ES441385A1 - Substituted imidazolidines and pharmaceutical uses thereo - Google Patents
Substituted imidazolidines and pharmaceutical uses thereoInfo
- Publication number
- ES441385A1 ES441385A1 ES441385A ES441385A ES441385A1 ES 441385 A1 ES441385 A1 ES 441385A1 ES 441385 A ES441385 A ES 441385A ES 441385 A ES441385 A ES 441385A ES 441385 A1 ES441385 A1 ES 441385A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical uses
- substituted imidazolidines
- novel
- thereo
- uses thereo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Novel ortho- and ortho'-disubstituted 2-phenyliminoimidazolidines of the formula I are obtained by reaction of ethylenediamine with a compound of the formula II. The latter is prepared from novel 2,6-disubstituted anilines. The meaning of Z follows from Claim 1. The novel 2-phenyliminoimidazolidines have useful therapeutic, in particular hypotensive, action.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2446758A DE2446758C3 (en) | 1974-10-01 | 1974-10-01 | 2- (2-Fluoro-6-trifluoromethylphenylimino) -imidazolidine, its acid addition salts, processes for the preparation of these compounds and their use in combating hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES441385A1 true ES441385A1 (en) | 1977-08-01 |
Family
ID=5927202
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES441385A Expired ES441385A1 (en) | 1974-10-01 | 1975-09-30 | Substituted imidazolidines and pharmaceutical uses thereo |
| ES444898A Expired ES444898A1 (en) | 1974-10-01 | 1976-02-04 | Substituted imidazolidines and pharmaceutical uses thereo |
| ES444901A Expired ES444901A1 (en) | 1974-10-01 | 1976-02-04 | Substituted imidazolidines and pharmaceutical uses thereo |
| ES444900A Expired ES444900A1 (en) | 1974-10-01 | 1976-02-04 | Substituted imidazolidines and pharmaceutical uses thereo |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES444898A Expired ES444898A1 (en) | 1974-10-01 | 1976-02-04 | Substituted imidazolidines and pharmaceutical uses thereo |
| ES444901A Expired ES444901A1 (en) | 1974-10-01 | 1976-02-04 | Substituted imidazolidines and pharmaceutical uses thereo |
| ES444900A Expired ES444900A1 (en) | 1974-10-01 | 1976-02-04 | Substituted imidazolidines and pharmaceutical uses thereo |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS6018653B2 (en) |
| AT (1) | AT344159B (en) |
| BE (1) | BE834051A (en) |
| BG (2) | BG25220A3 (en) |
| CA (1) | CA1056836A (en) |
| CH (5) | CH620682A5 (en) |
| CS (1) | CS193524B2 (en) |
| DD (1) | DD123602A5 (en) |
| DE (1) | DE2446758C3 (en) |
| DK (1) | DK441875A (en) |
| ES (4) | ES441385A1 (en) |
| FI (1) | FI61883C (en) |
| FR (1) | FR2286649A1 (en) |
| GB (1) | GB1515019A (en) |
| HU (1) | HU178469B (en) |
| IE (1) | IE42130B1 (en) |
| IL (1) | IL48214A (en) |
| LU (1) | LU73472A1 (en) |
| NL (1) | NL7511490A (en) |
| NO (1) | NO143459C (en) |
| NZ (1) | NZ178810A (en) |
| PH (1) | PH13653A (en) |
| PL (2) | PL97003B1 (en) |
| SE (1) | SE418497B (en) |
| SU (1) | SU575026A3 (en) |
| YU (1) | YU230281A (en) |
| ZA (1) | ZA756185B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2630060C2 (en) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2- (2-Bromo-6-fluoro-phenylimino) -imidazolidine, its acid addition salts, medicaments containing them and processes for their preparation |
| DE2806775A1 (en) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLIMINO IMIDAZOLIDINE THEIR ACID ADDITION SALTS, MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF |
| DE2806811A1 (en) * | 1978-02-17 | 1979-08-23 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINE, THEIR ACID-ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR MANUFACTURING THE SAME |
