CA3135724C - Anti-CD3 antibodies, bispecific antigen-binding molecules that bind to both CD3 and CD20, and related uses - Google Patents

Anti-CD3 antibodies, bispecific antigen-binding molecules that bind to both CD3 and CD20, and related uses

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Publication number
CA3135724C
CA3135724C CA3135724A CA3135724A CA3135724C CA 3135724 C CA3135724 C CA 3135724C CA 3135724 A CA3135724 A CA 3135724A CA 3135724 A CA3135724 A CA 3135724A CA 3135724 C CA3135724 C CA 3135724C
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CA
Canada
Prior art keywords
antigen
antibody
binding
binding fragment
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3135724A
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English (en)
French (fr)
Other versions
CA3135724A1 (en
Inventor
Eric Smith
Nicholas J. Papadopoulos
Original Assignee
Regeneron Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49304338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3135724(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Priority to CA3253502A priority Critical patent/CA3253502A1/en
Priority to CA3135724A priority patent/CA3135724C/en
Publication of CA3135724A1 publication Critical patent/CA3135724A1/en
Application granted granted Critical
Publication of CA3135724C publication Critical patent/CA3135724C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Secondary Cells (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Prostheses (AREA)
  • Liquid Crystal Substances (AREA)
CA3135724A 2012-09-21 2013-09-19 Anti-CD3 antibodies, bispecific antigen-binding molecules that bind to both CD3 and CD20, and related uses Active CA3135724C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA3253502A CA3253502A1 (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
CA3135724A CA3135724C (en) 2012-09-21 2013-09-19 Anti-CD3 antibodies, bispecific antigen-binding molecules that bind to both CD3 and CD20, and related uses

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201261704029P 2012-09-21 2012-09-21
US61/704,029 2012-09-21
US201361753461P 2013-01-17 2013-01-17
US61/753,461 2013-01-17
US201361763110P 2013-02-11 2013-02-11
US61/763,110 2013-02-11
US201361827098P 2013-05-24 2013-05-24
US61/827,098 2013-05-24
CA2885156A CA2885156C (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
CA3135724A CA3135724C (en) 2012-09-21 2013-09-19 Anti-CD3 antibodies, bispecific antigen-binding molecules that bind to both CD3 and CD20, and related uses

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2885156A Division CA2885156C (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3253502A Division CA3253502A1 (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Publications (2)

Publication Number Publication Date
CA3135724A1 CA3135724A1 (en) 2014-03-27
CA3135724C true CA3135724C (en) 2025-07-08

Family

ID=49304338

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3135724A Active CA3135724C (en) 2012-09-21 2013-09-19 Anti-CD3 antibodies, bispecific antigen-binding molecules that bind to both CD3 and CD20, and related uses
CA2885156A Active CA2885156C (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
CA3253502A Pending CA3253502A1 (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2885156A Active CA2885156C (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
CA3253502A Pending CA3253502A1 (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Country Status (34)

Country Link
US (6) US9657102B2 (enExample)
EP (3) EP3778641B1 (enExample)
JP (7) JP6923292B2 (enExample)
KR (2) KR102163136B1 (enExample)
CN (3) CN110041429B (enExample)
AR (1) AR092612A1 (enExample)
AU (3) AU2013318059C1 (enExample)
BR (1) BR112015005380B1 (enExample)
CA (3) CA3135724C (enExample)
CL (3) CL2015000713A1 (enExample)
CO (1) CO7400860A2 (enExample)
DK (2) DK2897981T5 (enExample)
EA (1) EA033400B1 (enExample)
ES (2) ES2968913T3 (enExample)
FI (2) FI3778641T3 (enExample)
HR (2) HRP20240149T1 (enExample)
HU (2) HUE065481T2 (enExample)
IL (2) IL237301B (enExample)
JO (3) JOP20200236A1 (enExample)
LT (2) LT2897981T (enExample)
MX (2) MX373931B (enExample)
MY (1) MY179577A (enExample)
NZ (2) NZ706232A (enExample)
PH (2) PH12019502070B1 (enExample)
PL (2) PL3778641T3 (enExample)
PT (2) PT3778641T (enExample)
RS (2) RS64378B1 (enExample)
SG (3) SG10202111095XA (enExample)
SI (2) SI2897981T1 (enExample)
SM (2) SMT202300226T1 (enExample)
TW (4) TWI688573B (enExample)
UY (1) UY35042A (enExample)
WO (1) WO2014047231A1 (enExample)
ZA (2) ZA201501097B (enExample)

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