CA3041673A1 - Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion - Google Patents

Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion Download PDF

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Publication number
CA3041673A1
CA3041673A1 CA3041673A CA3041673A CA3041673A1 CA 3041673 A1 CA3041673 A1 CA 3041673A1 CA 3041673 A CA3041673 A CA 3041673A CA 3041673 A CA3041673 A CA 3041673A CA 3041673 A1 CA3041673 A1 CA 3041673A1
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population
protein
til
cell
aapc
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CA3041673A
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English (en)
French (fr)
Inventor
Anand Veerapathran
Aishwarya GOKULDASS
Brian Rabinovich
Michael T. Lotze
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Iovance Biotherapeutics Inc
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Iovance Biotherapeutics Inc
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Publication of CA3041673A1 publication Critical patent/CA3041673A1/en
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    • C12N5/0635—B lymphocytes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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CA3041673A 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion Pending CA3041673A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662415274P 2016-10-31 2016-10-31
US62/415,274 2016-10-31
US201662438600P 2016-12-23 2016-12-23
US62/438,600 2016-12-23
US201762475053P 2017-03-22 2017-03-22
US62/475,053 2017-03-22
US201762481831P 2017-04-05 2017-04-05
US62/481,831 2017-04-05
PCT/US2017/059271 WO2018081789A1 (en) 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

Publications (1)

Publication Number Publication Date
CA3041673A1 true CA3041673A1 (en) 2018-05-03

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Application Number Title Priority Date Filing Date
CA3041673A Pending CA3041673A1 (en) 2016-10-31 2017-10-31 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion

Country Status (14)

Country Link
US (4) US10415015B2 (https=)
EP (1) EP3532608A1 (https=)
JP (2) JP7576912B2 (https=)
KR (2) KR20190071802A (https=)
CN (2) CN110312790A (https=)
AU (2) AU2017347942A1 (https=)
BR (1) BR112019008560A2 (https=)
CA (1) CA3041673A1 (https=)
IL (1) IL266221B2 (https=)
MA (1) MA46668A (https=)
MX (2) MX2019004708A (https=)
SG (1) SG11201903825SA (https=)
TW (1) TWI788307B (https=)
WO (1) WO2018081789A1 (https=)

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TWI788307B (zh) * 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
JOP20190224A1 (ar) 2017-03-29 2019-09-26 Iovance Biotherapeutics Inc عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي
US11254913B1 (en) 2017-03-29 2022-02-22 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
US20200377855A1 (en) * 2017-05-05 2020-12-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Rapid method for the culture of tumor infiltrating lymphocytes
EP3635097A1 (en) 2017-06-05 2020-04-15 Iovance Biotherapeutics, Inc. Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
SG11202006541UA (en) 2018-01-08 2020-08-28 Iovance Biotherapeutics Inc Processes for generating til products enriched for tumor antigen-specific t-cells
US20190284553A1 (en) 2018-03-15 2019-09-19 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
US20210130779A1 (en) 2018-04-27 2021-05-06 Iovance Biotherapeutics, Inc. Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2019217753A1 (en) 2018-05-10 2019-11-14 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
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