CA2821886A1 - Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid - Google Patents
Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid Download PDFInfo
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- CA2821886A1 CA2821886A1 CA2821886A CA2821886A CA2821886A1 CA 2821886 A1 CA2821886 A1 CA 2821886A1 CA 2821886 A CA2821886 A CA 2821886A CA 2821886 A CA2821886 A CA 2821886A CA 2821886 A1 CA2821886 A1 CA 2821886A1
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- Prior art keywords
- glp
- mmol
- ethoxy
- amino
- carboxy
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 title claims abstract description 84
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 title claims abstract description 59
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims abstract description 54
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 title claims abstract description 42
- 229960002446 octanoic acid Drugs 0.000 title claims abstract description 42
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- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical group CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 claims description 35
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| US201061425087P | 2010-12-20 | 2010-12-20 | |
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| PCT/EP2011/073060 WO2012080471A1 (en) | 2010-12-16 | 2011-12-16 | Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
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| EP2827845B1 (en) | 2012-03-22 | 2018-12-26 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
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| EP4324475A1 (en) * | 2012-03-22 | 2024-02-21 | Novo Nordisk A/S | Compositions of glp-1 peptides and preparation thereof |
| CN104487056A (zh) | 2012-06-20 | 2015-04-01 | 诺和诺德A/S（股份有限公司） | 包含肽和递送剂的片剂制剂 |
| JP6059802B2 (ja) | 2012-07-01 | 2017-01-11 | ノヴォ ノルディスク アー／エス | 長時間作用型ｇｌｐ−１ペプチドの使用 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| RS57531B1 (sr) | 2012-12-21 | 2018-10-31 | Sanofi Sa | Derivati eksendina-4 kao dualni glp1/gip- ili trigonalni glp1/gip/glukagon agonisti |
| EP2964193B1 (en) | 2013-03-05 | 2019-12-11 | Enteris BioPharma, Inc. | Pharmaceuticals for oral delivery |
| CN104055735B (zh) * | 2013-03-22 | 2016-08-03 | 深圳翰宇药业股份有限公司 | 一种萨摩鲁泰的脂质体及其制备方法 |
| PL2991671T3 (pl) * | 2013-05-02 | 2019-01-31 | Novo Nordisk As | Doustne dawkowanie związków glp-1 |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| ES2630106T3 (es) * | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
| CN105777872B (zh) * | 2014-12-16 | 2019-06-07 | 深圳翰宇药业股份有限公司 | 一种萨摩鲁肽的纯化方法 |
| CN107427469B (zh) | 2015-01-12 | 2021-01-26 | 安特里斯生物制药公司 | 固体口服剂型 |
| US10265384B2 (en) * | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
| WO2016128970A1 (en) | 2015-02-09 | 2016-08-18 | Entera Bio Ltd. | Treatment of hypoparathyroidism |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| ES2835033T3 (es) | 2016-03-03 | 2021-06-21 | Novo Nordisk As | Derivados de GLP-1 y sus usos |
| RU2768283C2 (ru) * | 2016-04-28 | 2022-03-23 | Ново Нордиск А/С | Семаглутид при сердечно-сосудистых состояниях |
| EP3500291A4 (en) | 2016-08-17 | 2020-03-11 | Entera Bio Ltd. | FORMULA FOR ORAL ADMINISTRATION OF ACTIVE SUBSTANCES |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| EP3615002A4 (en) | 2017-04-25 | 2021-01-06 | Proteus Digital Health, Inc. | LISINOPRIL COMPOSITIONS CONTAINING AN INGERABLE EVENT MARKER |
| TWI797133B (zh) * | 2017-06-09 | 2023-04-01 | 丹麥商諾佛 儂迪克股份有限公司 | 用於經口投予的固體組成物 |
