CA2973674A1 - Production of steviol glycosides in recombinant hosts - Google Patents
Production of steviol glycosides in recombinant hosts Download PDFInfo
- Publication number
- CA2973674A1 CA2973674A1 CA2973674A CA2973674A CA2973674A1 CA 2973674 A1 CA2973674 A1 CA 2973674A1 CA 2973674 A CA2973674 A CA 2973674A CA 2973674 A CA2973674 A CA 2973674A CA 2973674 A1 CA2973674 A1 CA 2973674A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- polypeptide
- compound
- steviol
- ent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ICCWHQJEHKAEBT-ZKDAHQIZSA-N C[C@@](CC(OC(C(C1O)OC(C(C2O)O)OC(CO)C2O)OC(CO)C1O)=O)(CCC1)C2C1(C)[C@H](CCC(C1)(C(C3)=C)OC(O)OC(C(C4O)O)OC(CO)C4O)C13CC2 Chemical compound C[C@@](CC(OC(C(C1O)OC(C(C2O)O)OC(CO)C2O)OC(CO)C1O)=O)(CCC1)C2C1(C)[C@H](CCC(C1)(C(C3)=C)OC(O)OC(C(C4O)O)OC(CO)C4O)C13CC2 ICCWHQJEHKAEBT-ZKDAHQIZSA-N 0.000 description 1
- NHJUPBDCSOGIKX-UHFFFAOYSA-N OCC(COC(C(C1O)O)OC(CO)C1O)O Chemical compound OCC(COC(C(C1O)O)OC(CO)C1O)O NHJUPBDCSOGIKX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562110207P | 2015-01-30 | 2015-01-30 | |
| US62/110,207 | 2015-01-30 | ||
| PCT/EP2016/052007 WO2016120486A1 (en) | 2015-01-30 | 2016-01-29 | Production of steviol glycosides in recombinant hosts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2973674A1 true CA2973674A1 (en) | 2016-08-04 |
Family
ID=55398256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2973674A Pending CA2973674A1 (en) | 2015-01-30 | 2016-01-29 | Production of steviol glycosides in recombinant hosts |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10364450B2 (https=) |
| EP (2) | EP4148137A1 (https=) |
| JP (1) | JP2018503388A (https=) |
| CN (1) | CN108337892B (https=) |
| AU (3) | AU2016211124B2 (https=) |
| BR (1) | BR112017016338A2 (https=) |
| CA (1) | CA2973674A1 (https=) |
| SG (1) | SG11201705606PA (https=) |
| WO (1) | WO2016120486A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| CN108396044A (zh) | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| AU2015314251A1 (en) | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3232817A4 (en) * | 2014-12-17 | 2018-10-10 | Cargill, Incorporated | Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| EP3718417B1 (en) * | 2015-04-03 | 2025-09-03 | DSM IP Assets B.V. | Steviol glycosides |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201804542YA (en) * | 2015-11-30 | 2018-06-28 | Cargill Inc | Steviol glycoside compositions for oral ingestion or use |
| US20190048356A1 (en) * | 2016-03-11 | 2019-02-14 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) * | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP2019517812A (ja) * | 2016-06-17 | 2019-06-27 | カーギル インコーポレイテッド | 経口摂取または経口使用のためのステビオールグリコシド組成物 |
| WO2017218888A1 (en) * | 2016-06-17 | 2017-12-21 | Cargill, Incorporated | Steviol glycoside compositions for oral ingestion or use |
| AU2017308143B2 (en) | 2016-08-12 | 2022-04-07 | Amyris, Inc. | UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides |
| EP3522737B1 (en) | 2016-10-04 | 2025-12-03 | The Coca-Cola Company | Diterpene glycosides containing an ent-atisene core, compositions and methods |
| CN110191643B (zh) * | 2016-10-14 | 2023-06-06 | 科纳根公司 | 甜菊醇糖苷的生物合成生产及其工艺 |