| ZA801680B (en) * | 1979-04-03 | 1981-03-25 | Fujisawa Pharmaceutical Co | 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same |
| HU192986B (en) | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| CA2637292A1 (en) * | 2006-01-27 | 2007-08-16 | F. Hoffmann-La Roche Ag | Use of 2-imidazoles for the treatment of cns disorders |
| JP5248528B2 (en) | 2007-02-02 | 2013-07-31 | エフ．ホフマン−ラ ロシュ アーゲー | Novel 2-aminooxazolines as TAAR1 ligands for CNS diseases |
| CA2676944C (en) | 2007-02-15 | 2016-01-19 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
| US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| SG11201807516UA (en) | 2016-03-17 | 2018-09-27 | Hoffmann La Roche | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236857A (en) * | 1961-10-09 | 1966-02-22 | Boehringer Sohn Ingelheim | 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products |
| DE1670807A1 (en) * | 1967-02-17 | 1971-03-11 | Bayer Ag | Process for the preparation of cyclic guanidines |
| DE1670918A1 (en) * | 1967-09-07 | 1971-04-08 | Bayer Ag | Process for the preparation of 2-aryl-amino-substituted nitrogen-containing heterocycles |
| BE787683A (en) * | 1971-08-20 | 1973-02-19 | Boehringer Sohn Ingelheim | 2-PHENYLIMINO-IMIDAZOLIDINES, THEIR ADDITIONAL SALTS WITH ACIDS AND METHODS FOR MAKING THEM |
-
1974
- 1974-10-01 DE DE2446758A patent/DE2446758C3/en not_active Expired
-
1975
- 1975-09-22 AT AT722875A patent/AT344159B/en not_active IP Right Cessation
- 1975-09-23 SU SU7502174605A patent/SU575026A3/en active
- 1975-09-26 PH PH17613A patent/PH13653A/en unknown
- 1975-09-29 CS CS756573A patent/CS193524B2/en unknown
- 1975-09-29 LU LU73472A patent/LU73472A1/xx unknown
- 1975-09-29 BG BG031110A patent/BG25220A3/en unknown
- 1975-09-29 DD DD188613A patent/DD123602A5/xx unknown
- 1975-09-29 BG BG032014A patent/BG25221A3/en unknown
- 1975-09-30 NL NL7511490A patent/NL7511490A/en not_active Application Discontinuation
- 1975-09-30 NO NO753314A patent/NO143459C/en unknown
- 1975-09-30 ZA ZA756185A patent/ZA756185B/en unknown
- 1975-09-30 BE BE160578A patent/BE834051A/en not_active IP Right Cessation
- 1975-09-30 CH CH1267875A patent/CH620682A5/en not_active IP Right Cessation
- 1975-09-30 PL PL1975183670A patent/PL97003B1/en unknown
- 1975-09-30 GB GB40012/75A patent/GB1515019A/en not_active Expired
- 1975-09-30 HU HU75BO1573A patent/HU178469B/en unknown
- 1975-09-30 CA CA236,670A patent/CA1056836A/en not_active Expired
- 1975-09-30 FI FI752728A patent/FI61883C/en not_active IP Right Cessation
- 1975-09-30 ES ES441385A patent/ES441385A1/en not_active Expired
- 1975-09-30 IL IL48214A patent/IL48214A/en unknown
- 1975-09-30 NZ NZ178810A patent/NZ178810A/en unknown
- 1975-09-30 PL PL1975197816A patent/PL98984B1/en unknown
- 1975-09-30 DK DK441875A patent/DK441875A/en not_active Application Discontinuation
- 1975-09-30 JP JP50118196A patent/JPS6018653B2/en not_active Expired
- 1975-10-01 FR FR7530117A patent/FR2286649A1/en active Granted
- 1975-10-01 IE IE2150/75A patent/IE42130B1/en unknown
- 1975-10-01 SE SE7511028A patent/SE418497B/en not_active IP Right Cessation
-
1976
- 1976-02-04 ES ES444898A patent/ES444898A1/en not_active Expired
- 1976-02-04 ES ES444901A patent/ES444901A1/en not_active Expired
- 1976-02-04 ES ES444900A patent/ES444900A1/en not_active Expired
-
1980
- 1980-07-01 CH CH506480A patent/CH626352A5/en not_active IP Right Cessation
- 1980-07-01 CH CH506280A patent/CH627452A5/en not_active IP Right Cessation
- 1980-07-01 CH CH506380A patent/CH627453A5/en not_active IP Right Cessation
- 1980-07-01 CH CH506580A patent/CH627454A5/en not_active IP Right Cessation
-
1981
- 1981-09-24 YU YU02302/81A patent/YU230281A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |