ES444900A1 - PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED. - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED.

Info

Publication number
ES444900A1
ES444900A1 ES444900A ES444900A ES444900A1 ES 444900 A1 ES444900 A1 ES 444900A1 ES 444900 A ES444900 A ES 444900A ES 444900 A ES444900 A ES 444900A ES 444900 A1 ES444900 A1 ES 444900A1
Authority
ES
Spain
Prior art keywords
fenyliminoimi
dazolidines
disustituted
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES444900A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES444900A1 publication Critical patent/ES444900A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Novel ortho- and ortho'-disubstituted 2-phenyliminoimidazolidines of the formula I are obtained by reaction of ethylenediamine with a compound of the formula II. The latter is prepared from novel 2,6-disubstituted anilines. The meaning of Z follows from Claim 1. The novel 2-phenyliminoimidazolidines have useful therapeutic, in particular hypotensive, action.
ES444900A 1974-10-01 1976-02-04 PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED. Expired ES444900A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2446758A DE2446758C3 (en) 1974-10-01 1974-10-01 2- (2-Fluoro-6-trifluoromethylphenylimino) -imidazolidine, its acid addition salts, processes for the preparation of these compounds and their use in combating hypertension

Publications (1)

Publication Number Publication Date
ES444900A1 true ES444900A1 (en) 1977-04-16

Family

ID=5927202

Family Applications (4)

Application Number Title Priority Date Filing Date
ES441385A Expired ES441385A1 (en) 1974-10-01 1975-09-30 Substituted imidazolidines and pharmaceutical uses thereo
ES444900A Expired ES444900A1 (en) 1974-10-01 1976-02-04 PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED.
ES444901A Expired ES444901A1 (en) 1974-10-01 1976-02-04 Substituted imidazolidines and pharmaceutical uses thereo
ES444898A Expired ES444898A1 (en) 1974-10-01 1976-02-04 PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES441385A Expired ES441385A1 (en) 1974-10-01 1975-09-30 Substituted imidazolidines and pharmaceutical uses thereo

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES444901A Expired ES444901A1 (en) 1974-10-01 1976-02-04 Substituted imidazolidines and pharmaceutical uses thereo
ES444898A Expired ES444898A1 (en) 1974-10-01 1976-02-04 PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED.

Country Status (27)

Country Link
JP (1) JPS6018653B2 (en)
AT (1) AT344159B (en)
BE (1) BE834051A (en)
BG (2) BG25221A3 (en)
CA (1) CA1056836A (en)
CH (5) CH620682A5 (en)
CS (1) CS193524B2 (en)
DD (1) DD123602A5 (en)
DE (1) DE2446758C3 (en)
DK (1) DK441875A (en)
ES (4) ES441385A1 (en)
FI (1) FI61883C (en)
FR (1) FR2286649A1 (en)
GB (1) GB1515019A (en)
HU (1) HU178469B (en)
IE (1) IE42130B1 (en)
IL (1) IL48214A (en)
LU (1) LU73472A1 (en)
NL (1) NL7511490A (en)
NO (1) NO143459C (en)
NZ (1) NZ178810A (en)
PH (1) PH13653A (en)
PL (2) PL97003B1 (en)
SE (1) SE418497B (en)
SU (1) SU575026A3 (en)
YU (1) YU230281A (en)
ZA (1) ZA756185B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2630060C2 (en) * 1976-07-03 1984-04-19 C.H. Boehringer Sohn, 6507 Ingelheim 2- (2-Bromo-6-fluoro-phenylimino) -imidazolidine, its acid addition salts, medicaments containing them and processes for their preparation
DE2806775A1 (en) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO IMIDAZOLIDINE THEIR ACID ADDITION SALTS, MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
DE2806811A1 (en) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO-IMIDAZOLIDINE, THEIR ACID-ADDITIONAL SALTS, THESE MEDICINAL PRODUCTS AND METHOD FOR MANUFACTURING THE SAME
CA1138451A (en) * 1979-04-03 1982-12-28 Ikuo Ueda 2-imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same
HU192986B (en) 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
CN101370500A (en) * 2006-01-27 2009-02-18 弗·哈夫曼-拉罗切有限公司 Use of 2-imidazole compounds for the treatment of CNS disorders
BRPI0806940A2 (en) 2007-02-02 2014-05-06 Hoffmann La Roche 2-AMINO-OXAZOLINES AS TAAR1 LEADERS FOR CNS DISORDERS
RU2460725C2 (en) 2007-02-15 2012-09-10 Ф. Хоффманн-Ля Рош Аг Novel 2-aminooxazolines as taar1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
EP3430010B1 (en) 2016-03-17 2020-07-15 H. Hoffnabb-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
DE1670807A1 (en) * 1967-02-17 1971-03-11 Bayer Ag Process for the preparation of cyclic guanidines
DE1670918A1 (en) * 1967-09-07 1971-04-08 Bayer Ag Process for the preparation of 2-aryl-amino-substituted nitrogen-containing heterocycles
BE787683A (en) * 1971-08-20 1973-02-19 Boehringer Sohn Ingelheim 2-PHENYLIMINO-IMIDAZOLIDINES, THEIR ADDITIONAL SALTS WITH ACIDS AND METHODS FOR MAKING THEM

Also Published As

Publication number Publication date
PL97003B1 (en) 1978-01-31
BE834051A (en) 1976-03-30
NZ178810A (en) 1978-04-03
DE2446758A1 (en) 1976-04-22
JPS5159863A (en) 1976-05-25
DD123602A5 (en) 1977-01-05
ZA756185B (en) 1977-06-29
AT344159B (en) 1978-07-10
AU8529875A (en) 1977-04-07
CH627453A5 (en) 1982-01-15
CH627454A5 (en) 1982-01-15
GB1515019A (en) 1978-06-21
NL7511490A (en) 1976-04-05
NO143459C (en) 1981-02-18
SE418497B (en) 1981-06-09
LU73472A1 (en) 1977-05-16
DK441875A (en) 1976-04-02
FI61883C (en) 1982-10-11
DE2446758C3 (en) 1979-01-04
PH13653A (en) 1980-08-21
CH627452A5 (en) 1982-01-15
IL48214A0 (en) 1975-11-25
IE42130L (en) 1976-04-01
DE2446758B2 (en) 1978-05-18
CA1056836A (en) 1979-06-19
FI752728A7 (en) 1976-04-02
IE42130B1 (en) 1980-06-04
ATA722875A (en) 1977-11-15
IL48214A (en) 1979-10-31
SU575026A3 (en) 1977-09-30
CS193524B2 (en) 1979-10-31
SE7511028L (en) 1976-04-02
ES441385A1 (en) 1977-08-01
PL98984B1 (en) 1978-06-30
FR2286649B1 (en) 1979-09-14
NO143459B (en) 1980-11-10
ES444901A1 (en) 1977-04-16
BG25221A3 (en) 1978-08-10
JPS6018653B2 (en) 1985-05-11
FR2286649A1 (en) 1976-04-30
BG25220A3 (en) 1978-08-10
CH620682A5 (en) 1980-12-15
NO753314L (en) 1976-04-02
HU178469B (en) 1982-05-28
YU230281A (en) 1982-02-28
ES444898A1 (en) 1977-05-16
CH626352A5 (en) 1981-11-13
FI61883B (en) 1982-06-30

Similar Documents

Publication Publication Date Title
ES444900A1 (en) PROCEDURE FOR THE PREPARATION OF NEW 2-FENYLIMINOIMI-DAZOLIDINES DISUSTITUTED.
ES430370A1 (en) A PROCEDURE FOR THE PREPARATION OF DE-HOMOSTEROIDS.
ES418924A1 (en) 9,11,15-Trihydroxy prost-5-enoic acid analogues
ES447011A1 (en) PROCEDURE FOR PREPARING 1,1,1, -TRIARYL-ALKYLAMINES.
ES418114A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW 5-METHYLTIO PYRIMIDINES.
ES428005A1 (en) PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 3-4-DIHI-DRO-2H-NAFTALENOM- (1) -5-OXI-PROPIL-PIPERAZINA.
ES415241A1 (en) PROCEDURE FOR THE PREPARATION OF 4- (4-BISENYLIL) -1-EV- TANOL.
GB1346787A (en) Aromatic polyamides and a method for the preparation thereof
ES445812A1 (en) PROCEDURE FOR THE PREPARATION OF NEW REPLACED ARILALCOHILAMINS.
ES430587A1 (en) PROCEDURE FOR THE PREPARATION OF 4 AMINO-3,5-DIHALOGENO-PENYLETHANOLAMINES.
ES8507506A1 (en) PROCEDURE FOR OBTAINING DIARIL-IMIDAZOLE DERIVATIVES.
GB1491184A (en) Naphthacene derivatives
BG29871A3 (en) METHOD FOR PREPARATION OF 6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-1-ISOQUINOLYLACETAMIDES
GB1341204A (en) Process for the manufacture of triarylmethane compounds
ES423546A1 (en) {62 -Pyridyl-carbonamido-alkane-sulfonic acid salts
ES428011A1 (en) PROCEDURE FOR THE PREPARATION OF 2-AMINO-3,5-DIBROMO-BENZYLAMINE.
ES428004A1 (en) Biphenyl compounds
GB1271571A (en) Basic monoazo dyes, their production and use
GB1328528A (en) Production of acylphenoxyaliphatic acid derivatives
GB1419407A (en)
ES411327A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW BENZYLPIRIMIDINS.
ES479628A1 (en) Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride
GB1470509A (en) Dihalobenzyl ethers
GB1396042A (en) Derivatives of 1-2-thienyl-2-amino-ethanol and their preparation
GB1409936A (en) Prostaglandin-type compounds