PL2292611T3 - Nowa pochodna tiofenodiaminy mająca strukturę mocznikową - Google Patents

Nowa pochodna tiofenodiaminy mająca strukturę mocznikową

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Publication number
PL2292611T3
PL2292611T3 PL09750683T PL09750683T PL2292611T3 PL 2292611 T3 PL2292611 T3 PL 2292611T3 PL 09750683 T PL09750683 T PL 09750683T PL 09750683 T PL09750683 T PL 09750683T PL 2292611 T3 PL2292611 T3 PL 2292611T3
Authority
PL
Poland
Prior art keywords
urea structure
novel
derivative
thiophenediamine derivative
novel thiophenediamine
Prior art date
Application number
PL09750683T
Other languages
English (en)
Inventor
Hiroyuki Mogi
Hisashi Tajima
Noriko Mishina
Yusuke Yamazaki
Shinji Yoneda
Katsuhiko Watanabe
Junko Fujikawa
Minoru Yamamoto
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of PL2292611T3 publication Critical patent/PL2292611T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
PL09750683T 2008-05-23 2009-05-25 Nowa pochodna tiofenodiaminy mająca strukturę mocznikową PL2292611T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008134902 2008-05-23
EP09750683A EP2292611B1 (en) 2008-05-23 2009-05-25 Novel thiophenediamine derivative having urea structure
PCT/JP2009/059494 WO2009142321A1 (ja) 2008-05-23 2009-05-25 ウレア構造を有する新規チオフェンジアミン誘導体

Publications (1)

Publication Number Publication Date
PL2292611T3 true PL2292611T3 (pl) 2012-11-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL09750683T PL2292611T3 (pl) 2008-05-23 2009-05-25 Nowa pochodna tiofenodiaminy mająca strukturę mocznikową

Country Status (9)

Country Link
US (2) US8198271B2 (pl)
EP (1) EP2292611B1 (pl)
JP (1) JP2010001289A (pl)
KR (1) KR20110028262A (pl)
CN (1) CN102036978A (pl)
CA (1) CA2724357A1 (pl)
ES (1) ES2389754T3 (pl)
PL (1) PL2292611T3 (pl)
WO (1) WO2009142321A1 (pl)

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CN106977443A (zh) * 2017-04-24 2017-07-25 南昌大学 一类o‑苄基取代的异羟肟酸衍生物及其制备方法和药物的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005723A1 (en) 1988-11-24 1990-05-31 Yoshitomi Pharmaceutical Industries, Ltd. Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use
US5798380A (en) 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
CN1195547C (zh) 1998-08-17 2005-04-06 千寿制药株式会社 青光眼预防、治疗药
AU2002327627B2 (en) 2001-09-14 2006-09-14 Methylgene Inc. Inhibitors of histone deacetylase
RU2324483C2 (ru) * 2002-11-12 2008-05-20 Алькон, Инк. Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз
TW200426138A (en) * 2002-12-10 2004-12-01 Hoffmann La Roche Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
WO2004065354A1 (en) 2003-01-17 2004-08-05 Topotarget Uk Limited Carbamic acid compounds comprising an ester or ketone linkage as hdac inhibitors
WO2005030704A1 (en) 2003-09-24 2005-04-07 Methylgene, Inc. Inhibitors of histone deacetylase
JP2005272419A (ja) 2004-03-26 2005-10-06 Nippon Kayaku Co Ltd ヒストン脱アセチル化酵素阻害剤
WO2007100657A2 (en) * 2006-02-28 2007-09-07 Merck & Co., Inc. Inhibitors of histone deacetylase
ES2375522T3 (es) 2006-12-26 2012-03-01 Santen Pharmaceutical Co., Ltd Nuevo derivado de n-(2-aminofenil)benzamida con estructura urea.
CA2680517A1 (en) 2007-03-28 2008-10-02 Santen Pharmaceutical Co., Ltd. Novel pyridinecarboxylic acid (2-aminophenyl)amide derivative having urea structure
KR20090125209A (ko) 2007-03-28 2009-12-03 산텐 세이야꾸 가부시키가이샤 히스톤 탈아세틸화 효소 저해 작용을 갖는 화합물을 유효 성분으로서 함유하는 안압 하강제

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JP2010001289A (ja) 2010-01-07
EP2292611A4 (en) 2011-06-22
CN102036978A (zh) 2011-04-27
EP2292611B1 (en) 2012-07-25
US20120202808A1 (en) 2012-08-09
US8288380B2 (en) 2012-10-16
CA2724357A1 (en) 2009-11-26
US8198271B2 (en) 2012-06-12
ES2389754T3 (es) 2012-10-31
WO2009142321A1 (ja) 2009-11-26
EP2292611A1 (en) 2011-03-09
US20110077244A1 (en) 2011-03-31

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