| AU2017345605B2 (en) * | 2016-10-20 | 2022-04-14 | The Coca-Cola Company | Diterpene glycosides isolated from Stevia, compositions and methods |
| BR112019008048A2 (pt) | 2016-10-21 | 2019-07-02 | Pepsico Inc | método para preparar rebaudiosídeo n com o uso de método enzimático |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA3175070A1 (en) | 2017-02-03 | 2018-08-09 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| MX2019015404A (es) | 2017-06-30 | 2020-07-20 | Conagen Inc | Hidrólisis de glucósidos de esteviol por beta-glucosidasa. |
| US11365417B2 (en) | 2017-09-12 | 2022-06-21 | Bio Capital Holdings, LLC | Biological devices and methods of use thereof to produce steviol glycosides |
| JP2021518369A (ja) * | 2018-03-16 | 2021-08-02 | ピュアサークル ユーエスエー インコーポレイテッド | 高純度ステビオール配糖体 |
| AU2019282411B2 (en) * | 2018-06-08 | 2024-09-19 | Purecircle Usa Inc. | High-purity steviol glycosides |
| WO2020028039A1 (en) | 2018-07-30 | 2020-02-06 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| MX2021004192A (es) * | 2018-10-15 | 2021-05-27 | Amyris Inc | Variantes de acido kaurenoico hidroxilasa de stevia rebaudiana para la produccion de rebaudiosidos de alta eficiencia. |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| BR112021010189A2 (pt) * | 2018-11-27 | 2021-11-09 | Purecircle Usa Inc | Glicosídeos de esteviol i-xvi, métodos para produção de ao menos um glicosídeo de esteviol, para intensificação do dulçor de um produto alimentício ou de bebida, para modificação do sabor de um produto alimentício ou de bebida e para supressão da formação de espuma em um produto alimentício ou de bebida, e, produto consumível |
| MX2021006986A (es) * | 2018-12-12 | 2021-08-16 | Conagen Inc | Produccion biosintetica de variantes de glucosidos de esteviol. |
| MX2021009619A (es) * | 2019-02-15 | 2021-11-04 | Purecircle Usa Inc | Glicósidos de esteviol de alta pureza. |
| EP3947409A4 (en) * | 2019-03-29 | 2023-04-12 | Conagen Inc. | BIOSYNTHETIC MANUFACTURE OF UDP-RHAMNOSE |
| US12467039B2 (en) | 2019-05-03 | 2025-11-11 | Amyris, Inc. | Kaurenoic acid 13-hydroxylase (KAH) variants and uses thereof |
| CN112080480B (zh) * | 2019-06-14 | 2023-01-03 | 中国科学院分子植物科学卓越创新中心 | 糖基转移酶突变体及其应用 |
| CN110305855B (zh) * | 2019-06-26 | 2022-03-22 | 昆明理工大学 | 天麻GeCPR基因及其应用 |
| KR20220123019A (ko) * | 2019-12-31 | 2022-09-05 | 에어 프로틴 인코포레이티드 | 고단백질 식품 조성물 |
| CN113444131B (zh) * | 2021-06-24 | 2022-10-21 | 鲁东大学 | N-乙酰氨基葡萄糖类化合物及其制备方法和应用 |
Family Cites Families (159)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58149697A (ja) | 1982-02-27 | 1983-09-06 | Dainippon Ink & Chem Inc | β−１，３グリコシルステビオシドの製造方法 |
| JPS59101408A (ja) | 1982-12-02 | 1984-06-12 | Junichi Iwamura | 植物生長調整剤 |
| US5198360A (en) | 1990-01-19 | 1993-03-30 | Eli Lilly And Company | Dna sequence conferring a plaque inhibition phenotype |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| JPH03277275A (ja) | 1990-03-28 | 1991-12-09 | Dainippon Ink & Chem Inc | 新規酵素及びその酵素を用いた配糖体の製造方法 |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5712112A (en) | 1992-11-04 | 1998-01-27 | National Science Council Of R.O.C. | Gene expression system comprising the promoter region of the alpha-amylase genes |
| CN1129953A (zh) | 1993-07-15 | 1996-08-28 | 尼奥斯药品公司 | 糖组分的合成方法 |
