CN100347185C - 新的无环核苷膦酸酯衍生物,其盐及其制备方法 - Google Patents

新的无环核苷膦酸酯衍生物,其盐及其制备方法 Download PDF

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Publication number
CN100347185C
CN100347185C CNB028037774A CN02803777A CN100347185C CN 100347185 C CN100347185 C CN 100347185C CN B028037774 A CNB028037774 A CN B028037774A CN 02803777 A CN02803777 A CN 02803777A CN 100347185 C CN100347185 C CN 100347185C
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China
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methyl
amino
purin
oxy
cyclopropyl
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Expired - Lifetime
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CNB028037774A
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Chinese (zh)
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CN1487949A (zh
Inventor
崔钟类
金政民
卢寄润
曹栋奎
林宰弘
黄载泽
曹雨永
张贤淑
李彰浩
崔泰生
金清美
金容柱
金泰均
赵承柱
金京圆
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LG Chem Ltd
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LG Life Sciences Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028037774A 2001-01-19 2002-01-18 新的无环核苷膦酸酯衍生物,其盐及其制备方法 Expired - Lifetime CN100347185C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR2001/3087 2001-01-19
KR20010003087 2001-01-19

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CN1487949A CN1487949A (zh) 2004-04-07
CN100347185C true CN100347185C (zh) 2007-11-07

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US (3) US7157448B2 (enExample)
EP (1) EP1358198B1 (enExample)
JP (1) JP3959348B2 (enExample)
KR (1) KR100441638B1 (enExample)
CN (1) CN100347185C (enExample)
AR (1) AR035933A1 (enExample)
AT (1) ATE478887T1 (enExample)
AU (1) AU2002230230B2 (enExample)
BR (1) BR0206165A (enExample)
CA (1) CA2433591C (enExample)
DE (1) DE60237429D1 (enExample)
DK (1) DK1358198T3 (enExample)
EG (1) EG24382A (enExample)
ES (1) ES2350197T3 (enExample)
MX (1) MXPA03006001A (enExample)
MY (1) MY141789A (enExample)
NZ (1) NZ526632A (enExample)
PL (1) PL212730B1 (enExample)
PT (1) PT1358198E (enExample)
RU (1) RU2266294C2 (enExample)
WO (1) WO2002057288A1 (enExample)
ZA (1) ZA200304181B (enExample)

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CN102286026A (zh) * 2010-06-18 2011-12-21 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物

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AU2003263644A1 (en) * 2002-09-26 2004-04-19 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
KR20050062940A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-할로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
KR20050062944A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-클로로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
US20060052346A1 (en) * 2004-02-17 2006-03-09 Averett Devron R Nucleoside phosphonate derivatives useful in the treatment of HIV infections
KR101033290B1 (ko) * 2004-07-02 2011-05-09 주식회사 엘지생명과학 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법
EP1831235B1 (en) 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
CA2602257A1 (en) * 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
US7674018B2 (en) * 2006-02-27 2010-03-09 Illumination Management Solutions Inc. LED device for wide beam generation
US8434912B2 (en) * 2006-02-27 2013-05-07 Illumination Management Solutions, Inc. LED device for wide beam generation
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
EA019919B1 (ru) 2007-04-13 2014-07-30 Саузерн Рисерч Инститьют Способ подавления роста или метастазирования ангиогенез-зависимой опухоли
WO2008144672A1 (en) * 2007-05-21 2008-11-27 Illumination Management Solutions, Inc. An improved led device for wide beam generation and method of making the same
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WO2010065663A2 (en) * 2008-12-03 2010-06-10 Illumination Management Solutions, Inc. An led replacement lamp and a method of replacing preexisting luminaires with led lighting assemblies
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
FI2648701T3 (fi) 2010-12-10 2023-06-12 Sigmapharm Laboratories Llc Hyvin stabiileja adefovirdipivoksiilin koostumuksia
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
EP3401320B1 (en) 2013-03-15 2020-05-13 The Regents of the University of California Acyclic nucleoside phosphonate diesters for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
RS63250B1 (sr) 2014-09-15 2022-06-30 Univ California Nukleotidni analozi
CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
KR102623581B1 (ko) * 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN113880883A (zh) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 核苷类磷酸酯前药的制备方法
CN114560463B (zh) * 2022-03-23 2023-10-20 福州大学 一种核壳结构的氮掺杂碳壳包裹碳化钼核微米球材料的制备方法
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Publication number Priority date Publication date Assignee Title
CN102286026A (zh) * 2010-06-18 2011-12-21 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物

Also Published As

Publication number Publication date
MY141789A (en) 2010-06-30
DE60237429D1 (de) 2010-10-07
US7157448B2 (en) 2007-01-02
PL212730B1 (pl) 2012-11-30
ES2350197T3 (es) 2011-01-20
ATE478887T1 (de) 2010-09-15
KR20020062216A (ko) 2002-07-25
PL373670A1 (en) 2005-09-05
PT1358198E (pt) 2010-10-01
US7723319B2 (en) 2010-05-25
JP2004518675A (ja) 2004-06-24
KR100441638B1 (ko) 2004-07-23
US20040063668A1 (en) 2004-04-01
US20100004440A1 (en) 2010-01-07
EP1358198B1 (en) 2010-08-25
EP1358198A4 (en) 2008-03-05
ZA200304181B (en) 2004-10-06
AR035933A1 (es) 2004-07-28
CA2433591C (en) 2009-07-28
US7605147B2 (en) 2009-10-20
CA2433591A1 (en) 2002-07-25
MXPA03006001A (es) 2003-09-10
JP3959348B2 (ja) 2007-08-15
EP1358198A1 (en) 2003-11-05
WO2002057288A1 (en) 2002-07-25
CN1487949A (zh) 2004-04-07
BR0206165A (pt) 2004-02-03
EG24382A (en) 2009-04-05
RU2266294C2 (ru) 2005-12-20
RU2003125372A (ru) 2005-01-20
US20060293284A1 (en) 2006-12-28
HK1062017A1 (en) 2004-10-15
DK1358198T3 (da) 2010-10-04
NZ526632A (en) 2005-10-28
AU2002230230B2 (en) 2005-05-26

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