CA3016424A1 - Cell injury inducing therapeutic drug for use in cancer therapy - Google Patents
Cell injury inducing therapeutic drug for use in cancer therapy Download PDFInfo
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- CA3016424A1 CA3016424A1 CA3016424A CA3016424A CA3016424A1 CA 3016424 A1 CA3016424 A1 CA 3016424A1 CA 3016424 A CA3016424 A CA 3016424A CA 3016424 A CA3016424 A CA 3016424A CA 3016424 A1 CA3016424 A1 CA 3016424A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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- Peptides Or Proteins (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/JP2017/007033 WO2017159287A1 (ja) | 2016-03-14 | 2017-02-24 | 癌の治療に用いるための細胞傷害誘導治療剤 |
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| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| LT2647707T (lt) | 2010-11-30 | 2018-11-12 | Chugai Seiyaku Kabushiki Kaisha | Citotoksiškumą indukuojantis terapinis agentas |
| ES2881306T3 (es) | 2013-09-27 | 2021-11-29 | Chugai Pharmaceutical Co Ltd | Método para la producción de heteromultímeros de polipéptidos |
| MX380176B (es) | 2014-04-07 | 2025-03-12 | Chugai Pharmaceutical Co Ltd | Molecula ligada a antigeno inmunoactivada. |
| US11505605B2 (en) | 2014-05-13 | 2022-11-22 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| EP3378488A4 (en) | 2015-11-18 | 2019-10-30 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR IMPROVING THE HUMORAL IMMUNE REACTION |
| JP6931329B2 (ja) * | 2015-11-18 | 2021-09-01 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法 |
| EP3431102A4 (en) | 2016-03-14 | 2019-09-25 | Chugai Seiyaku Kabushiki Kaisha | CELL DAMAGING THERAPEUTIC MEDICAMENT FOR USE IN CANCER THERAPY |
| TW201834688A (zh) | 2017-02-24 | 2018-10-01 | 日商中外製藥股份有限公司 | 藥學組成物、抗原結合分子、治療方法以及篩選方法 |
| JP7466442B2 (ja) * | 2018-02-14 | 2024-04-12 | 中外製薬株式会社 | 抗原結合分子および組合せ |
| CN109536444B (zh) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法 |
| CN113329770A (zh) * | 2019-01-24 | 2021-08-31 | 中外制药株式会社 | 新型癌抗原及所述抗原的抗体 |
| EP4146702A4 (en) * | 2020-05-07 | 2024-07-10 | Phanes Therapeutics, Inc. | Anti-tumor associated antigen antibodies and uses thereof |
| AU2021292932A1 (en) * | 2020-06-19 | 2023-01-05 | Chugai Seiyaku Kabushiki Kaisha | Anti-T cell antigen-binding molecule for use in combination with angiogenesis inhibitor |
| US12492252B2 (en) | 2020-07-01 | 2025-12-09 | Shandong Boan Biotechnology Co., Ltd. | Anti-GPC3 antibody, anti-GPC3 chimeric antigen receptor and GPC3/CD3 bispecific antibody |
| CN118878694A (zh) * | 2020-11-23 | 2024-11-01 | 康诺亚生物医药科技（成都）有限公司 | 一种双特异性抗体及其用途 |
| IL303783A (en) * | 2020-12-18 | 2023-08-01 | Sanofi Sa | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
| US20240368303A1 (en) * | 2021-09-24 | 2024-11-07 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Antibodies against gpc3 and uses thereof |
| WO2023045151A1 (en) * | 2021-09-24 | 2023-03-30 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Antibodies against gpc3 and uses thereof |
| US12122850B2 (en) | 2022-03-14 | 2024-10-22 | LamKap Bio gamma AG | Bispecific GPC3xCD28 and GPC3xCD3 antibodies and their combination for targeted killing of GPC3 positive malignant cells |
| KR20250096769A (ko) * | 2022-11-01 | 2025-06-27 | 상하이 치루 파마슈티컬 리서치 앤 디벨롭먼트 센터 리미티드 | 글리피칸-3에 대한 이중특이성 항체 및 이의 용도 |
| CN116949156B (zh) * | 2023-09-19 | 2023-12-08 | 美迪西普亚医药科技(上海)有限公司 | 一种基于核酸变体的通用型检测人t细胞的分析方法 |
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| US3773719A (en) | 1966-12-06 | 1973-11-20 | Hoffmann La Roche | 2-aminoxy-2'-acyl-acetanilide |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
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| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
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| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9206422D0 (en) | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| WO1993019172A1 (en) | 1992-03-24 | 1993-09-30 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
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| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
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| WO1995015388A1 (en) | 1993-12-03 | 1995-06-08 | Medical Research Council | Recombinant binding proteins and peptides |
