KR100441638B1 - 새로운 에이사이클릭 뉴클레오사이드 포스포네이트유도체, 그의 염 및 합성 방법 - Google Patents

새로운 에이사이클릭 뉴클레오사이드 포스포네이트유도체, 그의 염 및 합성 방법 Download PDF

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KR100441638B1
KR100441638B1 KR10-2002-0003051A KR20020003051A KR100441638B1 KR 100441638 B1 KR100441638 B1 KR 100441638B1 KR 20020003051 A KR20020003051 A KR 20020003051A KR 100441638 B1 KR100441638 B1 KR 100441638B1
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South Korea
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methyl
compound
amino
oxy
purin
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Expired - Fee Related
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KR10-2002-0003051A
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English (en)
Korean (ko)
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KR20020062216A (ko
Inventor
최종류
김정민
노기윤
조동규
임재홍
황재택
조우영
장현숙
이장호
김태균
조승주
김경원
최태생
김청미
김용주
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주식회사 엘지생명과학
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR10-2002-0003051A 2001-01-19 2002-01-18 새로운 에이사이클릭 뉴클레오사이드 포스포네이트유도체, 그의 염 및 합성 방법 Expired - Fee Related KR100441638B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020010003087 2001-01-19
KR20010003087 2001-01-19

Publications (2)

Publication Number Publication Date
KR20020062216A KR20020062216A (ko) 2002-07-25
KR100441638B1 true KR100441638B1 (ko) 2004-07-23

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KR10-2002-0003051A Expired - Fee Related KR100441638B1 (ko) 2001-01-19 2002-01-18 새로운 에이사이클릭 뉴클레오사이드 포스포네이트유도체, 그의 염 및 합성 방법

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US (3) US7157448B2 (enExample)
EP (1) EP1358198B1 (enExample)
JP (1) JP3959348B2 (enExample)
KR (1) KR100441638B1 (enExample)
CN (1) CN100347185C (enExample)
AR (1) AR035933A1 (enExample)
AT (1) ATE478887T1 (enExample)
AU (1) AU2002230230B2 (enExample)
BR (1) BR0206165A (enExample)
CA (1) CA2433591C (enExample)
DE (1) DE60237429D1 (enExample)
DK (1) DK1358198T3 (enExample)
EG (1) EG24382A (enExample)
ES (1) ES2350197T3 (enExample)
MX (1) MXPA03006001A (enExample)
MY (1) MY141789A (enExample)
NZ (1) NZ526632A (enExample)
PL (1) PL212730B1 (enExample)
PT (1) PT1358198E (enExample)
RU (1) RU2266294C2 (enExample)
WO (1) WO2002057288A1 (enExample)
ZA (1) ZA200304181B (enExample)

Cited By (2)

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KR100935904B1 (ko) 2007-01-17 2010-01-07 주식회사 엘지생명과학 항바이러스성 약물의 말레산 단일염 및 이를 함유하는약제학적 조성물
KR20180009195A (ko) 2016-07-18 2018-01-26 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물

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WO2003037860A2 (en) 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
AU2003263644A1 (en) * 2002-09-26 2004-04-19 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
KR20050062940A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-할로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
KR20050062944A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-클로로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
US20060052346A1 (en) * 2004-02-17 2006-03-09 Averett Devron R Nucleoside phosphonate derivatives useful in the treatment of HIV infections
KR101033290B1 (ko) * 2004-07-02 2011-05-09 주식회사 엘지생명과학 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법
EP1831235B1 (en) 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
CA2602257A1 (en) * 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
US7674018B2 (en) * 2006-02-27 2010-03-09 Illumination Management Solutions Inc. LED device for wide beam generation
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EA019919B1 (ru) 2007-04-13 2014-07-30 Саузерн Рисерч Инститьют Способ подавления роста или метастазирования ангиогенез-зависимой опухоли
WO2008144672A1 (en) * 2007-05-21 2008-11-27 Illumination Management Solutions, Inc. An improved led device for wide beam generation and method of making the same
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WO2010065663A2 (en) * 2008-12-03 2010-06-10 Illumination Management Solutions, Inc. An led replacement lamp and a method of replacing preexisting luminaires with led lighting assemblies
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
FI2648701T3 (fi) 2010-12-10 2023-06-12 Sigmapharm Laboratories Llc Hyvin stabiileja adefovirdipivoksiilin koostumuksia
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
EP3401320B1 (en) 2013-03-15 2020-05-13 The Regents of the University of California Acyclic nucleoside phosphonate diesters for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
RS63250B1 (sr) 2014-09-15 2022-06-30 Univ California Nukleotidni analozi
CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN113880883A (zh) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 核苷类磷酸酯前药的制备方法
CN114560463B (zh) * 2022-03-23 2023-10-20 福州大学 一种核壳结构的氮掺杂碳壳包裹碳化钼核微米球材料的制备方法
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JPH04253989A (ja) * 1990-07-04 1992-09-09 Merrell Dow Pharmaceut Inc ９−プリニルホスホン酸誘導体
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100935904B1 (ko) 2007-01-17 2010-01-07 주식회사 엘지생명과학 항바이러스성 약물의 말레산 단일염 및 이를 함유하는약제학적 조성물
KR20180009195A (ko) 2016-07-18 2018-01-26 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물

Also Published As

Publication number Publication date
MY141789A (en) 2010-06-30
DE60237429D1 (de) 2010-10-07
US7157448B2 (en) 2007-01-02
PL212730B1 (pl) 2012-11-30
ES2350197T3 (es) 2011-01-20
ATE478887T1 (de) 2010-09-15
KR20020062216A (ko) 2002-07-25
PL373670A1 (en) 2005-09-05
PT1358198E (pt) 2010-10-01
US7723319B2 (en) 2010-05-25
JP2004518675A (ja) 2004-06-24
US20040063668A1 (en) 2004-04-01
US20100004440A1 (en) 2010-01-07
EP1358198B1 (en) 2010-08-25
EP1358198A4 (en) 2008-03-05
ZA200304181B (en) 2004-10-06
AR035933A1 (es) 2004-07-28
CA2433591C (en) 2009-07-28
US7605147B2 (en) 2009-10-20
CA2433591A1 (en) 2002-07-25
MXPA03006001A (es) 2003-09-10
JP3959348B2 (ja) 2007-08-15
CN100347185C (zh) 2007-11-07
EP1358198A1 (en) 2003-11-05
WO2002057288A1 (en) 2002-07-25
CN1487949A (zh) 2004-04-07
BR0206165A (pt) 2004-02-03
EG24382A (en) 2009-04-05
RU2266294C2 (ru) 2005-12-20
RU2003125372A (ru) 2005-01-20
US20060293284A1 (en) 2006-12-28
HK1062017A1 (en) 2004-10-15
DK1358198T3 (da) 2010-10-04
NZ526632A (en) 2005-10-28
AU2002230230B2 (en) 2005-05-26

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