CL2007002031A1 - Composicion farmaceutica que comprende una droga antiparasitaria insoluble en agua y un portador soluble en agua, en donde la droga se encuentra en la forma nano-dispersa; dispersion acuosa que la comprende; proceso para prepararla, util para el tratamiento o profilaxis de la malaria. - Google Patents

Composicion farmaceutica que comprende una droga antiparasitaria insoluble en agua y un portador soluble en agua, en donde la droga se encuentra en la forma nano-dispersa; dispersion acuosa que la comprende; proceso para prepararla, util para el tratamiento o profilaxis de la malaria.

Info

Publication number
CL2007002031A1
CL2007002031A1 CL2007002031A CL2007002031A CL2007002031A1 CL 2007002031 A1 CL2007002031 A1 CL 2007002031A1 CL 2007002031 A CL2007002031 A CL 2007002031A CL 2007002031 A CL2007002031 A CL 2007002031A CL 2007002031 A1 CL2007002031 A1 CL 2007002031A1
Authority
CL
Chile
Prior art keywords
water
drug
prepare
pharmaceutical composition
malaria
Prior art date
Application number
CL2007002031A
Other languages
English (en)
Inventor
David John Duncalf
Alison Jayne Foster
James Long
Steven Paul Rannard
Dong Wang
Asha Hassan Essa
Original Assignee
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv filed Critical Unilever Nv
Publication of CL2007002031A1 publication Critical patent/CL2007002031A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Composición farmacéutica que comprende al menos una droga antiparasitaria insoluble en agua en una forma nanodispersa; y proceso para preparar la composición.
CL2007002031A 2006-07-13 2007-07-12 Composicion farmaceutica que comprende una droga antiparasitaria insoluble en agua y un portador soluble en agua, en donde la droga se encuentra en la forma nano-dispersa; dispersion acuosa que la comprende; proceso para prepararla, util para el tratamiento o profilaxis de la malaria. CL2007002031A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0613925.7A GB0613925D0 (en) 2006-07-13 2006-07-13 Improvements relating to nanodispersions

Publications (1)

Publication Number Publication Date
CL2007002031A1 true CL2007002031A1 (es) 2008-01-18

Family

ID=36955583

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2007002031A CL2007002031A1 (es) 2006-07-13 2007-07-12 Composicion farmaceutica que comprende una droga antiparasitaria insoluble en agua y un portador soluble en agua, en donde la droga se encuentra en la forma nano-dispersa; dispersion acuosa que la comprende; proceso para prepararla, util para el tratamiento o profilaxis de la malaria.
CL2007002030A CL2007002030A1 (es) 2006-07-13 2007-07-12 Composicion y proceso de preparacion de un biocida libre de solvente que comprende al menos un biocida insoluble en agua y un material portador soluble en agua en forma nano-dispersa con un diametro pico bajo 1000 nm.
CL2007002032A CL2007002032A1 (es) 2006-07-13 2007-07-12 Proceso para elaborar nanodispersiones contra solubles de materiales escasamente solubles en un material vehiculo que comprende proveer una mezcla de una unica fase de una mezcla de solventes miscibles,un material vehiculo soluble en el solvente y un material de carga util soluble en el solvente y secar por aspersion la mezcla por remocion del solvente.
CL2010000516A CL2010000516A1 (es) 2006-07-13 2010-05-19 Composicion fungicida sin solvente que comprende estrobirulina insoluble en agua dispersado a traves del material portador en forma nano-dispersa teniendo un diametro pico de la forma nano-dispersa menor a 1000 nm; proceso para preparar dicha composicion; uso de dicha composicion para tratar una infestacion (divisional de la sol. 2030-07).

Family Applications After (3)

Application Number Title Priority Date Filing Date
CL2007002030A CL2007002030A1 (es) 2006-07-13 2007-07-12 Composicion y proceso de preparacion de un biocida libre de solvente que comprende al menos un biocida insoluble en agua y un material portador soluble en agua en forma nano-dispersa con un diametro pico bajo 1000 nm.
CL2007002032A CL2007002032A1 (es) 2006-07-13 2007-07-12 Proceso para elaborar nanodispersiones contra solubles de materiales escasamente solubles en un material vehiculo que comprende proveer una mezcla de una unica fase de una mezcla de solventes miscibles,un material vehiculo soluble en el solvente y un material de carga util soluble en el solvente y secar por aspersion la mezcla por remocion del solvente.
CL2010000516A CL2010000516A1 (es) 2006-07-13 2010-05-19 Composicion fungicida sin solvente que comprende estrobirulina insoluble en agua dispersado a traves del material portador en forma nano-dispersa teniendo un diametro pico de la forma nano-dispersa menor a 1000 nm; proceso para preparar dicha composicion; uso de dicha composicion para tratar una infestacion (divisional de la sol. 2030-07).

