BR0206165A - Derivado de fosfonato de nucleosìdeo acìclico, processo para preparar o composto, composto de fosfonato, e, uso do derivado de fosfonato de nucleosìdeo acìclico - Google Patents
Derivado de fosfonato de nucleosìdeo acìclico, processo para preparar o composto, composto de fosfonato, e, uso do derivado de fosfonato de nucleosìdeo acìclicoInfo
- Publication number
- BR0206165A BR0206165A BR0206165-1A BR0206165A BR0206165A BR 0206165 A BR0206165 A BR 0206165A BR 0206165 A BR0206165 A BR 0206165A BR 0206165 A BR0206165 A BR 0206165A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- acyclic nucleoside
- phosphonate
- derivative
- phosphonate derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"DERIVADO DE FOSFONATO DE NUCLEOSìDEO ACìCLICO, PROCESSO PARA PREPARAR O COMPOSTO, COMPOSTO DE FOSFONATO, E, USO DO DERIVADO DE FOSFONATO DE NUCLEOSìDEO ACìCLICO". A presente invenção diz respeito a um derivado de fosfonato de nucleosídeo acíclico que é útil como um agente antiviral (particularmente contra o vírus da hepatite B), a sais, estereoisómeros farmaceuticamente aceitáveis e a um processo para a preparação destes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20010003087 | 2001-01-19 | ||
PCT/KR2002/000086 WO2002057288A1 (en) | 2001-01-19 | 2002-01-18 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206165A true BR0206165A (pt) | 2004-02-03 |
Family
ID=36241797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206165-1A BR0206165A (pt) | 2001-01-19 | 2002-01-18 | Derivado de fosfonato de nucleosìdeo acìclico, processo para preparar o composto, composto de fosfonato, e, uso do derivado de fosfonato de nucleosìdeo acìclico |
Country Status (23)
Country | Link |
---|---|
US (3) | US7157448B2 (pt) |
EP (1) | EP1358198B1 (pt) |
JP (1) | JP3959348B2 (pt) |
KR (1) | KR100441638B1 (pt) |
CN (1) | CN100347185C (pt) |
AR (1) | AR035933A1 (pt) |
AT (1) | ATE478887T1 (pt) |
AU (1) | AU2002230230B2 (pt) |
BR (1) | BR0206165A (pt) |
CA (1) | CA2433591C (pt) |
DE (1) | DE60237429D1 (pt) |
DK (1) | DK1358198T3 (pt) |
EG (1) | EG24382A (pt) |
ES (1) | ES2350197T3 (pt) |
HK (1) | HK1062017A1 (pt) |
MX (1) | MXPA03006001A (pt) |
MY (1) | MY141789A (pt) |
NZ (1) | NZ526632A (pt) |
PL (1) | PL212730B1 (pt) |
PT (1) | PT1358198E (pt) |
RU (1) | RU2266294C2 (pt) |
WO (1) | WO2002057288A1 (pt) |
ZA (1) | ZA200304181B (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY141789A (en) | 2001-01-19 | 2010-06-30 | Lg Chem Investment Ltd | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same. |
EP1423080A4 (en) * | 2001-03-01 | 2009-06-03 | Conforma Therapeutics Corp | PROCESS FOR TREATING PROLIFERATIVE GENETIC DISORDERS WITH HSP90 INHIBITORS |
JP4397691B2 (ja) | 2001-10-30 | 2010-01-13 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害活性を有するプリン類似体 |
EP1546164A4 (en) * | 2002-09-26 | 2006-06-07 | Lg Life Sciences Ltd | (+) - TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION OF STEREO-ISOMERS THEREOF, AND THE USE OF ANTIVIRAL AGENTS PRODUCED THEREOF |
KR20060070572A (ko) * | 2003-09-18 | 2006-06-23 | 콘포마 세러퓨틱스 코포레이션 | Hsp90-저해제로서의 신규 헤테로시클릭 화합물 |
