CA2560489C - Pyranone compounds useful to treat retroviral infections - Google Patents

Pyranone compounds useful to treat retroviral infections Download PDF

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Publication number
CA2560489C
CA2560489C CA002560489A CA2560489A CA2560489C CA 2560489 C CA2560489 C CA 2560489C CA 002560489 A CA002560489 A CA 002560489A CA 2560489 A CA2560489 A CA 2560489A CA 2560489 C CA2560489 C CA 2560489C
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CA
Canada
Prior art keywords
methyl
phenyl
formula
hydroxy
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002560489A
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English (en)
French (fr)
Other versions
CA2560489A1 (en
Inventor
Karen Rene Romines
Gordon L. Bundy
Theresa M. Schwartz
Ruben A. Tommasi
Joseph Walter Strohbach
Steven Ronald Turner
Suvit Thaisrivongs
Paul Adrian Aristoff
Paul D. Johnson
Harvey Irving Skulnick
Louis L. Skaletzky
David John Anderson
Joel Morris
Ronald B. Gammill
George P. Luke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of CA2560489A1 publication Critical patent/CA2560489A1/en
Application granted granted Critical
Publication of CA2560489C publication Critical patent/CA2560489C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002560489A 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections Expired - Lifetime CA2560489C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23881794A 1994-05-06 1994-05-06
US238,817 1994-05-06
US34936194A 1994-12-02 1994-12-02
US349,361 1994-12-02
CA002187523A CA2187523C (en) 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002187523A Division CA2187523C (en) 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections

Publications (2)

Publication Number Publication Date
CA2560489A1 CA2560489A1 (en) 1995-11-16
CA2560489C true CA2560489C (en) 2010-01-12

Family

ID=26931995

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002560489A Expired - Lifetime CA2560489C (en) 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections
CA002187523A Expired - Lifetime CA2187523C (en) 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002187523A Expired - Lifetime CA2187523C (en) 1994-05-06 1995-05-04 Pyranone compounds useful to treat retroviral infections

Country Status (32)

Country Link
US (2) US5852195A (OSRAM)
EP (1) EP0758327B1 (OSRAM)
JP (1) JP3883206B2 (OSRAM)
KR (1) KR100445929B1 (OSRAM)
CN (2) CN1329378C (OSRAM)
AT (1) ATE236894T1 (OSRAM)
AU (2) AU701965B2 (OSRAM)
BR (1) BR9507615A (OSRAM)
CA (2) CA2560489C (OSRAM)
CO (1) CO4810313A1 (OSRAM)
CZ (1) CZ296515B6 (OSRAM)
DE (2) DE122006000014I2 (OSRAM)
DK (1) DK0758327T3 (OSRAM)
ES (1) ES2192201T3 (OSRAM)
FI (1) FI117387B (OSRAM)
FR (1) FR05C0047I2 (OSRAM)
HU (1) HU228057B1 (OSRAM)
IL (3) IL129871A (OSRAM)
LU (1) LU91220I2 (OSRAM)
MX (1) MX9605391A (OSRAM)
MY (2) MY127701A (OSRAM)
NL (1) NL300216I2 (OSRAM)
NO (2) NO315799B1 (OSRAM)
NZ (1) NZ285510A (OSRAM)
PE (1) PE23196A1 (OSRAM)
PL (1) PL190540B1 (OSRAM)
PT (1) PT758327E (OSRAM)
RU (1) RU2139284C1 (OSRAM)
SI (1) SI0758327T1 (OSRAM)
SK (1) SK284407B6 (OSRAM)
TW (1) TW504507B (OSRAM)
WO (1) WO1995030670A2 (OSRAM)

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