ES8308559A1 - Un procedimiento para la preparacion de nuevos derivados de quinazolina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de quinazolina.

Info

Publication number
ES8308559A1
ES8308559A1 ES480121A ES480121A ES8308559A1 ES 8308559 A1 ES8308559 A1 ES 8308559A1 ES 480121 A ES480121 A ES 480121A ES 480121 A ES480121 A ES 480121A ES 8308559 A1 ES8308559 A1 ES 8308559A1
Authority
ES
Spain
Prior art keywords
radical
lower alkoxy
cardiovascular
hydrogen atom
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480121A
Other languages
English (en)
Other versions
ES480121A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of ES8308559A1 publication Critical patent/ES8308559A1/es
Publication of ES480121A0 publication Critical patent/ES480121A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE QUINAZOLINA. SE HACE REACCIONAR UNA QUINAZOLINA (II) CON EL COMPUESTO (III) O CON SU EQUIVALENTE FUNCIONAL COMO AGENTE ACILANTE, SEGUIDO OPCIONALMENTE DE LA TRANSFORMACION DEL PRODUCTO OBTENIDO (I) EN LA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE. EL EQUIVALENTE FUNCIONAL EMPLEADO ES UN BROMURO O CLORURO DE ACIDO O UN ESTER SUCCINIMIDO DEL COMPUESTO (III); RN ES 6,7-DI (ALCOXI INFERIOR) O 6,7,8-TRI (ALCOXI INFERIOR); M VALE 1 O 2; X ES -CHR>1 O CH<2CH<2, R>1 SON HIDROGENO O ALQUILO; R>2 Y R>3 SON HIDROGENO, ALQUILO, ALCOXI, HALOGENO U OTROS.
ES480121A 1977-11-05 1979-04-30 Un procedimiento para la preparacion de nuevos derivados de quinazolina. Granted ES480121A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4612877 1977-11-05

Publications (2)

Publication Number Publication Date
ES8308559A1 true ES8308559A1 (es) 1980-07-16
ES480121A0 ES480121A0 (es) 1980-07-16

Family

ID=10439957

Family Applications (2)

Application Number Title Priority Date Filing Date
ES474805A Expired ES474805A1 (es) 1977-11-05 1978-11-03 Un procedimiento para la preparacion de nuevos derivados de quinazolina
ES480121A Granted ES480121A0 (es) 1977-11-05 1979-04-30 Un procedimiento para la preparacion de nuevos derivados de quinazolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES474805A Expired ES474805A1 (es) 1977-11-05 1978-11-03 Un procedimiento para la preparacion de nuevos derivados de quinazolina

Country Status (36)

Country Link
JP (1) JPS5498792A (es)
AR (2) AR219562A1 (es)
AT (1) AT365186B (es)
AU (1) AU509329B2 (es)
BE (1) BE871771A (es)
CA (1) CA1088059A (es)
CH (1) CH643255A5 (es)
CS (2) CS207671B2 (es)
DD (1) DD139850A5 (es)
DE (1) DE2847623C2 (es)
DK (1) DK154082C (es)
EG (1) EG13594A (es)
ES (2) ES474805A1 (es)
FI (1) FI64366C (es)
FR (1) FR2407929A1 (es)
GR (1) GR81514B (es)
HK (1) HK94284A (es)
HU (1) HU176306B (es)
IE (1) IE47888B1 (es)
IL (1) IL55857A (es)
IN (1) IN148828B (es)
IT (1) IT1100919B (es)
KE (1) KE3350A (es)
LU (2) LU80470A1 (es)
MY (1) MY8500286A (es)
NL (2) NL174549C (es)
NO (1) NO150158C (es)
NZ (1) NZ188813A (es)
PH (1) PH13966A (es)
PL (2) PL119586B1 (es)
PT (1) PT68735A (es)
SE (1) SE437518B (es)
SU (1) SU816403A3 (es)
UA (1) UA8324A1 (es)
YU (2) YU40204B (es)
ZA (1) ZA786184B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004658A1 (en) * 1984-04-04 1985-10-24 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepine derivatives and their preparation
WO1985002617A1 (en) * 1983-12-14 1985-06-20 Takeda Chemical Industries. Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
WO1986002644A1 (en) * 1984-11-01 1986-05-09 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
ES2282997T3 (es) * 1996-12-20 2007-10-16 Heumann Pcs Gmbh Nueva forma polimorfa de mesilato e doxazosina (forma iii).
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
TW448155B (en) * 1999-03-29 2001-08-01 Dev Center Biotechnology Method for producing amide compounds and quinazolin derivatives
EP1403263B1 (en) * 2002-09-27 2005-06-22 Council of Scientific and Industrial Research Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663706A (en) * 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
AR223015A1 (es) 1981-07-15
DD139850A5 (de) 1980-01-23
IL55857A (en) 1982-07-30
NL174549B (nl) 1984-02-01
PL210681A1 (es) 1979-11-05
IE782179L (en) 1979-05-05
IT7829434A0 (it) 1978-11-03
NL174549C (nl) 1984-07-02
IT1100919B (it) 1985-09-28
AR219562A1 (es) 1980-08-29
CA1088059A (en) 1980-10-21
NL930062I2 (nl) 1993-11-16
PT68735A (en) 1978-12-01
CH643255A5 (en) 1984-05-30
AU4132278A (en) 1979-05-17
NL7810909A (nl) 1979-05-08
LU80470A1 (fr) 1980-06-05
PL119419B1 (en) 1981-12-31
FI783347A (fi) 1979-05-06
NO150158B (no) 1984-05-21
JPS5498792A (en) 1979-08-03
LU88331I2 (fr) 1994-05-04
DK154082B (da) 1988-10-10
ZA786184B (en) 1979-10-31
FR2407929B1 (es) 1981-02-27
FR2407929A1 (fr) 1979-06-01
YU40204B (en) 1985-08-31
NO783705L (no) 1979-05-08
NZ188813A (en) 1980-10-08
JPS5625233B2 (es) 1981-06-11
AU509329B2 (en) 1980-05-08
YU38683A (en) 1983-06-30
MY8500286A (en) 1985-12-31
ES474805A1 (es) 1980-01-16
FI64366C (fi) 1983-11-10
AT365186B (de) 1981-12-28
PH13966A (en) 1980-11-12
SE437518B (sv) 1985-03-04
IE47888B1 (en) 1984-07-11
IL55857A0 (en) 1979-01-31
HU176306B (en) 1981-01-28
EG13594A (en) 1982-03-31
NL930062I1 (nl) 1993-09-01
DE2847623C2 (de) 1983-06-01
DK428678A (da) 1979-05-06
BE871771A (fr) 1979-05-03
PL119586B1 (en) 1982-01-30
NO150158C (no) 1984-08-29
YU255378A (en) 1983-06-30
CS354491A3 (en) 1992-06-17
IN148828B (es) 1981-06-27
HK94284A (en) 1984-12-07
CS207671B2 (en) 1981-08-31
GR81514B (es) 1984-12-11
YU40419B (en) 1985-12-31
KE3350A (en) 1983-12-16
DK154082C (da) 1989-02-27
ES480121A0 (es) 1980-07-16
UA8324A1 (uk) 1996-03-29
FI64366B (fi) 1983-07-29
DE2847623A1 (de) 1979-05-23
ATA784378A (de) 1981-05-15
SE7811382L (sv) 1979-05-06
SU816403A3 (ru) 1981-03-23

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