| US7186891B1 (en) | 1996-04-12 | 2007-03-06 | University Of Kentucky, Research Foundation | Plant cells and plants expressing chimeric isoprenoid synthases |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| WO1999018224A1 (en) | 1997-10-06 | 1999-04-15 | The Centre National De Recherche Scientifique | Plant fatty acid hydroxylase genes |
| US6255557B1 (en) | 1998-03-31 | 2001-07-03 | Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada | Stevia rebaudiana with altered steviol glycoside composition |
| CA2736981A1 (en) | 1998-04-14 | 1999-10-21 | Kyowa Hakko Bio Co., Ltd. | Process for producing isoprenoid compounds by microorganisms |
| EP0955363A3 (en) | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
| TWI250210B (en) | 1998-05-06 | 2006-03-01 | Dsm Ip Assets Bv | An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate |
| JP4579415B2 (ja) | 1998-07-06 | 2010-11-10 | ディーシーブイ・インコーポレイテッド・ドゥーイング・ビジネス・アズ・バイオ−テクニカル・リソーシィズ | ビタミン製造方法 |
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| AR021636A1 (es) | 1998-12-17 | 2002-07-31 | Rubicon Forests Holdings Ltd | Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides |
| JP2002533090A (ja) | 1998-12-23 | 2002-10-08 | ザ、サミュアル、ラバツ、ノゥブル、ファウンデイシャン、インク | 植物形質転換法 |
| JP2003527077A (ja) | 1999-04-15 | 2003-09-16 | カルジーン エルエルシー | トコフェロール合成に関与するタンパク質の核酸配列 |
| WO2000063400A2 (en) | 1999-04-21 | 2000-10-26 | The Samuel Roberts Noble Foundation | Plant transformation process |
| ATE373715T1 (de) | 1999-08-04 | 2007-10-15 | Adelbert Bacher | Isoprenoid biosynthese |
| WO2001012828A1 (en) | 1999-08-18 | 2001-02-22 | Paradigm Genetics, Inc. | Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration |
| WO2001083769A2 (en) | 2000-05-03 | 2001-11-08 | The Salk Institute For Biological Studies | Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis |
| DE10027821A1 (de) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
| AU2001278098A1 (en) | 2000-07-31 | 2002-02-13 | Frederick M. Hahn | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| EP1313867A2 (en) | 2000-08-24 | 2003-05-28 | The Scripps Research Institute | Stress-regulated genes of plants, transgenic plants containing same, and methods of use |
| US6689601B2 (en) | 2000-09-01 | 2004-02-10 | E. I. Du Pont De Nemours And Company | High growth methanotropic bacterial strain |
| US6660507B2 (en) | 2000-09-01 | 2003-12-09 | E. I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| US6818424B2 (en) | 2000-09-01 | 2004-11-16 | E. I. Du Pont De Nemours And Company | Production of cyclic terpenoids |
| EP1409530A2 (en) | 2000-09-19 | 2004-04-21 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
| EP1383864B1 (en) | 2000-09-29 | 2008-01-16 | Cargill Incorporated | Isoprenoid production |
| US6949362B2 (en) | 2000-12-12 | 2005-09-27 | E. I. Du Pont De Nemours And Company | Rhodococcus cloning and expression vectors |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| US7034140B2 (en) | 2001-04-24 | 2006-04-25 | E.I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| DE60228439D1 (de) | 2001-06-06 | 2008-10-02 | Dsm Ip Assets Bv | Verbesserte isoprenoid herstellung |
| AU2002341541A1 (en) | 2001-06-22 | 2003-03-03 | Syngenta Participations Ag | Abiotic stress responsive polynucleotides and polypeptides |
