CH622250A5 - - Google Patents

Download PDF

Info

Publication number
CH622250A5
CH622250A5 CH1599575A CH1599575A CH622250A5 CH 622250 A5 CH622250 A5 CH 622250A5 CH 1599575 A CH1599575 A CH 1599575A CH 1599575 A CH1599575 A CH 1599575A CH 622250 A5 CH622250 A5 CH 622250A5
Authority
CH
Switzerland
Prior art keywords
amino
indazole
formula
trifluoromethyl
carboxylic acid
Prior art date
Application number
CH1599575A
Other languages
German (de)
English (en)
Inventor
Karl Heinrich Mayer
Siegfried Petersen
Erich Klauke
Friedrich Hoffmeister
Wolfgang Wuttke
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CH622250A5 publication Critical patent/CH622250A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CH1599575A 1974-12-13 1975-12-09 CH622250A5 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2458965A DE2458965C3 (de) 1974-12-13 1974-12-13 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
CH622250A5 true CH622250A5 (sv) 1981-03-31

Family

ID=5933305

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1599575A CH622250A5 (sv) 1974-12-13 1975-12-09

Country Status (27)

Country Link
US (1) US4051252A (sv)
JP (1) JPS5182266A (sv)
AT (1) AT343653B (sv)
BE (1) BE836528A (sv)
CA (1) CA1059523A (sv)
CH (1) CH622250A5 (sv)
CS (1) CS189731B2 (sv)
DD (1) DD125484A5 (sv)
DE (1) DE2458965C3 (sv)
DK (1) DK137082C (sv)
ES (1) ES443429A1 (sv)
FI (1) FI753493A (sv)
FR (1) FR2293928A1 (sv)
GB (1) GB1490306A (sv)
HK (1) HK52580A (sv)
HU (1) HU173557B (sv)
IE (1) IE42208B1 (sv)
IL (1) IL48642A (sv)
KE (1) KE3078A (sv)
LU (1) LU73993A1 (sv)
NL (1) NL7514521A (sv)
NO (1) NO145382C (sv)
PL (1) PL99858B1 (sv)
SE (1) SE419645B (sv)
SU (1) SU604487A3 (sv)
YU (1) YU315275A (sv)
ZA (1) ZA757777B (sv)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431657A (en) * 1982-05-24 1984-02-14 Ayerst, Mckenna & Harrison Inc. Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives
KR20010086657A (ko) * 2000-03-02 2001-09-15 성재갑 아미노인다졸 유도체 및 이를 함유하는 싸이클린 의존키나아제 저해제 조성물
CN1926132B (zh) * 2000-09-15 2010-12-29 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡唑化合物
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
SI1318997T1 (sl) * 2000-09-15 2006-12-31 Vertex Pharma Pirazolne spojine, uporabne kot inhibitorji protein-kinaze
DE60120193T2 (de) 2000-09-15 2007-03-29 Vertex Pharmaceuticals Inc., Cambridge Pyrazolverbindungen als protein-kinasehemmer
ATE528303T1 (de) 2000-12-21 2011-10-15 Vertex Pharma Pyrazoleverbindungen als proteinkinasehemmer
KR100406634B1 (ko) * 2001-03-12 2003-11-20 주식회사 엘지생명과학 3,5-디아미노인다졸 유도체, 그의 제조방법 및 사이클린의존성 키나아제 저해제로서의 그의 용도
MXPA04001114A (es) 2001-09-26 2004-05-20 Pharmacia Italia Spa Derivados de aminoindazol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
SG159380A1 (en) * 2002-02-06 2010-03-30 Vertex Pharma Heteroaryl compounds useful as inhibitors of gsk-3
FR2836915B1 (fr) 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
DE60332604D1 (de) 2002-03-15 2010-07-01 Vertex Pharma Azolylaminoazine als proteinkinasehemmer
AU2003227741A1 (en) 2002-05-17 2003-12-02 Pharmacia Italia S.P.A. Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
JP4733388B2 (ja) 2002-08-02 2011-07-27 バーテックス ファーマシューティカルズ インコーポレイテッド Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物
AU2003270701B2 (en) * 2002-10-31 2009-11-12 Amgen Inc. Antiinflammation agents
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
AU2004297235A1 (en) * 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
DE102004005172A1 (de) 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
US7737151B2 (en) 2005-08-18 2010-06-15 Vertex Pharmaceuticals Incorporated Pyrazine kinase inhibitors
CA2627830A1 (en) * 2005-11-03 2007-05-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
US7847104B2 (en) * 2006-04-14 2010-12-07 Abbott Laboratories Process for the preparation of indazolyl ureas that inhibit Vanilloid subtype1 (VR1) receptors
JP2010509231A (ja) 2006-11-02 2010-03-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼの阻害剤として有用なアミノピリジンおよびアミノピリミジン
AU2007333650A1 (en) 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
ES2435997T3 (es) 2007-03-09 2013-12-26 Vertex Pharmaceuticals, Inc. Aminopirimidinas útiles como inhibidores de las proteínas cinasas
AU2008226461A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
EP2137183B1 (en) 2007-03-09 2011-09-28 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
JP2010523700A (ja) 2007-04-13 2010-07-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼインヒビターとして有用なアミノピリミジン
CN101801959A (zh) 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶类化合物
EP2155730A2 (en) * 2007-05-02 2010-02-24 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
CA2685876A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
WO2008147626A2 (en) * 2007-05-24 2008-12-04 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
CN101790532B (zh) * 2007-07-31 2013-11-20 沃泰克斯药物股份有限公司 5-氟-1H-吡唑并[3，4-b]吡啶-3-胺及其衍生物的制备方法
MX2011002312A (es) * 2008-09-03 2011-04-26 Vertex Pharma Co-cristales y formulaciones farmaceuticas que comprenden los mismos.
DE102009004245A1 (de) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung
ES2667056T3 (es) 2012-07-24 2018-05-09 Bial-Portela & Ca, S.A. Compuestos de urea y su uso como inhibidores enzimáticos
RU2015104103A (ru) * 2012-07-27 2016-09-20 Биал - Портела Энд К, С.А. Способ синтеза замещенных соединений мочевины
EP3024825B1 (en) 2013-07-24 2017-06-21 BIAL - PORTELA & Cª, S.A. Imidazolecarboxamides and their use as faah inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133081A (en) * 1964-05-12 J-aminoindazole derivatives
CH397698A (de) * 1961-09-08 1965-08-31 Siegfried Ag Verfahren zur Herstellung neuer 1-Carbamyl-indazole
US3274203A (en) * 1963-05-31 1966-09-20 Du Pont 1-carbamyl and thiocarbamyl-3-amino-4-nonsubstituted and substituted pyrazoles
NL6707299A (sv) * 1966-07-16 1968-01-17
DE1770649A1 (de) * 1968-06-15 1971-11-11 Bayer Ag Substituierte 3-Amino-indazole

