HK1062017A1 - Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same - Google Patents

Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

Info

Publication number
HK1062017A1
HK1062017A1 HK04103052.5A HK04103052A HK1062017A1 HK 1062017 A1 HK1062017 A1 HK 1062017A1 HK 04103052 A HK04103052 A HK 04103052A HK 1062017 A1 HK1062017 A1 HK 1062017A1
Authority
HK
Hong Kong
Prior art keywords
salts
preparation
same
acyclic nucleoside
phosphonate derivatives
Prior art date
Application number
HK04103052.5A
Other languages
English (en)
Inventor
Jong-Ryoo Choi
Jeong-Min Kim
Kee-Yoon Roh
Dong-Gyu Cho
Jae-Hong Lim
Jae-Taeg Hwang
Woo-Young Cho
Hyun-Sook Jang
Chang-Ho Lee
Tae-Saeng Choi
Chung-Mi Kim
Yong-Zu Kim
Tae-Kyun Kim
Seung-Joo Cho
Gyoung-Won Kim
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of HK1062017A1 publication Critical patent/HK1062017A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
HK04103052.5A 2001-01-19 2004-04-29 Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same HK1062017A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20010003087 2001-01-19
PCT/KR2002/000086 WO2002057288A1 (en) 2001-01-19 2002-01-18 Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

Publications (1)

Publication Number Publication Date
HK1062017A1 true HK1062017A1 (en) 2004-10-15

Family

ID=36241797

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04103052.5A HK1062017A1 (en) 2001-01-19 2004-04-29 Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

Country Status (23)

Country Link
US (3) US7157448B2 (xx)
EP (1) EP1358198B1 (xx)
JP (1) JP3959348B2 (xx)
KR (1) KR100441638B1 (xx)
CN (1) CN100347185C (xx)
AR (1) AR035933A1 (xx)
AT (1) ATE478887T1 (xx)
AU (1) AU2002230230B2 (xx)
BR (1) BR0206165A (xx)
CA (1) CA2433591C (xx)
DE (1) DE60237429D1 (xx)
DK (1) DK1358198T3 (xx)
EG (1) EG24382A (xx)
ES (1) ES2350197T3 (xx)
HK (1) HK1062017A1 (xx)
MX (1) MXPA03006001A (xx)
MY (1) MY141789A (xx)
NZ (1) NZ526632A (xx)
PL (1) PL212730B1 (xx)
PT (1) PT1358198E (xx)
RU (1) RU2266294C2 (xx)
WO (1) WO2002057288A1 (xx)
ZA (1) ZA200304181B (xx)

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CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
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Also Published As

Publication number Publication date
JP2004518675A (ja) 2004-06-24
ATE478887T1 (de) 2010-09-15
CA2433591C (en) 2009-07-28
MY141789A (en) 2010-06-30
ZA200304181B (en) 2004-10-06
AU2002230230B2 (en) 2005-05-26
NZ526632A (en) 2005-10-28
US7605147B2 (en) 2009-10-20
EP1358198B1 (en) 2010-08-25
EP1358198A1 (en) 2003-11-05
DE60237429D1 (de) 2010-10-07
US20060293284A1 (en) 2006-12-28
US20040063668A1 (en) 2004-04-01
CN100347185C (zh) 2007-11-07
RU2003125372A (ru) 2005-01-20
US7723319B2 (en) 2010-05-25
EP1358198A4 (en) 2008-03-05
MXPA03006001A (es) 2003-09-10
WO2002057288A1 (en) 2002-07-25
JP3959348B2 (ja) 2007-08-15
ES2350197T3 (es) 2011-01-20
KR20020062216A (ko) 2002-07-25
RU2266294C2 (ru) 2005-12-20
PT1358198E (pt) 2010-10-01
EG24382A (en) 2009-04-05
AR035933A1 (es) 2004-07-28
CA2433591A1 (en) 2002-07-25
US20100004440A1 (en) 2010-01-07
KR100441638B1 (ko) 2004-07-23
CN1487949A (zh) 2004-04-07
DK1358198T3 (da) 2010-10-04
PL212730B1 (pl) 2012-11-30
BR0206165A (pt) 2004-02-03
US7157448B2 (en) 2007-01-02
PL373670A1 (en) 2005-09-05

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