202256B2 (en) 2000-06-16 2012-06-19 Novo Nordisk A/S Injection device
US8226618B2 (en) 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8298194B2 (en) 2006-03-10 2012-10-30 Novo Nordisk A/S Injection device and a method of changing a cartridge in the device
US8303574B2 (en) 2006-02-09 2012-11-06 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8353878B2 (en) 2007-03-23 2013-01-15 Novo Nordisk A/S Injection device comprising a locking nut
US8361036B2 (en) 2006-03-10 2013-01-29 Novo Nordisk A/S Injection device having a gearing arrangement
US8414563B2 (en) 2007-12-31 2013-04-09 Deka Products Limited Partnership Pump assembly with switch
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US8708957B2 (en) 2007-12-31 2014-04-29 Novo Nordisk A/S Electronically monitored injection device
US8840587B2 (en) 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US9108006B2 (en) 2007-08-17 2015-08-18 Novo Nordisk A/S Medical device with value sensor
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
WO2018041708A1 (en) * 2016-09-02 2018-03-08 Roche Diabetes Care Gmbh Fluid drug cartridge type identification

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808203A (en) * 1997-05-12 1998-09-15 Medrad, Inc. Fluid pressure measurement devices
GB2356349A (en) * 1999-10-08 2001-05-23 Sarmed Ltd Syringe actuator assembly
EP1188454A2 (en) * 2000-08-16 2002-03-20 Smiths Group PLC Syringe pumps
US20020107477A1 (en) * 1999-10-05 2002-08-08 Urs Kipfer Device for administering an injectable product in doses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808203A (en) * 1997-05-12 1998-09-15 Medrad, Inc. Fluid pressure measurement devices
US20020107477A1 (en) * 1999-10-05 2002-08-08 Urs Kipfer Device for administering an injectable product in doses
GB2356349A (en) * 1999-10-08 2001-05-23 Sarmed Ltd Syringe actuator assembly
EP1188454A2 (en) * 2000-08-16 2002-03-20 Smiths Group PLC Syringe pumps

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9022991B2 (en) 2000-06-16 2015-05-05 Novo Nordisk A/S Injection device
US8206361B2 (en) 2000-06-16 2012-06-26 Novo Nordisk A/S Injection device
US8267899B2 (en) 2000-06-16 2012-09-18 Novo Nordisk A/S Injection device
US8333739B2 (en) 2000-06-16 2012-12-18 Novo Nordisk A/S Injection device
US10245383B2 (en) 2000-06-16 2019-04-02 Novo Nordisk A/S Injection device
US8202256B2 (en) 2000-06-16 2012-06-19 Novo Nordisk A/S Injection device
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US8641683B2 (en) 2005-04-24 2014-02-04 Novo Nordisk A/S Injection device
US8197450B2 (en) 2005-04-24 2012-06-12 Novo Nordisk A/S Injection device
US7935085B2 (en) 2005-05-06 2011-05-03 Medtronic Minimed, Inc. Infusion device and method with disposable portion
US9180248B2 (en) 2005-05-06 2015-11-10 Medtronic Minimed, Inc. Infusion device with base portion and durable portion
US9233203B2 (en) 2005-05-06 2016-01-12 Medtronic Minimed, Inc. Medical needles for damping motion
US7955305B2 (en) 2005-05-06 2011-06-07 Medtronic Minimed, Inc. Needle inserter and method for infusion device
US7686787B2 (en) 2005-05-06 2010-03-30 Medtronic Minimed, Inc. Infusion device and method with disposable portion
US10220143B2 (en) 2005-05-06 2019-03-05 Medtronic Minimed, Inc. Infusion device with base portion and durable portion
US7699833B2 (en) 2005-05-06 2010-04-20 Moberg Sheldon B Pump assembly and method for infusion device
US8529553B2 (en) 2005-08-23 2013-09-10 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US9259531B2 (en) 2006-02-09 2016-02-16 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US8414522B2 (en) 2006-02-09 2013-04-09 Deka Products Limited Partnership Fluid delivery systems and methods
US8303574B2 (en) 2006-02-09 2012-11-06 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US8496646B2 (en) 2006-02-09 2013-07-30 Deka Products Limited Partnership Infusion pump assembly
US8545445B2 (en) 2006-02-09 2013-10-01 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US8585377B2 (en) 2006-02-09 2013-11-19 Deka Products Limited Partnership Pumping fluid delivery systems and methods using force application assembly
US8998850B2 (en) 2006-02-09 2015-04-07 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US8298194B2 (en) 2006-03-10 2012-10-30 Novo Nordisk A/S Injection device and a method of changing a cartridge in the device
US8361036B2 (en) 2006-03-10 2013-01-29 Novo Nordisk A/S Injection device having a gearing arrangement
US8226618B2 (en) 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
US8202250B2 (en) 2006-08-23 2012-06-19 Medtronic Minimed, Inc. Infusion pumps and methods and delivery devices and methods with same
US7682338B2 (en) 2006-08-23 2010-03-23 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8137314B2 (en) 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US7736338B2 (en) 2006-08-23 2010-06-15 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7789857B2 (en) 2006-08-23 2010-09-07 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7736344B2 (en) 2006-08-23 2010-06-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7744589B2 (en) 2006-08-23 2010-06-29 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8226615B2 (en) 2006-08-23 2012-07-24 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7794434B2 (en) 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8172804B2 (en) 2006-08-23 2012-05-08 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US8444607B2 (en) 2006-08-23 2013-05-21 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8475432B2 (en) 2006-08-23 2013-07-02 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US8840587B2 (en) 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8840586B2 (en) 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8187228B2 (en) 2006-08-23 2012-05-29 Medtronic Minimed, Inc. Infusion pumps and methods and delivery devices and methods with same
US7828764B2 (en) 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8632509B2 (en) 2006-09-29 2014-01-21 Novo Nordisk A/S Injection device with electronic detecting means
US8052655B2 (en) 2006-09-29 2011-11-08 Novo Nordisk A/S Injection device with electronic detecting means
WO2008083692A1 (en) * 2006-12-22 2008-07-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device and method for checking and monitoring the pressure in pressure pipes and/or conduits
US8011250B2 (en) 2006-12-22 2011-09-06 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Apparatus and method for controlling and monitoring the pressure in pressure line or pipes
US8353878B2 (en) 2007-03-23 2013-01-15 Novo Nordisk A/S Injection device comprising a locking nut
US9901514B2 (en) 2007-04-30 2018-02-27 Medtronic Minimed, Inc. Automated filling systems and methods
US9980879B2 (en) 2007-04-30 2018-05-29 Medtronic Minimed, Inc. Automated filling systems and methods
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8172929B2 (en) 2007-04-30 2012-05-08 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8083716B2 (en) 2007-04-30 2011-12-27 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8025658B2 (en) 2007-04-30 2011-09-27 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8597270B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Automated filling systems and methods
US9522225B2 (en) 2007-04-30 2016-12-20 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US9108006B2 (en) 2007-08-17 2015-08-18 Novo Nordisk A/S Medical device with value sensor
US9526830B2 (en) 2007-12-31 2016-12-27 Deka Products Limited Partnership Wearable pump assembly
US8414563B2 (en) 2007-12-31 2013-04-09 Deka Products Limited Partnership Pump assembly with switch
US8491570B2 (en) 2007-12-31 2013-07-23 Deka Products Limited Partnership Infusion pump assembly
US8708957B2 (en) 2007-12-31 2014-04-29 Novo Nordisk A/S Electronically monitored injection device
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
WO2018041708A1 (en) * 2016-09-02 2018-03-08 Roche Diabetes Care Gmbh Fluid drug cartridge type identification

Similar Documents

Publication Publication Date Title
US7654127B2 (en) Malfunction detection in infusion pumps
US6368314B1 (en) Monitoring of the pressure of a product fluid to be administered in dosed amounts during infusion or injection
US4952205A (en) Pressure infusion device
AU2006331839B2 (en) Needle-free injection device
US9375557B2 (en) Hydraulic remote for a medical fluid injector
US6551277B1 (en) Syringe pumps
US5501665A (en) Process and device for detection of obstructions in a perfusion line
US6422057B1 (en) Drug pump testing system and methods
CA2406026C (en) Improved methods, apparatuses, and uses for infusion pump fluid pressure and force detection
ES2385630T3 (en) Electronically controlled injection device
JP5205645B2 (en) Improved systems and methods for low flow medical pump discharge
US5254096A (en) Syringe pump with graphical display or error conditions
US4950244A (en) Pressure sensor assembly for disposable pump cassette
ES2296638T3 (en) Device for the metered administration of an injectable product.
US20030205587A1 (en) Syringe pumps
US5935106A (en) Occlusion detection system for an infusion pump
US9731072B2 (en) Infusion pump system
US20050051580A1 (en) Drive system for an infusion pump
US20110224615A1 (en) Fluid Delivery Device with Autocalibration
US20030233075A1 (en) Piston stopper for injection device, product container and injection device
EP0589356B1 (en) Syringe pump having continuous pressure monitoring and display
JP4149657B2 (en) Automated delivery device
US20090026146A1 (en) Flow Control System and Method with Variable Pressure and Variable Resistance
US20090067989A1 (en) Occlusion Sensing System for Infusion Pumps
US10232112B2 (en) Reservoir plunger position monitoring and medical device incorporating same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWW Wipo information: withdrawn in national office

Country of ref document: DE

NENP Non-entry into the national phase in:

Ref country code: DE

NENP Non-entry into the national phase in:

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

122 Ep: pct app. not ent. europ. phase

Ref document number: 06722910

Country of ref document: EP

Kind code of ref document: A1