| WO2019004088A1 (ja) | 2017-06-27 | 2019-01-03 | 株式会社バイオセレンタック | 粘膜付着性経口製剤 |
| TWI847306B (zh) | 2017-08-24 | 2024-07-01 | 丹麥商諾佛 儂迪克股份有限公司 | Ｇｌｐ-１組成物及其用途 |
| BR112020006246A2 (pt) | 2017-10-12 | 2021-03-30 | Novo Nordisk A/S | Método para controle do peso de um sujeito em necessidade |
| JP6898518B2 (ja) | 2018-02-02 | 2021-07-07 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アゴニスト、ｎ−（８−（２−ヒドロキシベンゾイル）アミノ）カプリル酸の塩及び滑沢剤を含む固形組成物 |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| HRP20230929T1 (hr) | 2018-10-26 | 2023-11-24 | Novo Nordisk A/S | Stabilni pripravci semaglutida i njihova upotreba |
| CN113329810A (zh) | 2019-01-24 | 2021-08-31 | 诺和诺德股份有限公司 | 辊压机和使用辊压机的干法制粒方法 |
| MA55592A (fr) | 2019-04-10 | 2022-02-16 | Genfit | Polythérapie comprenant des composés de formule (i) et des agonistes du récepteur glp-1 |
| KR20220046565A (ko) | 2019-08-07 | 2022-04-14 | 노보 노르디스크 에이/에스 | Egf(a) 유도체 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물 |
| CN114206375A (zh) * | 2019-08-07 | 2022-03-18 | 诺和诺德股份有限公司 | 包含pyy化合物和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物 |
| EP4025192B1 (en) | 2019-09-02 | 2025-12-03 | Novo Nordisk A/S | Process for producing a tablet comprising glp-1 peptides |
| WO2021043971A1 (en) * | 2019-09-06 | 2021-03-11 | Novo Nordisk A/S | Method and equipment for fractionation of granules for use in pharmaceutical compositions |
| AU2020377469A1 (en) * | 2019-11-06 | 2022-04-28 | Novo Nordisk A/S | GLP-1 receptor agonists in dementia |
| EP4054536A1 (en) | 2019-11-07 | 2022-09-14 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| EP4054520A1 (en) | 2019-11-07 | 2022-09-14 | Novo Nordisk A/S | Solid compositions comprising a pcsk9 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| CN115461044B (zh) * | 2020-04-29 | 2025-06-10 | 诺和诺德股份有限公司 | 包含glp-1激动剂和组氨酸的固体组合物 |
| ES3030918T3 (en) | 2020-05-29 | 2025-07-02 | Sciwind Biosciences Co Ltd | N-[8-(2-hydroxybenzoyl)amino]potassium octanoate crystal polymorph, and preparation method therefor and use thereof |
| CN113735733B (zh) * | 2020-05-29 | 2024-04-26 | 杭州先为达生物科技股份有限公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途 |
| IL299701A (en) | 2020-07-22 | 2023-03-01 | Novo Nordisk As | GLP-1 and GIP receptor co-agonists suitable for oral administration |
| CN112274633B (zh) * | 2020-09-16 | 2023-11-07 | 广州新济薇娜生物科技有限公司 | 索马鲁肽降糖减重微针贴片及其制备方法和应用 |
| CN112062690A (zh) * | 2020-11-11 | 2020-12-11 | 北京先为达生物科技有限公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途 |
| CR20230308A (es) | 2020-12-11 | 2023-09-08 | Civi Biopharma Inc | Entrega oral de conjugados antisentido que tienen por blanco a pcsk9 |
| TWI850611B (zh) | 2020-12-18 | 2024-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
| FR3120189B1 (fr) | 2021-03-01 | 2024-11-29 | Farid Bennis | Composition pharmaceutique pour une administration par voie orale d’un agoniste du récepteur du GLP-1 |
| JP7772778B2 (ja) | 2021-03-24 | 2025-11-18 | 塩野義製薬株式会社 | 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物 |
| WO2022221629A1 (en) | 2021-04-16 | 2022-10-20 | Navinta Iii Inc | Process for the preparation of highly pure salcaprozic acid and pharmaceutically acceptable salts thereof |
| US11667614B2 (en) | 2021-04-16 | 2023-06-06 | Navinta III Inc. | Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof |
| BR112023021766A2 (pt) | 2021-04-22 | 2024-01-23 | Civi Biopharma Inc | Dispensação oral de oligonucleotídeo |
| US20250276043A1 (en) * | 2021-06-25 | 2025-09-04 | Gan & Lee Pharmaceuticals Co., Ltd. | Pharmaceutical Composition Containing GLP-1 Compound |