KR20050062944A (ko) * | 2003-12-19 | 2005-06-28 | 주식회사 엘지생명과학 | 디이소프로필((1-((2-아미노-6-클로로-9h-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법 |
KR20050062940A (ko) * | 2003-12-19 | 2005-06-28 | 주식회사 엘지생명과학 | 디이소프로필((1-((2-아미노-6-할로-9h-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법 |
TW200533358A (en) * | 2004-02-17 | 2005-10-16 | Anadys Pharmaceuticals Inc | Nucleoside phosphonate derivatives useful in the treatment of hiv infections |
KR101033290B1 (ko) * | 2004-07-02 | 2011-05-09 | 주식회사 엘지생명과학 | 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법 |
EP1831235B1 (en) | 2004-12-16 | 2013-02-20 | The Regents of The University of California | Lung-targeted drugs |
NZ561939A (en) | 2005-03-30 | 2011-03-31 | Conforma Therapeutics Corp | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
KR101156272B1 (ko) * | 2006-02-27 | 2012-06-21 | 일루미네이션 매니지먼트 솔루션스 인코퍼레이티드 | 배열, 조명 설비 및 조사 장치 |
US8434912B2 (en) * | 2006-02-27 | 2013-05-07 | Illumination Management Solutions, Inc. | LED device for wide beam generation |
GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
CA2681267C (en) | 2007-04-13 | 2013-11-19 | Southern Research Institute | Anti-angiogenic agents and methods of use |
WO2008144672A1 (en) * | 2007-05-21 | 2008-11-27 | Illumination Management Solutions, Inc. | An improved led device for wide beam generation and method of making the same |
BRPI0918716A2 (pt) * | 2008-08-14 | 2015-12-01 | Cooper Technologies Co | dispositivos de diodo emissor de luz para a geracao de feixe largo offset |
MX2011005753A (es) * | 2008-12-03 | 2011-11-18 | Illumination Man Solutions Inc | Una lámpara led de repuesto y un método de sustitución de luminarias preexistentes con ensamble de luminaria led. |
CN102093422B (zh) * | 2009-12-10 | 2015-02-25 | 中国人民解放军军事医学科学院毒物药物研究所 | 无环核苷膦酸酯衍生物及其医药用途 |
CN102286026B (zh) * | 2010-06-18 | 2014-07-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 无环核苷酸类似物的盐及其晶型和药物组合物 |
US9622967B2 (en) | 2010-12-10 | 2017-04-18 | Sigmapharm Laboratories, Llc | Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs |
CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
CN108619161A (zh) | 2013-03-15 | 2018-10-09 | 加利福尼亚大学董事会 | 无环核苷膦酸二酯 |
CN104119385B (zh) * | 2014-07-24 | 2017-04-05 | 廖国超 | 核苷类似物的磷酸酯前药及其应用 |
EA036391B1 (ru) | 2014-09-15 | 2020-11-05 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Нуклеотидные аналоги |
CN106432330B (zh) * | 2015-08-11 | 2019-02-01 | 天津科伦药物研究有限公司 | Lb80380药物的中间体化合物及其制备方法和用途 |
EP3350191B9 (en) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nucleotide analogs |
CN106977548A (zh) * | 2016-01-19 | 2017-07-25 | 四川海思科制药有限公司 | 倍司福韦复合物及其制备方法和用途 |
WO2017124895A1 (zh) * | 2016-01-19 | 2017-07-27 | 四川海思科制药有限公司 | 一种核苷类似物的烷氧烷基酯前药及其应用 |
KR102623581B1 (ko) | 2016-07-18 | 2024-01-11 | 일동제약(주) | 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물 |
CN108276443A (zh) * | 2017-01-06 | 2018-07-13 | 米文君 | 一种新的化合物及其用途 |
KR102096144B1 (ko) * | 2017-07-03 | 2020-04-01 | 주식회사 엘지화학 | 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법 |