| NZ513755A (en) | 2001-08-24 | 2001-09-28 | Ann Rachel Holmes | Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs |
| US20040072311A1 (en) | 2001-08-28 | 2004-04-15 | Dicosimo Deana J. | Production of cyclic terpenoids |
| US20040010815A1 (en) | 2001-09-26 | 2004-01-15 | Lange B. Markus | Identification and characterization of plant genes |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| DE60329505D1 (de) | 2002-08-20 | 2009-11-12 | Suntory Holdings Ltd | Neue glycosyltransferase-gene |
| CA2498800C (en) | 2002-09-27 | 2012-01-03 | Dsm Ip Assets B.V. | Sqs gene |
| US7098000B2 (en) | 2003-06-04 | 2006-08-29 | E. I. Du Pont De Nemoure And Company | Method for production of C30-aldehyde carotenoids |
| DE602004020218D1 (de) | 2003-06-12 | 2009-05-07 | Dsm Ip Assets Bv | Feedback resistante mevalonate kinase |
| US7569389B2 (en) | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| CN101023181A (zh) | 2004-05-21 | 2007-08-22 | 加利福尼亚大学董事会 | 提高类异戊二烯化合物的产生的方法 |
| EP2080769A3 (en) | 2004-07-02 | 2010-12-01 | Metanomics GmbH | Process for the production of fine chemicals |
| US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| WO2006016395A1 (ja) | 2004-08-09 | 2006-02-16 | National University Corporation Tohoku University | Ｕｄｐ−グルクロニル基転移酵素およびその遺伝子 |
| US7572609B2 (en) | 2004-08-19 | 2009-08-11 | Dsm Ip Assets B.V. | Production of isoprenoids |
| US7923552B2 (en) | 2004-10-18 | 2011-04-12 | SGF Holdings, LLC | High yield method of producing pure rebaudioside A |
| EP1824969B1 (en) | 2004-12-14 | 2011-03-02 | DSM IP Assets B.V. | Improved mevalonate kinase |
| WO2006092449A2 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| WO2006096392A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them |
| WO2006093289A1 (ja) | 2005-03-04 | 2006-09-08 | National Institute Of Advanced Industrial Science And Technology | Udp-キシロースの製造方法 |
| US7989677B2 (en) | 2005-08-17 | 2011-08-02 | Nestec S. A. | Nucleic acids and proteins associated with sucrose accumulation in coffee |
| CA2624230A1 (en) | 2005-08-22 | 2007-03-01 | Co2 Boost Llc | A device and process to generate co2 used for indoor crop production and underwater gardening |
| US8293307B2 (en) | 2005-10-11 | 2012-10-23 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
| US8367137B2 (en) * | 2005-11-23 | 2013-02-05 | The Coca-Cola Company | High-potency sweetener composition with fatty acid and compositions sweetened therewith |
| EP1971228A1 (en) | 2005-11-23 | 2008-09-24 | The Coca-Cola Company | Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses |
| KR100784261B1 (ko) | 2006-01-02 | 2007-12-11 | 한국과학기술원 | 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법 |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| CA2644273A1 (en) | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| WO2007136847A2 (en) | 2006-05-19 | 2007-11-29 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| US7964376B2 (en) | 2006-06-19 | 2011-06-21 | Givaudan Sa | Chimeric proteins and their use in methods to screen for sweet taste modulators |
| WO2008008256A2 (en) | 2006-07-07 | 2008-01-17 | The Regents Of The University Of California | Methods for enhancing production of isoprenoid compounds by host cells |