| DE4419399C1 (de) | 1994-06-03 | 1995-03-09 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von heterologen bispezifischen Antikörpern |
| EP0770628B9 (en) | 1994-07-13 | 2007-02-28 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
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| AU700819B2 (en) | 1994-10-07 | 1999-01-14 | Chugai Seiyaku Kabushiki Kaisha | Rheumatoid arthritis remedy containing IL-6 antagonist as effective component |
| WO1996012503A1 (en) | 1994-10-21 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Remedy for diseases caused by il-6 production |
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| MA40764A (fr) * | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| WO2017010423A1 (ja) | 2015-07-10 | 2017-01-19 | 中外製薬株式会社 | 内因性ｃｄ３遺伝子をヒトｃｄ３遺伝子に置換した非ヒト動物 |
| EP3378488A4 (en) | 2015-11-18 | 2019-10-30 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR IMPROVING THE HUMORAL IMMUNE REACTION |
| EP3431102A4 (en) | 2016-03-14 | 2019-09-25 | Chugai Seiyaku Kabushiki Kaisha | CELL DAMAGING THERAPEUTIC MEDICAMENT FOR USE IN CANCER THERAPY |
| JP6175590B1 (ja) | 2016-03-14 | 2017-08-02 | 中外製薬株式会社 | 癌の治療に用いるための細胞傷害誘導治療剤 |
| UA128389C2 (uk) | 2017-09-29 | 2024-07-03 | Чугаі Сейяку Кабусікі Кайся | Мультиспецифічна антигензв'язувальна молекула, яка має активність заміщувати кофакторну функцію фактора коагуляції крові viii (fviii), та фармацевтичний склад, який містить згадану молекулу як активний інгредієнт |
| WO2019131988A1 (en) | 2017-12-28 | 2019-07-04 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| AU2019270624B2 (en) | 2018-05-16 | 2024-05-02 | Janssen Biotech, Inc. | Methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics |
-
2017
- 2017-02-24 EP EP17766292.1A patent/EP3431102A4/en active Pending
- 2017-02-24 AU AU2017233658A patent/AU2017233658B2/en not_active Ceased
- 2017-02-24 WO PCT/JP2017/007033 patent/WO2017159287A1/ja not_active Ceased
- 2017-02-24 BR BR112018068363-9A patent/BR112018068363A2/pt not_active Application Discontinuation
- 2017-02-24 TW TW110132434A patent/TW202214700A/zh unknown
- 2017-02-24 CA CA3016424A patent/CA3016424A1/en active Pending
- 2017-02-24 KR KR1020177011763A patent/KR101834708B1/ko not_active Expired - Fee Related
- 2017-02-24 US US16/083,975 patent/US11072666B2/en not_active Expired - Fee Related
- 2017-02-24 SG SG10202007025PA patent/SG10202007025PA/en unknown
- 2017-02-24 RU RU2018135317A patent/RU2746754C2/ru active
- 2017-02-24 TW TW106106363A patent/TW201735947A/zh unknown
- 2017-02-24 MX MX2018010988A patent/MX2018010988A/es unknown
- 2017-02-24 CN CN201780025881.4A patent/CN109069640B/zh active Active
- 2017-02-24 TW TW112109985A patent/TW202342540A/zh unknown
- 2017-02-24 KR KR1020187005500A patent/KR20180116215A/ko active Pending
- 2017-02-24 SG SG11201807936VA patent/SG11201807936VA/en unknown
- 2017-07-10 JP JP2017134287A patent/JP2017214405A/ja active Pending
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2018
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- 2018-09-13 PH PH12018501977A patent/PH12018501977A1/en unknown
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2022
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2024
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| Publication number | Publication date |
|---|---|
| CN109069640A (zh) | 2018-12-21 |
| MX2023005645A (es) | 2023-05-25 |
| US11072666B2 (en) | 2021-07-27 |
| EP3431102A1 (en) | 2019-01-23 |
| US20200048361A1 (en) | 2020-02-13 |
| TW202342540A (zh) | 2023-11-01 |
| KR20180116215A (ko) | 2018-10-24 |
| BR112018068363A2 (pt) | 2019-01-15 |
| JP2017214405A (ja) | 2017-12-07 |
| WO2017159287A1 (ja) | 2017-09-21 |
| TW202214700A (zh) | 2022-04-16 |
| JP2024054340A (ja) | 2024-04-16 |
| KR101834708B1 (ko) | 2018-03-06 |
| JP7440569B2 (ja) | 2024-02-28 |
| EP3431102A4 (en) | 2019-09-25 |
| SG10202007025PA (en) | 2020-08-28 |
| PH12018501977A1 (en) | 2019-06-17 |
| RU2018135317A (ru) | 2020-04-15 |
| RU2746754C2 (ru) | 2021-04-20 |
| MX2018010988A (es) | 2019-01-21 |
| AU2017233658B2 (en) | 2023-09-21 |
| CN109069640B (zh) | 2023-10-03 |
| SG11201807936VA (en) | 2018-10-30 |
| JP2022116257A (ja) | 2022-08-09 |
| TW201735947A (zh) | 2017-10-16 |
| AU2017233658A1 (en) | 2018-09-13 |
| RU2018135317A3 (enExample) | 2020-06-29 |
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