Country Status (17)

Country Link
US (10) US20100015233A1 (es)
EP (8) EP2040678A2 (es)
JP (9) JP2009542762A (es)
CN (11) CN101849911A (es)
AP (1) AP2008004713A0 (es)
AR (4) AR061992A1 (es)
AU (9) AU2007271831B2 (es)
BR (8) BRPI0714230A2 (es)
CA (8) CA2656217A1 (es)
CL (4) CL2007002031A1 (es)
ES (2) ES2741124T3 (es)
GB (1) GB0613925D0 (es)
IL (2) IL195911A0 (es)
MX (2) MX2009000307A (es)
TW (1) TW200812694A (es)
WO (8) WO2008006716A2 (es)
ZA (7) ZA200900031B (es)

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US8821932B2 (en) 2014-09-02
AU2007271829B2 (en) 2011-10-27
ES2752460T3 (es) 2020-04-06
WO2008006714A3 (en) 2008-02-21
EP2040679A2 (en) 2009-04-01
CN101516341A (zh) 2009-08-26
JP2009542763A (ja) 2009-12-03
TW200812694A (en) 2008-03-16
US9060937B2 (en) 2015-06-23
AU2007271830A1 (en) 2008-01-17
US20090239749A1 (en) 2009-09-24
US20120134940A1 (en) 2012-05-31
CL2007002030A1 (es) 2008-01-18
WO2008006712A2 (en) 2008-01-17
JP2009542794A (ja) 2009-12-03
US20100008995A1 (en) 2010-01-14
ZA200900029B (en) 2010-04-28
BRPI0714230A2 (pt) 2013-01-15
AR077195A2 (es) 2011-08-10
CA2656229A1 (en) 2008-01-17
WO2008006713A3 (en) 2008-07-31
CN101489531A (zh) 2009-07-22
CA2656229C (en) 2014-05-27
CL2010000516A1 (es) 2010-10-15
JP2010202665A (ja) 2010-09-16
ZA200900345B (en) 2010-05-26
EP2269581A1 (en) 2011-01-05
AP2008004713A0 (en) 2008-12-31
AR061990A1 (es) 2008-08-10
BRPI0714352A2 (pt) 2013-03-19
AU2007271827B2 (en) 2010-10-14
WO2008006716A3 (en) 2008-03-13
WO2008007152A2 (en) 2008-01-17
BRPI0714353A2 (pt) 2013-05-07
ZA200900031B (en) 2010-04-28
AR061991A1 (es) 2008-08-10
CA2656233A1 (en) 2008-01-17
BRPI0714176A2 (pt) 2012-12-25
US8945626B2 (en) 2015-02-03
US20120135058A1 (en) 2012-05-31
AU2007271829A1 (en) 2008-01-17
AU2007274039A1 (en) 2008-01-17
EP2386292A1 (en) 2011-11-16
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ZA200900347B (en) 2010-04-28
WO2008007150A1 (en) 2008-01-17
WO2008007152A3 (en) 2008-03-06
AU2007271831B2 (en) 2010-11-18
JP2009542795A (ja) 2009-12-03
BRPI0722376A2 (pt) 2012-05-22
AU2007274041A1 (en) 2008-01-17
BRPI0714351A2 (pt) 2013-03-19
EP2040677B1 (en) 2019-05-08
BRPI0714177A2 (pt) 2011-05-03
WO2008006715A2 (en) 2008-01-17
WO2008006712A3 (en) 2009-02-26
AU2007271831A1 (en) 2008-01-17
CN101516342A (zh) 2009-08-26
AR061992A1 (es) 2008-08-10
EP2387992A1 (en) 2011-11-23
AU2010201900A1 (en) 2010-06-03
ZA200900028B (en) 2010-04-28
US20090325995A1 (en) 2009-12-31
EP2040678A2 (en) 2009-04-01
CA2656217A1 (en) 2008-01-17
CN101849911A (zh) 2010-10-06
CA2657586A1 (en) 2008-01-17
AU2007271827A1 (en) 2008-01-17
WO2008007151A3 (en) 2008-03-06
CA2656223A1 (en) 2008-01-17
JP2009542764A (ja) 2009-12-03
WO2008006714A2 (en) 2008-01-17
CN101516340A (zh) 2009-08-26
US20090175953A1 (en) 2009-07-09
JP2009542760A (ja) 2009-12-03
CN102671585A (zh) 2012-09-19
CA2657548A1 (en) 2008-01-17
AU2007271830B2 (en) 2010-11-11
CA2657582A1 (en) 2008-01-17
EP2040680B1 (en) 2019-08-07
CN101489535A (zh) 2009-07-22
JP2009542762A (ja) 2009-12-03
IL195933A (en) 2013-06-27
ES2741124T3 (es) 2020-02-10
US7691873B2 (en) 2010-04-06
WO2008006715A3 (en) 2008-05-08
IL195933A0 (en) 2009-09-01
CN102631874A (zh) 2012-08-15
WO2008007151A2 (en) 2008-01-17
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US20100068282A1 (en) 2010-03-18
WO2008006713A2 (en) 2008-01-17
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WO2008006716A2 (en) 2008-01-17
AU2007271828B2 (en) 2010-12-02
BRPI0714179A2 (pt) 2012-12-25
US20100015229A1 (en) 2010-01-21
GB0613925D0 (en) 2006-08-23
EP2040681A2 (en) 2009-04-01
US20090304806A1 (en) 2009-12-10
EP2040681B1 (en) 2017-08-09
AU2007274040A1 (en) 2008-01-17
US20100015233A1 (en) 2010-01-21
CA2659666A1 (en) 2008-01-17
CL2007002032A1 (es) 2008-01-18
CN101489534A (zh) 2009-07-22
AU2007271828A1 (en) 2008-01-17
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