| DK2066778T3 (en) | 2006-09-26 | 2016-04-18 | Amyris Biotechnologies Inc | PREPARATION OF ISOPRENOIDS AND ISOPRENOID PRECURSORS |
| US7629156B2 (en) | 2006-09-28 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Ethanol production in fermentation of mixed sugars containing xylose |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| CN101200480B (zh) | 2006-12-15 | 2011-03-30 | 成都华高药业有限公司 | 莱鲍迪甙a的提取方法 |
| JP4915917B2 (ja) | 2006-12-22 | 2012-04-11 | 独立行政法人農業・食品産業技術総合研究機構 | ラクト−ｎ−ビオースｉ及びガラクト−ｎ−ビオースの製造方法 |
| JP5307730B2 (ja) | 2007-01-22 | 2013-10-02 | カーギル・インコーポレイテッド | 溶媒／貧溶媒晶析を用いる精製レバウディオサイドａ組成物の製法 |
| JP2008237110A (ja) | 2007-03-27 | 2008-10-09 | Institute Of Physical & Chemical Research | ステビオール合成酵素遺伝子及びステビオールの製造方法 |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| US20080292775A1 (en) | 2007-05-22 | 2008-11-27 | The Coca-Cola Company | Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses |
| WO2009005704A1 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| GB0715226D0 (en) * | 2007-08-01 | 2007-09-12 | Cadbury Schweppes Plc | Sweetener compositions |
| JP2009034080A (ja) | 2007-08-03 | 2009-02-19 | Sanei Gen Ffi Inc | 新規糖転移酵素、及びそれを利用した配糖体の製造 |
| US7964232B2 (en) | 2007-09-17 | 2011-06-21 | Pepsico, Inc. | Steviol glycoside isomers |
| EP2193202A2 (en) | 2007-09-21 | 2010-06-09 | BASF Plant Science GmbH | Plants with increased yield |
| MY155722A (en) | 2007-12-03 | 2015-11-30 | Dsm Ip Assets Bv | Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof |
| NZ586358A (en) | 2007-12-27 | 2013-04-26 | Mcneil Nutritionals Llc | Synergistic sweetening compositions comprising sucralose and a purified extract of stevia |
| BRPI0907786B1 (pt) | 2008-02-20 | 2021-06-01 | Ceres, Inc. | Método de produção de uma planta e método de aumentar o nível de tolerância a baixo teor de nitrogênio em uma planta |
| TWI475963B (zh) | 2008-02-25 | 2015-03-11 | 可口可樂公司 | 甜菊糖苷ａ衍生性產物以及製造彼的方法 |
| EP2285948B1 (en) | 2008-03-03 | 2014-01-08 | Joule Unlimited Technologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| US9005444B2 (en) | 2008-05-13 | 2015-04-14 | Cargill, Incorporated | Separation of rebaudioside A from stevia glycosides using chromatography |
| WO2010021001A2 (en) | 2008-08-19 | 2010-02-25 | Kaushik Ramakrishnan S | Process for preparing sweetener from stevia rebaudiana |
| CN102202523A (zh) * | 2008-08-26 | 2011-09-28 | 梅里桑特公司 | 包含莱鲍迪甙a、赤藓糖醇、二糖碳水化合物或果糖以及口味改善量的纤维素的甜味剂组合物及其制造方法 |
| CN107033200A (zh) | 2008-10-03 | 2017-08-11 | 守田化学工业株式会社 | 新的甜菊醇糖苷 |
| CN101720910B (zh) | 2008-10-23 | 2012-07-25 | 大闽食品（漳州）有限公司 | 一种甜菊糖甙的制备方法 |
| US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| US20100297722A1 (en) | 2009-05-20 | 2010-11-25 | Board Of Trustees Of Southern Illinois University | Transgenic moss producing terpenoids |
| DK2440661T3 (en) | 2009-06-08 | 2018-03-12 | Jennewein Biotechnologie Gmbh | HMO synthesis |
| EP2826386B1 (en) | 2009-06-16 | 2022-12-28 | Sweet Green Fields International Co., Limited | Stevia composition comprising rebaudioside A and D |
| CA2773134A1 (en) | 2009-09-04 | 2011-03-10 | Redpoint Bio Corporation | Sweetness enhancers including rebaudioside a or d |
| MX2012003489A (es) | 2009-09-22 | 2012-07-30 | Redpoint Bio Corp | Polimorfos novedosos de rebaudiosida c y metodos para elaborarlos y utilizarlos. |