| JP2024525377A (ja) | 2021-07-15 | 2024-07-12 | ノヴォ ノルディスク アー／エス | Ｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩を含む錠剤 |
| CA3223247A1 (en) | 2021-07-16 | 2023-01-19 | Thomas Kvistgaard Vilhelmsen | Sodium n-(8-(2- hydroxybenzoyl)amino)caprylate polymorphic form a |
| US20230053812A1 (en) * | 2021-07-27 | 2023-02-23 | Aurobindo Pharma Ltd | Stable peptide formulations for oral use |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| WO2023086499A1 (en) | 2021-11-10 | 2023-05-19 | I2O Therapeutics, Inc. | Ionic liquid compositions |
| EP4180060A1 (en) * | 2021-11-15 | 2023-05-17 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| EP4299057A1 (en) * | 2022-06-30 | 2024-01-03 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| CN119031930A (zh) * | 2022-02-24 | 2024-11-26 | 安提拉生物有限公司 | 包含酸中和聚合物用于口服胰高血糖素样肽-1及其类似物的制剂 |
| CN117241821B (zh) * | 2022-03-25 | 2024-04-09 | 北京质肽生物医药科技有限公司 | 多肽缀合物的药物组合物及其使用方法 |
| WO2024017139A1 (zh) * | 2022-07-20 | 2024-01-25 | 成都海博为药业有限公司 | 一种含有glp-1受体激动剂类似物的药物组合物 |
| JPWO2024063143A1 (cg-RX-API-DMAC7.html) | 2022-09-22 | 2024-03-28 | ||
| TW202421645A (zh) | 2022-11-25 | 2024-06-01 | 丹麥商諾佛 儂迪克股份有限公司 | 如ｇｌｐ—１之肽治療劑的口服投與 |
| EP4642440A1 (en) | 2022-12-30 | 2025-11-05 | Algipharma As | Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration |
| WO2025017454A1 (en) * | 2023-07-14 | 2025-01-23 | Biophore India Pharmaceuticals Pvt. Ltd | Stable solid dispersions of salcaprozate with various active pharmaceutical ingredients |
| JP7755031B2 (ja) | 2023-11-30 | 2025-10-15 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１、ｇｉｐ、およびアミリン受容体の三重作動薬 |
| WO2025169190A2 (en) | 2024-02-06 | 2025-08-14 | Opko Biologics Ltd. | Modified oxyntomodulin and methods of use thereof |
| WO2025220032A1 (en) * | 2024-04-16 | 2025-10-23 | Bhami's Research Laboratory, Pvt. Ltd. | Polypeptide formulations for oral delivery |
| CN118319871B (zh) * | 2024-04-19 | 2025-08-05 | 鲁南新时代生物技术有限公司 | 一种司美格鲁肽药物组合物 |
Family Cites Families (192)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918098A (en) | 1986-03-12 | 1990-04-17 | American Cyanamid Company | Macrolide compounds |
| ES2113879T3 (es) | 1990-01-24 | 1998-05-16 | Douglas I Buckley | Analogos de glp-1 utiles para el tratamiento de diabetes. |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
| WO1994022467A1 (en) | 1993-03-29 | 1994-10-13 | University Of Cincinnati | Analogs of peptide yy and uses thereof |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5968899A (en) | 1994-06-03 | 1999-10-19 | Tsumura & Co. | Medicinal compositions of peptides with EACA or tranexamic acid for enhanced mucosal absorption |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| BR9604880A (pt) | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica |
| SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| DE69737479T4 (de) | 1996-08-30 | 2010-05-06 | Novo Nordisk A/S | Glp-1 derivate |
| AU4863797A (en) | 1996-11-12 | 1998-06-03 | Novo Nordisk A/S | Use of glp-1 peptides |
| WO1998020885A1 (en) | 1996-11-13 | 1998-05-22 | University Of Cincinnati | Analogs of peptide yy and uses thereof |
| US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| EP0908515A3 (en) | 1997-09-16 | 2000-04-26 | Smithkline Beecham Plc | Pancreatic polypeptide |
| EP1056775B1 (en) | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| ATE466027T1 (de) | 1998-02-27 | 2010-05-15 | Novo Nordisk As | Abkömmlinge von glp-1 analogen |
| WO1999043707A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
| JP2002508162A (ja) | 1998-02-27 | 2002-03-19 | ノボ ノルディスク アクティーゼルスカブ | Ｎ末端を短縮したｇｌｐ−１誘導体 |
| EP1061946B1 (en) | 1998-02-27 | 2004-04-28 | Novo Nordisk A/S | Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
| US6046167A (en) | 1998-03-25 | 2000-04-04 | University Of Cincinnati | Peptide YY analogs |
| ATE232200T1 (de) | 1998-06-08 | 2003-02-15 | Schering Corp | Neuropeptid y5-rezeptorantagonisten |
| SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| EP1306091A3 (en) | 1998-07-31 | 2003-05-21 | Novo Nordisk A/S | Stimulation of beta cell proliferation |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| CN100540566C (zh) | 1998-12-07 | 2009-09-16 | 研究及应用科学协会股份有限公司 | 胰高血糖素样肽-1的类似物 |
| AU3357800A (en) | 1999-02-05 | 2000-08-25 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
| WO2000048589A1 (en) | 1999-02-22 | 2000-08-24 | Emisphere Holdings, Inc. | Solid oral dosage form containing heparin or a heparinoid in combination with a carrier |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| JP2002537321A (ja) | 1999-02-22 | 2002-11-05 | エラン コーポレイション ピーエルスィー | 促進剤を含む固体経口剤形 |
| CN1372570A (zh) | 1999-04-30 | 2002-10-02 | 安米林药品公司 | 修饰的exendin和exendin激动剂 |
| CA2363712C (en) | 1999-05-17 | 2011-05-10 | Conjuchem Inc. | Long lasting insulinotropic peptides |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| GB9923436D0 (en) | 1999-10-04 | 1999-12-08 | American Home Prod | Pharmaceutical compositions |
| US6793934B1 (en) | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| WO2001092206A1 (en) | 2000-06-02 | 2001-12-06 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
| US7049283B2 (en) | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| AU2002228608A1 (en) | 2000-12-13 | 2002-06-24 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| US8273713B2 (en) | 2000-12-14 | 2012-09-25 | Amylin Pharmaceuticals, Llc | Methods of treating obesity using PYY[3-36] |
| US6589938B2 (en) | 2001-06-29 | 2003-07-08 | National University Of Singapore | Use of angiotensin I derivatives as an agent for the treatment and prevention of infarction-related cardiac injuries and disorders |
| US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| EP2022505B1 (en) | 2001-07-31 | 2011-12-14 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | GLP-1, exendin-4, peptide analogs and uses thereof |
| ATE419863T1 (de) | 2001-09-24 | 2009-01-15 | Imp Innovations Ltd | Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeit |
| AU2002352974A1 (en) | 2001-11-29 | 2003-06-10 | Emisphere Technologies, Inc. | Formulations for oral administration of cromolyn sodium |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| WO2003063838A1 (en) | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Dry granulated formulations of azithromycin |
| JP4417113B2 (ja) * | 2002-02-20 | 2010-02-17 | エミスフェアー・テクノロジーズ・インク | Ｇｌｐ−１分子の投与方法 |
| ES2327328T3 (es) | 2002-07-04 | 2009-10-28 | Zealand Pharma A/S | Glp-1 y procedimientos para el tratamiento de la diabetes. |
| JP2004131398A (ja) | 2002-10-08 | 2004-04-30 | Taihei Chemical Industrial Co Ltd | 錠剤用滑沢剤 |
| EP2277527A3 (en) | 2003-01-17 | 2011-08-31 | Ipsen Pharma | Peptide YY analogs |
| US20050059605A1 (en) | 2003-01-31 | 2005-03-17 | Krishna Peri | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
| US7557183B2 (en) | 2003-03-19 | 2009-07-07 | Eli Lilly And Company | Polyethylene glycol linked GLP-1 compounds |
| CA2525168A1 (en) | 2003-05-14 | 2004-12-02 | Emisphere Technologies, Inc. | Compositions for delivering peptide yy and pyy agonists |
| US7572581B2 (en) | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
| PL1651248T3 (pl) | 2003-07-11 | 2010-02-26 | Novartis Ag | Doustnie dawkowana kompozycja farmaceutyczna zawierająca środek dostarczający w postaci mikronizowanej |
| WO2005014049A2 (en) | 2003-08-08 | 2005-02-17 | Novo Nordisk A/S | Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides |
| JP2007537981A (ja) | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| JP4949838B2 (ja) | 2003-09-19 | 2012-06-13 | ノヴォ ノルディスク アー／エス | 新規ｇｌｐ−１誘導体 |
| CN100444898C (zh) | 2003-09-19 | 2008-12-24 | 诺沃挪第克公司 | 治疗肽的清蛋白结合型衍生物 |
| CN1882356B (zh) | 2003-11-20 | 2015-02-25 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
| EP1704165B1 (en) | 2003-12-18 | 2010-03-17 | Novo Nordisk A/S | Glp-1 compounds |
| AU2004298425A1 (en) | 2003-12-18 | 2005-06-30 | Novo Nordisk A/S | Novel GLP-1 analogues linked to albumin-like agents |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| EP1718665B1 (en) | 2004-02-11 | 2013-04-10 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| EP2335715A3 (en) | 2004-02-11 | 2013-12-18 | Amylin Pharmaceuticals, LLC | Pancreatic polypeptide family motifs and polypeptides comprising the same |
| CN101361967A (zh) | 2004-03-17 | 2009-02-11 | 7Tm制药联合股份有限公司 | 用于治疗性干预的y2/y4选择性受体激动剂 |
| CA2560174A1 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
| CA2560166A1 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y2/y4 selective receptor agonists for therapeutic interventions |
| EP1807099A2 (en) | 2004-03-17 | 2007-07-18 | 7TM Pharma A/S | Y2 selective receptor agonists for therapeutic interventions |
| WO2005099672A1 (en) | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | A modified release pharmaceutical formulation comprising amoxicillin and clavulanate |
| CN102040536B (zh) | 2004-05-06 | 2013-06-19 | 爱密斯菲尔科技公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸一钠的晶体的多晶 |
| JP2007536268A (ja) | 2004-05-06 | 2007-12-13 | エミスフェアー・テクノロジーズ・インク | 固体剤形の湿性ヘパリン |
| EP1756039B1 (en) * | 2004-05-14 | 2012-10-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| WO2005121090A1 (en) | 2004-06-02 | 2005-12-22 | Abbott Laboratories | Substituted piperidines that have antiangiogenic activity |
| TW200611704A (en) | 2004-07-02 | 2006-04-16 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
| US20070021346A1 (en) | 2005-05-26 | 2007-01-25 | Ewing William R | N-terminally modified GLP-1 receptor modulators |
| CN101010339B (zh) | 2004-07-02 | 2011-11-09 | 布里斯托尔-迈尔斯斯奎布公司 | 人类胰高血糖素样肽-1调节剂及它们在治疗糖尿病及相关病况中的用途 |
| ES2564167T3 (es) | 2004-07-08 | 2016-03-18 | Novo Nordisk A/S | Conjugados de polipéptidos de acción prolongada que contienen una fracción tetrazol |
| WO2006017251A2 (en) | 2004-07-12 | 2006-02-16 | Emisphere Technologies, Inc. | Compositions for delivering peptide yy and pyy agonists |
| US7994119B2 (en) | 2004-07-19 | 2011-08-09 | University Of Cincinnati | Compounds for control of appetite |
| EP1781257B1 (en) | 2004-08-13 | 2018-12-19 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
| WO2006049681A2 (en) | 2004-08-30 | 2006-05-11 | Bayer Pharmaceuticals Corporation | Selective neuropeptide y2 receptor agonists |
| US7893017B2 (en) | 2004-10-07 | 2011-02-22 | Novo Nordisk A/S | Protracted GLP-1 compounds |
| WO2006037811A2 (en) | 2004-10-07 | 2006-04-13 | Novo Nordisk A/S | Protracted exendin-4 compounds |
| RU2007126522A (ru) | 2004-12-09 | 2009-01-20 | Радиал Корпорэйшин Лимитед (Au) | Транспортировка материала для радиального пиления древесины |
| US7410949B2 (en) | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
| EP1843755B1 (en) | 2005-02-01 | 2015-04-01 | Emisphere Technologies, Inc. | Gastric retention and controlled release delivery system |
| EP1846446B1 (en) | 2005-02-02 | 2013-06-26 | Novo Nordisk A/S | Insulin derivatives |
| CA2599723A1 (en) | 2005-03-04 | 2006-09-14 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins |
| GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| WO2006097535A2 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Peptide agonists of the glucagon family with secretin like activity |
| KR20070120112A (ko) | 2005-03-18 | 2007-12-21 | 노보 노르디스크 에이/에스 | 연장형 ｇｌｐ-1 화합물 |
| TWI362392B (en) * | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| WO2006097536A2 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Dimeric peptide agonists of the glp-1 receptor |
| US20080260818A1 (en) | 2005-03-28 | 2008-10-23 | Dexcel Pharma Technologies Ltd. | Controlled Absorption of Statins in the Intestine |
| US20090054326A1 (en) | 2005-07-11 | 2009-02-26 | Nastech Pharmaceutical Company Inc. | Formulations for enhanced mucosal delivery of pyy |
| US8975227B2 (en) | 2005-07-15 | 2015-03-10 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
| KR20080031414A (ko) | 2005-07-18 | 2008-04-08 | 노보 노르디스크 에이/에스 | 비만치료에 사용하기 위한 신규 펩티드 |
| PT3524261T (pt) | 2005-08-19 | 2024-01-12 | Amylin Pharmaceuticals Llc | Exendina para o tratamento da diabetes e redução do peso corporal |
| US20070049557A1 (en) | 2005-08-24 | 2007-03-01 | Hashim Ahmed | Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers |
| CA2623094A1 (en) | 2005-09-21 | 2007-04-12 | 7Tm Pharma A/S | Y2 selective receptor agonists for therapeutic interventions |
| BRPI0520563A2 (pt) | 2005-09-21 | 2009-05-19 | 7Tm Pharma As | agonistas de receptores y4 seletivos para intervenções terapêuticas |
| WO2007061434A2 (en) | 2005-11-10 | 2007-05-31 | Nastech Pharmaceutical Company Inc. | A pharmaceutical formulation of glp-1 and its use for treating a metabolic syndrome |
| KR101432313B1 (ko) | 2005-11-17 | 2014-08-20 | 노파르티스 아게 | 약제학적 조성물 |
| RU2430108C2 (ru) | 2005-12-07 | 2011-09-27 | Ф.Хоффманн-Ля Рош Аг | Агонисты рецептора нейропептида-2 |
| BRPI0620571A2 (pt) | 2005-12-08 | 2011-11-22 | Nastech Pharm Co | formulação farmacêutica aquosa, forma de dosagem de exendina, solução aquosa, uso de uma formulação farmacêutica, e uso de uma formulação farmacêutica aquosa |
| US20100029903A1 (en) | 2005-12-14 | 2010-02-04 | Novo Nordisk A/S | Polypeptide Protracting Tags |
| US20070197445A1 (en) | 2006-01-18 | 2007-08-23 | University Of Cincinnati | Compounds for control of appetite |
| JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
| BRPI0710503A2 (pt) | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| EP2386572B1 (en) | 2006-05-09 | 2015-07-08 | Novo Nordisk A/S | Insulin derivative |
| JP2009539862A (ja) | 2006-06-09 | 2009-11-19 | メリオン リサーチ Ｉｉｉ リミテッド | 強化剤を含む固体経口投与剤形 |
| EP2040718B1 (en) | 2006-06-28 | 2017-12-27 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| ES2296529B1 (es) | 2006-08-07 | 2009-04-01 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con promotores de absorcion. |
| EP2057189B1 (en) | 2006-08-25 | 2013-03-06 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| JP5021033B2 (ja) | 2006-09-07 | 2012-09-05 | エフ．ホフマン−ラ ロシュ アーゲー | Ｓｎａｃ（サルカプロザートナトリウム）の製造法 |
| PE20121528A1 (es) | 2006-09-13 | 2012-12-12 | Smithkline Beecham Corp | Metodos para administrar agentes hipoglucemiantes de larga duracion |
| AR062925A1 (es) | 2006-09-22 | 2008-12-17 | Novartis Ag | Metodo para fabricar tabletas que contienen agentes farmacologicamente activos |
| GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
| WO2008070547A1 (en) | 2006-12-01 | 2008-06-12 | Emisphere Technologies Inc. | Improved acyclovir formulations |
| US20090099074A1 (en) | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| US20100022446A1 (en) | 2007-01-18 | 2010-01-28 | Novo Nordisk A/S | Use of Peptides in Combination with Surgical Intervention for the Treatment of Obesity |
| WO2008087186A2 (en) | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| PL2131810T3 (pl) | 2007-03-02 | 2011-09-30 | Novartis Ag | Podawanie doustne kalcytoniny |
| GB0708226D0 (en) | 2007-04-27 | 2007-06-06 | 7Tm Pharma As | Y-receptor agonists |
| JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー／エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
| WO2008154619A1 (en) | 2007-06-12 | 2008-12-18 | Smithkline Beecham Corporation | Methods for detecting protein in plasma |
| US20100279930A1 (en) | 2007-07-09 | 2010-11-04 | Stephen Robert Bloom | Human pancreatic polypeptide (hpp) analogues and their effects on feeding behaviour |
| US20110183889A1 (en) | 2007-08-29 | 2011-07-28 | The Regents Of The University Of California | Salicylanilide modified peptides for use as oral therapeutics |
| WO2009030771A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| WO2009030738A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| CN101842386A (zh) | 2007-09-05 | 2010-09-22 | 诺沃-诺迪斯克有限公司 | 截短的glp-1衍生物和它们的治疗用途 |
| CA2699083A1 (en) | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| WO2009042922A2 (en) | 2007-09-27 | 2009-04-02 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of making and using same |
| MX2010003979A (es) | 2007-10-16 | 2010-06-02 | Biocon Ltd | Composicion farmaceutica oralmente administrable y proceso para su preparacion. |
| MX2010004716A (es) | 2007-11-02 | 2010-12-17 | Emisphere Tech Inc | Metodo para tratar la deficiencia de vitamina b12. |
| US20090124639A1 (en) | 2007-11-06 | 2009-05-14 | Emisphere Technologies Inc. | valacyclovir formulations |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| US20110275559A1 (en) | 2008-05-16 | 2011-11-10 | Novo Nordisk A/S | Long-Acting Y2 and/or Y4 Receptor Agonists |
| NZ591497A (en) | 2008-08-18 | 2012-11-30 | Entera Bio Ltd | A compositions comprising a protein, a protease inhibitor and N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC) or N-(10[2-hydroxybenzoyl]amino)decanoate (SNAD) for diabetes mellitus treatment |
| CN102149411A (zh) | 2008-09-12 | 2011-08-10 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| US8299023B2 (en) | 2008-09-17 | 2012-10-30 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists |
| GB0817067D0 (en) | 2008-09-18 | 2008-10-22 | 7Tm Pharma As | Intestinal treatment |
| DK2271219T3 (da) | 2008-10-15 | 2012-03-05 | Bayer Cropscience Ag | Anvendelse af dithiin-tetracarboximider til bekæmpelse af fytopatogene svampe |
| BRPI0921230A2 (pt) | 2008-11-05 | 2018-10-30 | Hoffmann La Roche | agonistas de receptor de neuropeptídeos-2 (y-2r) e usos dos mesmo. |
| CN101463081B (zh) | 2009-01-12 | 2012-07-04 | 华东师范大学 | 一种glp-1衍生物 |
| CN117547538A (zh) * | 2009-02-13 | 2024-02-13 | 勃林格殷格翰国际有限公司 | 包含dpp-4抑制剂(利格列汀)任选地组合其它抗糖尿病药的抗糖尿病药物 |
| CA2752608A1 (en) | 2009-02-20 | 2010-08-26 | Ipsen Pharma S.A.S. | Cytotoxic conjugates having neuropeptide y receptor binding compound |
| ITRM20090347A1 (it) | 2009-07-03 | 2011-01-04 | Univ Siena | Dispositivo di analisi del sistema nervoso centrale attraverso l applicazione di stimoli di diversa natura combinati tra loro e lo studio delle corrispondenti reazioni. |
| AR077956A1 (es) | 2009-09-14 | 2011-10-05 | Bayer Cropscience Ag | Combinaciones de compuestos activos |
| EP2477643A1 (en) | 2009-09-18 | 2012-07-25 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| CN102596228A (zh) | 2009-10-13 | 2012-07-18 | 霍夫曼-拉罗奇有限公司 | 神经肽-2受体(y-2r)激动剂 |
| JP2013510829A (ja) | 2009-11-13 | 2013-03-28 | ノヴォ ノルディスク アー／エス | 長時間作用型ｙ２受容体アゴニスト |
| CN102791731B (zh) | 2009-12-16 | 2016-04-20 | 诺沃—诺迪斯克有限公司 | Glp-1类似物和衍生物 |
| AU2010339907A1 (en) | 2009-12-16 | 2012-07-05 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
| US20110182985A1 (en) | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| WO2011109787A1 (en) | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Methods of administering insulinotropic peptides |
| WO2011116139A2 (en) | 2010-03-16 | 2011-09-22 | Chiasma Inc. | Improved pharmaceutical compositions and methods of delivery |
| WO2011131646A1 (en) | 2010-04-20 | 2011-10-27 | Novo Nordisk A/S | Long-acting gastrin derivatives |
| KR20130093470A (ko) | 2010-04-30 | 2013-08-22 | 가부시키가이샤산와카가쿠켄큐쇼 | 생리활성 물질 등의 생체 내 안정성 향상을 위한 펩티드 및 생체 내 안정성이 향상된 생리활성 물질 |
| CN107961377B (zh) | 2010-05-05 | 2022-11-22 | 勃林格殷格翰国际有限公司 | 组合疗法 |
| DE202010015867U1 (de) | 2010-11-25 | 2011-05-05 | Buchhalter, Thomas | Elektromechanische Halterung zur Aufnahme von Navigations- und Kommunikationsgeräte im KFZ |
| PT2651398T (pt) | 2010-12-16 | 2018-03-09 | Novo Nordisk As | Composições sólidas compreendendo um agonista de glp-1 e um sal de ácido n-(8-(2-hidroxibenzoil)amino) caprílico |
| GB201101459D0 (en) | 2011-01-27 | 2011-03-16 | Imp Innovations Ltd | Novel compounds and thier effects on fedding behaviour |
| MY161450A (en) | 2011-04-12 | 2017-04-14 | Novo Nordisk As | Double-acylated glp-1 derivatives |
| EP2729481B1 (en) | 2011-07-08 | 2018-10-17 | Amylin Pharmaceuticals, LLC | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
| DK2827845T3 (en) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
| EP2827845B1 (en) | 2012-03-22 | 2018-12-26 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
| EP4324475A1 (en) | 2012-03-22 | 2024-02-21 | Novo Nordisk A/S | Compositions of glp-1 peptides and preparation thereof |
| EP2855517A1 (en) | 2012-05-29 | 2015-04-08 | Novo Nordisk A/S | Pancreatic polypeptide compounds and use |
| CN104487056A (zh) | 2012-06-20 | 2015-04-01 | 诺和诺德A/S（股份有限公司） | 包含肽和递送剂的片剂制剂 |
| JP6059802B2 (ja) | 2012-07-01 | 2017-01-11 | ノヴォ ノルディスク アー／エス | 長時間作用型ｇｌｐ−１ペプチドの使用 |
| PL2991671T3 (pl) | 2013-05-02 | 2019-01-31 | Novo Nordisk As | Doustne dawkowanie związków glp-1 |
| SG11201508469YA (en) | 2013-05-02 | 2015-11-27 | Glaxosmithkline Ip Dev Ltd | Therapeutic peptides |
| WO2015071355A1 (en) | 2013-11-15 | 2015-05-21 | Novo Nordisk A/S | Selective pyy compounds and uses thereof |
| CN105764919B (zh) | 2013-11-15 | 2021-04-27 | 诺和诺德股份有限公司 | 在位置35具有β-高精氨酸置换的hPYY(1-36) |
| WO2016128970A1 (en) | 2015-02-09 | 2016-08-18 | Entera Bio Ltd. | Treatment of hypoparathyroidism |
| TWI694082B (zh) | 2015-06-12 | 2020-05-21 | 丹麥商諾佛 儂迪克股份有限公司 | 選擇性ｐｙｙ化合物及其用途 |
| CA2997343A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
| JP6898518B2 (ja) | 2018-02-02 | 2021-07-07 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アゴニスト、ｎ−（８−（２−ヒドロキシベンゾイル）アミノ）カプリル酸の塩及び滑沢剤を含む固形組成物 |
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