CA2751220A1 - Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function - Google Patents
Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function Download PDFInfo
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- CA2751220A1 CA2751220A1 CA2751220A CA2751220A CA2751220A1 CA 2751220 A1 CA2751220 A1 CA 2751220A1 CA 2751220 A CA2751220 A CA 2751220A CA 2751220 A CA2751220 A CA 2751220A CA 2751220 A1 CA2751220 A1 CA 2751220A1
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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| PCT/US2010/025611 WO2010099458A1 (en) | 2009-02-27 | 2010-02-26 | Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function |
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| NZ565059A (en) | 2005-07-25 | 2011-08-26 | Intermune Inc | Novel macrocyclic inhibitors of hepatitus C virus replication |
| GEP20104956B (en) * | 2005-10-11 | 2010-04-12 | Array Biopharma Inc | Compounds for inhibiting hepatitis c viral replication and use thereof |
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
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| KR101848099B1 (ko) | 2009-09-21 | 2018-04-11 | 길리애드 사이언시즈, 인코포레이티드 | 1'-치환된 카바-뉴클레오사이드 유사체의 제조를 위한 방법 및 중간체 |
| KR20200052384A (ko) | 2010-07-19 | 2020-05-14 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
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| WO2012062691A1 (en) * | 2010-11-09 | 2012-05-18 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions for treating hcv infections |
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| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
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| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| MX2014014878A (es) * | 2012-06-12 | 2015-04-08 | Hoffmann La Roche | Combinacion de agentes terapueticos para tratar infeccion por el virus de la hepatitis c (hcv). |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| PT2897611T (pt) * | 2012-09-18 | 2019-11-27 | Abbvie Inc | Métodos para tratamento da hepatite c |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| EP4667053A2 (en) | 2015-03-06 | 2025-12-24 | ATEA Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| BR122020020217B1 (pt) | 2015-09-16 | 2021-08-17 | Gilead Sciences, Inc | Uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por arenaviridae |
| US11192914B2 (en) | 2016-04-28 | 2021-12-07 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
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| CN106674224A (zh) * | 2016-12-20 | 2017-05-17 | 天津迈德新医药科技有限公司 | mPEG4‑阿巴卡韦及其制备方法和应用 |
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| JP2021521118A (ja) | 2018-04-10 | 2021-08-26 | アテア ファーマシューティカルズ， インコーポレイテッド | 肝硬変を伴うｈｃｖ感染患者の治療 |
| EP4096678A1 (en) | 2020-01-27 | 2022-12-07 | Gilead Sciences, Inc. | Methods for treating sars cov-2 infections |
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| US11701372B2 (en) | 2020-04-06 | 2023-07-18 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs |
| PL4157272T3 (pl) | 2020-05-29 | 2025-10-20 | Gilead Sciences, Inc. | Remdesiwir do leczenia zakażeń wirusowych |
| TWI819321B (zh) | 2020-06-24 | 2023-10-21 | 美商基利科學股份有限公司 | 1'-氰基核苷類似物及其用途 |
| DK4204421T3 (da) | 2020-08-27 | 2024-05-27 | Gilead Sciences Inc | Forbindelser og fremgangsmåder til behandling af virale infektioner |
| AU2022291927A1 (en) | 2021-06-17 | 2024-01-04 | Atea Pharmaceuticals, Inc. | Advantageous anti-hcv combination therapy |
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- 2010-02-23 AR ARP100100517A patent/AR075584A1/es unknown
- 2010-02-26 KR KR1020117021515A patent/KR20110135941A/ko not_active Ceased
- 2010-02-26 NZ NZ594524A patent/NZ594524A/xx not_active IP Right Cessation
- 2010-02-26 BR BRPI1009338A patent/BRPI1009338A2/pt not_active IP Right Cessation
- 2010-02-26 JP JP2011552194A patent/JP2012519181A/ja active Pending
- 2010-02-26 TW TW99105744A patent/TWI473810B/zh not_active IP Right Cessation
- 2010-02-26 US US13/203,334 patent/US20120128628A1/en not_active Abandoned
- 2010-02-26 MA MA34087A patent/MA33236B1/fr unknown
- 2010-02-26 US US12/713,497 patent/US8735345B2/en not_active Expired - Fee Related
- 2010-02-26 RU RU2011139180/15A patent/RU2011139180A/ru unknown
- 2010-02-26 EP EP10706121A patent/EP2400966A1/en not_active Withdrawn
- 2010-02-26 CN CN2010800099017A patent/CN102361641A/zh active Pending
- 2010-02-26 AU AU2010217818A patent/AU2010217818A1/en not_active Abandoned
- 2010-02-26 SG SG2011059904A patent/SG173774A1/en unknown
- 2010-02-26 CA CA2751220A patent/CA2751220A1/en not_active Abandoned
- 2010-02-26 PE PE2011001548A patent/PE20120777A1/es not_active Application Discontinuation
- 2010-02-26 MX MX2011008980A patent/MX2011008980A/es active IP Right Grant
- 2010-02-26 WO PCT/US2010/025611 patent/WO2010099458A1/en not_active Ceased
-
2011
- 2011-08-21 IL IL214760A patent/IL214760A0/en unknown
- 2011-08-23 CR CR20110453A patent/CR20110453A/es not_active Application Discontinuation
- 2011-08-25 CO CO11108893A patent/CO6410304A2/es not_active Application Discontinuation
- 2011-08-26 CL CL2011002082A patent/CL2011002082A1/es unknown
- 2011-08-26 EC EC2011011292A patent/ECSP11011292A/es unknown
-
2015
- 2015-03-03 JP JP2015041648A patent/JP2015098501A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MA33236B1 (fr) | 2012-05-02 |
| CR20110453A (es) | 2011-12-08 |
| JP2015098501A (ja) | 2015-05-28 |
| US8735345B2 (en) | 2014-05-27 |
| SG173774A1 (en) | 2011-09-29 |
| CL2011002082A1 (es) | 2012-04-13 |
| TW201035099A (en) | 2010-10-01 |
| WO2010099458A1 (en) | 2010-09-02 |
| AR075584A1 (es) | 2011-04-20 |
| IL214760A0 (en) | 2011-11-30 |
| US20120128628A1 (en) | 2012-05-24 |
| CN102361641A (zh) | 2012-02-22 |
| NZ594524A (en) | 2013-09-27 |
| EP2400966A1 (en) | 2012-01-04 |
| KR20110135941A (ko) | 2011-12-20 |
| BRPI1009338A2 (pt) | 2016-11-01 |
| CO6410304A2 (es) | 2012-03-30 |
| TWI473810B (zh) | 2015-02-21 |
| RU2011139180A (ru) | 2013-04-10 |
| JP2012519181A (ja) | 2012-08-23 |
| AU2010217818A1 (en) | 2011-08-18 |
| PE20120777A1 (es) | 2012-06-27 |
| ECSP11011292A (es) | 2011-12-30 |
| MX2011008980A (es) | 2011-11-18 |
| US20100221217A1 (en) | 2010-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150223 |
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| FZDE | Discontinued |
Effective date: 20170227 |