CN100347185C - 新的无环核苷膦酸酯衍生物,其盐及其制备方法 - Google Patents

新的无环核苷膦酸酯衍生物,其盐及其制备方法 Download PDF

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Publication number
CN100347185C
CN100347185C CNB028037774A CN02803777A CN100347185C CN 100347185 C CN100347185 C CN 100347185C CN B028037774 A CNB028037774 A CN B028037774A CN 02803777 A CN02803777 A CN 02803777A CN 100347185 C CN100347185 C CN 100347185C
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China
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methyl
amino
purin
oxy
cyclopropyl
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Expired - Lifetime
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CNB028037774A
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Chinese (zh)
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CN1487949A (zh
Inventor
崔钟类
金政民
卢寄润
曹栋奎
林宰弘
黄载泽
曹雨永
张贤淑
李彰浩
崔泰生
金清美
金容柱
金泰均
赵承柱
金京圆
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LG Chem Ltd
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LG Life Sciences Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028037774A 2001-01-19 2002-01-18 新的无环核苷膦酸酯衍生物,其盐及其制备方法 Expired - Lifetime CN100347185C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR2001/3087 2001-01-19
KR20010003087 2001-01-19

Publications (2)

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CN1487949A CN1487949A (zh) 2004-04-07
CN100347185C true CN100347185C (zh) 2007-11-07

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Country Status (22)

Country Link
US (3) US7157448B2 (https=)
EP (1) EP1358198B1 (https=)
JP (1) JP3959348B2 (https=)
KR (1) KR100441638B1 (https=)
CN (1) CN100347185C (https=)
AR (1) AR035933A1 (https=)
AT (1) ATE478887T1 (https=)
AU (1) AU2002230230B2 (https=)
BR (1) BR0206165A (https=)
CA (1) CA2433591C (https=)
DE (1) DE60237429D1 (https=)
DK (1) DK1358198T3 (https=)
EG (1) EG24382A (https=)
ES (1) ES2350197T3 (https=)
MX (1) MXPA03006001A (https=)
MY (1) MY141789A (https=)
NZ (1) NZ526632A (https=)
PL (1) PL212730B1 (https=)
PT (1) PT1358198E (https=)
RU (1) RU2266294C2 (https=)
WO (1) WO2002057288A1 (https=)
ZA (1) ZA200304181B (https=)

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CN102286026A (zh) * 2010-06-18 2011-12-21 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物

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KR20050062944A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-클로로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
KR20050062940A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-할로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
JP2007523180A (ja) * 2004-02-17 2007-08-16 エルジー・ライフ・サイエンシーズ・リミテッド Ｈｉｖ感染治療に有用なヌクレオシドホスホネート誘導体
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CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
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CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
CN111808136B (zh) 2014-09-15 2024-06-11 加利福尼亚大学董事会 核苷酸类似物
CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
KR102623581B1 (ko) * 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN113880883A (zh) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 核苷类磷酸酯前药的制备方法
CN114560463B (zh) * 2022-03-23 2023-10-20 福州大学 一种核壳结构的氮掺杂碳壳包裹碳化钼核微米球材料的制备方法
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Publication number Priority date Publication date Assignee Title
CN102286026A (zh) * 2010-06-18 2011-12-21 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物

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RU2003125372A (ru) 2005-01-20
US7157448B2 (en) 2007-01-02
PT1358198E (pt) 2010-10-01
ZA200304181B (en) 2004-10-06
PL212730B1 (pl) 2012-11-30
DE60237429D1 (de) 2010-10-07
US7723319B2 (en) 2010-05-25
JP2004518675A (ja) 2004-06-24
EP1358198B1 (en) 2010-08-25
US20040063668A1 (en) 2004-04-01
BR0206165A (pt) 2004-02-03
KR20020062216A (ko) 2002-07-25
PL373670A1 (en) 2005-09-05
WO2002057288A1 (en) 2002-07-25
EP1358198A4 (en) 2008-03-05
CN1487949A (zh) 2004-04-07
US20060293284A1 (en) 2006-12-28
AU2002230230B2 (en) 2005-05-26
ATE478887T1 (de) 2010-09-15
CA2433591C (en) 2009-07-28
AR035933A1 (es) 2004-07-28
KR100441638B1 (ko) 2004-07-23
EP1358198A1 (en) 2003-11-05
DK1358198T3 (da) 2010-10-04
ES2350197T3 (es) 2011-01-20
US7605147B2 (en) 2009-10-20
JP3959348B2 (ja) 2007-08-15
HK1062017A1 (en) 2004-10-15
RU2266294C2 (ru) 2005-12-20
EG24382A (en) 2009-04-05
NZ526632A (en) 2005-10-28
MXPA03006001A (es) 2003-09-10
CA2433591A1 (en) 2002-07-25
US20100004440A1 (en) 2010-01-07
MY141789A (en) 2010-06-30

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