CA2539117A1 - Inhibitors of histone deacetylase - Google Patents

Inhibitors of histone deacetylase Download PDF

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Publication number
CA2539117A1
CA2539117A1 CA002539117A CA2539117A CA2539117A1 CA 2539117 A1 CA2539117 A1 CA 2539117A1 CA 002539117 A CA002539117 A CA 002539117A CA 2539117 A CA2539117 A CA 2539117A CA 2539117 A1 CA2539117 A1 CA 2539117A1
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Canada
Prior art keywords
6alkyl
alkyl
4alkyl
aminoc1
hydroxyc1
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Abandoned
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CA002539117A
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English (en)
French (fr)
Inventor
Oscar Moradei
Isabelle Paquin
Silvana Leit
Sylvie Frechette
Arkadii Vaisburg
Jeffrey M. Besterman
Pierre Tessier
Tammy C. Mallais
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Individual
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Publication of CA2539117A1 publication Critical patent/CA2539117A1/en
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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