| US8299224B2 (en) | 2009-10-15 | 2012-10-30 | Purecircle Sdn Bhd | High-purity Rebaudioside D |
| ES2457641T3 (es) | 2009-10-15 | 2014-04-28 | Purecircle Sdn Bhd | Procedimiento para preparar rebaudiósido D de pureza elevada |
| US8703224B2 (en) | 2009-11-04 | 2014-04-22 | Pepsico, Inc. | Method to improve water solubility of Rebaudioside D |
| EP2504441B1 (en) | 2009-11-23 | 2020-07-22 | E. I. du Pont de Nemours and Company | Sucrose transporter genes for increasing plant seed lipids |
| WO2011072246A2 (en) | 2009-12-10 | 2011-06-16 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| CA2783621C (en) | 2009-12-28 | 2018-05-29 | The Coca-Cola Company | Sweetness enhancers, compositions thereof, and methods for use |
| KR101244315B1 (ko) | 2010-10-19 | 2013-03-14 | 이화여자대학교 산학협력단 | 에탄올―저항성 효모 유전자 및 이의 용도 |
| WO2011140329A1 (en) | 2010-05-06 | 2011-11-10 | Ceres, Inc. | Transgenic plants having increased biomass |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| EP2575499A2 (en) | 2010-05-31 | 2013-04-10 | Vib Vzw | The use of transporters to modulate flavor production by yeast |
| CN105671108A (zh) * | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| US20120021111A1 (en) | 2010-07-23 | 2012-01-26 | Aexelon Therapeutics, Inc. | Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture |
| ES2673730T3 (es) * | 2010-10-01 | 2018-06-25 | The Procter & Gamble Company | Composiciones para el cuidado bucal con dulzor mejorado |
| US20120083593A1 (en) | 2010-10-01 | 2012-04-05 | Shanghai Yongyou Bioscience Inc. | Separation and Purification of Stevioside and Rebaudioside A |
| CA2819253A1 (en) | 2010-11-30 | 2012-06-07 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| US20130344217A1 (en) * | 2010-12-29 | 2013-12-26 | Glg Life Tech Corporation | Sweetener Compositions and Methods of Making Same |
| MX2013010690A (es) * | 2011-03-22 | 2014-04-30 | Purecircle Usa | Composicion de glicosido de esteviol glucosilado como un aumentador de gusto y sabor. |
| KR20130014227A (ko) | 2011-07-29 | 2013-02-07 | 한국생명공학연구원 | 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법 |
| IN2014CN01129A (https=) | 2011-08-08 | 2015-04-10 | Evolva Sa | |
| CN108396044A (zh) * | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| KR101791597B1 (ko) | 2011-11-23 | 2017-10-30 | 에볼바 에스아 | 모그로사이드 화합물을 효소에 의해 합성하기 위한 방법 및 재료 |
| CN103159808B (zh) | 2011-12-09 | 2017-03-29 | 上海泓博智源医药股份有限公司 | 一种制备天然甜味剂的工艺方法 |
| EP3009010B1 (en) | 2011-12-19 | 2020-02-05 | PureCircle SDN BHD | Methods for purifying steviol glycosides |
| AU2013211605B2 (en) | 2012-01-23 | 2017-04-06 | Dsm Ip Assets B.V. | Diterpene production |
| US10000783B2 (en) | 2012-03-16 | 2018-06-19 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| EP2832858B1 (en) * | 2012-03-27 | 2020-07-08 | Suntory Holdings Limited | Method for producing steviol glycoside |
| BR112014028819A2 (pt) | 2012-05-22 | 2017-07-25 | Purecircle Sdn Bhd | glicosídeos de esteviol de pureza elevada |
| CN103710318B (zh) | 2012-09-29 | 2017-01-18 | 中国科学院上海生命科学研究院 | 利用微生物生产甜菊糖苷类化合物的方法 |
| EP2928321A1 (en) | 2012-12-05 | 2015-10-14 | Evolva SA | Steviol glycoside compositions sensory properties |
