CH643255A5 - 4-Amino-2-(piperazin-1-yl or homopiperazin-1-yl)quinazoline derivatives, processes for their preparation and medicaments containing them - Google Patents

4-Amino-2-(piperazin-1-yl or homopiperazin-1-yl)quinazoline derivatives, processes for their preparation and medicaments containing them Download PDF

Info

Publication number
CH643255A5
CH643255A5 CH1132178A CH1132178A CH643255A5 CH 643255 A5 CH643255 A5 CH 643255A5 CH 1132178 A CH1132178 A CH 1132178A CH 1132178 A CH1132178 A CH 1132178A CH 643255 A5 CH643255 A5 CH 643255A5
Authority
CH
Switzerland
Prior art keywords
radical
formula
lower alkyl
hydrogen atom
mixture
Prior art date
Application number
CH1132178A
Other languages
German (de)
English (en)
Inventor
Simon Fraser Campbell
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CH643255A5 publication Critical patent/CH643255A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CH1132178A 1977-11-05 1978-11-02 4-Amino-2-(piperazin-1-yl or homopiperazin-1-yl)quinazoline derivatives, processes for their preparation and medicaments containing them CH643255A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4612877 1977-11-05

Publications (1)

Publication Number Publication Date
CH643255A5 true CH643255A5 (en) 1984-05-30

Family

ID=10439957

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1132178A CH643255A5 (en) 1977-11-05 1978-11-02 4-Amino-2-(piperazin-1-yl or homopiperazin-1-yl)quinazoline derivatives, processes for their preparation and medicaments containing them

Country Status (36)

Country Link
JP (1) JPS5498792A (fi)
AR (2) AR219562A1 (fi)
AT (1) AT365186B (fi)
AU (1) AU509329B2 (fi)
BE (1) BE871771A (fi)
CA (1) CA1088059A (fi)
CH (1) CH643255A5 (fi)
CS (2) CS207671B2 (fi)
DD (1) DD139850A5 (fi)
DE (1) DE2847623C2 (fi)
DK (1) DK154082C (fi)
EG (1) EG13594A (fi)
ES (2) ES474805A1 (fi)
FI (1) FI64366C (fi)
FR (1) FR2407929A1 (fi)
GR (1) GR81514B (fi)
HK (1) HK94284A (fi)
HU (1) HU176306B (fi)
IE (1) IE47888B1 (fi)
IL (1) IL55857A (fi)
IN (1) IN148828B (fi)
IT (1) IT1100919B (fi)
KE (1) KE3350A (fi)
LU (2) LU80470A1 (fi)
MY (1) MY8500286A (fi)
NL (2) NL174549C (fi)
NO (1) NO150158C (fi)
NZ (1) NZ188813A (fi)
PH (1) PH13966A (fi)
PL (2) PL119586B1 (fi)
PT (1) PT68735A (fi)
SE (1) SE437518B (fi)
SU (1) SU816403A3 (fi)
UA (1) UA8324A1 (fi)
YU (2) YU40204B (fi)
ZA (1) ZA786184B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004658A1 (en) * 1984-04-04 1985-10-24 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepine derivatives and their preparation
WO1985002617A1 (en) * 1983-12-14 1985-06-20 Takeda Chemical Industries. Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
WO1986002644A1 (en) * 1984-11-01 1986-05-09 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
ES2282997T3 (es) * 1996-12-20 2007-10-16 Heumann Pcs Gmbh Nueva forma polimorfa de mesilato e doxazosina (forma iii).
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
TW448155B (en) * 1999-03-29 2001-08-01 Dev Center Biotechnology Method for producing amide compounds and quinazolin derivatives
EP1403263B1 (en) * 2002-09-27 2005-06-22 Council of Scientific and Industrial Research Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663706A (en) * 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
AR223015A1 (es) 1981-07-15
DD139850A5 (de) 1980-01-23
IL55857A (en) 1982-07-30
NL174549B (nl) 1984-02-01
PL210681A1 (fi) 1979-11-05
IE782179L (en) 1979-05-05
IT7829434A0 (it) 1978-11-03
NL174549C (nl) 1984-07-02
IT1100919B (it) 1985-09-28
AR219562A1 (es) 1980-08-29
ES8308559A1 (es) 1980-07-16
CA1088059A (en) 1980-10-21
NL930062I2 (nl) 1993-11-16
PT68735A (en) 1978-12-01
AU4132278A (en) 1979-05-17
NL7810909A (nl) 1979-05-08
LU80470A1 (fr) 1980-06-05
PL119419B1 (en) 1981-12-31
FI783347A (fi) 1979-05-06
NO150158B (no) 1984-05-21
JPS5498792A (en) 1979-08-03
LU88331I2 (fr) 1994-05-04
DK154082B (da) 1988-10-10
ZA786184B (en) 1979-10-31
FR2407929B1 (fi) 1981-02-27
FR2407929A1 (fr) 1979-06-01
YU40204B (en) 1985-08-31
NO783705L (no) 1979-05-08
NZ188813A (en) 1980-10-08
JPS5625233B2 (fi) 1981-06-11
AU509329B2 (en) 1980-05-08
YU38683A (en) 1983-06-30
MY8500286A (en) 1985-12-31
ES474805A1 (es) 1980-01-16
FI64366C (fi) 1983-11-10
AT365186B (de) 1981-12-28
PH13966A (en) 1980-11-12
SE437518B (sv) 1985-03-04
IE47888B1 (en) 1984-07-11
IL55857A0 (en) 1979-01-31
HU176306B (en) 1981-01-28
EG13594A (en) 1982-03-31
NL930062I1 (nl) 1993-09-01
DE2847623C2 (de) 1983-06-01
DK428678A (da) 1979-05-06
BE871771A (fr) 1979-05-03
PL119586B1 (en) 1982-01-30
NO150158C (no) 1984-08-29
YU255378A (en) 1983-06-30
CS354491A3 (en) 1992-06-17
IN148828B (fi) 1981-06-27
HK94284A (en) 1984-12-07
CS207671B2 (en) 1981-08-31
GR81514B (fi) 1984-12-11
YU40419B (en) 1985-12-31
KE3350A (en) 1983-12-16
DK154082C (da) 1989-02-27
ES480121A0 (es) 1980-07-16
UA8324A1 (uk) 1996-03-29
FI64366B (fi) 1983-07-29
DE2847623A1 (de) 1979-05-23
ATA784378A (de) 1981-05-15
SE7811382L (sv) 1979-05-06
SU816403A3 (ru) 1981-03-23