Also Published As

Publication number Publication date
JPS5182266A (en) 1976-07-19
IE42208B1 (en) 1980-06-18
SU604487A3 (ru) 1978-04-25
ZA757777B (en) 1976-11-24
CA1059523A (en) 1979-07-31
DD125484A5 (sv) 1977-04-20
HK52580A (en) 1980-09-26
NL7514521A (nl) 1976-06-15
YU315275A (en) 1982-02-28
GB1490306A (en) 1977-11-02
HU173557B (hu) 1979-06-28
US4051252A (en) 1977-09-27
IL48642A0 (en) 1976-02-29
ATA939775A (de) 1977-10-15
FI753493A (sv) 1976-06-14
FR2293928A1 (fr) 1976-07-09
NO145382C (no) 1982-03-10
PL99858B1 (pl) 1978-08-31
DK567275A (da) 1976-06-14
SE7513990L (sv) 1976-06-14
KE3078A (en) 1980-10-03
IE42208L (en) 1976-06-13
DE2458965C3 (de) 1979-10-11
DE2458965B2 (de) 1979-02-22
CS189731B2 (en) 1979-04-30
BE836528A (fr) 1976-06-11
LU73993A1 (sv) 1976-11-11
SE419645B (sv) 1981-08-17
DK137082B (da) 1978-01-16
DK137082C (da) 1978-06-19
ES443429A1 (es) 1977-04-16
FR2293928B1 (sv) 1979-09-21
IL48642A (en) 1979-12-30
DE2458965A1 (de) 1976-06-16
NO145382B (no) 1981-11-30
AU8717075A (en) 1977-06-09
AT343653B (de) 1978-06-12
NO754024L (sv) 1976-06-15

Similar Documents

Publication Publication Date Title
CH622250A5 (sv)
DE1493536B1 (de) Neue gamma-Amino-beta-phenyl-buttersaeuren
DE2419970A1 (de) Tertiaere cyclische amine und verfahren zu ihrer herstellung
DE2846945A1 (de) Pharmazeutische praeparate
AT262274B (de) Verfahren zur Herstellung neuer Indolderivate
CH646156A5 (de) Schwefelhaltige benzimidazol-derivate und verfahren zu ihrer herstellung.
EP0380712B1 (de) Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten
DE2118315C3 (de) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3514843C2 (sv)
CH620899A5 (sv)
DE2845857A1 (de) Benzo eckige klammer auf d eckige klammer zu thiazolderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittelzubereitungen
DE3642497A1 (de) Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
AT390952B (de) Verfahren zur herstellung von neuen furan- oder thiophenderivaten
DD249479A5 (de) Verfahren zur herstellung von propionamidin-derivaten
DE2330124A1 (de) Anilidderivate, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2354931C2 (de) trans-2-Phenylbicyclooctan-Verbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE1645974A1 (de) Isonicotinsaeureamide enthaltende Arzneimittel
DE3129718A1 (de) 4-oximino-1,2,3,4-tetrahydrochinolinderivate und verfahren zu ihrer herstellung
AT390791B (de) Verfahren zur herstellung neuer kondensierter as-triazinium-derivate sowie von deren isomeren
CH653335A5 (de) Verfahren zur herstellung von 9-amino-6,7dihydro-4h-pyrido (1,2-a)pyrimidin-4-on-derivaten.
DE1226105B (de) Verfahren zur Herstellung von neuen 3,4-Dihydrochinazolon-(4)-derivaten
DE1695092A1 (de) Verfahren zur Herstellung von Sulfonamiden
CH612186A5 (en) Process for the preparation of 2(1H)-quinazolinone derivatives
AT251584B (de) Verfahren zur Herstellung von neuen 4(3H)-Chinazolinon-Derivaten
AT270630B (de) Verfahren zur Herstellung von neuen Pyrrolinderivaten und ihren Salzen

Legal Events

Date Code Title Description
PL Patent ceased