DE60237429D1 - Neue acyclische nukleosidphosphonatderivate, deren salze und verfahren zu deren herstellung - Google Patents

Neue acyclische nukleosidphosphonatderivate, deren salze und verfahren zu deren herstellung

Info

Publication number
DE60237429D1
DE60237429D1 DE60237429T DE60237429T DE60237429D1 DE 60237429 D1 DE60237429 D1 DE 60237429D1 DE 60237429 T DE60237429 T DE 60237429T DE 60237429 T DE60237429 T DE 60237429T DE 60237429 D1 DE60237429 D1 DE 60237429D1
Authority
DE
Germany
Prior art keywords
salts
processes
preparation
acyclic nucleoside
phosphonate derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237429T
Other languages
German (de)
English (en)
Inventor
Jong-Ryoo Choi
Jeong-Min Kim
Kee-Yoon Roh
Dong-Gyu Cho
Jae-Hong Lim
Jae-Taeg Hwang
Woo-Young Cho
Hyun-Sook Jang
Chang-Ho Lee
Tae-Saeng Choi
Chung-Mi Kim
Yong-Zu Kim
Tae-Kyun Kim
Seung-Joo Cho
Gyoung-Won Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LG Life Sciences Ltd filed Critical LG Life Sciences Ltd
Application granted granted Critical
Publication of DE60237429D1 publication Critical patent/DE60237429D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60237429T 2001-01-19 2002-01-18 Neue acyclische nukleosidphosphonatderivate, deren salze und verfahren zu deren herstellung Expired - Lifetime DE60237429D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20010003087 2001-01-19
PCT/KR2002/000086 WO2002057288A1 (en) 2001-01-19 2002-01-18 Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

Publications (1)

Publication Number Publication Date
DE60237429D1 true DE60237429D1 (de) 2010-10-07

Family

ID=36241797

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237429T Expired - Lifetime DE60237429D1 (de) 2001-01-19 2002-01-18 Neue acyclische nukleosidphosphonatderivate, deren salze und verfahren zu deren herstellung

Country Status (22)

Country Link
US (3) US7157448B2 (enExample)
EP (1) EP1358198B1 (enExample)
JP (1) JP3959348B2 (enExample)
KR (1) KR100441638B1 (enExample)
CN (1) CN100347185C (enExample)
AR (1) AR035933A1 (enExample)
AT (1) ATE478887T1 (enExample)
AU (1) AU2002230230B2 (enExample)
BR (1) BR0206165A (enExample)
CA (1) CA2433591C (enExample)
DE (1) DE60237429D1 (enExample)
DK (1) DK1358198T3 (enExample)
EG (1) EG24382A (enExample)
ES (1) ES2350197T3 (enExample)
MX (1) MXPA03006001A (enExample)
MY (1) MY141789A (enExample)
NZ (1) NZ526632A (enExample)
PL (1) PL212730B1 (enExample)
PT (1) PT1358198E (enExample)
RU (1) RU2266294C2 (enExample)
WO (1) WO2002057288A1 (enExample)
ZA (1) ZA200304181B (enExample)

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AU2003263644A1 (en) * 2002-09-26 2004-04-19 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
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EP1831235B1 (en) 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
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CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
FI2648701T3 (fi) 2010-12-10 2023-06-12 Sigmapharm Laboratories Llc Hyvin stabiileja adefovirdipivoksiilin koostumuksia
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
EP3401320B1 (en) 2013-03-15 2020-05-13 The Regents of the University of California Acyclic nucleoside phosphonate diesters for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
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CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
KR102623581B1 (ko) * 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
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CN113880883A (zh) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 核苷类磷酸酯前药的制备方法
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Also Published As

Publication number Publication date
MY141789A (en) 2010-06-30
US7157448B2 (en) 2007-01-02
PL212730B1 (pl) 2012-11-30
ES2350197T3 (es) 2011-01-20
ATE478887T1 (de) 2010-09-15
KR20020062216A (ko) 2002-07-25
PL373670A1 (en) 2005-09-05
PT1358198E (pt) 2010-10-01
US7723319B2 (en) 2010-05-25
JP2004518675A (ja) 2004-06-24
KR100441638B1 (ko) 2004-07-23
US20040063668A1 (en) 2004-04-01
US20100004440A1 (en) 2010-01-07
EP1358198B1 (en) 2010-08-25
EP1358198A4 (en) 2008-03-05
ZA200304181B (en) 2004-10-06
AR035933A1 (es) 2004-07-28
CA2433591C (en) 2009-07-28
US7605147B2 (en) 2009-10-20
CA2433591A1 (en) 2002-07-25
MXPA03006001A (es) 2003-09-10
JP3959348B2 (ja) 2007-08-15
CN100347185C (zh) 2007-11-07
EP1358198A1 (en) 2003-11-05
WO2002057288A1 (en) 2002-07-25
CN1487949A (zh) 2004-04-07
BR0206165A (pt) 2004-02-03
EG24382A (en) 2009-04-05
RU2266294C2 (ru) 2005-12-20
RU2003125372A (ru) 2005-01-20
US20060293284A1 (en) 2006-12-28
HK1062017A1 (en) 2004-10-15
DK1358198T3 (da) 2010-10-04
NZ526632A (en) 2005-10-28
AU2002230230B2 (en) 2005-05-26

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