CH623574A5 - - Google Patents

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Publication number
CH623574A5
CH623574A5 CH1287676A CH1287676A CH623574A5 CH 623574 A5 CH623574 A5 CH 623574A5 CH 1287676 A CH1287676 A CH 1287676A CH 1287676 A CH1287676 A CH 1287676A CH 623574 A5 CH623574 A5 CH 623574A5
Authority
CH
Switzerland
Prior art keywords
compound
acid addition
formula
dimethylaminopropyl
addition salts
Prior art date
Application number
CH1287676A
Other languages
German (de)
English (en)
Inventor
Philippe Dr Dostert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1287676A priority Critical patent/CH623574A5/de
Priority to FI772675A priority patent/FI62531C/fi
Priority to NLAANVRAGE7710194,A priority patent/NL183943C/xx
Priority to YU2209/77A priority patent/YU40482B/xx
Priority to IT7728172A priority patent/IT1143697B/it
Priority to CA288,106A priority patent/CA1075688A/en
Priority to ZA00775974A priority patent/ZA775974B/xx
Priority to AU29391/77A priority patent/AU512561B2/en
Priority to IL7753074A priority patent/IL53074A/xx
Priority to IE2051/77A priority patent/IE45709B1/en
Priority to DE2745280A priority patent/DE2745280C2/de
Priority to NZ185378A priority patent/NZ185378A/xx
Priority to PH20315A priority patent/PH13371A/en
Priority to MC771263A priority patent/MC1169A1/xx
Priority to LU7778280A priority patent/LU78280A1/xx
Priority to HU77HO2017A priority patent/HU173607B/hu
Priority to FR7730429A priority patent/FR2367749A1/fr
Priority to PT67142A priority patent/PT67142B/pt
Priority to BE181609A priority patent/BE859569A/xx
Priority to AT726177A priority patent/AT362378B/de
Priority to SE7711433A priority patent/SE427557B/sv
Priority to NO77773473A priority patent/NO145135C/no
Priority to ES77463133A priority patent/ES463133A1/es
Priority to GR54557A priority patent/GR66109B/el
Priority to GB42276/77A priority patent/GB1583590A/en
Priority to US05/840,790 priority patent/US4138482A/en
Priority to DK451477A priority patent/DK153786C/da
Priority to JP12157377A priority patent/JPS5346991A/ja
Priority to AR269561A priority patent/AR216106A1/es
Priority to AT463180A priority patent/AT363484B/de
Priority to AT463380A priority patent/AT375345B/de
Priority to AT463280A priority patent/AT363485B/de
Priority to CH846880A priority patent/CH625226A5/de
Priority to CH847080A priority patent/CH627169A5/de
Priority to CH846980A priority patent/CH625227A5/de
Publication of CH623574A5 publication Critical patent/CH623574A5/de
Priority to SG609/83A priority patent/SG60983G/en
Priority to HK263/84A priority patent/HK26384A/xx
Priority to MY97/85A priority patent/MY8500097A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH1287676A 1976-10-12 1976-10-12 CH623574A5 (sv)

Priority Applications (38)