Similar Documents

Publication Publication Date Title
DE1695959C3 (de) 6-Amino-1,2-dihydro-1 -hydroxy-2imino-4-phenoxy-pyrimidine
US4188390A (en) Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
DE69011628T2 (de) 1,2-Benzisoxazolderivate, Verfahren zu deren Herstellung, und sie enthaltende pharmazeutische Zusammensetzungen.
DE2300491A1 (de) Neue pyrrolo eckige klammer auf 3,4-b eckige klammer zu pyrazinderivate, ihre herstellung und die medizinischen zusammensetzungen, die sie enthalten
DD273833A5 (de) N 9 - cyclopentylsubstituierte adeninderivate
EP0258729A2 (de) Dihydropyridinverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
CH643255A5 (en) 4-Amino-2-(piperazin-1-yl or homopiperazin-1-yl)quinazoline derivatives, processes for their preparation and medicaments containing them
EP0161218A2 (de) Benzo-(pyrano und thiopyrano)-pyridine
EP0019172A1 (de) 6-Substituierte 11-Alkylen-morphantridine, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel
CH643553A5 (de) 4-amino-2-piperidinochinazolin-derivate, verfahren zu ihrer herstellung und solche derivate enthaltende arzneimittel.
DD249271A5 (de) Verfahren zur herstellung von 9-chlor-1,5-benzothiazepin-derivaten
DE2351411A1 (de) Eckige klammer auf 1-oxo-2,3hydrocarbylen-5-indanyloxy-(oder -thio) eckige klammer zu alkancarbonsaeuren
DE1695812C3 (de) Dibenzo [c,f] -1,2-thiazepin-derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitung
DE2841644C2 (fi)
DE68903019T2 (de) 4,5,6,7-tetrahydroisothiazolo (4,5-c)pyridin-derivate und isomere.
DE3129718C2 (fi)
DE2410699A1 (de) Verfahren zur herstellung von indolderivaten
DE3419223A1 (de) Substituierte acylpiperazinochinazoline, ein verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen
DE1909406B2 (fi)
EP0095641B1 (de) Chinazolinonderivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE1944468A1 (de) Perhydro-5-phenyl-cycloalkapolyen-4,1-oxazepine und Verfahren zu deren Herstellung
DE2707072C2 (de) Derivate des Dithiepino[1,4][2,3-c]pyrrols, ihre Herstellung und sie enthaltende Zusammensetzungen
DE2230394A1 (de) Verfahren zur herstellung von 4-phenyl2(1h)-chinazolinonen
DE2100654A1 (de) Derivate von 2,3-Dihydrobenz- eckige Klammer auf eckige Klammer zu 1,4 oxazepin, deren Salze und deren Herstellung
CH645106A5 (de) Substituierte chinazoline sowie mittel zur behandlung von hypertonie und bradykardie.

Legal Events

Date Code Title Description
SPCF Supplementary protection certificate filed

Free format text: IKS 47791/870731

SPCF Supplementary protection certificate filed

Free format text: IKS 47791/870731, 951208

SPCR Supplementary protection certificate rejected

Free format text: IKS 47791/870731, 951208

PL Patent ceased