ES474805A1 - Un procedimiento para la preparacion de nuevos derivados de quinazolina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de quinazolina

Info

Publication number
ES474805A1
ES474805A1 ES474805A ES474805A ES474805A1 ES 474805 A1 ES474805 A1 ES 474805A1 ES 474805 A ES474805 A ES 474805A ES 474805 A ES474805 A ES 474805A ES 474805 A1 ES474805 A1 ES 474805A1
Authority
ES
Spain
Prior art keywords
radical
lower alkoxy
cardiovascular
hydrogen atom
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474805A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp
Original Assignee
Pfizer Corp Belgium
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp filed Critical Pfizer Corp Belgium
Publication of ES474805A1 publication Critical patent/ES474805A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Esta invención se refiera a agentes terapéuticos que son nuevos derivados de 4-amino-2- (piperazin-1-il u homopierazin-1-il)quinazolina. Estos compuestos son útiles como reguladores del sistema cardiovascular y, en especial, en el tratamiento de la hipertensión. Las sales de adición de ácido farmacéuticamente aceptables de los compuestos son las formadas con ácidos cuyas sales de adición no son tóxicas y contienen aniones farmacéuticamente aceptables, como las sales hidrocloruro, hidrobromuro, sulfato o bisulfato, fosfato o fosfato ácido, acetato, maletato, fumarato, succinato, lactato, tertrato, citrato, gluconato, sacarato y p-toluensulfonato.
ES474805A 1977-11-05 1978-11-03 Un procedimiento para la preparacion de nuevos derivados de quinazolina Expired ES474805A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4612877 1977-11-05

Publications (1)

Publication Number Publication Date
ES474805A1 true ES474805A1 (es) 1980-01-16

Family

ID=10439957

Family Applications (2)

Application Number Title Priority Date Filing Date
ES474805A Expired ES474805A1 (es) 1977-11-05 1978-11-03 Un procedimiento para la preparacion de nuevos derivados de quinazolina
ES480121A Expired ES8308559A1 (es) 1977-11-05 1979-04-30 Un procedimiento para la preparacion de nuevos derivados de quinazolina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES480121A Expired ES8308559A1 (es) 1977-11-05 1979-04-30 Un procedimiento para la preparacion de nuevos derivados de quinazolina.

Country Status (36)

Country Link
JP (1) JPS5498792A (es)
AR (2) AR219562A1 (es)
AT (1) AT365186B (es)
AU (1) AU509329B2 (es)
BE (1) BE871771A (es)
CA (1) CA1088059A (es)
CH (1) CH643255A5 (es)
CS (2) CS207671B2 (es)
DD (1) DD139850A5 (es)
DE (1) DE2847623C2 (es)
DK (1) DK154082C (es)
EG (1) EG13594A (es)
ES (2) ES474805A1 (es)
FI (1) FI64366C (es)
FR (1) FR2407929A1 (es)
GR (1) GR81514B (es)
HK (1) HK94284A (es)
HU (1) HU176306B (es)
IE (1) IE47888B1 (es)
IL (1) IL55857A (es)
IN (1) IN148828B (es)
IT (1) IT1100919B (es)
KE (1) KE3350A (es)
LU (2) LU80470A1 (es)
MY (1) MY8500286A (es)
NL (2) NL174549C (es)
NO (1) NO150158C (es)
NZ (1) NZ188813A (es)
PH (1) PH13966A (es)
PL (2) PL119586B1 (es)
PT (1) PT68735A (es)
SE (1) SE437518B (es)
SU (1) SU816403A3 (es)
UA (1) UA8324A1 (es)
YU (2) YU40204B (es)
ZA (1) ZA786184B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002617A1 (en) * 1983-12-14 1985-06-20 Takeda Chemical Industries. Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
WO1985004658A1 (en) * 1984-04-04 1985-10-24 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepine derivatives and their preparation
WO1986002644A1 (en) * 1984-11-01 1986-05-09 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
DK0849266T3 (da) * 1996-12-20 2007-06-04 Heumann Pcs Gmbh Hidtil ukendt polymorf form af doxazosin-mesylat (form III)
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
TW448155B (en) * 1999-03-29 2001-08-01 Dev Center Biotechnology Method for producing amide compounds and quinazolin derivatives
EP1403263B1 (en) * 2002-09-27 2005-06-22 Council of Scientific and Industrial Research Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
JPS5498792A (en) 1979-08-03
AU4132278A (en) 1979-05-17
CH643255A5 (en) 1984-05-30
IT1100919B (it) 1985-09-28
UA8324A1 (uk) 1996-03-29
FI64366B (fi) 1983-07-29
BE871771A (fr) 1979-05-03
AT365186B (de) 1981-12-28
ZA786184B (en) 1979-10-31
NL930062I2 (nl) 1993-11-16
JPS5625233B2 (es) 1981-06-11
DE2847623A1 (de) 1979-05-23
AR223015A1 (es) 1981-07-15
LU88331I2 (fr) 1994-05-04
SU816403A3 (ru) 1981-03-23
YU38683A (en) 1983-06-30
NO150158C (no) 1984-08-29
IT7829434A0 (it) 1978-11-03
IE782179L (en) 1979-05-05
FR2407929A1 (fr) 1979-06-01
DK154082B (da) 1988-10-10
IE47888B1 (en) 1984-07-11
DE2847623C2 (de) 1983-06-01
FR2407929B1 (es) 1981-02-27
NL930062I1 (nl) 1993-09-01
IL55857A (en) 1982-07-30
PT68735A (en) 1978-12-01
GR81514B (es) 1984-12-11
PH13966A (en) 1980-11-12
SE437518B (sv) 1985-03-04
NL7810909A (nl) 1979-05-08
CA1088059A (en) 1980-10-21
DK428678A (da) 1979-05-06
DK154082C (da) 1989-02-27
NL174549B (nl) 1984-02-01
NO150158B (no) 1984-05-21
KE3350A (en) 1983-12-16
PL119419B1 (en) 1981-12-31
PL119586B1 (en) 1982-01-30
PL210681A1 (es) 1979-11-05
AR219562A1 (es) 1980-08-29
FI64366C (fi) 1983-11-10
HK94284A (en) 1984-12-07
NL174549C (nl) 1984-07-02
FI783347A (fi) 1979-05-06
EG13594A (en) 1982-03-31
YU40204B (en) 1985-08-31
YU40419B (en) 1985-12-31
IN148828B (es) 1981-06-27
ES480121A0 (es) 1980-07-16
NO783705L (no) 1979-05-08
HU176306B (en) 1981-01-28
IL55857A0 (en) 1979-01-31
CS207671B2 (en) 1981-08-31
LU80470A1 (fr) 1980-06-05
DD139850A5 (de) 1980-01-23
ATA784378A (de) 1981-05-15
CS354491A3 (en) 1992-06-17
YU255378A (en) 1983-06-30
ES8308559A1 (es) 1980-07-16
AU509329B2 (en) 1980-05-08
MY8500286A (en) 1985-12-31
SE7811382L (sv) 1979-05-06
NZ188813A (en) 1980-10-08

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