CH620682A5 - Process for the preparation of novel 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts - Google Patents
Process for the preparation of novel 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts Download PDFInfo
- Publication number
- CH620682A5 CH620682A5 CH1267875A CH1267875A CH620682A5 CH 620682 A5 CH620682 A5 CH 620682A5 CH 1267875 A CH1267875 A CH 1267875A CH 1267875 A CH1267875 A CH 1267875A CH 620682 A5 CH620682 A5 CH 620682A5
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- chloro
- formula
- acid addition
- imidazolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2446758A DE2446758C3 (de) | 1974-10-01 | 1974-10-01 | 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH620682A5 true CH620682A5 (en) | 1980-12-15 |
Family
ID=5927202
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1267875A CH620682A5 (en) | 1974-10-01 | 1975-09-30 | Process for the preparation of novel 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506480A CH626352A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506280A CH627452A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506380A CH627453A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506580A CH627454A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH506480A CH626352A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506280A CH627452A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506380A CH627453A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
| CH506580A CH627454A5 (en) | 1974-10-01 | 1980-07-01 | Process for the preparation of 2,6-disubstituted 2-phenyliminoimidazolidines and their acid addition salts |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS6018653B2 (uk) |
| AT (1) | AT344159B (uk) |
| BE (1) | BE834051A (uk) |
| BG (2) | BG25221A3 (uk) |
| CA (1) | CA1056836A (uk) |
| CH (5) | CH620682A5 (uk) |
| CS (1) | CS193524B2 (uk) |
| DD (1) | DD123602A5 (uk) |
| DE (1) | DE2446758C3 (uk) |
| DK (1) | DK441875A (uk) |
| ES (4) | ES441385A1 (uk) |
| FI (1) | FI61883C (uk) |
| FR (1) | FR2286649A1 (uk) |
| GB (1) | GB1515019A (uk) |
| HU (1) | HU178469B (uk) |
| IE (1) | IE42130B1 (uk) |
| IL (1) | IL48214A (uk) |
| LU (1) | LU73472A1 (uk) |
| NL (1) | NL7511490A (uk) |
| NO (1) | NO143459C (uk) |
| NZ (1) | NZ178810A (uk) |
| PH (1) | PH13653A (uk) |
| PL (2) | PL97003B1 (uk) |
| SE (1) | SE418497B (uk) |
| SU (1) | SU575026A3 (uk) |
| YU (1) | YU230281A (uk) |
| ZA (1) | ZA756185B (uk) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2630060C2 (de) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
| DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2806811A1 (de) * | 1978-02-17 | 1979-08-23 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben |
| CA1138451A (en) * | 1979-04-03 | 1982-12-28 | Ikuo Ueda | 2-imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same |
| HU192986B (en) | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| AU2007213887A1 (en) * | 2006-01-27 | 2007-08-16 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of CNS disorders |
| BRPI0806940A2 (pt) | 2007-02-02 | 2014-05-06 | Hoffmann La Roche | 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc |
| MX2009008465A (es) | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
| US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| BR112018015389B1 (pt) | 2016-03-17 | 2023-12-19 | F. Hoffmann-La Roche Ag | Derivado de 5-etil-4-metil-pirazol-3-carboxamida, seu processo de fabricação, preparação farmacêutica oral e uso |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236857A (en) * | 1961-10-09 | 1966-02-22 | Boehringer Sohn Ingelheim | 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products |
| DE1670807A1 (de) * | 1967-02-17 | 1971-03-11 | Bayer Ag | Verfahren zur Herstellung von cyclischen Guanidinen |
| DE1670918A1 (de) * | 1967-09-07 | 1971-04-08 | Bayer Ag | Verfahren zur Herstellung von 2-Aryl-amino-substituierten stickstoffhaltigen Heterocyclen |
| BE787683A (fr) * | 1971-08-20 | 1973-02-19 | Boehringer Sohn Ingelheim | 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
-
1974
- 1974-10-01 DE DE2446758A patent/DE2446758C3/de not_active Expired
-
1975
- 1975-09-22 AT AT722875A patent/AT344159B/de not_active IP Right Cessation
- 1975-09-23 SU SU7502174605A patent/SU575026A3/ru active
- 1975-09-26 PH PH17613A patent/PH13653A/en unknown
- 1975-09-29 BG BG032014A patent/BG25221A3/xx unknown
- 1975-09-29 LU LU73472A patent/LU73472A1/xx unknown
- 1975-09-29 BG BG031110A patent/BG25220A3/xx unknown
- 1975-09-29 CS CS756573A patent/CS193524B2/cs unknown
- 1975-09-29 DD DD188613A patent/DD123602A5/xx unknown
- 1975-09-30 GB GB40012/75A patent/GB1515019A/en not_active Expired
- 1975-09-30 PL PL1975183670A patent/PL97003B1/pl unknown
- 1975-09-30 NO NO753314A patent/NO143459C/no unknown
- 1975-09-30 ES ES441385A patent/ES441385A1/es not_active Expired
- 1975-09-30 IL IL48214A patent/IL48214A/xx unknown
- 1975-09-30 JP JP50118196A patent/JPS6018653B2/ja not_active Expired
- 1975-09-30 FI FI752728A patent/FI61883C/fi not_active IP Right Cessation
- 1975-09-30 HU HU75BO1573A patent/HU178469B/hu unknown
- 1975-09-30 DK DK441875A patent/DK441875A/da not_active Application Discontinuation
- 1975-09-30 NL NL7511490A patent/NL7511490A/xx not_active Application Discontinuation
- 1975-09-30 CH CH1267875A patent/CH620682A5/de not_active IP Right Cessation
- 1975-09-30 NZ NZ178810A patent/NZ178810A/xx unknown
- 1975-09-30 CA CA236,670A patent/CA1056836A/en not_active Expired
- 1975-09-30 PL PL1975197816A patent/PL98984B1/pl unknown
- 1975-09-30 BE BE160578A patent/BE834051A/xx not_active IP Right Cessation
- 1975-09-30 ZA ZA756185A patent/ZA756185B/xx unknown
- 1975-10-01 FR FR7530117A patent/FR2286649A1/fr active Granted
- 1975-10-01 SE SE7511028A patent/SE418497B/xx not_active IP Right Cessation
- 1975-10-01 IE IE2150/75A patent/IE42130B1/en unknown
-
1976
- 1976-02-04 ES ES444900A patent/ES444900A1/es not_active Expired
- 1976-02-04 ES ES444898A patent/ES444898A1/es not_active Expired
- 1976-02-04 ES ES444901A patent/ES444901A1/es not_active Expired
-
1980
- 1980-07-01 CH CH506480A patent/CH626352A5/de not_active IP Right Cessation
- 1980-07-01 CH CH506280A patent/CH627452A5/de not_active IP Right Cessation
- 1980-07-01 CH CH506380A patent/CH627453A5/de not_active IP Right Cessation
- 1980-07-01 CH CH506580A patent/CH627454A5/de not_active IP Right Cessation
-
1981
- 1981-09-24 YU YU02302/81A patent/YU230281A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |