ES458957A1 - 1-aryloxy-2 - hydroxy - 3 - aminopropanes and process for their preparation - Google Patents
1-aryloxy-2 - hydroxy - 3 - aminopropanes and process for their preparationInfo
- Publication number
- ES458957A1 ES458957A1 ES458957A ES458957A ES458957A1 ES 458957 A1 ES458957 A1 ES 458957A1 ES 458957 A ES458957 A ES 458957A ES 458957 A ES458957 A ES 458957A ES 458957 A1 ES458957 A1 ES 458957A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- adrenolytic
- reacting
- compound
- aminopropanes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
Abstract
Novel compounds of the formula I are prepared by reacting a 2,3-oxidopropyl phenyl ether, or a 3-halo-2-hydroxypropyl phenyl ether, with an appropriately substituted amine, or by reacting a compound of the formula V with the compound X-R<4>. The symbols in the formulae I and V have the meaning given in the patent claim. The compounds of formula I, and their physiologically tolerated acid addition salts, have valuable therapeutic properties, in particular beta -adrenolytic, beta 1-adrenolytic and/or hypotensive and/or antiarrhythmic properties.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2623314A DE2623314C2 (en) | 1976-05-25 | 1976-05-25 | 1-aryloxy-2-hydroxy-3-aminopropanes, processes for their preparation and pharmaceuticals containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ES458957A1 true ES458957A1 (en) | 1978-07-16 |
Family
ID=5978907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES458957A Expired ES458957A1 (en) | 1976-05-25 | 1977-05-19 | 1-aryloxy-2 - hydroxy - 3 - aminopropanes and process for their preparation |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5312827A (en) |
AT (1) | AT354421B (en) |
AU (1) | AU511704B2 (en) |
BE (1) | BE855041A (en) |
CA (1) | CA1108633A (en) |
CH (5) | CH637105A5 (en) |
DE (1) | DE2623314C2 (en) |
DK (1) | DK227177A (en) |
ES (1) | ES458957A1 (en) |
FI (1) | FI67698C (en) |
FR (1) | FR2353520A1 (en) |
GB (1) | GB1577670A (en) |
HU (1) | HU179198B (en) |
IL (1) | IL52148A (en) |
IT (1) | IT1077193B (en) |
NL (1) | NL7705587A (en) |
SE (1) | SE440903B (en) |
ZA (1) | ZA773120B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2415622A1 (en) * | 1978-01-25 | 1979-08-24 | Lipha | AMINO ALCOHOLS DERIVED FROM METHYL ORTHO-HYDROXY CINNAMATE APPLICABLE ESPECIALLY AS MEDICINAL PRODUCTS |
DE2824764A1 (en) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | NEW PYRIDYL PIPERAZINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
EP0008711B1 (en) * | 1978-08-15 | 1981-11-04 | Smithkline Beckman Corporation | A method of preparing a 2-hydroxy-3-isopropyl or a 2-hydroxy-3-tert-butylaminopropyl aromatic ether |
FR2459235A1 (en) * | 1979-06-14 | 1981-01-09 | Sanofi Sa | NOVEL SULFONYL-ANILINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
JPH0629833B2 (en) * | 1984-06-15 | 1994-04-20 | 株式会社島津製作所 | Fatigue testing machine |
GB8603120D0 (en) * | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
AU777594B2 (en) | 1999-05-24 | 2004-10-21 | Mitsubishi Pharma Corporation | Phenoxypropylamine compounds |
DE19941657A1 (en) * | 1999-09-01 | 2001-03-08 | Schwabe Willmar Gmbh & Co | Cinnamic acid nitriles, process for their preparation and use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA945172A (en) * | 1969-02-21 | 1974-04-09 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
FR2132570B1 (en) * | 1971-04-09 | 1974-08-02 | Lipha | |
BE791650R (en) * | 1971-11-18 | 1973-05-21 | Ici Ltd | ALKANOLAMINE DERIVATIVES. |
ES411826A1 (en) * | 1973-02-20 | 1976-01-01 | Liade Sa Lab | Process for preparing pharmacologically active 1-aryloxy-2- propanolamines |
-
1976
- 1976-05-25 DE DE2623314A patent/DE2623314C2/en not_active Expired
-
1977
- 1977-05-19 ES ES458957A patent/ES458957A1/en not_active Expired
- 1977-05-20 NL NL7705587A patent/NL7705587A/en not_active Application Discontinuation
- 1977-05-20 CH CH624077A patent/CH637105A5/en not_active IP Right Cessation
- 1977-05-23 IT IT23892/77A patent/IT1077193B/en active
- 1977-05-23 FI FI771630A patent/FI67698C/en not_active IP Right Cessation
- 1977-05-24 IL IL52148A patent/IL52148A/en unknown
- 1977-05-24 CA CA278,974A patent/CA1108633A/en not_active Expired
- 1977-05-24 AU AU25434/77A patent/AU511704B2/en not_active Expired
- 1977-05-24 ZA ZA00773120A patent/ZA773120B/en unknown
- 1977-05-24 SE SE7706059A patent/SE440903B/en unknown
- 1977-05-24 DK DK227177A patent/DK227177A/en not_active Application Discontinuation
- 1977-05-24 HU HU77HO1987A patent/HU179198B/en unknown
- 1977-05-24 AT AT370177A patent/AT354421B/en not_active IP Right Cessation
- 1977-05-25 JP JP6000477A patent/JPS5312827A/en active Granted
- 1977-05-25 BE BE177909A patent/BE855041A/en unknown
- 1977-05-25 FR FR7715881A patent/FR2353520A1/en active Granted
- 1977-05-25 GB GB22051/77A patent/GB1577670A/en not_active Expired
-
1981
- 1981-10-13 CH CH655581A patent/CH637108A5/en not_active IP Right Cessation
- 1981-10-13 CH CH655681A patent/CH637109A5/en not_active IP Right Cessation
- 1981-10-13 CH CH655781A patent/CH640507A5/en not_active IP Right Cessation
- 1981-10-13 CH CH655481A patent/CH637107A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI67698B (en) | 1985-01-31 |
DE2623314A1 (en) | 1977-12-08 |
IL52148A (en) | 1982-07-30 |
ZA773120B (en) | 1978-04-26 |
IT1077193B (en) | 1985-05-04 |
CH640507A5 (en) | 1984-01-13 |
NL7705587A (en) | 1977-11-29 |
CH637109A5 (en) | 1983-07-15 |
AT354421B (en) | 1979-01-10 |
AU2543477A (en) | 1978-11-30 |
DK227177A (en) | 1977-11-26 |
CH637107A5 (en) | 1983-07-15 |
SE440903B (en) | 1985-08-26 |
DE2623314C2 (en) | 1984-08-02 |
JPS5312827A (en) | 1978-02-04 |
FI771630A (en) | 1977-11-26 |
IL52148A0 (en) | 1977-07-31 |
GB1577670A (en) | 1980-10-29 |
SE7706059L (en) | 1977-11-26 |
BE855041A (en) | 1977-11-25 |
CH637108A5 (en) | 1983-07-15 |
AU511704B2 (en) | 1980-09-04 |
FR2353520B1 (en) | 1980-07-25 |
HU179198B (en) | 1982-09-28 |
CH637105A5 (en) | 1983-07-15 |
FR2353520A1 (en) | 1977-12-30 |
ATA370177A (en) | 1979-06-15 |
CA1108633A (en) | 1981-09-08 |
FI67698C (en) | 1985-05-10 |
JPS6214545B2 (en) | 1987-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990201 |