CN100369898C - 用作p38抑制剂的烟酰胺衍生物 - Google Patents
用作p38抑制剂的烟酰胺衍生物 Download PDFInfo
- Publication number
- CN100369898C CN100369898C CNB038038064A CN03803806A CN100369898C CN 100369898 C CN100369898 C CN 100369898C CN B038038064 A CNB038038064 A CN B038038064A CN 03803806 A CN03803806 A CN 03803806A CN 100369898 C CN100369898 C CN 100369898C
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- Prior art keywords
- methyl
- niacinamide
- fluoro
- phenyl
- cyclopropyl
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Cardiology (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0203301.7 | 2002-02-12 | ||
| GBGB0203301.7A GB0203301D0 (en) | 2002-02-12 | 2002-02-12 | Novel compounds |
| GB0225385A GB0225385D0 (en) | 2002-10-31 | 2002-10-31 | Novel compounds |
| GB0225385.4 | 2002-10-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1633416A CN1633416A (zh) | 2005-06-29 |
| CN100369898C true CN100369898C (zh) | 2008-02-20 |
Family
ID=27736200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038038064A Expired - Lifetime CN100369898C (zh) | 2002-02-12 | 2003-02-10 | 用作p38抑制剂的烟酰胺衍生物 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US7125898B2 (https=) |
| EP (3) | EP2258687B1 (https=) |
| JP (2) | JP4472349B2 (https=) |
| KR (1) | KR101058292B1 (https=) |
| CN (1) | CN100369898C (https=) |
| AT (2) | ATE485275T1 (https=) |
| AU (1) | AU2003207298B2 (https=) |
| BR (1) | BRPI0307351B8 (https=) |
| CA (1) | CA2474192C (https=) |
| CO (1) | CO5611147A2 (https=) |
| CY (2) | CY1107117T1 (https=) |
| DE (2) | DE60316913T2 (https=) |
| DK (2) | DK1474395T3 (https=) |
| ES (2) | ES2400486T3 (https=) |
| IL (1) | IL163090A (https=) |
| IS (1) | IS2520B (https=) |
| MX (1) | MXPA04007838A (https=) |
| NO (1) | NO327418B1 (https=) |
| NZ (1) | NZ533865A (https=) |
| PL (1) | PL212910B1 (https=) |
| PT (2) | PT1864975E (https=) |
| RU (1) | RU2309951C2 (https=) |
| SI (2) | SI1864975T1 (https=) |
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