Application Number Priority Date Filing Date Title
CH1287676A CH623574A5 (sv) 1976-10-12 1976-10-12
FI772675A FI62531C (fi) 1976-10-12 1977-09-09 Foerfarande foer framstaellning av terapeutiskt anvaendbart 3-yan-n-(n n-dimetylamino-propyl)-iminodibensyl och syraadd itonssalter daerav
NLAANVRAGE7710194,A NL183943C (nl) 1976-10-12 1977-09-16 Werkwijze voor het bereiden van een geneesmiddel met een antidepressieve activiteit, alsmede werkwijze voor het bereiden van een 5-(n,n-dimethylaminopropyl)-10,11-dihydro-5h-dibenzo(b,f)azepine derivaat.
YU2209/77A YU40482B (en) 1976-10-12 1977-09-19 Process for obtining 3-cyano-n-(n,n-dimethylamino-propyl)-imino-dibenzyl
IT7728172A IT1143697B (it) 1976-10-12 1977-09-30 Composti triciclici in particolare 3 cian-n-(nmn dimetilammino-propil)-imminodibenzile,sali di addizione di detti composti e loro impiego farmaceutico,e procedimenti preparativi
CA288,106A CA1075688A (en) 1976-10-12 1977-10-04 Iminodibenzyl derivatives
ZA00775974A ZA775974B (en) 1976-10-12 1977-10-05 Tricyclic compounds
AU29391/77A AU512561B2 (en) 1976-10-12 1977-10-05 3-cyano N (N, N-dimethylamino-propyl) iminodibenzyl
IL7753074A IL53074A (en) 1976-10-12 1977-10-06 3-cyano-n-(dimethylaminopropyl)(b,f)dibenzazepin and its salts,their manufacture and novel intermediates thereof and pharmaceutical compositions containing them
IE2051/77A IE45709B1 (en) 1976-10-12 1977-10-07 Tricyclic compounds
DE2745280A DE2745280C2 (de) 1976-10-12 1977-10-07 3-Cyano-10,11-dihydro-5H-dibenz[b,f]azepin
NZ185378A NZ185378A (en) 1976-10-12 1977-10-07 3-cyano-n-(n,n-dimethyl aminopropyl)-imino-dibenzyl and pharmaceutical compositions
PH20315A PH13371A (en) 1976-10-12 1977-10-07 3-cyano-n-(n,n-dimethylaminopropyl)-iminodibenzyl compositions containing same and method
MC771263A MC1169A1 (fr) 1976-10-12 1977-10-10 Composes tricycliques
LU7778280A LU78280A1 (sv) 1976-10-12 1977-10-10
HU77HO2017A HU173607B (hu) 1976-10-12 1977-10-10 Sposob poluchenija novogo proizvodnogo dibenzazepina i ego solej
FR7730429A FR2367749A1 (fr) 1976-10-12 1977-10-10 Nouveaux composes tricycliques utiles comme medicaments
AT726177A AT362378B (de) 1976-10-12 1977-10-11 Verfahren zur herstellung des neuen 3-cyan-n- -(n,n-dimethylaminopropyl)-iminodibenzyls und dessen saeureadditionssalzen
BE181609A BE859569A (fr) 1976-10-12 1977-10-11 Composes tricycliques
PT67142A PT67142B (pt) 1976-10-12 1977-10-11 Process for preparing tricyclic compounds
SE7711433A SE427557B (sv) 1976-10-12 1977-10-11 Forfarande for framstellning av 3-cyan-n-(n,n-dimetylamino-propyl)-iminodibensyl samt syraadditionssalter derav
NO77773473A NO145135C (no) 1976-10-12 1977-10-11 Analogifremgangsmaate ved fremstilling av den terapeutisk aktive forbindelse 3-cyan-n-(n,n-diemtylaminopropyl)-iminodibenzyl
ES77463133A ES463133A1 (es) 1976-10-12 1977-10-11 Un procedimiento para la preparacion de 3-ciano-n(n,n-dime- tilamino-propil)-iminodibencilo
GR54557A GR66109B (sv) 1976-10-12 1977-10-11
GB42276/77A GB1583590A (en) 1976-10-12 1977-10-11 Tricycle compounds
US05/840,790 US4138482A (en) 1976-10-12 1977-10-11 3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl and salts thereof
DK451477A DK153786C (da) 1976-10-12 1977-10-11 Analogifremgangsmaade til fremstilling af 3-cyan-n-(n,n-dimethylaminopropyl)-iminodibenzyl eller syreadditionssalte deraf
AR269561A AR216106A1 (es) 1976-10-12 1977-10-12 Procedimiento para la preparacion de 3-ciano-n-(n,n-dimetilaminopropil)-iminodibencilo
JP12157377A JPS5346991A (en) 1976-10-12 1977-10-12 Tricyclic compound
AT463180A AT363484B (de) 1976-10-12 1980-09-16 Verfahren zur herstellung des neuen 3-cyan-n(n,n-dimethylaminopropyl)-iminodibenzyls und dessen saeureadditionssalzen
AT463380A AT375345B (de) 1976-10-12 1980-09-16 Verfahren zur herstellung des neuen 3-cyan-n-(n,n-dimethylaminopropyl)-iminodibenzy s und dessen saeureadditionssalzen
AT463280A AT363485B (de) 1976-10-12 1980-09-16 Verfahren zur herstellung des neuen 3-cyan-n-(n,n-dimethylaminopropyl)-iminodibenzyls und dessen saeureadditionssalzen
CH846880A CH625226A5 (sv) 1976-10-12 1980-11-14
CH847080A CH627169A5 (sv) 1976-10-12 1980-11-14
CH846980A CH625227A5 (sv) 1976-10-12 1980-11-14
SG609/83A SG60983G (en) 1976-10-12 1983-09-28 Tricyclic compounds
HK263/84A HK26384A (en) 1976-10-12 1984-03-22 Tricyclic compounds
MY97/85A MY8500097A (en) 1976-10-12 1985-12-30 Tricyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1287676A CH623574A5 (sv) 1976-10-12 1976-10-12

Publications (1)

Publication Number Publication Date
CH623574A5 true CH623574A5 (sv) 1981-06-15

Family

ID=4387222

Family Applications (4)

Application Number Title Priority Date Filing Date
CH1287676A CH623574A5 (sv) 1976-10-12 1976-10-12
CH847080A CH627169A5 (sv) 1976-10-12 1980-11-14
CH846880A CH625226A5 (sv) 1976-10-12 1980-11-14
CH846980A CH625227A5 (sv) 1976-10-12 1980-11-14

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH847080A CH627169A5 (sv) 1976-10-12 1980-11-14
CH846880A CH625226A5 (sv) 1976-10-12 1980-11-14
CH846980A CH625227A5 (sv) 1976-10-12 1980-11-14

Country Status (32)