CN108997429B (zh) * | 2018-07-27 | 2020-10-30 | 广州粤美医药科技有限公司 | 一种制备贝西福韦的方法 |
CN113735863A (zh) * | 2021-09-29 | 2021-12-03 | 武汉九州钰民医药科技有限公司 | Wee1抑制剂adavosertib的制备工艺 |
CN113880883A (zh) * | 2021-11-11 | 2022-01-04 | 奥锐特药业股份有限公司 | 核苷类磷酸酯前药的制备方法 |
CN114560463B (zh) * | 2022-03-23 | 2023-10-20 | 福州大学 | 一种核壳结构的氮掺杂碳壳包裹碳化钼核微米球材料的制备方法 |
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US5922695A (en) * | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
US5935946A (en) | 1997-07-25 | 1999-08-10 | Gilead Sciences, Inc. | Nucleotide analog composition and synthesis method |
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MY141789A (en) * | 2001-01-19 | 2010-06-30 | Lg Chem Investment Ltd | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same. |
JP5420135B2 (ja) * | 2002-03-15 | 2014-02-19 | ウエイン・ステイト・ユニバーシテイ | 抗ウイルス薬としての新規2−アミノ−9−[(2−ヒドロキシメチル)シクロプロピリデンメチル]プリン |
EP1546164A4 (en) * | 2002-09-26 | 2006-06-07 | Lg Life Sciences Ltd | (+) - TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION OF STEREO-ISOMERS THEREOF, AND THE USE OF ANTIVIRAL AGENTS PRODUCED THEREOF |
-
2002
- 2002-01-16 MY MYPI20020143A patent/MY141789A/en unknown
- 2002-01-18 NZ NZ526632A patent/NZ526632A/en not_active IP Right Cessation
- 2002-01-18 PT PT02711484T patent/PT1358198E/pt unknown
- 2002-01-18 WO PCT/KR2002/000086 patent/WO2002057288A1/en active IP Right Grant
- 2002-01-18 EP EP02711484A patent/EP1358198B1/en not_active Expired - Lifetime
- 2002-01-18 DE DE60237429T patent/DE60237429D1/de not_active Expired - Lifetime
- 2002-01-18 RU RU2003125372/04A patent/RU2266294C2/ru not_active IP Right Cessation
- 2002-01-18 JP JP2002557964A patent/JP3959348B2/ja not_active Expired - Fee Related
- 2002-01-18 ES ES02711484T patent/ES2350197T3/es not_active Expired - Lifetime
- 2002-01-18 BR BR0206165-1A patent/BR0206165A/pt not_active IP Right Cessation
- 2002-01-18 CA CA002433591A patent/CA2433591C/en not_active Expired - Fee Related
- 2002-01-18 KR KR10-2002-0003051A patent/KR100441638B1/ko active Protection Beyond IP Right Term
- 2002-01-18 CN CNB028037774A patent/CN100347185C/zh not_active Expired - Lifetime
- 2002-01-18 US US10/450,780 patent/US7157448B2/en not_active Expired - Fee Related
- 2002-01-18 MX MXPA03006001A patent/MXPA03006001A/es active IP Right Grant
- 2002-01-18 PL PL373670A patent/PL212730B1/pl not_active IP Right Cessation
- 2002-01-18 AT AT02711484T patent/ATE478887T1/de active
- 2002-01-18 AU AU2002230230A patent/AU2002230230B2/en not_active Ceased
- 2002-01-18 DK DK02711484.2T patent/DK1358198T3/da active
- 2002-01-19 EG EG20020063A patent/EG24382A/xx active
- 2002-01-21 AR ARP020100197A patent/AR035933A1/es active IP Right Grant
-
2003
- 2003-05-29 ZA ZA200304181A patent/ZA200304181B/en unknown
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2004
- 2004-04-29 HK HK04103052.5A patent/HK1062017A1/xx not_active IP Right Cessation
-
2006
- 2006-06-20 US US11/455,679 patent/US7605147B2/en not_active Expired - Fee Related
-
2009
- 2009-09-09 US US12/585,229 patent/US7723319B2/en not_active Expired - Fee Related
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