GB1515019A - Substituted imidazolidines and pharmaceutical uses thereo - Google Patents

Substituted imidazolidines and pharmaceutical uses thereo

Info

Publication number
GB1515019A
GB1515019A GB40012/75A GB4001275A GB1515019A GB 1515019 A GB1515019 A GB 1515019A GB 40012/75 A GB40012/75 A GB 40012/75A GB 4001275 A GB4001275 A GB 4001275A GB 1515019 A GB1515019 A GB 1515019A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical uses
substituted imidazolidines
novel
thereo
uses thereo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40012/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH filed Critical CH Boehringer Sohn AG and Co KG
Publication of GB1515019A publication Critical patent/GB1515019A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Novel ortho- and ortho'-disubstituted 2-phenyliminoimidazolidines of the formula I are obtained by reaction of ethylenediamine with a compound of the formula II. The latter is prepared from novel 2,6-disubstituted anilines. The meaning of Z follows from Claim 1. The novel 2-phenyliminoimidazolidines have useful therapeutic, in particular hypotensive, action. <IMAGE>
GB40012/75A 1974-10-01 1975-09-30 Substituted imidazolidines and pharmaceutical uses thereo Expired GB1515019A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2446758A DE2446758C3 (en) 1974-10-01 1974-10-01 2- (2-Fluoro-6-trifluoromethylphenylimino) -imidazolidine, its acid addition salts, processes for the preparation of these compounds and their use in combating hypertension

Publications (1)

Publication Number Publication Date
GB1515019A true GB1515019A (en) 1978-06-21

Family

ID=5927202

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40012/75A Expired GB1515019A (en) 1974-10-01 1975-09-30 Substituted imidazolidines and pharmaceutical uses thereo

Country Status (27)

Country Link
JP (1) JPS6018653B2 (en)
AT (1) AT344159B (en)
BE (1) BE834051A (en)
BG (2) BG25221A3 (en)
CA (1) CA1056836A (en)
CH (5) CH620682A5 (en)
CS (1) CS193524B2 (en)
DD (1) DD123602A5 (en)
DE (1) DE2446758C3 (en)
DK (1) DK441875A (en)
ES (4) ES441385A1 (en)
FI (1) FI61883C (en)
FR (1) FR2286649A1 (en)
GB (1) GB1515019A (en)
HU (1) HU178469B (en)
IE (1) IE42130B1 (en)
IL (1) IL48214A (en)
LU (1) LU73472A1 (en)
NL (1) NL7511490A (en)
NO (1) NO143459C (en)
NZ (1) NZ178810A (en)
PH (1) PH13653A (en)
PL (2) PL97003B1 (en)
SE (1) SE418497B (en)
SU (1) SU575026A3 (en)
YU (1) YU230281A (en)
ZA (1) ZA756185B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2630060C2 (en) * 1976-07-03 1984-04-19 C.H. Boehringer Sohn, 6507 Ingelheim 2- (2-Bromo-6-fluoro-phenylimino) -imidazolidine, its acid addition salts, medicaments containing them and processes for their preparation
DE2806775A1 (en) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO IMIDAZOLIDINE THEIR ACID ADDITION SALTS, MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
DE2806811A1 (en) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINE, THEIR ACID-ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR MANUFACTURING THE SAME
CA1138451A (en) * 1979-04-03 1982-12-28 Ikuo Ueda 2-imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same
HU192986B (en) 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
AU2007213887A1 (en) * 2006-01-27 2007-08-16 F. Hoffmann-La Roche Ag Use of 2-imidazoles for the treatment of CNS disorders
BRPI0806940A2 (en) 2007-02-02 2014-05-06 Hoffmann La Roche 2-AMINO-OXAZOLINES AS TAAR1 LEADERS FOR CNS DISORDERS
MX2009008465A (en) 2007-02-15 2009-08-20 Hoffmann La Roche 2-aminooxazolines as taar1 ligands.
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
BR112018015389B1 (en) 2016-03-17 2023-12-19 F. Hoffmann-La Roche Ag 5-Ethyl-4-methyl-pyrazol-3-carboxamide derivative, its manufacturing process, oral pharmaceutical preparation and use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
DE1670807A1 (en) * 1967-02-17 1971-03-11 Bayer Ag Process for the preparation of cyclic guanidines
DE1670918A1 (en) * 1967-09-07 1971-04-08 Bayer Ag Process for the preparation of 2-aryl-amino-substituted nitrogen-containing heterocycles
BE787683A (en) * 1971-08-20 1973-02-19 Boehringer Sohn Ingelheim 2-PHENYLIMINO-IMIDAZOLIDINES, THEIR ADDITIONAL SALTS WITH ACIDS AND METHODS FOR MAKING THEM

Also Published As

Publication number Publication date
DE2446758C3 (en) 1979-01-04
PH13653A (en) 1980-08-21
YU230281A (en) 1982-02-28
LU73472A1 (en) 1977-05-16
BE834051A (en) 1976-03-30
IL48214A0 (en) 1975-11-25
IE42130B1 (en) 1980-06-04
BG25221A3 (en) 1978-08-10
ZA756185B (en) 1977-06-29
ES444901A1 (en) 1977-04-16
CS193524B2 (en) 1979-10-31
CH626352A5 (en) 1981-11-13
AT344159B (en) 1978-07-10
SE418497B (en) 1981-06-09
FR2286649B1 (en) 1979-09-14
JPS6018653B2 (en) 1985-05-11
SE7511028L (en) 1976-04-02
FI752728A (en) 1976-04-02
SU575026A3 (en) 1977-09-30
DE2446758A1 (en) 1976-04-22
AU8529875A (en) 1977-04-07
DD123602A5 (en) 1977-01-05
CA1056836A (en) 1979-06-19
NO143459C (en) 1981-02-18
ES444900A1 (en) 1977-04-16
DK441875A (en) 1976-04-02
DE2446758B2 (en) 1978-05-18
ES444898A1 (en) 1977-05-16
BG25220A3 (en) 1978-08-10
NZ178810A (en) 1978-04-03
FR2286649A1 (en) 1976-04-30
PL98984B1 (en) 1978-06-30
ATA722875A (en) 1977-11-15
HU178469B (en) 1982-05-28
FI61883C (en) 1982-10-11
ES441385A1 (en) 1977-08-01
NO143459B (en) 1980-11-10
NL7511490A (en) 1976-04-05
IL48214A (en) 1979-10-31
CH627453A5 (en) 1982-01-15
CH620682A5 (en) 1980-12-15
PL97003B1 (en) 1978-01-31
CH627454A5 (en) 1982-01-15
IE42130L (en) 1976-04-01
NO753314L (en) 1976-04-02
JPS5159863A (en) 1976-05-25
FI61883B (en) 1982-06-30
CH627452A5 (en) 1982-01-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee