IL237301B - Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof - Google Patents

Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Info

Publication number
IL237301B
IL237301B IL237301A IL23730115A IL237301B IL 237301 B IL237301 B IL 237301B IL 237301 A IL237301 A IL 237301A IL 23730115 A IL23730115 A IL 23730115A IL 237301 B IL237301 B IL 237301B
Authority
IL
Israel
Prior art keywords
antibodies
bind
binding molecules
bispecific antigen
bispecific
Prior art date
Application number
IL237301A
Other languages
Hebrew (he)
Other versions
IL237301A0 (en
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49304338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL237301(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IL237301A0 publication Critical patent/IL237301A0/en
Publication of IL237301B publication Critical patent/IL237301B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Secondary Cells (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Prostheses (AREA)
IL237301A 2012-09-21 2015-02-18 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof IL237301B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261704029P 2012-09-21 2012-09-21
US201361753461P 2013-01-17 2013-01-17
US201361763110P 2013-02-11 2013-02-11
US201361827098P 2013-05-24 2013-05-24
PCT/US2013/060511 WO2014047231A1 (en) 2012-09-21 2013-09-19 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Publications (2)

Publication Number Publication Date
IL237301A0 IL237301A0 (en) 2015-04-30
IL237301B true IL237301B (en) 2020-08-31

Family

ID=49304338

Family Applications (2)

Application Number Title Priority Date Filing Date
IL237301A IL237301B (en) 2012-09-21 2015-02-18 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
IL268369A IL268369B (en) 2012-09-21 2019-07-30 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL268369A IL268369B (en) 2012-09-21 2019-07-30 Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof

Country Status (34)

Country Link
US (4) US9657102B2 (en)
EP (3) EP4309740A3 (en)
JP (6) JP6923292B2 (en)
KR (2) KR102470709B1 (en)
CN (3) CN113980132A (en)
AR (1) AR092612A1 (en)
AU (3) AU2013318059C1 (en)
BR (1) BR112015005380B1 (en)
CA (2) CA2885156C (en)
CL (3) CL2015000713A1 (en)
CO (1) CO7400860A2 (en)
DK (2) DK2897981T5 (en)
EA (1) EA033400B1 (en)
ES (2) ES2968913T3 (en)
FI (2) FI3778641T3 (en)
HK (1) HK1212996A1 (en)
HR (2) HRP20240149T1 (en)
HU (2) HUE065481T2 (en)
IL (2) IL237301B (en)
JO (3) JOP20200236A1 (en)
LT (2) LT2897981T (en)
MX (2) MX2015003206A (en)
MY (1) MY179577A (en)
NZ (2) NZ742078A (en)
PH (2) PH12015500328B1 (en)
PL (2) PL2897981T3 (en)
PT (2) PT2897981T (en)
RS (2) RS65123B1 (en)
SG (3) SG10202111095XA (en)
SI (2) SI3778641T1 (en)
TW (4) TWI618716B (en)
UY (1) UY35042A (en)
WO (1) WO2014047231A1 (en)
ZA (2) ZA201501097B (en)

Families Citing this family (278)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101874042B9 (en) 2007-09-26 2019-01-01 中外制药株式会社 Method for changing isoelectric point of antibody by using amino acid substitution of CDR
EP4303236A3 (en) 2010-11-30 2024-03-20 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
EP2747781B1 (en) 2011-08-23 2017-11-15 Roche Glycart AG Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
TWI679212B (en) 2011-11-15 2019-12-11 美商安進股份有限公司 Binding molecules for e3 of bcma and cd3
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
WO2014056783A1 (en) 2012-10-08 2014-04-17 Roche Glycart Ag Fc-free antibodies comprising two fab-fragments and methods of use
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10738132B2 (en) 2013-01-14 2020-08-11 Xencor, Inc. Heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
TWI682941B (en) 2013-02-01 2020-01-21 美商再生元醫藥公司 Antibodies comprising chimeric constant domains
ES2775207T3 (en) 2013-02-26 2020-07-24 Roche Glycart Ag CD3 and CEA specific bispecific T lymphocyte activating antigen binding molecules
JP6499087B2 (en) 2013-02-26 2019-04-10 ロシュ グリクアート アーゲー Bispecific T cell activation antigen binding molecule
AR095374A1 (en) 2013-03-15 2015-10-14 Amgen Res (Munich) Gmbh UNION MOLECULES FOR BCMA AND CD3
US10519242B2 (en) 2013-03-15 2019-12-31 Xencor, Inc. Targeting regulatory T cells with heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
EP3421495A3 (en) 2013-03-15 2019-05-15 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
AR095196A1 (en) 2013-03-15 2015-09-30 Regeneron Pharma SERUM FREE CELL CULTIVATION MEDIA
KR101815265B1 (en) * 2013-06-20 2018-01-04 한올바이오파마주식회사 FcRn specific human antibody and composition for treatment of autoimmune diseases
EP3024851B1 (en) 2013-07-25 2018-05-09 CytomX Therapeutics, Inc. Multispecific antibodies, multispecific activatable antibodies and methods of using the same
DK3736292T3 (en) 2013-12-17 2024-07-22 Genentech Inc Anti-CD3 Antibodies and Methods of Use
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
TWI680138B (en) 2014-01-23 2019-12-21 美商再生元醫藥公司 Human antibodies to pd-l1
EP3105252B1 (en) 2014-02-12 2019-07-24 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
TWI754319B (en) * 2014-03-19 2022-02-01 美商再生元醫藥公司 Methods and antibody compositions for tumor treatment
BR112016022385A2 (en) 2014-03-28 2018-06-19 Xencor, Inc specific antibodies that bind to cd38 and cd3
WO2015153912A1 (en) 2014-04-03 2015-10-08 Igm Biosciences, Inc. Modified j-chain
CA2943943C (en) 2014-04-07 2023-01-10 Chugai Seiyaku Kabushiki Kaisha Immunoactivating antigen-binding molecule
SG11201609370QA (en) 2014-05-13 2016-12-29 Chugai Pharmaceutical Co Ltd T cell-redirected antigen-binding molecule for cells having immunosuppression function
CN107108738A (en) * 2014-07-25 2017-08-29 西托姆克斯治疗公司 Anti-cd 3 antibodies, it anti-cd 3 antibodies, polyspecific anti-cd 3 antibodies, polyspecific can be activated can activate anti-cd 3 antibodies and its application method
PL3177643T3 (en) 2014-08-04 2019-09-30 F.Hoffmann-La Roche Ag Bispecific t cell activating antigen binding molecules
WO2016019969A1 (en) 2014-08-08 2016-02-11 Ludwig-Maximilians-Universität München Subcutaneously administered bispecific antibodies for use in the treatment of cancer
AR101846A1 (en) 2014-09-12 2017-01-18 Genentech Inc ANTI-CLL-1 ANTIBODIES AND IMMUNOCATE PLAYERS
CA2963991A1 (en) 2014-09-29 2016-04-07 Duke University Bispecific molecules comprising an hiv-1 envelope targeting arm
WO2016077720A1 (en) * 2014-11-14 2016-05-19 Protein One, Llc Binding agents and uses thereof
EP3699198A1 (en) * 2014-11-17 2020-08-26 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using cd3xcd20 bispecific antibody
DK3789402T3 (en) 2014-11-20 2022-09-19 Hoffmann La Roche Combination therapy with T-cell-activating bispecific antigen-binding molecules and PD-1 axis-binding antagonists
RS60615B1 (en) 2014-11-20 2020-08-31 Hoffmann La Roche Common light chains and methods of use
CN113016720B (en) 2014-11-24 2023-02-21 瑞泽恩制药公司 Non-human animals expressing humanized CD3 complexes
CN110894240B (en) 2014-11-26 2022-04-15 森科股份有限公司 Heterodimeric antibodies that bind CD3 and tumor antigens
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
AU2015353416C1 (en) 2014-11-26 2022-01-27 Xencor, Inc. Heterodimeric antibodies that bind CD3 and CD38
AR102918A1 (en) 2014-12-05 2017-04-05 Genentech Inc ANTI-CD79B ANTIBODIES AND METHODS OF USE
DK3029137T3 (en) 2014-12-06 2019-04-08 Gemoab Monoclonals Gmbh GENETICALLY MODIFIED PLURI OR MULTIPOTENT STEM CELLS AND USE THEREOF
WO2016089610A1 (en) 2014-12-06 2016-06-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
WO2016105450A2 (en) 2014-12-22 2016-06-30 Xencor, Inc. Trispecific antibodies
JP6853176B2 (en) * 2015-01-08 2021-03-31 ゲンマブ エー／エス Bispecific antibody against CD3 and CD20
BR112017018941B8 (en) * 2015-03-04 2023-01-10 Igm Biosciences Inc CD20-BINDING MOLECULE, ITS USE, COMPOSITION AND METHOD IN VITRO TO DIRECTION COMPLEMENT-MEDIATED DEATH OF A CELL THAT EXPRESSES CD20
WO2016141387A1 (en) 2015-03-05 2016-09-09 Xencor, Inc. Modulation of t cells with bispecific antibodies and fc fusions
WO2016149710A2 (en) 2015-03-19 2016-09-22 Duke University Hiv-1 neutralizing antibodies and uses thereof
AU2016232693B2 (en) 2015-03-19 2021-08-12 Duke University HIV-1 neutralizing antibodies and uses thereof
US10450368B2 (en) 2015-03-19 2019-10-22 Duke University HIV-1 neutralizing antibodies and uses thereof (CD4bs antibodies)
US10344077B2 (en) 2015-03-19 2019-07-09 Duke University HIV-1 neutralizing antibodies and uses thereof (V3 antibodies)
US10556952B2 (en) 2015-03-30 2020-02-11 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to Fc gamma receptors
SG11201708620QA (en) * 2015-05-08 2017-11-29 Xencor Inc Heterodimeric antibodies that bind cd3 and tumor antigens
EA039429B1 (en) * 2015-05-13 2022-01-26 Ридженерон Фармасьютикалз, Инк. Methods for tumor treatment using cd3cd20 bispecific antibody
EP3297672B1 (en) 2015-05-21 2021-09-01 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
EP3795679A1 (en) 2015-05-28 2021-03-24 Genentech, Inc. Cell-based assay for detecting anti-cd3 homodimers
CN104931699A (en) * 2015-05-29 2015-09-23 北京海思特临床检验所有限公司 Bone marrow smear atypical lymphocyte staining kit and application method thereof
KR20180023949A (en) * 2015-06-09 2018-03-07 메모리얼 슬로안-케터링 캔서 센터 A T cell receptor-like antibody agonist specific for EBV latent membrane protein 2A peptides presented by human HLA
AR105026A1 (en) 2015-06-16 2017-08-30 Genentech Inc ANTIBODIES MATURED BY AFFINITY AND HUMANIZED FOR FcRH5 AND METHODS FOR USE
US10501545B2 (en) 2015-06-16 2019-12-10 Genentech, Inc. Anti-CLL-1 antibodies and methods of use
HUE057952T2 (en) 2015-06-24 2022-06-28 Hoffmann La Roche Anti-transferrin receptor antibodies with tailored affinity
WO2017005649A1 (en) * 2015-07-09 2017-01-12 Genmab A/S Bispecific and multispecific antibodies and method for isolation of such
TWI796283B (en) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Antibody constructs for msln and cd3
JOP20160154B1 (en) 2015-07-31 2021-08-17 Regeneron Pharma Anti-psma antibodies, bispecific antigen-binding molecules that bind psma and cd3, and uses thereof
TWI829617B (en) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Antibody constructs for flt3 and cd3
TW202340452A (en) 2015-08-04 2023-10-16 美商再生元醫藥公司 Taurine supplemented cell culture medium and methods of use
EP3352760A4 (en) * 2015-09-21 2019-03-06 Aptevo Research and Development LLC Cd3 binding polypeptides
ES2901133T3 (en) * 2015-09-23 2022-03-21 Regeneron Pharma Optimized anti-CD3 bispecific antibodies and uses thereof
US10618978B2 (en) 2015-09-30 2020-04-14 Igm Biosciences, Inc. Binding molecules with modified J-chain
WO2017059387A1 (en) 2015-09-30 2017-04-06 Igm Biosciences, Inc. Binding molecules with modified j-chain
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
EP3356410B1 (en) 2015-10-02 2021-10-20 F. Hoffmann-La Roche AG Bispecific anti-ceaxcd3 t cell activating antigen binding molecules
JP6657392B2 (en) 2015-10-02 2020-03-04 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Bispecific anti-human CD20 / human transferrin receptor antibodies and methods of use
AR106189A1 (en) 2015-10-02 2017-12-20 Hoffmann La Roche BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE
TWI756187B (en) 2015-10-09 2022-03-01 美商再生元醫藥公司 Anti-lag3 antibodies and uses thereof
CR20180288A (en) 2015-10-25 2018-09-11 Us Health THREE-SPECIFIC AND / OR TRIVALENT UNION PROTEINS FOR THE PREVENTION OR TREATMENT OF HIV INFECTION
US11660340B2 (en) 2015-11-18 2023-05-30 Chugai Seiyaku Kabushiki Kaisha Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
US11649293B2 (en) 2015-11-18 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
CN106810611A (en) * 2015-11-30 2017-06-09 中国科学院深圳先进技术研究院 Double targeting antibodies of anti-cMet and CD3 specificity and its preparation method and application, the minicircle dna containing this pair of targeting antibodies expression cassette and application
CN106810610A (en) * 2015-11-30 2017-06-09 中国科学院深圳先进技术研究院 Anti-EpCAM and the double targeting antibodies of CD3 specificity and its preparation method and application, the minicircle dna containing this pair of targeting antibodies expression cassette and application
JP7058219B2 (en) 2015-12-07 2022-04-21 ゼンコア インコーポレイテッド Heterodimer antibody that binds to CD3 and PSMA
AU2016368469B2 (en) 2015-12-09 2023-11-02 F. Hoffmann-La Roche Ag Type II anti-CD20 antibody for reducing formation of anti-drug antibodies
WO2017112775A1 (en) 2015-12-22 2017-06-29 Regeneron Pharmaceuticals, Inc. Combination of anti-pd-1 antibodies and bispecific anti-cd20/anti-cd3 antibodies to treat cancer
AR107303A1 (en) 2016-01-08 2018-04-18 Hoffmann La Roche METHODS OF TREATMENT OF POSITIVE CANCER FOR ACE USING ANTAGONISTS OF AXISION TO AXIS PD-1 AND ANTI-ACE / ANTI-CD3, USE, COMPOSITION, KIT
WO2017132279A1 (en) 2016-01-25 2017-08-03 Genentech, Inc. Methods for assaying t-cell dependent bispecific antibodies
EA039859B1 (en) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Bispecific antibody constructs binding egfrviii and cd3
MX2018010988A (en) * 2016-03-14 2019-01-21 Chugai Pharmaceutical Co Ltd Cell injury inducing therapeutic drug for use in cancer therapy.
SI3433280T1 (en) 2016-03-22 2023-07-31 F. Hoffmann-La Roche Ag Protease-activated t cell bispecific molecules
JP7195929B2 (en) 2016-04-13 2022-12-26 サノフイ Trispecific and/or trivalent binding proteins
MY192090A (en) 2016-04-13 2022-07-26 Sanofi Sa Trispecific and/or trivalent binding proteins
CA3015389A1 (en) 2016-04-20 2017-10-26 Regeneron Pharmaceuticals, Inc. Compositions and methods for making antibodies based on use of expression-enhancing loci
KR20180134894A (en) 2016-04-20 2018-12-19 리제너론 파마슈티칼스 인코포레이티드 Compositions and methods for making antibodies based on the use of expression-enhancing loci
TW202408578A (en) 2016-05-13 2024-03-01 美商再生元醫藥公司 Methods of treating skin cancer by administering a pd-1 inhibitor
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
BR112018073761A2 (en) * 2016-05-20 2019-02-26 Harpoon Therapeutics, Inc. single chain variable fragment cd3 binding proteins
SG11201810327XA (en) 2016-05-20 2018-12-28 Harpoon Therapeutics Inc Single domain serum albumin binding protein
KR20220148306A (en) * 2016-05-27 2022-11-04 알토 바이오사이언스 코포레이션 Construction and characterization of multimeric il-15-based molecules with cd3 binding domains
EP3252078A1 (en) 2016-06-02 2017-12-06 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
CN110603266A (en) 2016-06-02 2019-12-20 豪夫迈·罗氏有限公司 Type II anti-CD 20 and anti-CD 20/CD3 bispecific antibodies for the treatment of cancer
CA3026151A1 (en) 2016-06-14 2017-12-21 Xencor, Inc. Bispecific checkpoint inhibitor antibodies
EP3471753A1 (en) 2016-06-20 2019-04-24 Kymab Limited Anti-pd-l1 and il-2 cytokines
US11613572B2 (en) * 2016-06-21 2023-03-28 Teneobio, Inc. CD3 binding antibodies
WO2017219974A1 (en) 2016-06-22 2017-12-28 本康生物制药（深圳）有限公司 Bispecific antibody and antibody conjugate for tumour therapy and use thereof
EP3475304B1 (en) 2016-06-28 2022-03-23 Xencor, Inc. Heterodimeric antibodies that bind somatostatin receptor 2
CN107573416A (en) * 2016-06-30 2018-01-12 中国科学院深圳先进技术研究院 The double targeting antibodies of anti-IGF1R and CD3 specificity, the minicircle dna containing this pair of targeting antibodies expression cassette and application
US11555177B2 (en) 2016-07-13 2023-01-17 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
CN107759694B (en) * 2016-08-19 2023-01-13 安源医药科技（上海）有限公司 Bispecific antibody, preparation method and application thereof
EP3504328A1 (en) 2016-08-24 2019-07-03 Regeneron Pharmaceuticals, Inc. Host cell protein modification
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
CR20220408A (en) 2016-09-14 2022-10-20 Teneobio Inc Cd3 binding antibodies
RS63660B1 (en) * 2016-09-23 2022-11-30 Regeneron Pharma Anti-muc16 (mucin 16) antibodies
CA3037732A1 (en) 2016-09-23 2018-03-29 Regeneron Pharmaceuticals, Inc. Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof
JP2019529499A (en) * 2016-09-30 2019-10-17 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ Antibody-based gene therapy using tissue-directed expression
WO2018060301A1 (en) 2016-09-30 2018-04-05 F. Hoffmann-La Roche Ag Bispecific antibodies against cd3
PE20191034A1 (en) 2016-10-14 2019-08-05 Xencor Inc BISPECIFIC HETERODIMERIC FUSION PROTEINS CONTAINING FC IL-15 / IL-15R FUSION PROTEINS AND PD-1 ANTIBODY FRAGMENTS
MX2019005438A (en) * 2016-11-15 2019-08-16 Genentech Inc Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies.
CA3044659A1 (en) 2016-11-23 2018-05-31 Harpoon Therapeutics, Inc. Prostate specific membrane antigen binding protein
US10844134B2 (en) 2016-11-23 2020-11-24 Harpoon Therapeutics, Inc. PSMA targeting trispecific proteins and methods of use
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
CN118557758A (en) 2017-02-10 2024-08-30 瑞泽恩制药公司 Radiolabeled anti-LAG 3 antibodies for immune-PET imaging
US11292842B2 (en) 2017-02-21 2022-04-05 Regeneron Pharmaceuticals, Inc. Anti-PD-1 antibodies for treatment of lung cancer
CN110325209A (en) 2017-02-24 2019-10-11 宏观基因有限公司 CD137 and the bi-specific binding molecule of tumour antigen and application thereof can be combined
WO2018160754A2 (en) 2017-02-28 2018-09-07 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
EP3604340A4 (en) * 2017-03-24 2021-01-06 Zenyaku Kogyo Co., Ltd ANTI-IgM/B CELL SURFACE ANTIGEN BISPECIFIC ANTIBODY
EP4108183A1 (en) 2017-03-30 2022-12-28 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
CA3063362A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
CA3063359A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Mesothelin binding proteins
EP3409322A1 (en) 2017-06-01 2018-12-05 F. Hoffmann-La Roche AG Treatment method
CN110945026B (en) 2017-06-20 2024-03-19 特纳奥尼股份有限公司 Heavy chain-only anti-BCMA antibodies
IL312322A (en) 2017-06-20 2024-06-01 Teneobio Inc Anti-bcma heavy chain-only antibodies
AU2018291497A1 (en) 2017-06-30 2020-01-16 Xencor, Inc. Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
SG11201912548XA (en) 2017-07-06 2020-01-30 Regeneron Pharma Cell culture process for making a glycoprotein
EP3676294A4 (en) * 2017-08-28 2021-12-22 Systimmune, Inc. Anti-cd3 antibodies and methods of making and using thereof
WO2019060823A1 (en) * 2017-09-22 2019-03-28 The Regents Of The University Of California Interferon-gamma attenuates anti-tumor immune response to checkpoint blockade
BR112020004977A2 (en) * 2017-09-29 2020-10-06 Regeneron Pharmaceuticals, Inc. bispecific antigen binding molecules that bind staphyocococcus target antigen and complement component and uses thereof
JP7066837B2 (en) 2017-10-13 2022-05-13 ハープーン セラピューティクス，インク． B cell maturation antigen binding protein
PT3694529T (en) 2017-10-13 2024-09-20 Harpoon Therapeutics Inc Trispecific proteins and methods of use
JP7438106B2 (en) 2017-10-14 2024-02-26 シートムエックス セラピューティクス，インコーポレイテッド Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
KR101973060B1 (en) * 2017-10-20 2019-04-26 주식회사 녹십자 Antibody against cd3 and pharmaceutical composition for treating cancer comprising the same
EP3706793A1 (en) 2017-11-08 2020-09-16 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-pd-1 sequences
US10981992B2 (en) 2017-11-08 2021-04-20 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
JP2021506291A (en) 2017-12-19 2021-02-22 ゼンコア インコーポレイテッド Modified IL-2 FC fusion protein
JOP20200157A1 (en) 2017-12-22 2022-10-30 Teneobio Inc Heavy chain antibodies binding to cd22
BR112020010615A2 (en) 2017-12-22 2020-10-27 Regeneron Pharmaceuticals, Inc. protein pharmaceutical product, method and system for characterizing protein pharmaceutical product and low molecular weight impurities, method for producing an antibody, antibody, and, method and system uses
MX2020008095A (en) 2018-01-31 2020-09-24 Regeneron Pharma System and method for characterizing size and charge variant drug product impurities.
TWI786265B (en) 2018-02-02 2022-12-11 美商再生元醫藥公司 System and method for characterizing protein dimerization
AR115360A1 (en) 2018-02-08 2021-01-13 Genentech Inc ANTIGEN BINDING MOLECULES AND METHODS OF USE
CA3090840A1 (en) 2018-02-09 2019-08-15 Genmab A/S Pharmaceutical compositions comprising bispecific antibodies directed against cd3 and cd20 and their uses
BR112020013426A2 (en) 2018-02-28 2020-12-01 Regeneron Pharmaceuticals, Inc. methods for identifying a virus in a sample and for detecting viral nucleic acids in a cell culture sample
BR112020015291B1 (en) 2018-03-19 2023-09-26 Regeneron Pharmaceuticals, Inc AQUEOUS ELECTROPHORESIS SAMPLE BUFFER, METHOD FOR IDENTIFYING CONTAMINANTS OR IMPURITIES IN A PROTEIN DRUG SAMPLE, AND, KIT
CA3096052A1 (en) 2018-04-04 2019-10-10 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
US11524991B2 (en) 2018-04-18 2022-12-13 Xencor, Inc. PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof
CA3097741A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
TW202016125A (en) 2018-05-10 2020-05-01 美商再生元醫藥公司 Systems and methods for quantifying and modifying protein viscosity
CR20200568A (en) * 2018-05-24 2021-02-26 Janssen Biotech Inc Anti-cd3 antibodies and uses thereof
CN110540593B (en) * 2018-05-29 2022-05-17 上海药明生物技术有限公司 Novel anti-CD 3/anti-CD 20 bispecific antibodies
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US20230009902A1 (en) 2018-06-20 2023-01-12 Progenity, Inc. Treatment of a disease or condition in a tissue orginating from the endoderm
US11548947B2 (en) 2018-06-21 2023-01-10 Regeneron Pharmaceuticals, Inc. Bispecific anti-PSMA X anti-CD28 antibodies and uses thereof
TWI838389B (en) 2018-07-19 2024-04-11 美商再生元醫藥公司 BISPECIFIC ANTI-BCMAxANTI-CD3 ANTIBODIES AND USES THEREOF
EA202190601A1 (en) * 2018-08-23 2021-07-14 Ридженерон Фармасьютикалз, Инк. ANTI-Fc ANTIBODIES EPSILON-R1 ALPHA (FCER1A), BISPECIFIC ANTIGEN-BINDING MOLECULES BINDING FCΕR1Α AND CD3 AND THEIR APPLICATION
SG11202011970TA (en) 2018-08-27 2020-12-30 Regeneron Pharma Use of raman spectroscopy in downstream purification
MX2021002281A (en) 2018-08-30 2021-05-27 Regeneron Pharma Methods for characterizing protein complexes.
CA3110513A1 (en) * 2018-08-31 2020-03-05 Regeneron Pharmaceuticals, Inc. Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies
WO2020069028A1 (en) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
SG11202103192RA (en) 2018-10-03 2021-04-29 Xencor Inc Il-12 heterodimeric fc-fusion proteins
KR20210111243A (en) 2018-10-31 2021-09-10 리제너론 파아마슈티컬스, 인크. Methods and systems for identifying and quantifying proteins
KR20210095165A (en) 2018-11-19 2021-07-30 프로제너티, 인크. Methods and devices for treating diseases with biopharmaceuticals
US11249089B2 (en) 2018-12-12 2022-02-15 Regeneron Pharmaceuticals, Inc. System and method of analysis of a protein using liquid chromatography-mass spectrometry
EP3898695A1 (en) 2018-12-19 2021-10-27 Regeneron Pharmaceuticals, Inc. Bispecific anti-muc16 x anti-cd28 antibodies and uses thereof
WO2020132066A1 (en) 2018-12-19 2020-06-25 Regeneron Pharmaceuticals, Inc. Bispecific anti-cd28 x anti-cd22 antibodies and uses thereof
CN113272651B (en) 2019-01-16 2023-06-16 瑞泽恩制药公司 Method for identifying free sulfhydryl groups in proteins
CN113660956A (en) * 2019-01-28 2021-11-16 Ab诊疗公司 Bispecific antibodies and uses thereof
US20220106398A1 (en) * 2019-02-08 2022-04-07 Igm Biosciences, Inc. Anti-gitr antigen-binding domains and uses thereof
AU2020223205A1 (en) 2019-02-12 2021-08-05 Regeneron Pharmaceuticals, Inc. Compositions and methods for using bispecific antibodies to bind complement and a target antigen
AU2020227580A1 (en) * 2019-02-25 2021-09-30 Pharmabcine Inc. Anti-Ang2 antibody and use thereof
JP2022523946A (en) 2019-03-01 2022-04-27 ゼンコア インコーポレイテッド Heterodimer antibody that binds to ENPP3 and CD3
CN113474653A (en) * 2019-03-08 2021-10-01 豪夫迈·罗氏有限公司 Method for detecting and quantifying membrane-associated proteins on extracellular vesicles
CA3134335A1 (en) 2019-03-22 2020-10-01 Regeneron Pharmaceuticals, Inc. Egfr x cd28 multispecific antibodies
TW202039578A (en) 2019-03-29 2020-11-01 荷蘭商美勒斯公司 Cd3 binding molecules
MA55551A (en) * 2019-04-04 2022-02-09 Janssen Biotech Inc ANTI-HLA-C ANTIBODIES AND THEIR USES
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof
JP7541534B2 (en) 2019-05-13 2024-08-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Improved competitive ligand binding assays
KR20230031981A (en) 2019-05-14 2023-03-07 프로벤션 바이오, 인코포레이티드 Methods and compositions for preventing type 1 diabetes
KR20220035368A (en) * 2019-06-07 2022-03-22 아디맵 엘엘씨 Engineered PH-dependent anti-CD3 antibodies, and methods of making and using the same
CA3140816A1 (en) 2019-06-14 2020-12-17 Nathan Trinklein Multispecific heavy chain antibodies binding to cd22 and cd3
CN112111012B (en) * 2019-06-20 2023-07-04 成都恩沐生物科技有限公司 Covalent multispecific antibodies
WO2020257681A1 (en) 2019-06-21 2020-12-24 Regeneron Pharmaceuticals, Inc. Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation
DE102019121007A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Antigen binding proteins that specifically bind to MAGE-A
JP2022548823A (en) 2019-08-15 2022-11-22 ジェンマブ エー／エス Pharmaceutical compositions comprising bispecific antibodies against CD3 and CD20 and uses thereof
TW202120553A (en) 2019-08-15 2021-06-01 美商再生元醫藥公司 Multispecific antigen-binding molecules for cell targeting and uses thereof
CN112390882A (en) * 2019-08-19 2021-02-23 杨洋 Bispecific antibody targeting CD3 and CD20 and application thereof
RU2738802C1 (en) * 2019-08-21 2020-12-17 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Complementarity-determining regions for binding cd3 and a bispecific antigen-binding molecule containing thereof
US20220323937A1 (en) 2019-09-24 2022-10-13 Regeneron Pharmaceuticals, Inc. Systems and methods for chromatography use and regeneration
IL293112A (en) 2019-11-25 2022-07-01 Regeneron Pharma Sustained release formulations using non-aqueous emulsions
AU2020398167A1 (en) 2019-12-06 2022-07-28 Regeneron Pharmaceuticals, Inc. Methods of treating multiple myeloma with bispecific anti-BCMA x anti-CD3 antibodies
WO2021112927A1 (en) 2019-12-06 2021-06-10 Regeneron Pharmaceuticals, Inc. Anti-vegf protein compositions and methods for producing the same
TW202135860A (en) 2019-12-10 2021-10-01 美商再生元醫藥公司 Stabilized formulations containing anti-cd20 x anti-cd3 bispecific antibodies
GB201918230D0 (en) 2019-12-11 2020-01-22 Prec Therapeutics Ltd Antibodies and their uses
TW202128767A (en) 2019-12-13 2021-08-01 美商建南德克公司 Anti-ly6g6d antibodies and methods of use
CN115666704A (en) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 Ingestible device for delivery of therapeutic agents to the gastrointestinal tract
CA3165060C (en) 2020-01-21 2023-06-20 Yiming Zhao Deglycosylation methods for electrophoresis of glycosylated proteins
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
BR112022016550A2 (en) 2020-02-21 2022-11-16 Harpoon Therapeutics Inc FLT3-BINDING PROTEINS AND METHODS OF USE
CN113563473A (en) 2020-04-29 2021-10-29 三生国健药业（上海）股份有限公司 Tetravalent bispecific antibody, preparation method and application thereof
JP2023526774A (en) 2020-04-29 2023-06-23 テネオバイオ， インコーポレイテッド Multispecific heavy chain antibodies with modified heavy chain constant regions
US20210341487A1 (en) 2020-05-01 2021-11-04 Regeneron Pharmaceuticals, Inc. Neutralizing antibody assay for therapeutic proteins
BR112022022730A2 (en) 2020-05-08 2023-02-14 Genmab As METHOD FOR TREATMENT OF B-CELL NON-HODGKIN LYMPHOMA IN A HUMAN INDIVIDUAL
WO2021226444A2 (en) 2020-05-08 2021-11-11 Regeneron Pharmaceuticals, Inc. Vegf traps and mini-traps and methods for treating ocular disorders and cancer
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
MX2022015872A (en) 2020-06-11 2023-05-16 Provention Bio Inc Methods and compositions for preventing type 1 diabetes.
CA3153085A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and cd19
JP2023538891A (en) 2020-08-19 2023-09-12 ゼンコア インコーポレイテッド Anti-CD28 composition
CN112062855B (en) * 2020-08-26 2024-08-30 北京天诺健成医药科技有限公司 Development and application of drug therapeutic agent containing adapter
KR20230058094A (en) 2020-08-31 2023-05-02 리제너론 파아마슈티컬스, 인크. Asparagine supply strategies to improve cell culture performance and mitigate asparagine sequence variants
AU2021341509A1 (en) 2020-09-10 2023-04-13 Genmab A/S Bispecific antibody against CD3 and CD20 in combination therapy for treating follicular lymphoma
AU2021339006A1 (en) 2020-09-10 2023-04-13 Genmab A/S Bispecific antibody against CD3 and CD20 in combination therapy for treating diffuse large B-cell lymphoma
CN116437956A (en) 2020-09-10 2023-07-14 健玛保 Bispecific antibodies against CD3 and CD20 for the treatment of chronic lymphocytic leukemia
IL301085A (en) 2020-09-10 2023-05-01 Genmab As Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
MX2023002540A (en) 2020-09-10 2023-03-14 Genmab As Bispecific antibody against cd3 and cd20 in combination therapy for treating follicular lymphoma.
KR20230084507A (en) * 2020-09-11 2023-06-13 얀센 바이오테크 인코포레이티드 Multi-specific immune targeting molecules and uses thereof
MX2023003214A (en) 2020-09-18 2023-05-24 Regeneron Pharma Antigen-binding molecules that bind cd38 and/or cd28, and uses thereof.
WO2022072762A1 (en) 2020-10-02 2022-04-07 Regeneron Pharmaceuticals, Inc. Combination of antibodies for treating cancer with reduced cytokine release syndrome
AU2021385363A1 (en) 2020-11-25 2023-06-08 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous membrane emulsification
MX2023007225A (en) 2020-12-17 2023-06-27 Regeneron Pharma Fabrication of protein-encapsulating microgels.
EP4281542A1 (en) 2021-01-20 2023-11-29 Regeneron Pharmaceuticals, Inc. Methods of improving protein titer in cell culture
JP2024506831A (en) 2021-01-28 2024-02-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Compositions and methods for treating cytokine release syndrome
AU2022230987A1 (en) 2021-03-03 2023-08-31 Regeneron Pharmaceuticals, Inc. Systems and methods for quantifying and modifying protein viscosity
AU2022232375A1 (en) 2021-03-09 2023-09-21 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
KR20230154311A (en) 2021-03-10 2023-11-07 젠코어 인코포레이티드 Heterodimeric antibodies binding to CD3 and GPC3
BR112023018665A2 (en) 2021-03-26 2023-10-03 Regeneron Pharma METHODS AND SYSTEMS FOR DEVELOPING MIXING PROTOCOLS
AU2021443318A1 (en) 2021-04-30 2023-09-07 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
JP2024509664A (en) 2021-04-30 2024-03-05 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Medication for treatment with anti-CD20/anti-CD3 bispecific antibodies
AU2022286340A1 (en) 2021-06-01 2024-01-04 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
EP4355785A1 (en) * 2021-06-17 2024-04-24 Amberstone Biosciences, Inc. Anti-cd3 constructs and uses thereof
JP2024523033A (en) 2021-06-17 2024-06-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel trispecific binding molecules
WO2023028612A2 (en) 2021-08-27 2023-03-02 Board Of Regents, The University Of Texas System Anti-tslpr (crlf2) antibodies
WO2023039457A1 (en) 2021-09-08 2023-03-16 Regeneron Pharmaceuticals, Inc. A high-throughput and mass-spectrometry-based method for quantitating antibodies and other fc-containing proteins
EP4405390A1 (en) 2021-09-20 2024-07-31 Regeneron Pharmaceuticals, Inc. Methods of controlling antibody heterogeneity
WO2023051656A1 (en) * 2021-09-30 2023-04-06 贝达药业股份有限公司 Bispecific antibody and application thereof
CN118076894A (en) 2021-10-07 2024-05-24 里珍纳龙药品有限公司 System and method for pH modeling and control
EP4413359A1 (en) 2021-10-07 2024-08-14 Regeneron Pharmaceuticals, Inc. Ph meter calibration and correction
EP4423018A1 (en) 2021-10-26 2024-09-04 Regeneron Pharmaceuticals, Inc. Systems and methods for generating laboratory water and distributing laboratory water at different temperatures
US20230181644A1 (en) 2021-10-28 2023-06-15 Lyell Immunopharma, Inc. Methods of generating cells
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
CN116462765A (en) * 2022-01-20 2023-07-21 上海君实生物医药科技股份有限公司 anti-CD 3 and anti-CD 20 bispecific antibodies and uses thereof
WO2023150518A1 (en) 2022-02-01 2023-08-10 Sana Biotechnology, Inc. Cd3-targeted lentiviral vectors and uses thereof
WO2023177836A1 (en) 2022-03-18 2023-09-21 Regeneron Pharmaceuticals, Inc. Methods and systems for analyzing polypeptide variants
WO2023180353A1 (en) 2022-03-23 2023-09-28 F. Hoffmann-La Roche Ag Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
WO2023179716A1 (en) * 2022-03-23 2023-09-28 上海济煜医药科技有限公司 Anti-cd3 antibody, preparation method therefor and use thereof
WO2023192850A1 (en) 2022-03-29 2023-10-05 Ngm Biopharmaceuticals, Inc. Ilt3 and cd3 binding agents and methods of use thereof
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
AU2023254191A1 (en) 2022-04-11 2024-10-17 Regeneron Pharmaceuticals, Inc. Compositions and methods for universal tumor cell killing
WO2023198839A2 (en) 2022-04-13 2023-10-19 Genmab A/S Bispecific antibodies against cd3 and cd20
TW202404637A (en) 2022-04-13 2024-02-01 瑞士商赫孚孟拉羅股份公司 Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use
WO2023214960A1 (en) 2022-05-02 2023-11-09 Regeneron Pharmaceuticals, Inc. Biochemical assays for therapeutic proteins
US20230416396A1 (en) 2022-05-18 2023-12-28 Regeneron Pharmaceuticals, Inc. Multispecific antigen binding molecules that bind cd38 and 4-1bb, and uses thereof
WO2023235805A2 (en) * 2022-06-01 2023-12-07 The Wistar Institute Of Anatomy And Biology Dna-encoded bispecific antibodies targeting carbonic anhydrase 9 and methods of use in cancer therapeutics
TW202413405A (en) * 2022-07-13 2024-04-01 美商翰森生物有限責任公司 Antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
WO2024030453A1 (en) 2022-08-02 2024-02-08 Regeneron Pharmaceuticals, Inc. Methods of treating metastatic castration-resistant prostate cancer with bispecific anti-psma x anti-cd28 antibodies in combination with anti-pd-1 antibodies
WO2024044655A1 (en) 2022-08-24 2024-02-29 Sana Biotechnology, Inc. Delivery of heterologous proteins
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024088987A1 (en) 2022-10-26 2024-05-02 F. Hoffmann-La Roche Ag Combination therapy for the treatment of cancer
CN116023499B (en) * 2022-10-26 2024-01-23 北京力邦生物医药科技有限公司 Bispecific antibody for CD3 and CD20
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024123698A1 (en) 2022-12-08 2024-06-13 Regeneron Pharmaceuticals, Inc. Methods to characterizing a fragment crystallizable domain of a bispecific antibody
US20240198253A1 (en) 2022-12-16 2024-06-20 Regeneron Pharmaceuticals, Inc. Methods and systems for assessing chromatographic column integrity
WO2024158961A1 (en) 2023-01-25 2024-08-02 Regeneron Pharmaceuticals, Inc. Mass spectrometry-based characterization of antibodies co-expressed in vivo
US20240245779A1 (en) 2023-01-25 2024-07-25 Regeneron Pharmaceuticals, Inc. Methods of modeling liquid protein composition stability
US20240277844A1 (en) 2023-02-17 2024-08-22 Regeneron Pharmaceuticals, Inc. Induced nk cells responsive to cd3/taa bispecific antibodies
WO2024178213A2 (en) 2023-02-22 2024-08-29 Regeneron Pharmaceuticals, Inc. System suitability parameters and column aging
WO2024191983A1 (en) 2023-03-13 2024-09-19 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with bispecific anti-cd22 x anti-cd28 molecules

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361549A (en) 1979-04-26 1982-11-30 Ortho Pharmaceutical Corporation Complement-fixing monoclonal antibody to human T cells, and methods of preparing same
US6893625B1 (en) 1986-10-27 2005-05-17 Royalty Pharma Finance Trust Chimeric antibody with specificity to human B cell surface antigen
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
MX9204374A (en) 1991-07-25 1993-03-01 Idec Pharma Corp RECOMBINANT ANTIBODY AND METHOD FOR ITS PRODUCTION.
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
DE69329503T2 (en) 1992-11-13 2001-05-03 Idec Pharma Corp Therapeutic use of chimeric and labeled antibodies directed against a differentiation antigen, the expression of which is restricted to human B lymphocyte, for the treatment of B cell lymphoma
ES2176574T3 (en) 1996-09-03 2002-12-01 Gsf Forschungszentrum Umwelt USE OF BI AND TRIESPECIFIC ANTIBODIES FOR INDUCTION OF TUMOR IMMUNITY.
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
NZ507381A (en) 1998-04-21 2003-12-19 Micromet Ag CD19xCD3 specific polypeptides and uses thereof
ATE414536T1 (en) 1998-08-11 2008-12-15 Biogen Idec Inc COMBINATION THERAPIES AGAINST B-CELL LYMPHOMAS INCLUDING THE ADMINISTRATION OF ANTI-CD20 ANTIBODIES
US6224866B1 (en) 1998-10-07 2001-05-01 Biocrystal Ltd. Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
EP2275541B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
MXPA01011279A (en) 1999-05-07 2002-07-02 Genentech Inc Treatment of autoimmune diseases with antagonists which bind to b cell surface markers.
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
ITMI991299A1 (en) 1999-06-11 2000-12-11 Consiglio Nazionale Ricerche USE OF ANTIBODIES AGAINST SURFACE ANTIGENS FOR THE TREATMENT OF DISEASE TRANSPLANT AGAINST GUESTS
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
CA2476166C (en) 2002-02-14 2011-11-15 Immunomedics, Inc. Anti-cd20 antibodies and fusion proteins thereof and methods of use
EP1400534B1 (en) * 2002-09-10 2015-10-28 Affimed GmbH Human CD3-specific antibody with immunosuppressive properties
MXPA05004022A (en) 2002-10-17 2005-10-05 Genmab As Human monoclonal antibodies against cd20.
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
AU2004252067B2 (en) 2003-05-09 2012-04-12 Duke University CD20-specific antibodies and methods of employing same
AR044388A1 (en) 2003-05-20 2005-09-07 Applied Molecular Evolution CD20 UNION MOLECULES
EP1629011B1 (en) * 2003-05-31 2010-01-13 Micromet AG Human anti-human cd3 binding molecules
CA2522894C (en) * 2003-05-31 2013-06-25 Micromet Ag Pharmaceutical composition comprising a bispecific antibody specific for epcam
AU2004270165A1 (en) 2003-08-29 2005-03-17 Genentech, Inc. Anti-CD20 therapy of ocular disorders
CA2542239C (en) * 2003-10-16 2014-12-30 Micromet Ag Multispecific deimmunized cd3-binders
AU2004303848A1 (en) 2003-12-19 2005-07-07 Genentech, Inc. Detection of CD20 in transplant rejection
US7339198B2 (en) 2004-01-16 2008-03-04 Yu-Nung Shen Light-emitting diode chip package body and packaging method thereof
WO2005103081A2 (en) 2004-04-20 2005-11-03 Genmab A/S Human monoclonal antibodies against cd20
EP1773393A2 (en) 2004-05-05 2007-04-18 Genentech, Inc. Preventing autoimmune disease by using an anti-cd20 antibody
SG155883A1 (en) 2004-06-03 2009-10-29 Novimmune Sa Anti-cd3 antibodies and methods of use thereof
EP1765400A2 (en) 2004-06-04 2007-03-28 Genentech, Inc. Method for treating lupus
ZA200702335B (en) 2004-10-05 2009-05-27 Genentech Inc Method for treating vasculitis
TW200714289A (en) 2005-02-28 2007-04-16 Genentech Inc Treatment of bone disorders
AR053579A1 (en) 2005-04-15 2007-05-09 Genentech Inc TREATMENT OF INTESTINAL INFLAMMATORY DISEASE (IBD)
MX2007012989A (en) 2005-04-22 2008-01-11 Genentech Inc Method for treating dementia or alzheimer's disease with a cd20 antibody.
US20070014720A1 (en) 2005-06-02 2007-01-18 Gadi Gazit-Bornstein Antibodies directed to CD20 and uses thereof
MY169746A (en) * 2005-08-19 2019-05-14 Abbvie Inc Dual variable domain immunoglobulin and uses thereof
EP2500356A3 (en) * 2005-08-19 2012-10-24 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP3770174A1 (en) * 2005-10-11 2021-01-27 Amgen Research (Munich) GmbH Compositions comprising cross-species-specific antibodies and uses thereof
EP1820513A1 (en) * 2006-02-15 2007-08-22 Trion Pharma Gmbh Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
PL2041177T3 (en) 2006-06-02 2012-09-28 Regeneron Pharma High affinity antibodies to human il-6 receptor
NO347649B1 (en) * 2006-12-14 2024-02-12 Regeneron Pharma Human antibody or antibody fragment that specifically binds human delta-like ligand 4 (hDII4), nucleic acid molecule that codes for such and vector and host-vector systems, as well as method for production, composition and use.
PL2155788T3 (en) 2007-04-03 2013-02-28 Amgen Res Munich Gmbh Cross-species-specific bispecific binders
CA2683370C (en) * 2007-04-03 2022-12-13 Micromet Ag Cross-species-specific binding domain
WO2008119567A2 (en) * 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific cd3-epsilon binding domain
MY147651A (en) * 2007-07-31 2012-12-31 Regeneron Pharma Human antibodies to human cd20 and method of using thereof
RU2473564C2 (en) * 2007-08-10 2013-01-27 Ридженерон Фармасьютикалз, Инк. Human antibodies with high affinity to human nerve growth factor
WO2009030368A1 (en) * 2007-09-05 2009-03-12 F. Hoffmann-La Roche Ag Combination therapy with type i and type ii anti-cd20 antibodies
WO2009106096A1 (en) * 2008-02-27 2009-09-03 Fresenius Biotech Gmbh Treatment of resistant tumors with trifunctional antibodies
PL2344539T3 (en) 2008-11-07 2015-07-31 Amgen Res Munich Gmbh Treatment of pediatric acute lymphoblastic leukemia
EP3916011A1 (en) * 2009-06-26 2021-12-01 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format
JO3182B1 (en) 2009-07-29 2018-03-08 Regeneron Pharma High Affinity Human Antibodies to Human Angiopoietin-2
ME02505B (en) * 2009-12-29 2017-02-20 Aptevo Res & Development Llc Heterodimer binding proteins and uses thereof
RU2724663C2 (en) 2010-02-08 2020-06-25 Ридженерон Фармасьютикалз, Инк. Mouse with common light chain
CN102250245B (en) * 2010-05-27 2014-05-14 四川大学 Bispecific antibody capable of resisting B cell lymphoma and application thereof
EP4303236A3 (en) 2010-11-30 2024-03-20 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
SG10201600899PA (en) * 2011-02-08 2016-03-30 Medimmune Llc Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use
CN104640562A (en) 2012-07-13 2015-05-20 酵活有限公司 Bispecific asymmetric heterodimers comprising anti-cd3 constructs
WO2014022540A1 (en) 2012-08-02 2014-02-06 Regeneron Pharmaceuticals, Inc. Multivalent antigen-binding proteins
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
TWI682941B (en) 2013-02-01 2020-01-21 美商再生元醫藥公司 Antibodies comprising chimeric constant domains
CN113248615A (en) 2013-07-05 2021-08-13 根马布股份公司 Humanized or chimeric CD3 antibodies
US20160355588A1 (en) 2013-07-12 2016-12-08 Zymeworks Inc. Bispecific CD3 and CD19 Antigen Binding Constructs
DK3736292T3 (en) 2013-12-17 2024-07-22 Genentech Inc Anti-CD3 Antibodies and Methods of Use
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
TWI754319B (en) 2014-03-19 2022-02-01 美商再生元醫藥公司 Methods and antibody compositions for tumor treatment

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