EG24382A - Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same - Google Patents

Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same

Info

Publication number
EG24382A
EG24382A EG20020063A EG20020063A EG24382A EG 24382 A EG24382 A EG 24382A EG 20020063 A EG20020063 A EG 20020063A EG 20020063 A EG20020063 A EG 20020063A EG 24382 A EG24382 A EG 24382A
Authority
EG
Egypt
Prior art keywords
salts
preparation
same
novel cyclic
phosphonate derivatives
Prior art date
Application number
EG20020063A
Other languages
English (en)
Inventor
Choi Jong-Ryoo
Original Assignee
Lg Chem Investment Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chem Investment Ltd filed Critical Lg Chem Investment Ltd
Application granted granted Critical
Publication of EG24382A publication Critical patent/EG24382A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EG20020063A 2001-01-19 2002-01-19 Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same EG24382A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20010003087 2001-01-19

Publications (1)

Publication Number Publication Date
EG24382A true EG24382A (en) 2009-04-05

Family

ID=36241797

Family Applications (1)

Application Number Title Priority Date Filing Date
EG20020063A EG24382A (en) 2001-01-19 2002-01-19 Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same

Country Status (23)

Country Link
US (3) US7157448B2 (xx)
EP (1) EP1358198B1 (xx)
JP (1) JP3959348B2 (xx)
KR (1) KR100441638B1 (xx)
CN (1) CN100347185C (xx)
AR (1) AR035933A1 (xx)
AT (1) ATE478887T1 (xx)
AU (1) AU2002230230B2 (xx)
BR (1) BR0206165A (xx)
CA (1) CA2433591C (xx)
DE (1) DE60237429D1 (xx)
DK (1) DK1358198T3 (xx)
EG (1) EG24382A (xx)
ES (1) ES2350197T3 (xx)
HK (1) HK1062017A1 (xx)
MX (1) MXPA03006001A (xx)
MY (1) MY141789A (xx)
NZ (1) NZ526632A (xx)
PL (1) PL212730B1 (xx)
PT (1) PT1358198E (xx)
RU (1) RU2266294C2 (xx)
WO (1) WO2002057288A1 (xx)
ZA (1) ZA200304181B (xx)

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CA2499889A1 (en) * 2002-09-26 2004-04-08 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
BRPI0414533A (pt) * 2003-09-18 2006-11-07 Conforma Therapeutics Corp composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
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CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
KR101880724B1 (ko) 2010-12-10 2018-08-17 시그마팜 래보러토리즈, 엘엘씨 경구 활성 뉴클레오티드 유사체 또는 경구 활성 뉴클레오티드 유사체 전구약물의 고 안정성 조성물
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
LT2970346T (lt) 2013-03-15 2018-11-26 The Regents Of The University Of California Acikliniai nukleozido fosfonato diesteriai
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
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CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
KR102623581B1 (ko) * 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
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Also Published As

Publication number Publication date
PT1358198E (pt) 2010-10-01
EP1358198B1 (en) 2010-08-25
PL212730B1 (pl) 2012-11-30
WO2002057288A1 (en) 2002-07-25
CN100347185C (zh) 2007-11-07
US7605147B2 (en) 2009-10-20
ZA200304181B (en) 2004-10-06
KR20020062216A (ko) 2002-07-25
MXPA03006001A (es) 2003-09-10
KR100441638B1 (ko) 2004-07-23
AR035933A1 (es) 2004-07-28
EP1358198A1 (en) 2003-11-05
US20040063668A1 (en) 2004-04-01
JP2004518675A (ja) 2004-06-24
US7723319B2 (en) 2010-05-25
AU2002230230B2 (en) 2005-05-26
ATE478887T1 (de) 2010-09-15
DE60237429D1 (de) 2010-10-07
DK1358198T3 (da) 2010-10-04
HK1062017A1 (en) 2004-10-15
MY141789A (en) 2010-06-30
PL373670A1 (en) 2005-09-05
NZ526632A (en) 2005-10-28
JP3959348B2 (ja) 2007-08-15
US20060293284A1 (en) 2006-12-28
CA2433591A1 (en) 2002-07-25
EP1358198A4 (en) 2008-03-05
CA2433591C (en) 2009-07-28
RU2266294C2 (ru) 2005-12-20
US7157448B2 (en) 2007-01-02
BR0206165A (pt) 2004-02-03
US20100004440A1 (en) 2010-01-07
ES2350197T3 (es) 2011-01-20
CN1487949A (zh) 2004-04-07
RU2003125372A (ru) 2005-01-20

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