Country Link
US (1) US4138482A (sv)
JP (1) JPS5346991A (sv)
AR (1) AR216106A1 (sv)
AT (1) AT362378B (sv)
AU (1) AU512561B2 (sv)
BE (1) BE859569A (sv)
CA (1) CA1075688A (sv)
CH (4) CH623574A5 (sv)
DE (1) DE2745280C2 (sv)
DK (1) DK153786C (sv)
ES (1) ES463133A1 (sv)
FI (1) FI62531C (sv)
FR (1) FR2367749A1 (sv)
GB (1) GB1583590A (sv)
GR (1) GR66109B (sv)
HK (1) HK26384A (sv)
HU (1) HU173607B (sv)
IE (1) IE45709B1 (sv)
IL (1) IL53074A (sv)
IT (1) IT1143697B (sv)
LU (1) LU78280A1 (sv)
MC (1) MC1169A1 (sv)
MY (1) MY8500097A (sv)
NL (1) NL183943C (sv)
NO (1) NO145135C (sv)
NZ (1) NZ185378A (sv)
PH (1) PH13371A (sv)
PT (1) PT67142B (sv)
SE (1) SE427557B (sv)
SG (1) SG60983G (sv)
YU (1) YU40482B (sv)
ZA (1) ZA775974B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505909A (en) * 1980-09-17 1985-03-19 Bernstein Joel E Method and composition for treating and preventing irritation of the eyes
US4370324A (en) * 1980-09-17 1983-01-25 Bernstein Joel E Method and composition for treating and preventing irritation of the eyes
JPH03129724U (sv) * 1990-04-09 1991-12-26
US10639313B2 (en) 2017-09-01 2020-05-05 Ndsu Research Foundation Compound for inhibition of delta-5-desaturase (D5D) and treatment of cancer and inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK34863C (da) * 1924-09-12 1925-08-17 Carl Christian Marius Nielsen Anordning ved Bagagebærere til Cykler, Motorcykler og lignende.
CH375360A (de) * 1959-01-12 1964-02-29 Geigy Ag J R Verfahren zur Herstellung von neuen N-heterocyclischen Verbindungen
DK93077C (da) * 1958-12-06 1962-03-26 Geigy Ag J R Fremgangsmåde til fremstilling af 5H-dibenzo[b,f]azepinforbindelser eller 10,11-dihydroforbindelser heraf eller salte heraf.
FR84219E (fr) 1963-01-14 1964-12-24 Rhone Poulenc Sa Nouveau procédé d'aminoalcoylation d'amines hétérocycliques
FR1359676A (fr) * 1963-01-14 1964-04-30 Rhone Poulenc Sa Nouveau procédé d'aminoalcoylation d'amines hétérocycliques

Also Published As

Publication number Publication date
NO145135C (no) 1982-01-20
CH627169A5 (sv) 1981-12-31
DE2745280A1 (de) 1978-04-13
MC1169A1 (fr) 1978-06-02
JPS5346991A (en) 1978-04-27
AU2939177A (en) 1979-04-12
FR2367749B1 (sv) 1982-03-26
IL53074A (en) 1981-10-30
YU220977A (en) 1983-12-31
JPS6229428B2 (sv) 1987-06-25
PH13371A (en) 1980-03-20
FI62531B (fi) 1982-09-30
GR66109B (sv) 1981-01-16
AU512561B2 (en) 1980-10-16
HU173607B (hu) 1979-06-28
NL7710194A (nl) 1978-04-14
SG60983G (en) 1985-01-11
CA1075688A (en) 1980-04-15
AT362378B (de) 1981-05-11
DK451477A (da) 1978-04-13
YU40482B (en) 1986-02-28
LU78280A1 (sv) 1979-02-02
ES463133A1 (es) 1979-01-01
DK153786B (da) 1988-09-05
IL53074A0 (en) 1977-12-30
NZ185378A (en) 1980-03-05
ZA775974B (en) 1978-08-30
ATA726177A (de) 1980-10-15
BE859569A (fr) 1978-04-11
PT67142B (pt) 1979-11-12
AR216106A1 (es) 1979-11-30
FI772675A (fi) 1978-04-13
NO145135B (no) 1981-10-12
PT67142A (pt) 1977-11-01
SE7711433L (sv) 1978-04-13
DK153786C (da) 1989-01-23
SE427557B (sv) 1983-04-18
CH625226A5 (sv) 1981-09-15
FI62531C (fi) 1983-01-10
NL183943B (nl) 1988-10-03
FR2367749A1 (fr) 1978-05-12
IE45709B1 (en) 1982-11-03
MY8500097A (en) 1985-12-31
CH625227A5 (sv) 1981-09-15
NL183943C (nl) 1989-03-01
IT1143697B (it) 1986-10-22
NO773473L (no) 1978-04-13
DE2745280C2 (de) 1986-02-06
US4138482A (en) 1979-02-06
IE45709L (en) 1978-04-12
GB1583590A (en) 1981-01-28
HK26384A (en) 1984-03-30

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PUE Assignment

Owner name: F. HOFFMANN-LA ROCHE AG

PL Patent ceased