| SG11201505597SA (en) | 2013-02-06 | 2015-08-28 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| CA2900882A1 (en) * | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| US20140342043A1 (en) * | 2013-05-14 | 2014-11-20 | Pepsico, Inc. | Rebaudioside Sweetener Compositions and Food Products Sweetened with Same |
| US10689681B2 (en) | 2013-05-31 | 2020-06-23 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| WO2014191580A1 (en) | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Extracellular diterpene production |
| KR101559478B1 (ko) | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | 효소전환법을 이용한 천연 고감미료의 제조방법 |
| US10039834B2 (en) * | 2013-07-12 | 2018-08-07 | The Coca-Cola Company | Compositions and methods using rebaudioside X to provide sweetness enhancement |
| EP3021689B1 (en) | 2013-07-15 | 2021-03-24 | DSM IP Assets B.V. | Diterpene production |
| EP3024941B1 (en) | 2013-07-23 | 2019-07-03 | DSM IP Assets B.V. | Diterpene production in yarrowia |
| CA2917615A1 (en) | 2013-07-31 | 2015-02-05 | Dsm Ip Assets B.V. | Steviol glycosides |
| AU2014298420B2 (en) | 2013-07-31 | 2018-10-04 | Dsm Ip Assets B.V. | Recovery of steviol glycosides |
| US9957539B2 (en) | 2013-08-02 | 2018-05-01 | Suntory Holdings Limited | Method for using hexenol glycosyl transferase |
| CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| EP3039132A2 (en) | 2013-08-30 | 2016-07-06 | Evolva SA | A method for producing modified resveratrol |
| WO2015051454A1 (en) | 2013-10-07 | 2015-04-16 | Vineland Research And Innovation Centre | Compositions and methods for producing steviol and steviol glycosides |
| EP3114210A2 (en) | 2014-03-07 | 2017-01-11 | Evolva SA | Methods for recombinant production of saffron compounds |
| US9522929B2 (en) * | 2014-05-05 | 2016-12-20 | Conagen Inc. | Non-caloric sweetener |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| AU2015314251A1 (en) | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| DK3200615T3 (da) * | 2014-10-03 | 2019-08-19 | Conagen Inc | Kaloriefrie sødestoffer og fremgangsmåder til syntetisering |
| EP3232817A4 (en) * | 2014-12-17 | 2018-10-10 | Cargill, Incorporated | Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility |
| SG11201705606PA (en) * | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| EP3718417B1 (en) * | 2015-04-03 | 2025-09-03 | DSM IP Assets B.V. | Steviol glycosides |
| CN104845990A (zh) | 2015-06-11 | 2015-08-19 | 山东大学 | 拟南芥糖基转移酶基因ugt73c7在提高植物抗病性中的应用 |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201804542YA (en) * | 2015-11-30 | 2018-06-28 | Cargill Inc | Steviol glycoside compositions for oral ingestion or use |
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| US11041183B2 (en) | 2021-06-22 |
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| SG11201705606PA (en) | 2017-08-30 |
| US10364450B2 (en) | 2019-07-30 |
| US20240026409A1 (en) | 2024-01-25 |
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| AU2024208814A1 (en) | 2024-09-05 |
| AU2022205176A1 (en) | 2022-08-04 |
| CN108337892A (zh) | 2018-07-27 |
| US11807888B2 (en) | 2023-11-07 |
| US20230033436A1 (en) | 2023-02-02 |
| AU2016211124A1 (en) | 2017-07-27 |
| EP3250686A1 (en) | 2017-12-06 |
| BR112017016338A2 (en) | 2018-03-27 |
| AU2022205176B2 (en) | 2024-07-11 |
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